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| 1 | China's Regional Disparity and Its Policy Responses显示文摘中国在 3 十年的快速的经济发展的水果没越过不同区域相当被散布。在 1998 期间用从 815 汉语的一件样品的数据列出了公司—2004,我们的错误修正投资模型嘘在不同区域在公司的投资上欠不同金融限制的证据。我们主张中国的地区性的发展政策极大地作出贡献到地区性的不平等。控制升起的不平等,中国从海岸转移了它的焦点到内部区域。然而,它正在变得为市场机制现在不得不指导经济,,的政府日益困难对经济的远更大的影响比政府做。当前的领导的以民族为中心的途径意味着实质的注意在一次尝试被放在地区性的发展不同上造“一个和谐社会” . 如果为减少地区性的不同的所有措施是有效,中国需要推进广泛的改革。 | Minjia Chen Yongnian Zheng | 2008 | China & World Economy2008，16，4： | 7 |
| 2 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 3 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 4 | SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways显示文摘 | Jeongsoon Park Yue Chen Daniel X. Tishkoff Chao Peng Minjia Tan Lunzhai Dai Zhongyu Xie Yi Zhang Bernadette M.M. Zwaans Mary E. Skinner David B. Lombard Yingming Zhao | 2013 | Molecular Cell2013，，6： | 1 |
| 5 | Study on mechanism of increased allergenicity induced by Ara h 3 from roasted peanut using bone marrow-derived dendritic cells显示文摘Little information was so far available about allergenic mechanism of the roasted peanut allergens during initial stages of allergy.The purpose of this study was to determine the influence of roasting(150℃,20 min)on biochemical and biological properties of Ara h 3,a major peanut allergen.Allergenicity of roasted peanut emulsion to mice,differences in uptakes between Ara h 3 purified from raw peanuts(named as Ara h 3-Raw)and that purified from roasted peanuts(named as Ara h 3-Roasted)by bone marrow-derived dendritic cells(BMDCs)and the implication of cell surface receptors involving in uptake,and changes in glycosylation and structure of Ara h 3 after roasting were analyzed in this study.This study suggested that roasting increased allergenicity of peanut to BALB/c mice.Maillard reaction and structural changes of Ara h 3 induced by roasting significantly altered the uptake of Ara h 3-Roasted by BMDCs,and modified Ara h 3 fate in processes involved in immunogenicity and hyper allergenicity,indicating that food processing pattern can change food allergenicity. | Minjia Wang Shuo Wang Xiaodong Sun Zhirui Deng Bing Niu Qin Chen | 2023 | Food Science and Human Wellness2023，12，3： | 1 |
| 6 | Internal financial constraints and firm productivity in China: Do liquidity and export behavior make a difference?显示文摘 | Minjia Chen Alessandra Guariglia | 2013 | Journal of Comparative Economics2013，，： | 1 |
| 7 | Efficient, continuous oxidation of durene to pyromellitic dianhydride mediated by a V-Ti-P ternary catalyst: The remarkable doping effect显示文摘Continuous preparation of pyromellitic dianhydride(PMDA) from durene has been studied using a fixedbed reactor. The reaction was performed using a phosphorus-vanadium-titanium ternary catalyst.Relatively high selectivity and yield of PMDA was obtained. The in-situ characterization was combined with theoretical calculation to reveal the reaction mechanisms, and the remarkable doping effect was discussed. | Da Ke Minjia Wang Jiancheng Ruan Xinzhi Chen Shaodong Zhou | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 8 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 9 | Determination of Glycyrrhizic Acid Dipotassium in Wash and Care Cosmetics by HPLC显示文摘To establish a method for the determination of glycyrrhizic acid dipotassium in various cosmetics(shampoo,shower gel,hair conditioner and cleanser)with High Performance Liquid Chromatography.ZORBAX SB-C18 column(4.6 mm×250 mm,5μm)was used.The 0.01 mol/L phosphoric acid solution-acetonitrile(63:37)was used as the flow equivalent elution.The sample was extracted by ultrasonic methanol and detected by diode array detector,The extraction solvent and chromatographic conditions were studied and optimized.Glycyrrhizic acid dipotassium has a good linear relationship in the concentration range of 1~200μg/mL(R²=0.9997).The average recovery rates of glycyrrhizic acid dipotassium in shampoo,shower gel,hair conditioner and cleanser were 92.92%~101.69%.The method was precise and accurate and could be used for the qualitative and quantitative analysis of Glycyrrhizic acid dipotassium in cosmetics. | Chen Yan Yuan Minjia Wang Yanling Yu Lili Hu Xincheng | 2020 | China Detergent & Cosmetics2020，5，4： | 0 |
| 10 | Insight into structure evolution of carbon nitrides and its energy conversion as luminescence显示文摘A series of carbon nitride(CN)materials represented by graphitic carbon nitride(g-C3N4)have been widely used in bioimaging,biosensing,and other fields in recent years due to their nontoxicity,low cost,and high luminescent quantum efficiency.What is more attractive is that the luminescent properties such as wavelength and intensity can be regulated by controlling the structure at the molecular level.Hence,it is time to summarize the related research on CN structural evolution and make a prospect on future developments.In this review,we first summarize the research history and multiple structural evolution of CN.Then,the progress of improving the luminescence performance of CN through structural evolution was discussed.Significantly,the relationship between CN structure evolution and energy conversion in the forms of photoluminescence,chemiluminescence,and electrochemiluminescence was reviewed.Finally,key challenges and opportunities such as nanoscale dispersion strategy,luminous efficiency improving methods,standardization evaluation,and macroscopic preparation of CN are highlighted. | Hao Zhang Jingwei Zhang Wenjie Chen Minjia Tao Xianguang Meng Yuanjian Zhang Guifu Zuo | 2024 | Carbon Energy2024，6，2： | 0 |
| 11 | Iterative photonic processor for fast complexvalued matrix inversion显示文摘An N×N iterative photonic processor is proposed for the first time, we believe, for fast computation of complexvalued matrix inversion, a fundamental but computationally expensive linear algebra operation. Compared to traditional digital electronic processing, optical signal processing has a few unparalleled features that could enable higher representational efficiency and faster computing speed. The proposed processor is based on photonic integration platforms–the inclusion of Ⅲ-V gain blocks offers net neutral loss in the phase-sensitive loops. This is essential for the Richardson iteration method that is adopted in this paper for complex linear systems. Wavelength multiplexing can be used to significantly improve the processing efficiency, allowing the computation of multiple columns of the inverse matrix using a single processor core. Performances of the key building blocks are modeled and simulated, followed by a system-level analysis, which serves as a guideline for designing an N×N Richardson iteration processor. An inversion accuracy of>98%can be predicted for a 64×64 photonic processor with a>80times faster inversion rate than electronic processors. Including the power consumed by both active components and electronic circuits, the power efficiency of the proposed processor is estimated to be over an order of magnitude more energy-efficient than electronic processors. The proposed iterative photonic integrated processor provides a promising solution for future optical signal processing systems. | MINJIA CHEN QIXIANG CHENG MASAFUMI AYATA MARK HOLM RICHARD PENTY | 2022 | Photonics Research2022，10，11： | 0 |
| 12 | Thin-film neural networks for optical inverse problem显示文摘The thin-film optical inverse problem has attracted a great deal of attention in science and industry,and is widely applied to optical coatings.However,as the number of layers increases,the time it takes to extract the parameters of thin films drastically increases.Here,we introduce the idea of exploiting the structural similarity of all-optical neural networks and applied it to the optical inverse problem.We propose thin-film neural networks(TFNNs)to efficiently adjust all the parameters of multilayer thin films.To test the performance of TFNNs,we implemented a TFNN algorithm,and a reflectometer at normal incidence was built.Operating on multilayer thin films with 232 layers,it is shown that TFNNs can reduce the time consumed by parameter extraction,which barely increased with the number of layers compared with the conventional method.TFNNs were also used to design multilayer thin films to mimic the optical response of three types of cone cells in the human retina.The light passing through these multilayer thin films was then recorded as a colored photo. | Lingjie Fan Ang Chen Tongyu Li Jiao Chu Yang Tang Jiajun Wang Maoxiong Zhao Tangyao Shen Minjia Zheng Fang Guan Haiwei Yin Lei Shi Jian Zi | 2021 | Light(Advanced Manufacturing)2021，2，4： | 0 |
| 13 | Photonic-dispersion neural networks for inverse scattering problems显示文摘Inferring the properties of a scattering objective by analyzing the optical far-field responses within the framework of inverse problems is of great practical significance.However,it still faces major challenges when the parameter range is growing and involves inevitable experimental noises.Here,we propose a solving strategy containing robust neuralnetworks-based algorithms and informative photonic dispersions to overcome such challenges for a sort of inverse scattering problem—reconstructing grating profiles.Using two typical neural networks,forward-mapping type and inverse-mapping type,we reconstruct grating profiles whose geometric features span hundreds of nanometers with nanometric sensitivity and several seconds of time consumption.A forward-mapping neural network with a parameters-to-point architecture especially stands out in generating analytical photonic dispersions accurately,featured by sharp Fano-shaped spectra.Meanwhile,to implement the strategy experimentally,a Fourier-optics-based angle-resolved imaging spectroscopy with an all-fixed light path is developed to measure the dispersions by a single shot,acquiring adequate information.Our forward-mapping algorithm can enable real-time comparisons between robust predictions and experimental data with actual noises,showing an excellent linear correlation(R2>0.982)with the measurements of atomic force microscopy.Our work provides a new strategy for reconstructing grating profiles in inverse scattering problems. | Tongyu Li Ang Chen Lingjie Fan Minjia Zheng Jiajun Wang Guopeng Lu Maoxiong Zhao Xinbin Cheng Wei Li Xiaohan Liu Haiwei Yin Lei Shi Jian Zi | 2021 | Light(Science & Applications)2021，10，10： | 0 |
| 14 | Determination of Oleuropein in Cosmetics by Ultra Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry显示文摘An ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-MS/MS)was established to quickly and accurately determine the content of oleuropein in cosmetics.The samples were extracted with methanol-aqueous solution,and the mobile phase with methanol-formic acid solution(0.1 mol/L)=40∶60 was separated by Agilent ZORBAX Eclipse Plus C18(2.1 mm×50 mm×1.8μm-Micron)column temperature 30℃,flow rate 0.3 mL/min.The MS end was detected by electrospray negative mode ionization(ESI-)and multiple reaction monitoring(MRM)mode.The results show a good linear relationship in the range of 0.002~5 mg/L,with a correlation coefficient R2 of 0.999,5.Method recovery range from 84.2%~107.6%and the relative standard deviation RSD is 5.8%.The detection time is 5 min,the detection limit is 0.000,6 mg/L,and the limit of quantification is 0.002 mg/L.This method has the advantages of convenient operation,low quantification limit,high precision and good repeatability,and is suitable for measuring the content of oleuropein in many kinds of cosmetics. | Pan Lijing Chen Weiwei Yuan Minjia | 2023 | China Detergent & Cosmetics2023，8，4： | 0 |
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