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| 1 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 2 | Influence of microbial community structure of seed sludge on the properties of aerobic nitrifying granules显示文摘In order to evaluate the influence of microbial community structure of seed sludge on the properties of aerobic nitrifying granules, these granules were cultivated with different seed sludge, and the variation of microbial community and dominant bacterial groups that impact the nitrogen removal efficiency of the aerobic nitrifying granules were analyzed and identified using 16 s rDNA sequence and denaturing gradient gel electrophoresis(DGGE) profiles. The results presented here demonstrated that the influence of the community structure of seed sludge on the properties of aerobic nitrifying granules was remarkable, and the granules cultivated by activated sludge from a beer wastewater treatment plant showed better performance, with a stable sludge volume index(SVI) value of 20 m L/g, high extracellular polymeric substance(EPS) content of 183.3 mg/L, high NH4+-N removal rate of 89.42% and abundant microbial population with 10 dominant bacterial groups. This indicated that activated sludge with abundant communities is suitable for use as seed sludge in culturing aerobic nitrifying granules. | Zhiwei Song Ting Li Qiuxu Wang Yu Pan Lixin Li | 2015 | Journal of Environmental Sciences2015，27，9： | 4 |
| 3 | CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects显示文摘The protein composition of cerebrospinal fluid(CSF) in neural tube defects(NTDs) remains unknown. We investigated the protein composition of CSF from 9 infants with NTDs using isobaric tags for relative and absolute quantitation(iTRAQ). We identified 568 proteins in the CSF of infants with spina bifida, which is the most common type of NTD. Among these, 18 proteins were associated with neural tube closure in the CSF during human embryonic neurulation and 5 were involved in NTDs. Based on these results, an animal model was further utilized to investigate early serum biomarkers for NTDs.We found that the myristoylated alanine-rich C-kinase substrate, Kunitz-type protease inhibitor 2, andapolipoprotein B-100 protein levels were decreased in both embryos and the sera of pregnant Sprague-Dawley rats carrying embryos with NTDs. CSF proteins may be useful in the discovery of potential serum biomarkers for NTDs. | Xinyu Yan Lixin Mai Changchun Lin Wenji He Gengsheng Yin Jiakang Yu Lian Huang Sanqiang Pan | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 4 | Numerical simulation of wellbore and formation temperature fields in carbonate formations during drilling and shut-in in the presence of lost circulation显示文摘Temperature curves reflect geothermal gradients and local temperature anomalies, thus providing a new understanding of the underground reservoir conditions. When encountering caverns or fractures and fissures during drilling, lost circulation may occur and result in a change to the original formation temperature field, and in severe cases, even the conventional open hole well logging data cannot be obtained. This paper uses finite element analysis software COMSOL to establish a heat transfer model for the wellbore/reservoir formation system during drilling and shut-in in the presence of lost circulation, and a case study is made in a carbonate reservoir in the Tahe oilfield. On the basis of the above, we analyze the temperature distribution in the leakage zone, and the studies have shown that the leakage and petrophysical properties have an impact on the temperature of the wellbore and formation, hence we can estimate the reservoir permeability using the temperature data. In addition, the determination of the temperature recovery time after some drilling fluids have leaked into the formation will help in recognizing the subsurface temperature field of the carbonate formation correctly, thus enhancing production logging interpretation accuracy and improving the understanding of later measurements. | Pan Baozhi Li Ding Chen Gang Wang Qincong Ma Lixin Liu Sihui | 2014 | Petroleum Science2014，11，2： | 3 |
| 5 | Identification of cancer patients using claims data from health insurance systems: A real-world comparative study显示文摘Objective: To evaluate the accuracy of identifying cancer patients by use of medical claims data in a health insurance system in China, and provide the basis for establishing the claims-based cancer surveillance system in China.Methods: We chose Hua County, Henan Province as the study site, and randomly selected 300 and 1,200 qualified inpatient electronic medical records(EMRs) as well as the New Rural Cooperative Medical Scheme(NCMS) claims records for cancer patients in Hua County People’s Hospital(HCPH) and Anyang Cancer Hospital(ACH) in 2017. Diagnostic information for NCMS claims was evaluated on an individual level, and sensitivity and positive predictive value(PPV) were calculated taking the EMRs as the gold standard.Results: The sensitivity of NCMS was 95.2%(93.8%-96.3%) and 92.0%(88.3%-94.8%) in ACH and HCPH,respectively. The PPV of the NCMS was 97.8%(96.7%-98.5%) in ACH and 89.0%(84.9%-92.3%) in HCPH.Overall, the weighted and combined sensitivity and PPV of NCMS in Hua County was 93.1% and 92.1%,respectively. Significantly higher sensitivity and PPV in identifying patients with common cancers than noncommon cancers were detected in HCPH and ACH separately(P<0.01).Conclusions: Identification of cancer patients by use of the NCMS is accurate on individual level, and it is therefore feasible to conduct claims-based cancer surveillance in areas not covered by cancer registries in China. | Hongrui Tian Ruiping Xu Fenglei Li Chuanhai Guo Lixin Zhang Zhen Liu Mengfei Liu Yaqi Pan Zhonghu He Yang Ke | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 6 | Using Evolutionary Computation to Solve Problems in Nonparametric Regression显示文摘This paper studies evolutionary mechanism of parameter selection in the construction of weightfunction for Nearest Neighbour Estimate in nonparametrlc regresslon. Construct an algorithm which adagetively evolves fine weight and makes good prediction about unknown points. The numerical experiments indicate that this method is errective. It is a meaningful discussion about practicability of nonparametric regression and methodology or adaptive model-building. | Ding Lixin Kang Lishan Chen Yuping Pan Zhengjun | 1998 | Wuhan University Journal of Natural Sciences1998，3，1： | 2 |
| 7 | Structure and performance of the circumfluent cyclone显示文摘 | WANG Weiwen ZHANG Pan WANG Lixin | 2010 | Powder Technology2010，200，3： | 1 |
| 8 | P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer显示文摘 | Lichao Sun Hai Hu Liang Peng Zhuan Zhou Xuan Zhao Jian Pan Lixin Sun Zhihua Yang Yuliang Ran | 2011 | The American Journal of Pathology2011，，： | 1 |
| 9 | Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrestin human gastric cancer cells显示文摘 | Jian Pan Hai Hu Zhuan Zhou Lichao Sun Liang Peng Long Yu Lixin Sun Jun Liu Zhihua Yang Yuliang Ran | 2010 | Oncology Reports2010，，1： | 1 |
| 10 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 11 | Combination of Haptoglobin and Osteopontin Could Predict Colorectal Cancer Hepatic Metastasis显示文摘 | Lichao Sun Jian Pan Liang Peng Lv Fang Xuan Zhao Lixin Sun Zhihua Yang Yuliang Ran | 2012 | Annals of Surgical Oncology2012，，7： | 1 |
| 12 | State of the art recent advances and perspectives in 2D MXenebased microwave absorbing materials:A review显示文摘Recently,great efforts have been made to explore high-performance microwave absorbing(MA)materials,which aim to reduce the booming electromagnetic wave(EMW)pollution caused by electronic devices.MXenes(i.e.,two-dimensional(2D)transition metal carbide/nitride),an emerging family of 2D nanomaterials,demonstrate superiority to conventional nanomaterials,such as tunable electrical conductivity,unique layer structure,abundant terminal groups,and great physico-chemical properties,becoming potential candidate materials for high-efficiency MA.By hybridizing MXenes with other lossy mediums and designing novel microstructures,MA properties can be further optimized and enhanced for practical applications.Furthermore,MXenebased materials,with smartly designed multi-functionality,become a research priority to develop new or advanced applications for the coming“intelligent era”.This review focuses on using MXenes to effectively absorb EMW energy.In the first part,the fabricating methods of MXenes are systematically introduced followed by a second part on the progress of MXene-based materials regarding the MA performances,as well as a summarization on their next-generation smart multifunctional materials.In the final part,opinions on the future perspectives and opportunities of MXene-based MA materials are presented.It is believed that this review will pave the way for further flourishing the development of MXene-based materials in MA field. | Hongtao Guo Xiao Wang Fei Pan Yuyang Shi Haojie Jiang Lei Cai Jie Cheng Xiang Zhang Yang Yang Lixin Li Zheng Xiu Dan Batalu Wei Lu | 2023 | Nano Research2023，16，7： | 1 |
| 13 | Laser remelting of plasma-sprayed conventional and nanostructured Al 2 O 3 –13<ce:hsp sp='0.25'/>wt.%TiO 2 coatings on titanium alloy显示文摘 | Chonggui Li You Wang Lixin Guo Junqi He Zhaoyi Pan Liang Wang | 2010 | Journal of Alloys and Compounds2010，，1： | 1 |
| 14 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 15 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 16 | Hydrothermal synthesis and photoluminescent properties of ZnO nanorods显示文摘 | Libo Fan Hongwei Song Te Li Lixin Yu Zhongxin Liu Guohui Pan Yanqiang Lei Xue Bai Tie Wang Zhuhong Zheng Xianggui Kong | 2006 | Journal of Luminescence2006，，： | 1 |
| 17 | Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy显示文摘 | Lixin Ma Liqiong Luo Haiquan Qiao Xuesong Dong Shangha Pan Hongchi Jiang Geoffrey W. Krissansen Xueying Sun | 2006 | Journal of Hepatology2006，，： | 1 |
| 18 | Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography- tandem mass spectrometry显示文摘 | ZHAO Yonggang ZHOU Lixin PAN Shengdong | 2014 | Journal of Chromatography A2014，1345，： | 1 |
| 19 | Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II显示文摘 | Wei Zhao Yulin Li Lixin Jia Lili Pan Huihua Li Jie Du | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 20 | High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors显示文摘The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development. | Yi Zang Mingbo Su Qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han Xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li | 2023 | Protein & Cell2023，14，1： | 0 |
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