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| 1 | Preparation and characterization of a composite membrane based on the asphaltene component of coal显示文摘Asphaltene-ceramic composite membranes were fabricated from ceramic supports and an asphaltene component, which was obtained from the separation of coal to give a kind of new carbonaceous precursor material. Using SEM and thermogravimetric analysis to measure the microstructure and properties of the asphaltene component allowed the porosity, permeability, and retention ratios to be determined. The results show that the asphaltene component can be regarded as a good carbon membrane precursor material because of its high carbon content and strong bonding capacity. When ceramic supports are impregnated with asphaltene colloid the asphaltene easily combines with the support surface and forms a good carbonaceous film after carbonization. Little of the asphaltene component permeates into the internal pores of the ceramic support. Although the number of coats applied to the substrate had little affect on the porosity of the asphaltene-ceramic composite membranes the permeability varied depending upon the number of times the substrate was treated. The way bubbles escape from the film, and the phenomenon of coalescence, as affected by different film thicknesses also seem closely related to the number of coats. A composite membrane carbonized at a final temperature of 600 °C is relatively dense and the permeability of Fe(OH) 3 colloid through it is very low. A membrane fired at 800 °C is porous and its permeability and retention of Fe(OH) 3 colloid are 88 L/(m 2 h MPa) and 85.3%, respectively when the trans-membrane pressure is 0.22 MPa. | Zhang Liying Qin Zhihong Li Xinyan Chen Juan Liu Peng Wang Xiaoyan | 2011 | Mining Science and Technology2011，21，3： | 7 |
| 2 | Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase Ⅱ oocytes显示文摘Oocyte cryopreservation is widely used for clinical and social reasons.Previous studies have demonstrated that conventional slow-freezing cryopreservation procedures,but not storage time,can alter the gene expression profiles of frozen oocytes.Whether vitrification procedures and the related frozen storage durations have any effects on the transcriptomes of human metaphase Ⅱ oocytes remain unknown.Four women(30–32 years old)who had undergone IVF treatment were recruited for this study.RNA-Seq profiles of 3 fresh oocytes and 13 surviving vitrified-thawed oocytes(3,3,4,and 3 oocytes were cryostored for 1,2,3,and 12 months)were analyzed at a single-cell resolution.A total of 1987 genes were differentially expressed in the 13 vitrifiedthawed oocytes.However,no differentially expressed genes were found between any two groups among the 1-,2-,3-,and 12-month storage groups.Further analysis revealed that the aberrant genes in the vitrified oocytes were closely related to oogenesis and development.Our findings indicated that the effects of vitrification on the transcriptomes of mature human oocytes are induced by the procedure itself,suggesting that long-term cryostorage of human oocytes is safe. | Ying Huo Peng Yuan Qingyuan Qin Zhiqiang Yan Liying Yan Ping Liu Rong Li Jie Yan Jie Qiao | 2021 | Frontiers of Medicine2021，15，1： | 6 |
| 3 | Genetic analysis and preimplantation genetic diagnosis of Chinese Marfan syndrome patients显示文摘Marfan syndrome (MFS)(OMIM 154700) is a relatively common autosomal dominant genetic disease that causes skeletal, ocular, and cardiovascular defects and was first described by a French pediatrician in 1896 (Bitterman and Sponseller, 2017). Its prevalence rate is 1/3000—1/5000, and more than 25% of cases are sporadic (Chiu et al., 2014). Studies have shown that about 90% of MFS is caused by variants in the fibrillin-1 gene (FBN1, OMIM 134797). FBN1, located on chromosome 15q21.1, encodes a macromolecular glycoprotein-fibrin 1, which aggregates to form microfibers in the extracellular matrix and distributes in various human connective tissues, such as periosteum, vessel wall, and crystal suspensor ligament. Variants in FNB1 have been reported in 65 exons, but the relationship between genotype and phenotype remains rather unclear (Sakai et al., 2016). Studies have also shown that patients with MFS and similar diseases may have variants in other related genes such as members of the transforming growth factor beta receptor (TGFBR) family (Mizuguchi et al., 2004;Sakai et al., 2006;Bolar et al., 2012;De Cario et al., 2018). For better prevention and treatment of MFS as well as for suspected MFS patients, there is a strong need for efficient genetic testing for early diagnosis and differential diagnoses of patients with related phenotypes (Aubart et al., 2018). | Meng Qin Xiaohui Zhu Zhe Zhang Xuemin Li Zhiqiang Yan Yuqian Wang Shuo Guan Yihua He Wenxin Zhang Liying Yan Jie Qiao Xu Zhi | 2019 | Journal of Genetics and Genomics2019，46，6： | 6 |
| 4 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 5 | Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV显示文摘 | Min Ren Dongdong Qin Kai Li Jialin Qu Liying Wang Zengchan Wang Ailong Huang Hua Tang | 2012 | Antiviral Research2012，，3： | 1 |
| 6 | Validation and correction of sea surface salinity retrieval from SMAP显示文摘In this study, sea surface salinity(SSS) Level 3(L3) daily product derived from soil moisture active passive(SMAP)during the year 2016, was validated and compared with SSS daily products derived from soil Moisture and ocean salinity(SMOS) and in-situ measurements. Generally, the root mean square error(RMSE) of the daily SSS products is larger along the coastal areas and at high latitudes and is smaller in the tropical regions and open oceans. Comparisons between the two types of daily satellite SSS product revealed that the RMSE was higher in the daily SMOS product than in the SMAP, whereas the bias of the daily SMOS was observed to be less than that of the SMAP when compared with Argo floats data. In addition, the latitude-dependent bias and RMSE of the SMAP SSS were found to be primarily influenced by the precipitation and the sea surface temperature(SST). Then, a regression analysis method which has adopted the precipitation and SST data was used to correct the larger bias of the daily SMAP product. It was confirmed that the corrected daily SMAP product could be used for assimilation in high-resolution forecast models, due to the fact that it was demonstrated to be unbiased and much closer to the in-situ measurements than the original uncorrected SMAP product. | Sisi Qin Hui Wang Jiang Zhu Liying Wan Yu Zhang Haoyun Wang | 2020 | Acta Oceanologica Sinica2020，39，3： | 1 |
| 7 | Steady state creep of in-situ TiB plus La2O3 reinforced high temperature titanium matrix composite显示文摘 | XIAO Lii LU Wei-jie QIN Ji-ning CHEN Yi-fei ZHANG Di WANG Min-min ZHU Feng JI Bo | 2009 | Materials Science and Engineering A2009，499，12： | 1 |
| 8 | Geographic distribution and prevalence of human echinococcosis at the township level in the Tibet Autonomous Region显示文摘Background Echinococcosis,a zoonotic parasitic disease,is caused by larval stages of cestodes in the Echinococcus genus.Echinococcosis is highly prevalent in ten provinces/autonomous regions of western and northern China.In 2016,an epidemiological survey of Tibet Autonomous Region(TAR)revealed that the prevalence of human echinococcosis was 1.66%,which was much higher than the average prevalence in China(0.24%).Therefore,to improve on the current prevention and control measures,it is important to understand the prevalence and spatial distribution characteristics of human echinococcosis at the township level in TAR.Methods Data for echinococcosis cases in 2018 were obtained from the annual report system of echinococcosis of Tibet Center for Disease Control and Prevention.Diagnosis had been performed via B-ultrasonography.The epidemic status of echinococcosis in all townships in TAR was classified according to the relevant standards of population prevalence indices as defined in the national technical plan for echinococcosis control.Spatial scan statistics were performed to establish the geographical townships that were most at risk of echinococcosis.Results In 2018,a total of 16,009 echinococcosis cases,whose prevalence was 0.53%,were recorded in 74 endemic counties in TAR.Based on the order of the epidemic degree,all the 692 townships were classified from high to low degrees.Among them,127 townships had prevalence rates≥1%.The high prevalence of human echinococcosis in TAR,which is associated with a wide geographic distribution,is a medical concern.Approximately 94.65%of the villages and towns reported echinococcosis cases.According to spatial distribution analysis,the prevalence of human echinococcosis was found to be clustered,with the specific clustering areas being identified.The cystic echinococcosis primary cluster covered 88 townships,while that of alveolar echinococcosis’s covered 38 townships.Conclusions This study shows spatial distributions of echinococcosis with different epidemic degrees in 692 townships of TAR and high-risk cluster areas at the township level.Our findings indicate that strengthening the echinococcosis prevention and control strategies in TAR should directed at townships with a high prevalence and high-risk clustering areas. | Liying Wang Gongsang Quzhen Min Qin Zehang Liu Huasheng Pang Roger Frutos Laurent Gavotte | 2022 | Infectious Diseases of Poverty2022，11，1： | 1 |
| 9 | Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems显示文摘Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ecological importance in hypersaline ecosystems.As a crucial live food in aquaculture,brine shrimp cysts have become one of the most important aquatic products traded worldwide.However,our understanding of the biodiversity,prevalence and global connectedness of viruses in brine shrimp is still very limited.A total of 143 batches of brine shrimp(belonging to seven species)cysts were collected from six continents including 21 countries and more than 100 geographic locations worldwide during 1977–2019.In total,55 novel RNA viruses were identified,which could be assigned to 18 different viral families and related clades.Eleven viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA viruses.Phylogenetic analyses of the RNA-directed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and fungi.Remarkably,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ecological niche.A notable case was the novel brine shrimp noda-like virus 3,which shared 79.25%(RdRp)and 63.88%(capsid proteins)amino acid identity with covert mortality nodavirus(CMNV)that may cause losses in aquaculture.In addition,both virome composition and phylogenetic analyses revealed global connectedness in certain brine shrimp viruses,particularly among Asia and Northern America.This highlights the incredible species diversity of viruses in these ancient species and provides essential data for the prevalence of RNA viruses in the global aquaculture industry.More broadly,these findings provide novel insights into the previously unrecognized RNA virosphere in hypersaline ecosystems worldwide and demonstrate that human activity might have driven the global connectedness of brine shrimp viruses. | Xuan Dong Cixiu Li Yiting Wang Tao Hu Fan Zhang Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwynck Edward CHolmes Patrick Sorgeloos Liying Sui Jie Huang Weifeng Shi | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 10 | Current research status of tumor cell biomarker detection显示文摘With the annual increases in the morbidity and mortality rates of tumors,the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great importance.Biomarkers used for tumor cell detection in body fluids include circulating tumor cells,nucleic acids,protein markers,and extracellular vesicles.Among them,circulating tumor cells,circulating tumor DNA,and exosomes have high potential for the prediction,diagnosis,and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution;in addition,in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real time.Various techniques,such as enzyme-linked immunosorbent assays,immunoblotting,and mass spectrometry,have been widely used for the detection of these markers.Among them,the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity,rapid detection and portable operation.Herein,we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors,outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells,and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods. | Liying Jiang Xinyi Lin Fenghua Chen Xiaoyun Qin Yanxia Yan Linjiao Ren Hongyu Yu Lingqian Chang ang Wang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 11 | Application value of Qisexingtai hand diagnostic method in diagnosis of coronary artery disease显示文摘OBJECTIVE:To evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method in the diagnosis of coronary artery disease(CAD).METHODS:This was an investigator-initiated,prospective,multi-center,cross-sectional study.All the participants from three hospitals in China had been diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.We compared the two diagnostic methods to calculate the sensitivity,the specificity,the omission diagnostic rate,the mistaken diagnostic rate and accuracy in order to evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method for CAD.RESULTS:A total of 326 subjects were enrolled,diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.As a result,there were 166 positive cases according to Qisexingtai hand diagnostic method,and 131 positive cases according to coronary angiography.Compared with the results of coronary angiography,the sensitivity of Qisexingtai hand diagnostic method was 80.2%,the specificity was 68.7%,the omission diagnostic rate was 19.8%,the mistaken diagnostic rate was 31.3%,and the accuracy was 73.3%.Area under the receiver operating characteristic curve was estimated as 0.735 for all,and 0.718,0.735,0.783 for the three sub-centers.CONCLUSION:Qisexingtai hand diagnostic method with high accuracy and sensitivity has certain application value in the diagnosis of CAD. | LIU Qian ZHAO Zhupei GUO Hua WANG Shiheng HAO Mingzhao QIN Peijie WANG Liuqing LIU Xuechun ZHANG Fengxia AN Hong LI Yu SHI Xueqin ZHU Tingyu LIU Jianfeng WANG Liying XU Tao ZHANG Limei ZOU Xu | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 12 | Assessment of echinococcosis control in Tibet Autonomous Region,China显示文摘Background:In China the highest prevalence of echinococcosis is in Tibet Autonomous Region(TAR).The government has issued documents and implemented comprehensive prevention and control measures focusing on controlling the source of infection of echinococcosis.It was very important to understand the implementation and effect of infectious source control measures.The purpose of this study was to examine the implementation of measures to control infectious source(domestic and stray dogs)in TAR and to assess their effectiveness.Methods:We collected data on domestic dog registration and deworming and stray dog sheltering in 74 counties/districts in the TAR from 2017 to 2019.Fecal samples from domestic dogs were collected from randomly selected towns to determine Echinococcus infection in dogs using coproantigen ELISA.We analyzed the data to compare the canine rate of infection between 2016 and 2019.The data analysis was performed by SPSS statistical to compare dog infection rate in 2016 and 2019 by chi-square test,and ArcGIS was used for mapping.Results:From 2017 to 2019,84 stray dog shelters were built in TAR,and accumulatively 446,660 stray or infected dogs were arrested,sheltered,or disposed of.The number of domestic dogs went downward,with an increased registration management rate of 78.4%(2017),88.8%(2018),and 99.0%(2019).Dogs were dewormed 5 times in 2017,12 times in 2018,and 12 times in 2019.The dog infection rate was 1.7%(252/14,584)in 2019,significantly lower than 7.3%(552/7564)from the survey of echinococcosis prevalence in Tibet in 2016(P<0.05).Conclusion:Between 2017 and 2019,the number of stray dogs and infection rate of Echinococcus spp.in domestic dogs decreased significantly,indicating that dogs were effectively controlled as a source of infection in TAR and reflecting a significant decrease in the risk of echinococcosis transmission. | Liying Wang Quzhen Gongsang Huasheng Pang Min Qin Ying Wang Jingzhong Li Roger Frutos Laurent Gavotte | 2022 | Infectious Diseases of Poverty2022，11，3： | 0 |
| 13 | A smart nanoprobe based on luminescent terbium metal-organic framework coated gold nanorods for monitoring and photo-stimulated combined thermal-chemotherapy显示文摘Real-time monitoring and accurate treatment are of great significance for reducing the side effects during the cancer therapy.In this work,we rationally prepared a smart nanoprobe based on core-shell terbium metal-organic gramework(MOF)with highly effective photothermal conversion capacity and drug release efficiency under near-infrared light irradiation for real-time fluorescence imaging-guided multimodal therapy.The nanoprobe can achieve prominent photothermal therapy and controllable drug release,act as a fluorescence thermometer,and also real-time feedback of temperature is expected to be achieved.At the same time,the two-photon ligand design significantly improves the tissue penetration ability of the nanoprobe.Our work is expected to provide a reference for precise treatment and real-time monitoring of tumors and at the same time provide new ideas for the formulation of individualized treatment plans. | Tong Zhang Liying Qin Liangliang Liu Meina Zhang Tianyi Du Yifan Fan Huicheng Yan Pingru Su Ping Zhou Yu Tang | 2022 | Journal of Rare Earths2022，40，9： | 0 |
| 14 | Investigation on the Management for Patients with Echinococcosis Treated with Albendazole-Three PLADs,China,2019显示文摘Summary What is already known about this topic?In China,patients with echinococcosis receive complimentary healthcare services,such as medical treatment,diagnostic examinations,and follow-up care.Despite this,no studies have been conducted to assess the quality of patient management to date.What is added by this report?This study reviewed the medical records of 899 patients who underwent albendazole treatment across 10 endemic counties.Out of 634 evaluable patient files,the proportion of patients with a ratio of actual followup and reexamination times to theoretical follow-up and reexamination times≥0.8 were both low(21.92%and 23.19%,respectively).What are the implications for public health practices?This study identified weaknesses and specific issues in patient management and proposed feasible recommendations to enhance patient file documentation,follow-up,and reexamination. | Min Qin Liying Wang Ying Wang Xu Wang Jiaxi Lei Xixi Cheng Yu Feng Yanyan Hou Qian Wang Chuizhao Xue Laurent Gavotte Roger Frutos | 2023 | China CDC weekly2023，5，20： | 0 |
| 15 | Synthesis of Co_(4)S_(3)/Co_(9)S_(8) nanosheets and comparison study toward the OER properties induced by different metal ion doping显示文摘Regulation of chemical composition and nanostructure, such as the introduction of dopant into two-dimensional nanomaterials, is a general and valid strategy for the efficient electrocatalyst design. In this work, Co_(4)S_(3)/Co_(9)S_(8) nanosheets, with an ultrathin layer structure, were successfully synthesized via an efficient solvothermal process combined with ultrasonic exfoliation. Different metal ions (M = Fe^(3+), Cr^(3+), Mn^(2+) and Ni^(2+)) were then doped by a simple cation exchange method and the effects of different dopants on the OER activities of Co_(4)S_(3)/Co_(9)S_(8) NS were further investigated in alkaline media. The corresponding results implied that M-doped Co_(4)S_(3)/Co_(9)S_(8) NS (M = Fe^(3+), Cr^(3+), Mn^(2+) and Ni^(2+)) exhibited different electrocatalytic properties. Evidenced by XPS spectra, the different OER activities were mainly aroused by the redistribution of charge at the interface due to an electronic interaction between the doped metal ions and Co_(4)S_(3)/Co_(9)S_(8) NS. | Fenghua Chen Zhaoqian Zhang Weiwei Liang Xiaoyun Qin Zhen Zhang Liying Jiang | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
| 16 | Annealing Effect of ZnO on the Performance of Inverted Organic Photovoltaic Devices显示文摘ZnO nanoparticles films were prepared via sol-gel process and incorporated into inverted organic photovoltaic devices with a structure of ITO/ZnO/P3HT:PCBM/MoO_3/Ag,in which ZnO film served as an electron selective layer.The effects of annealing temperature of ZnO film on the device performance were investigated.When the annealing temperature was 300 ℃,a well-arranged ZnO thin film was obtained,and the optimized device had doubled short circuit current density(J_(SC)) and seven-fold higher power conversion efficiency(PCE)compared to the devices without ZnO film.This improvement could be attributed to the enlarged interfacial area of ZnO/active layer and better energy band matching which causes an efficient electron extraction and a decreased interface energy barrier.At particularly high annealing temperature,dramatically increased sheet resistance of indium tin oxide(ITO) was found to cause PCE deterioration.Our finding indicates that it is highly important to investigate both morphology and electrical effects for understanding and optimizing organic photovoltaic(OPV) performance. | Wenjing Qin Guojing Ding Xinrui Xu Liying Yang Shougen Yin | 2014 | Journal of Materials Science & Technology2014，30，2： | 0 |
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