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| 1 | Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells显示文摘我们的以前的研究表明了那根骨头形态基因的蛋白质(BMP-9 ) 9 是最有效的 BMP 之一导致间充质的干细胞(MSC ) 的造骨细胞区别。然而,位于 MSC 的 BMP-9-induced osteogenic 区别下面的分子的机制尚待充分被阐明。在这研究,主导否定(DN ) 类型 II TGF- 受体被构造并且介绍干细胞进 C3H10T1/2,然后,在 vitro 并且在 vivo,试金被执行分析并且识别为 BMP-9-induced 要求的类型 II TGF- 受体成骨。我们发现那三 DN 类型 II TGF-受体, DN-BMPRII , DN-ActRII ,和 DN-ActRIIB ,减少的 BMP-9-induced 碱的磷酸酶(高山)活动,在有约束力的元素( SBE )控制了的 BMP-9-induced Smad 导致了减少记者活动, Smad6 和 Smad7 的减少的 BMP-9-induced 表达式,并且减少在在 vivo 的 vitro 和宫外的骨头形成的 BMP-9-induced 矿化作用,最后导致了减少的骨头群众和不成熟的成骨。这些调查结果强烈建议了那三野类型的 II TGF- 受体, BMPRII, ActRII 和 ActRIIB,可以在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别起一个功能的作用。然而, C3H10T1/2 干细胞能表示 BMPRII 和 ActRII,然而并非 ActRIIB。用 RNA 干扰(RNAi ) ,我们发现那项酶记者活动和高山活动被 BMP-9 导致了因此被禁止与一起 BMPRII 和 ActRII 击倒。一起拿,我们的结果证明 BMPRII 和 ActRII 是在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别的功能的类型 II TGF- 受体。 | Ningning Wu Yingze Zhao Yibing Yin Yan Zhang Jinyong Luo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 20 |
| 2 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 3 | Diameter-controlled growth of aligned single-walled carbon nanotubes on quartz using molecular nanoclusters as catalyst precursors显示文摘Molecular nanoclusters containing Fe and Mo atoms have been used as catalyst precursors for the growth of single-walled carbon nanotubes (SWNTs) on stable temperature (ST)-cut quartz substrates by chemical vapor deposition. Attribute to the uniform catalyst nanoparticles and the confinement effect of the crystalline substrates, well-aligned SWNTs with narrow diameter distribution have been synthesized. Atomic force microscopy measurements show that the mean diameter of the nanotubes obtained by thermal decomposition of ethanol at 900°C is 0.76 ± 0.16 nm, which is the smallest among all reported results for aligned SWNTs. The mean diameter of the nanotubes increases with growth temperature. In addition to using identical nanoclusters as the catalyst precursors, the avoidance of annealing treatment of catalyst precursors is also a key point for obtaining SWNTs with controlled diameters. Using these identical nanoclusters as catalyst precursors and carefully tuning the growth parameters make us closer to the ultimate goal of controlling the chirality of SWNTs. | PENG Fei LUO Da SUN Hao WANG JinYong YANG Feng LI RuoMing YANG Juan LI Yan | 2013 | Chinese Science Bulletin2013，58，4： | 3 |
| 4 | A protocol for rapid generation of recombinant adenoviruses using the AdEasy system 显示文摘 | Luo Jinyong Deng Zhongliang Luo Xiaoji | 2007 | Nature Protocols2007，2，5： | 1 |
| 5 | Effects of potassium loading and thermal aging on K/Pt/Al 2 O 3 high-temperature lean NO x trap catalysts显示文摘 | Jinyong Luo Feng Gao Do Heui Kim Charles H.F. Peden | 2013 | Catalysis Today2013，，： | 1 |
| 6 | Reaction Kinetics of C 3 H 6 Oxidation for Various Reaction Pathways Over Diesel Oxidation Catalysts显示文摘 | Harry Oh Izabela S. Pieta Jinyong Luo William S. Epling | 2013 | Topics in Catalysis (-)2013，，18： | 1 |
| 7 | BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression显示文摘 | Wei Ren Xiaoxiao Sun Ke Wang Honglei Feng Yuehong Liu Chang Fei Shaoheng Wan Wei Wang Jinyong Luo Qiong Shi Min Tang Guowei Zuo Yaguang Weng Tongchuan He Yan Zhang | 2014 | Molecular Biology Reports2014，，3： | 1 |
| 8 | TGFβ/BMP Type I Receptors ALKI and ALK2 Are Essential for BMP9 - induced Osteogenic Signaling in Mesenchymal Stem Cells显示文摘 | Jinyong Luo Min Tang and Jiayi Huang | 2010 | J Bio Chem2010，285，29： | 1 |
| 9 | Sulfur release from a model Pt/Al203 diesel oxidation catalyst: Temperature - pro-grammed and step -response techniques characterization显示文摘 | Luo Jinyong Darren Kisinger Ali Abedi | 2010 | Ap- plied Catalysis A : General2010，383，12： | 1 |
| 10 | L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia显示文摘Dear Editor,Telomere attrition is one of the hallmark of aging.Lategeneration Terc knockout mice exhibit impaired hematopoiesis,1 while the underling mechanisms remain poorly understood.Retrotransposon long interspersed element-1(L1)is the only human retrotransposable elements capable of autonomous retrotransposition,and evolutionarily inactive.Recent studies reported that L1 is derepressed during the aging process with redistribution and reorganization of the heterochromatin.2 Considering that telomere shortening can cause chromosome instability and rearrangements,3 we speculate that L1 may play a role in impaired hematopoiesis in telomere dysfunctional mice. | Ying Wang Jin-ping Zheng Ying Luo Junyi Wang Lingjie Xu Jinyong Wang John M.Sedivy Zhangfa Song Hu Wang Zhenyu Ju | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 11 | Sea-urchin-like ReS_(2) nanosheets with charge edge-collection effect as a novel cocatalyst for high-efficiency photocatalytic H_(2) evolution显示文摘The recombination of charge carriers arriving from the random charge movement in semiconductor pho-tocatalysts greatly limits the practical application of solar-driven H_(2)evolution.The design of photo-catalytic systems with spatially oriented charge-transfer is a promising route to achieve high charge-separation efficiency for photocatalysts.Herein,novel sea-urchin-like Re S_(2)nanosheet/TiO_(2)nanoparticle heterojunctions(SURTHs)are constructed.The unique sea-urchin-like structure endows the ReS_(2)cocat-alyst with an unusual charge edge-collection effect,which leads to a significant acceleration of charge separation and transfer,as evidenced by the well-designed selective photodeposition of Pt quantum dots in SURTHs.The markedly improved charge transfer capacity contributes to a high photocatalytic H_(2)evo-lution rate of 3.71 mmol h^(−1)g^(−1)for SURTHs(an apparent quantum efficiency(AQE)of 16.09%),up to 231.9 times by contrast with that of P25 TiO_(2).This work would provide a new platform for designing the high-efficiency cocatalyst/photocatalyst system with excellent charge transfer capacity. | Bo Lin Bowen Ma Jiangang Chen Yao Zhou Jiadong Zhou Xiaoqing Yan Chao Xue Xiao Luo Qing Liu Jinyong Wang Renji Bian Guidong Yang Fucai Liu | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 12 | Alantolactone inhibits proliferation,metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways显示文摘Although there are many therapeutic strategies such as surgery and chemotherapy,the prognosis of osteosarcoma(OS)is still far from being satisfactory.It is urgent to develop more effective,tolerable and safe drugs for the treatment of OS.In the present study,we investigated the anti-OS activity of Alantolactone(ALT),a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium,and probed the possible mechanism involved.We demonstrated that ALT significantly inhibited cell proliferation of various human OS cell lines while had relative lower cytotoxicity against normal cells.Then,we validated that ALT reduced migration,decreased invasion possibly through reversing epithelial mesenchymal transition(EMT)process and suppressing Matrix metalloproteinases(MMPs).Moreover,we confirmed that ALT promoted apoptosis and arrested cell cycle at G2/M phase of human OS cells in vitro.In addition,we confirmed that ALT restrained tumor growth and metastasis of OS 143 cells in a xenograft model in vivo.Mechanistically,ALT inhibited the activity of Wnt/β-catenin and p38,ERK1/2 and JNK Mitogen Activated Protein Kinases(MAPKs)signal pathway.Notably,the combination of ALT and Wnt/β-catenin inhibitor,as well as the combination of ALT and MAPKs inhibitors resulted in a synergistically effect on inhibiting the proliferation,migration and invasion of OS cells.Collectively,our results validate the ALT may inhibit proliferation,metastasis and promotes apoptosis of human OS cells possibly through suppressing Wnt/β-Catenin and MAPKs signaling pathways. | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2022 | Genes & Diseases2022，9，2： | 0 |
| 13 | Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]显示文摘 | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 14 | Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways显示文摘Bladder cancer (BC) is one of the most common malignant tumors in the urinary system.Due to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat BC.Echinatin (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential.Herein,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular mechanism.We found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC cells.Besides,Ecn had no notable cytotoxicity towards human normal cells.We subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC cells.Remarkably,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC cells.In summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling pathways.More meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn. | Xiaoxuan Wang Lijuan Luo Jingtao Xu Qiuping Lu Haichao Xia Yanran Huang Lulu Zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji Luo Jinyong Luo | 2024 | Genes & Diseases2024，11，2： | 0 |
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