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| 1 | An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. | Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang | 2020 | Journal of Molecular Cell Biology2020，12，4： | 17 |
| 2 | The privacy protection mechanism of Hyperledger Fabric and its application in supply chain finance显示文摘Blockchain technology ensures that data is tamper-proof,traceable,and trustworthy.This article introduces a wellknown blockchain technology implementation—Hyperledger Fabric.The basic framework and privacy protection mechanisms of Hyperledger Fabric such as certificate authority,channel,Private Data Collection,etc.are described.As an example,a specific business scenario of supply chain finance is figured out.And accordingly,some design details about how to apply these privacy protection mechanisms are described. | Chaoqun Ma Xiaolin Kong Qiujun Lan Zhongding Zhou | 2019 | Cybersecurity2019，2，1： | 6 |
| 3 | Control of endwall secondary flow in a compressor cascade with dielectric barrier discharge plasma actuation显示文摘Three dielectric barrier discharge plasma actuators were mounted at the positions of 20%,40%and 60%of chord length on the endwall in a compressor cascade.The downstream flow field of the cascade has been measured with a mini five-hole pressure probe with and without the plasma actuation.The measured results show that the plasma actuation most effectively reduces total pressure loss and flow blockage when the actuators are operated simultaneously.As each of the actuators is operated independently,the actuator at the position of 20%of chord length most effectively reduces flow blockage, and the actuator at the position of 60%of chord length fairly reduces total pressure loss.However, negative pressure loss reduction occurs with the plasma actuator at the position of 40%of chord length.In brief,the plasma actuation placed on the endwall in the cascade apparently influences the endwall secondary flow,and the optimal locations and strength of actuation are critical for the control of endwall secondary flow in a compressor cascade with the plasma actuators. | LI Gang XU YanJi LIN Bin ZHU JunQiang NIE ChaoQun MA HongWei WANG ZhaoFeng | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 4 | Spatiotemporal Trends and Ecological Determinants in Population by Elevation in China Since 1990显示文摘It is very important to understand the ecological and socio-economic factors in population distribution and their changes over time for the compilation of regional development planning and the guidance of rational population flow.Using surface-based population data for China from 1990 to 2015,the national distribution and dynamics of the human population by elevation are quantified based on 1-km cell-size gridded distribution datasets and 1-km cell-size DEM(digital elevation model).A geographical detector model is used to quantitatively analyze the dominant role of natural geographical factors,such as topography and climate,on the spatial distribution of population.Results show that:1)the population size and density decrease rapidly with elevation below 1000 m above the sea level,and the gap in population density between low-altitude areas and high-altitude areas increases with time because of the continuous growth of population density in low-altitude areas;2)the distribution of the population can be divided into five steps according to integrated population density(IPD),in proportions of 43∶35∶21∶1∶0,and that these proportions have remained stable over the last 25 yr;3)the basic pattern of population spatial distribution is determined by natural geographical environment factors,such as topography,climate,geomorphology,and their interactions;and 4)the development of society and the economy are the driving forces for the dynamic change in the population distribution during the study period,with the distribution pattern and dynamics of population by altitude in China providing a comprehensive reflection of various geographical elements on different spatial scales. | MA Chaoqun HE Yanfen | 2021 | Chinese Geographical Science2021，31，2： | 2 |
| 5 | Reliability analysis of monotone coherent multi-state systems based on Bayesian networks显示文摘The Bayesian networks(BNs) provide a robust probabilistic method of reasoning under uncertainty and have been successfully applied to a variety of real-world tasks. Aiming to explore the capabilities of the BN formalism in reliability analysis of monotone coherent multi-state systems, the BNs are compared with a popular tool for reliability analysis of monotone coherent multi-state systems, namely the multi-state fault trees(MFTs). It is shown that any MFT can be directly mapped into BN and the basic inference techniques on the latter may be used to obtain classical parameters computed from the former(i.e. probability distribution of top variable, minimal upper vectors and maximum lower vectors for any performance level, importance measures of components). Furthermore, some additional information can be obtained by using BN, both at the modeling and analysis level.At the modeling level, several restrictive assumptions implicit in the MFT methodology can be removed and various kinds of dependencies among components can be accommodated. At the analysis level, a general diagnostic analysis can be performed.The comparison of these methods is illustrated by an example of the water supply system. | Binghua Song Zhongbao Zhou Chaoqun Ma Jinglun Zhou Shaofeng Geng | 2016 | Journal of Systems Engineering and Electronics2016，27，6： | 2 |
| 6 | AMERICAN OPTION PRICING UNDER GARCH DIFFUSION MODEL: AN EMPIRICAL STUDY显示文摘 | WU Xinyu YANG Wenyu MA Chaoqun ZHAO Xiujuan | 2014 | Journal of Systems Science & Complexity2014，27，1： | 2 |
| 7 | Two- stage DEA models with undesirable input-intermediate- outputs显示文摘 | Liu Wenbin Zhou Zhongbao Ma Chaoqun | 2015 | Omega2015，56，： | 1 |
| 8 | Lightweight and flexible graphene foam composites for high-performance electromagnetic interference shielding显示文摘 | Zongping Chen Chuan Xu Chaoqun Ma etc | 2013 | Advanced Materials2013，，25： | 1 |
| 9 | Performance evaluation of anti-radiation based on the gamma degradation process显示文摘In the environment of space radiation, the high-energy charged particles or high-energy photons acting on a spacecraft can cause either temporary device degradation or permanent failure. The traditional probability model is difficult to obtain reliable estimation of unit radiation resistance performance with small samples. Considering that different products will change differently after high-energy particle radiation, we construct a model based on the gamma degradation process. This model can efficiently describe the law of unit radiation resistance variation with the total radiation dose levels under the effect of the total dose and displacement damage. Finally, the proposed model is used to assess the anti-radiation performance of the N-channel power MOSFET device STRH60N20FSY3 produced by STM to obtain average unit radiation resistance, survival probability, survival function, etc. | SONG BingHua ZHOU ZhongBao MA ChaoQun JIN Guang GENG ShaoFeng | 2017 | Science China(Technological Sciences)2017，60，4： | 1 |
| 10 | Game Cross Efficiency for Systems with Two-Stage Structures显示文摘 | Chaoqun Ma Debin Liu Zhongbao Zhou Wei Zhao Wenbin Liu Pu-yan Nie | 2014 | Journal of Applied Mathematics2014，，： | 1 |
| 11 | Scientific research compet- itiveness of world universities in computer science显示文摘 | Ma Ruimin Ni Chaoqun Qiu Junping | 2008 | Scientomet- rics2008，76，2： | 1 |
| 12 | Long-term memory in emerging markets: evidence from the Chinese stock market 显示文摘 | Chaoqun Ma Hongquan Li Lin Zou | 2006 | International Journal of Information Technology & Decision Making2006，5，3： | 1 |
| 13 | Comparisons of Three-Dimensional Variational Data Assimilation and Model Output Statistics in Improving Atmospheric Chemistry Forecasts显示文摘Atmospheric chemistry models usually perform badly in forecasting wintertime air pollution because of their uncertainties. Generally, such uncertainties can be decreased effectively by techniques such as data assimilation(DA) and model output statistics(MOS). However, the relative importance and combined effects of the two techniques have not been clarified. Here,a one-month air quality forecast with the Weather Research and Forecasting-Chemistry(WRF-Chem) model was carried out in a virtually operational setup focusing on Hebei Province, China. Meanwhile, three-dimensional variational(3 DVar) DA and MOS based on one-dimensional Kalman filtering were implemented separately and simultaneously to investigate their performance in improving the model forecast. Comparison with observations shows that the chemistry forecast with MOS outperforms that with 3 DVar DA, which could be seen in all the species tested over the whole 72 forecast hours. Combined use of both techniques does not guarantee a better forecast than MOS only, with the improvements and degradations being small and appearing rather randomly. Results indicate that the implementation of MOS is more suitable than 3 DVar DA in improving the operational forecasting ability of WRF-Chem. | Chaoqun MA Tijian WANG Zengliang ZANG Zhijin LI | 2018 | Advances in Atmospheric Sciences2018，35，7： | 1 |
| 14 | Scientific research competitiveness of world universities显示文摘 | RUIMIN MA CHAOQUN N1 JUNPING QIU | 2008 | Seiento- metrics2008，，2： | 1 |
| 15 | Will Tax Burden Be a Stumbling Block to Carbon-Emission Reduction? Evidence from OECD Countries显示文摘The influence of taxation on the economy and society is everywhere. Given the fact that CO_(2) emission is closely connected with human activities, the question naturally arises whether the tax burden affects the carbon emissions. To address this issue, based on the data of 21 OECD countries over the period from 1991–2014, we use the ratio of tax revenue to GDP as a proxy of the tax burden and employ a panel quantile model with the non-additive fixed effects for analysis. The results suggest that the impact of the tax burden on carbon emissions is heterogeneous across countries based on the level of carbon emissions. Moreover, we find a stable U-shaped relationship between the tax burden and carbon emissions whether for countries with a high or low level of carbon emissions. Our findings suggest that moderate taxes could help reduce carbon emissions, but the effect of excessive taxation is the opposite. | Yishuai REN Yong JIANG Chaoqun MA Jianglong LIU Jing CHEN | 2021 | Journal of Systems Science and Information2021，9，4： | 1 |
| 16 | Warrant pricing under GARCH diffusion model显示文摘 | Wu Xinyu Ma Chaoqun Wang Shouyang | 2012 | EconomicModelling2012，29，6： | 1 |
| 17 | Lightweight and flexible graphene foam composites for high-performance electromagnetic interference shielding显示文摘 | CHEN Zongping XU Chuan MA Chaoqun | 2013 | Advanced Materials2013，25，9： | 1 |
| 18 | General probability-time tradeoff and intertemporal risk-value model显示文摘 | SHE Shengxiang MA Chaoqun WU Desheng | 2010 | Risk Analysis2010，30，3： | 1 |
| 19 | High loading carbon nanotubes deposited onto porous nickel yarns by solution imbibition as flexible wire-shaped supercapacitor electrodes显示文摘The deposition of active materials directly onto metal wires is a general strategy to prepare wire-shaped electrodes for flexible and wearable energy storage devices. However, it is still a critical challenge to coat active materials onto the aimed metal wires because of their smooth surface and small specific surface area. In this work, high porous nickel yarns(PNYs) was fabricated using commercial nylon yarns as templates through step-wise electroless plating, electroplating and calcination processes. The PNYs are composed of multiplied fibers with hollow tubular structure of 5–10 μm in diameter, allowing the imbibition of carbon nanotubes(CNTs) solution by a facile capillary action process. The prepared CNTs/PNY electrodes showed a typical electrochemical double layer capacitive performance and the constructed allsolid flexible wire-shaped symmetric supercapacitors provided a specific capacitance of 4.67 F/cm3 with good cycling stability at a current density of 0.6 A/cm3. | Chaoqun Kang Dashun Cao Yuejiao Liu Zhiwei Liu Ruiqing Liu Xiaomiao Feng Dan Wang Yanwen Ma | 2018 | Journal of Energy Chemistry2018，27，3： | 1 |
| 20 | Orlistat induces ferroptosis-like cell death of lung cancer cells显示文摘Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers,including lung cancer;however,targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.In this study,we tested the anticancer activity of orlistat,an FDA-approved anti-obesity drug,in human and mouse cancer cells in vitro and in vivo,and we found that orlistat,as a single agent,inhibited the proliferation and viabilities of lung cancer cells and induced ferroptosis-like cell death in vitro.Mechanistically,we found that orlistat reduced the expression of GPX4,a central ferroptosis regulator,and induced lipid peroxidation.In addition,we systemically analyzed the genome-wide gene expression changes affected by orlistat treatment using RNA-seq and identified FAF2,a molecule regulating the lipid droplet homeostasis,as a novel target of orlistat.Moreover,in a mouse xenograft model,orlistat significantly inhibited tumor growth and reduced the tumor volumes compared with vehicle control(P<0.05).Our study showed a novel mechanism of the anticancer activity of orlistat and provided the rationale for repurposing this drug for the treatment of lung cancer and other types of cancer. | Wenjing Zhou Jing Zhang Mingkun Yan Jin Wu Shuo Lian Kang Sun Baiqing Li Jia Ma Jun Xia Chaoqun Lian | 2021 | Frontiers of Medicine2021，15，6： | 1 |
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