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| 1 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 2 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 3 | Dynamic Reliability Model of Components under Random Load 显示文摘 | Wang Zheng Xie Liyang | 2008 | IEEE Transac- tions on Reliability2008，57，3： | 1 |
| 4 | System-level load-strength interference based reliability modeling of k-out-of-n system 显示文摘 | XIE Liyang ZHOU Jinyu HAO Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 5 | System -level Load strength Interference Based Reliability Modeling of k-out-of-n System显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 6 | Dynamic reliability model of components under random load 显示文摘 | Wang Zheng Xie Liyang | 2008 | IEEE Transactions on Reliability2008，57，3： | 1 |
| 7 | System-level loadstrength interference based reliability modeling of k-out-of-n system 显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 8 | A Knowledge - based Multi - dimension Discrete Common Cause Failure Model 显示文摘 | Liyang Xie | 1998 | Nuclear Engineering and Design1998，183，： | 1 |
| 9 | System-level load strength interference based reliability modeling of k-out-of-n system 显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 10 | Reliability analysis method of a solar array by using fault tree analysis and fuzzy reasoning Petri net显示文摘 | Jianing Wu Shaoze Yan Liyang Xie | 2011 | Acta Astronautica2011，，11： | 1 |
| 11 | Multi-crack growth/coalescence simulation and its role in passive component leak-before-break concept 显示文摘 | Liyang Xie | 1999 | Nuclear Engineering and Design1999，，194： | 1 |
| 12 | Reliability apportionment approach for spacecraft solar array u- sing fuzzy reasoning Petri net and fuzzy comprehensive evaluation显示文摘 | Wu Jianing Yan Shaoze Xie Liyang | 2012 | Acta Astronautica2012，76，： | 1 |
| 13 | System-level load-strength interference based reliability modeling of k-out-of n system显示文摘 | XIE Liyang ZHOU Jinyu HAO Changzhong | 2004 | Reliability Engineering and System Safety2004，84，3： | 1 |
| 14 | Pipe Segment Failure Dependenee Analysis and Syslem Failure Probability Estimation显示文摘 | Xie Liyang | 1998 | Pressure Vessel and Piping1998，76，： | 1 |
| 15 | Reliability analysis method of a solar array by using fault tree analysis and fuzzy reasoning Petri net显示文摘 | WU Jianing YAN Shaoze XIE Liyang | 2011 | Acta Astronautica2011，69，1112： | 1 |
| 16 | A knowledge based multi-dimension discrete CCF model显示文摘 | XIE Liyang | 1998 | Nuclear Engineering Design1998，183，： | 1 |
| 17 | System level load-strength interference based reliability modeling of k-out-of n system显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhao | | 0，，： | 1 |
| 18 | Systemlevel Load-strength Interference Based Reliability Modeling of k- out - of- n System显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 19 | Dynamic reliability modeling of systems with common cause failure under random load 显示文摘 | Wang Zheng Kang Rui Xie Liyang | 2009 | Maintenance and Reliability2009，，3： | 1 |
| 20 | System-level Load-strength Interference Based Reliability Modeling of k-out-of-n System显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
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