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| 1 | Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2显示文摘 | Ji Liang Ruixiu Cao Xiongjun Wang Yajuan Zhang Pan Wang Hong Gao Chen Li Fan Yang Rong Zeng Ping Wei Dawei Li Wenfeng Li Weiwei Yang | 2017 | Cell Research2017，27，3： | 39 |
| 2 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 3 | Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response显示文摘Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin(100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin significantly improved neurological deficit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-α in the ischemic region. These data indicate that puerarin exerts an anti-inflammatory protective effect on brain tissue with ischemia/reperfusion damage by downregulating the expression of multiple inflammatory factors. | Feng Zhou Liang Wang Panpan Liu Weiwei Hu Xiangdong Zhu Hong Shen Yuanyuan Yao | 2014 | Neural Regeneration Research2014，9，23： | 27 |
| 4 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 5 | Mushroom Poisoning Outbreaks—China,2010–2020显示文摘ABSTRACT Introduction:Mushroom poisoning was the leading cause of foodborne disease outbreaks and outbreak-associated deaths in China.Mushroom poisoning outbreak surveillance can provide insight into the epidemiological characteristics of mushroom poisonings and guide policymaking and health education to reduce illnesses and deaths.Methods:Foodborne Disease Outbreak Surveillance System was upgraded in 2011 to collect foodborne disease outbreaks in China.Mushroom poisoning outbreaks during 2010–2020 were selected to analyze geographical distribution,seasonal distribution,and setting of food preparation.Results:A total of 10,036 outbreaks,which resulted in 38,676 illnesses and 788 deaths,were reported in this period.Mushroom poisonings occurred all over the country,but with highest incidence in the southwest and central China. | Weiwei Li Sara M.Pires Zhitao Liu Jinjun Liang Yafang Wang Wen Chen Chengwei Liu Jikai Liu Haihong Han Ping Fu Yunchang Guo | 2021 | China CDC weekly2021，3，24： | 18 |
| 6 | Mantle dynamics of the reactivating North China Craton:Constraints from the topographies of the 410-km and 660-km discontinuities显示文摘The topographies of the 410-km and 660-km discontinuities have important implications for mantle dynamics.Here we present high-resolution seismic imaging of the 410-km and 660-km discontinuities beneath the North China Craton (NCC) employing the receiver function method.Depth anomalies (deeper or shallower than the global average depths) at both discontinuities were detected by introducing a three-dimensional regional velocity model.The depressions of the 410-km discontinuity are mostly located in the eastern NCC.A local elevation of the 660-km discontinuity appeared in the northwest of the NCC and a significant depression of the 660-km discontinuity is located in the southeast of the NCC.Two dynamic mantle regimes are speculated to explain the formation of the anomalous depth zones in the NCC.One possibility is a complex mantle upwelling linked to edge-derived convection between the stagnant slab and the thick cratonic root.The other potential dynamic regime is slab stagnating,sinking,and induced upwelling at the neighboring slab front.These regimes hint that the mantle flow was possibly dominated by dynamic interactions among the subducting slab,cratonic root,and ambient mantle beneath the NCC. | XU WeiWei ZHENG TianYu ZHAO Liang | 2011 | Science China Earth Sciences2011，54，6： | 17 |
| 7 | Characteristics of Settings and Etiologic Agents of Foodborne Disease Outbreaks—China,2020显示文摘Introduction:Foodborne diseases are a growing public health problem and have caused a large burden of disease in China.This study analyzed epidemiological characteristics of foodborne diseases in China in 2020 to provide a scientific basis for prevention and control measures.Methods:Data were collected from 30 of 31 provincial-level administrative divisions(PLADs)in the mainland of China,excluding Xizang(Tibet)Autonomous Region,via the National Foodborne Disease Outbreaks Surveillance System・The number and proportion of outbreaks,illnesses,hospitalizations,deaths by setting,pathogen-food category pairs and etiology were calculated.Results:In 2020,7,073 foodborne disease outbreaks were reported,resulting in 37,454 illnesses and 143 deaths.Among the identified pathogens,microbial pathogens were the most common confirmed etiology,accounting for 41.7%of illnesses.Poisonous mushrooms caused the largest proportion of outbreaks(58.0%)and deaths(57.6%).For venues where foodborne disease outbreaks occur,household had the highest number of outbreaks(4,140)and deaths(128),and catering service locations caused the largest proportion of illnesses(59.9%).Outbreaks occurring between June and September accounted for 62.8%of total outbreaks.Conclusions:Foodborne disease outbreaks mainly occurred in households・Microbial pathogens remained the top cause of outbreak-associated illnesses.Poisonous mushrooms were ranked the top cause of deaths in private homes in China.The supervision and management of food safety and health education should be strengthened to reduce the burden of foodborne diseases・Publicity should be increased to reduce the incidence of mushroom poisonings in families,and supervision and management of food should be strengthened to reduce microbial contamination. | Hongqiu Li Weiwei Li Yue Dai Yuyan Jiang Junhua Liang Santao Wang Maoqiang Zhuang Zheng Huang Lizi Xu Bo Xue Jikai Liu Haihong Han Sara M.Pires Ping Fu Yunchang Guo | 2021 | China CDC weekly2021，3，42： | 14 |
| 8 | Three dimensional velocity structure and accurate earthquake location in Changning–Gongxian area of southeast Sichuan显示文摘In order to understand the crustal structure and tectonic background of the Changning–Gongxiang area, southeastern Sichuan Province, where a series of moderate-to-strong earthquakes occurred in recent years, we utilized the seismic phase data both from a local dense array and from the regional seismic networks;we used the tomoDD program to invert for the high-resolution three-dimensional velocity structure within the depth range of 0–10 km and for accurate hypocentral locations in this area. We analyzed the seismogenic structures for the events of Xingwen M5.7 in 2018 and Gongxian M5.3 and Changning M6.0 in 2019. The results show that:(1) widespread lateral inhomogeneity exists in the velocity structure of the study area, and the location of the velocity anomaly is largely consistent with known structures. In the range of distinguishable depth, the inhomogeneity decreases with increasing depth, and the velocity structure anomalies in some areas are continuous in depth;(2) earthquakes occurred in clusters, showing the characteristics of zonal folding trends in the NW-SE and NE-SW directions;the focal depth in the area is generally shallow in both the sedimentary cap and the crystalline basement. The seismogenic structures of small earthquake clusters are different in size and occurrence in different sections, and the clusters occurred mostly in regions with high P-or S-wave velocities;(3) synthesis of a variety of data suggests that the seismogenic structures of the Xingwen M5.7 and Changning M6.0 earthquakes are associated with slip faults that trend NW-SE in, respectively, the south wing and the axis of the Changning–Shuanghe anticline, while that of the Gongxian M5.3 earthquake is associated with thrust faults that trend N-S in the Jianwu syncline region. The dynamic sources of the three earthquakes are all from the SE pushing of the Qinghai–Tibet block on the Sichuan basin;(4) the risk of future strong earthquakes in this area must be reevaluated in light of the facts(a)that in recent years, moderate-to-strong earthquake swarms have occurred frequently in southeast Sichuan;(b) that the complex structural area exhibits the easy-to-trigger characteristic, and(c) that the small-scale faults in this area are characterized by the phenomenon of stress 'lock and release'. | Feng Long ZhiWei Zhang YuPing Qi MingJian Liang Xiang Ruan WeiWei Wu GuoMao Jiang LongQuan Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 13 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 11 | hMTERF4 knockdown in HeLa cells results in sub-G1 cell accumulation and cell death显示文摘Mitochondrial 活动和房间精力地位在房间周期和房间增长的规定起重要作用。mitochondrial 基因表示的规定为 mitochondrial 活动规定是关键的。mitochondrial 抄写结束因素(MTERF ) 家庭是一组重要 mitochondrial 抄写规章的因素。MTERF13 涉及 mitochondrial 基因抄写和氧化 phosphorylation 的规定,这被表明了。然而,最新的成员 MTERF4 的功能没被描绘。在这研究,人的 MTERF4 全身的开的读物框架被克隆,并且蛋白质结构预言表明那 hMTERF4 蛋白质包含了白氨酸拉链主题,它类似于人的 MTERF13。在 HeLa 房间的表示 pMTERF4 绿的荧光熔化蛋白质局部性线粒体。(3 (4,5 ) dimethylthiahiazo (zy1 ) 3,5diphenytetrazoliumromide )(MTT ) 增长试金和流动 cytometry 分析显示出那 hMTERF4 击倒的导致的 sub-G1 阶段房间累积,而它的 overexpression 支持了房间增长。而且,两倍与 Annexin V 和 PI 染色揭示了那 hMTERF4 击倒的增加的坏死然而并非 apoptosis。在结论,我们的数据建议 hMTERF4 是为房间增长的一个必要因素,它被 mitochondrial 抄写可能调制支持房间增长。 | Min Yu Jie Dai Weiwei Huang Yang Jiao Liang Liu Min Wu Deyong Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 9 |
| 12 | Function of note strings in Japanese Tit alarm calls to the Common Cuckoo:a playback experiment显示文摘Background: Birds produce alarm calls to convey information about threats. Some Passerine alarm calls consist of several note strings, but few studies have examined their function. Previous studies have shown that Japanese Tits(Parus minor) can alter the calling rate and number and combination of notes in response to predators. We previously found the combinations of note types in Japanese Tit alarm calls to be significantly different in response to the Sparrowhawk(Accipiter nisus) and Common Cuckoo(Cuculus canorus).Methods: Through playback experiments, we tested whether the note strings in Japanese Tit alarm calls to the Common Cuckoo have different functions in conveying information. The note strings of selected alarm calls were divided into the categories of C and D, and different calls were then constructed separately based on the two note string categories. Original alarm calls(C–D), C calls and D calls were played back to male Japanese Tits during the incubation period.Results: Male Japanese Tits had a significantly stronger response to C calls than to C–D calls, and they showed a significantly stronger response to both C and C–D calls than to D calls, suggesting that Japanese Tits discriminated between the C and D calls.Conclusions: Our study demonstrated that the C-and D-category note strings of Japanese Tit alarm calls to the Common Cuckoo have different functions, which supports the previous finding that different note strings in an alarm call can provide different information to receivers. However, the exact meanings of these note strings are not yet known, and further investigation is therefore required. | Jiangping Yu Weiwei Lv Hongwei Xu Nehafta Bibi Yangyang Yu Yunlei Jiang Wei Liang Haitao Wang | 2017 | Avian Research2017，8，3： | 8 |
| 13 | Effects of surfactants on enzyme-containing reversed micellar system显示文摘With the development of colloid interface and enzyme technologies,enzyme-containing reversed micellar system has been receiving much attention in bioseparation and bioconversion. Because of its high efficiency,it has brought new opportunities for the development of molecular biotechnology. Reversed micelles represent nano-sized aqueous droplets stabilized by surfactant amphiphiles inside the bulk organic solvents. The entrapped enzymes have enhanced activities under those conditions as suited in the lipid bilayers of biological membranes. The fundamentals of enzyme-containing reversed micellar system are described in this paper,with special emphasis on the effects of surfactants varying in concentrations and structures. The latest study progress on the surfactants application in enzyme-containing reversed micelles is reviewed. The introduction of novel functional surfactants in micellar enzymology and their future development are also discussed. | LIANG YunShan,YUAN XingZhong,ZENG GuangMing,ZHONG Hua,LI Hui & WANG WeiWei Key Laboratory of Environmental Biology and Pollution Control (Hunan University),Ministry of Education College of Environmental Science and Engineering,Hunan University,Changsha 410082,China | 2011 | Science China Chemistry2011，54，5： | 8 |
| 14 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 15 | Characterization of the soybean Gm ALMT family genes and the function of Gm ALMT5 in response to phosphate starvation显示文摘A potential mechanism to enhance utilization of sparingly soluble forms of phosphorus(P) is the root secretion of malate, which is mainly mediated by the ALMT gene family in plants. In this study, a total of 34 Gm ALMT genes were identified in the soybean genome. Expression patterns diverged considerably among Gm ALMTs in response to phosphate(Pi) starvation in leaves, roots and flowers, with expression altered by P availability in 26 of the 34 Gm ALMTs. One root-specific Gm ALMT whose expression was significantly enhanced by Pi-starvation,Gm ALMT_5, was studied in more detail to determine its possible role in soybean P nutrition. Analysis of Gm ALMT_5 tissue expression patterns, subcellular localization, and malate exudation from transgenic soybean hairy rootsoverexpressing Gm ALMT_5, demonstrated that Gm ALMT_5 is a plasma membrane protein that mediates malate efflux from roots. Furthermore, both growth and P content of transgenic Arabidopsis overexpressing Gm ALMT_5 were significantly increased when sparingly soluble Ca-P was used as the external P source. Taken together, these results indicate that members of the soybean Gm ALMT gene family exhibit diverse responses to Pi starvation. One member of this family, Gm ALMT_5, might contribute to soybean P efficiency by enhancing utilization of sparingly soluble P sources under P limited conditions. | Wenting Peng Weiwei Wu Junchu Peng Jiaojiao Li Yan Lin Yanan Wang Jiang Tian Lili Sun Cuiyue Liang Hong Liao | 2018 | Journal of Integrative Plant Biology2018，60，3： | 7 |
| 16 | Micro-droplet Digital Polymerase Chain Reaction and Real-Time Quantitative Polymerase Chain Reaction Technologies Provide Highly Sensitive and Accurate Detection of Zika Virus显示文摘The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus(ZIKV)and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction(ddPCR) and real-time quantitative PCR(RT-qPCR) protocols for the detection of ZIKV based on the amplification of the NS5 gene. For the ZIKV standard plasmid, the RT-qPCR results showed that the cycle threshold(Ct) value was linear from 10~1 to 10~8 copy/l L, with a standard curve R^2 of 0.999 and amplification efficiency of 92.203%;however, a concentration as low as 1 copy/l L could not be detected. In comparison with RT-qPCR, the dd PCR method resulted in a linear range of 10~1–10~4 copy/l L and was able to detect concentrations as low as 1 copy/l L. Thus, for detecting ZIKV from clinical samples, RT-qPCR is a better choice for high-concentration samples(above 10~1 copy/l L),while ddPCR has excellent accuracy and sensitivity for low-concentration samples. These results indicate that the ddPCR method should be of considerable use in the early diagnosis, laboratory study, and monitoring of ZIKV. | Yuan Hui Zhiming Wu Zhiran Qin Li Zhu Junhe Liang Xujuan Li Hanmin Fu Shiyu Feng Jianhai Yu Xiaoen He Weizhi Lu Weiwei Xiao Qinghua Wu Bao Zhang Wei Zhao | 2018 | Virologica Sinica2018，33，3： | 6 |
| 17 | Variation and selection analysis of Pinus koraiensis clones in northeast China显示文摘Understanding genetic variation is important for efficiently selecting excellent clones and utilizing genetic resources during tree breeding. We investigated 16 growth traits of 50 32-year-old Pinus koraiensis clones. Analyses of variance showed that all the test traits differed significantly among clones. Average height, diameter at breast height(DBH), and volume of all clones were 10.41 m, 21.30 cm,and 0.148 m3, respectively. Phenotypic coefficients of variation and repeatabilities of traits ranged from 4.37 to48.03% and from 0.013 to 0.900, respectively. There exists significant positive correlations among heights, diameter at different heights(1.3, 3.0, 5.0 m), and volumes; genetic correlation was close to phenotype correlation. Using four growth traits(height, DBH, volume, average crown width)as indices for a comprehensive evaluation, five clones(PK11, PK 19, PK 04, PK 14, and PK 28), whose traits scored in the top 10%, were selected as elite clones. For these clones,genetic gains in height, DBH, volume and crown height were 8.58, 13.02, 32.72 and 3.83%, respectively. These results provide important information for improving P.koraiensis breeding programs. | Deyang Liang Changjun Ding Guanghao Zhao Weiwei Leng Min Zhang Xiyang Zhao Guanzheng Qu | 2018 | Journal of Forestry Research2018，29，3： | 6 |
| 18 | Gd-EOB-DTPA-enhanced MRI radiomic features for predicting histological grade of hepatocellular carcinoma显示文摘Background:Prediction models for the histological grade of hepatocellular carcinoma(HCC)remain unsatisfactory.The purpose of this study is to develop preoperative models to predict histological grade of HCC based on gadolinium-ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)radiomics.And to compare the performance between artificial neural network(ANN)and logistic regression model.Methods:A total of 122 HCCs were randomly assigned to the training set(n=85)and the test set(n=37).There were 242 radiomic features extracted from volumetric of interest(VOI)of arterial and hepatobiliary phases images.The radiomic features and clinical parameters[gender,age,alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),alanine aminotransferase(ALT),aspartate transaminase(AST)]were selected by permutation test and decision tree.ANN of arterial phase(ANN-AP),logistic regression model of arterial phase(LR-AP),ANN of hepatobiliary phase(ANN-HBP),logistic regression mode of hepatobiliary phase(LR-HBP),ANN of combined arterial and hepatobiliary phases(ANN-AP+HBP),and logistic regression model of combined arterial and hepatobiliary phases(LR-AP+HBP)were built to predict HCC histological grade.Those prediction models were assessed and compared.Results:ANN-AP and LR-AP were composed by AST and radiomic features based on arterial phase.ANN-HBP and LR-HBP were composed by AFP and radiomic features based on hepatobiliary phase.ANN-AP+HBP and LR-AP+HBP were composed by AST and radiomic features based on arterial and hepatobiliary phases.The prediction models could distinguish between high-grade tumors[Edmondson-Steiner(E-S)grade III and IV]and low-grade tumors(E-S grade I and II)in both training set and test set.In the test set,the AUCs of ANN-AP,LR-AP,ANN-HBP,LR-HBP,ANN-AP+HBP and LR-AP+HBP were 0.889,0.777,0.941,0.819,0.944 and 0.792 respectively.The ANN-HBP was significantly superior to LR-HBP(P=0.001).And the ANN-AP+HBP was significantly superior to LR-AP+HBP(P=0.007).Conclusions:Prediction models consisting of clinical parameters and Gd-EOB-DTPA-enhanced MRI radiomic features(based on arterial phase,hepatobiliary phase,and combined arterial and hepatobiliary phases)could distinguish between high-grade HCCs and low-grade HCCs.And the ANN was superior to logistic regression model in predicting histological grade of HCC. | Yingfan Mao Jincheng Wang Yong Zhu Jun Chen Liang Mao Weiwei Kong Yudong Qiu Xiaoyan Wu Yue Guan Jian He | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 6 |
| 19 | Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms显示文摘Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.Here,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.We validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin expression.Interestingly,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s effects.In addition,AUR induces IL-6 via the NF-κB pathway.In C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin saturation.Whereas chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in females.Further analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)mice.Notably,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)activity.We demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron metabolism.In conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders. | Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 20 | Design and fabrication of superconducting HEB mixer显示文摘This paper describes the design and fabrication of superconducting hot electron bolometer (HEB) mixer based on ultra-thin superconducting NbN films. The high quality films were epitaxially grown on high resistance Si substrates. The device was fabricated by magnetron sputtering, electron beam lithography (EBL), reactive ion etching (RIE), lithography, and so on. The device's resistance-tempera-ture (R-T) curves and current-voltage (I-V) curves were studied. The results of THz response of the device are presented. Y-factor technique was used to measure the device's noise temperature. When the device was irradiated with a laser radiation of 2.5 THz, the obtained lowest noise temperature of the device was 2213 K. | WANG JinPing LI YangBin KANG Lin WANG Yu ZHONG YangYin LIANG Min CHEN Jian CAO ChunHai XU WeiWei WU PeiHeng | 2009 | Chinese Science Bulletin2009，54，12： | 5 |
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