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| 1 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 2 | Establishment of in Vitro Regeneration System of Bitter Melon (Momordica Charantia L. )显示文摘Explants of bitter melon can produce three types of callus: green, yellow green and fragile yellow callus. During the period of inducing callus, the explants are not sensitive to the kinds and proportions of phytohormone. The rate of callus inductivity is about 90.0%. However, in the process of callus differentiating adventitious bud, the kind, proportion and quantity of phytohormone and the type of callus made different result. The adventitious buds were induced successfully on MS medium+6-BA (N6-benzyladenine) 4.0 mg l-1+KT(kinetin) 2.0 mg l-1) by yellow green callus. The frequency was about 66.7 %. Yellow callus did not differentiated adventitious bud. The frequency of green callus differentiation was very low (<15.0 %) even under the most suitable conditions. The MS + ZT (zeatin) 5.0 mgl-1 +KT 0.5 mgl-1 medium was suitable for the proliferation of bud and three weeks later, the coefficient of proliferation was about 5-6. The 1/2 MS + ZT 0.02 mgl-1 or 1/2 MS media were suitable for in vitro rooting of shoot, the shoot on them could produce 6-7 new roots in three weeks. After plantation test, the survival rate of tube plantlets was about 70% and their characteristics were the same as those from seed by field test. | 杨满业 Zhao Maojun Zeng Yu Lan Liqong Chen Fang | 2004 | High Technology Letters2004，10，1： | 7 |
| 3 | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats显示文摘Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha”(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway. | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen | 2021 | Food Science and Human Wellness2021，10，2： | 6 |
| 4 | A comprehensive overview of cotton genomics,biotechnology and molecular biological studies显示文摘Cotton is an irreplaceable economic crop currently domesticated in the human world for its extremely elongated fiber cells specialized in seed epidermis,which makes it of high research and application value.To date,numerous research on cotton has navigated various aspects,from multi-genome assembly,genome editing,mechanism of fiber development,metabolite biosynthesis,and analysis to genetic breeding.Genomic and 3D genomic studies reveal the origin of cotton species and the spatiotemporal asymmetric chromatin structure in fibers.Mature multiple genome editing systems,such as CRISPR/Cas9,Cas12(Cpf1)and cytidine base editing(CBE),have been widely used in the study of candidate genes affecting fiber development.Based on this,the cotton fiber cell development network has been preliminarily drawn.Among them,the MYB-b HLH-WDR(MBW)transcription factor complex and IAA and BR signaling pathway regulate the initiation;various plant hormones,including ethylene,mediated regulatory network and membrane protein overlap fine-regulate elongation.Multistage transcription factors targeting Ces A 4,7,and 8 specifically dominate the whole process of secondary cell wall thickening.And fluorescently labeled cytoskeletal proteins can observe real-time dynamic changes in fiber development.Furthermore,research on the synthesis of cotton secondary metabolite gossypol,resistance to diseases and insect pests,plant architecture regulation,and seed oil utilization are all conducive to finding more high-quality breeding-related genes and subsequently facilitating the cultivation of better cotton varieties.This review summarizes the paramount research achievements in cotton molecular biology over the last few decades from the above aspects,thereby enabling us to conduct a status review on the current studies of cotton and provide strong theoretical support for the future direction. | Xingpeng Wen Zhiwen Chen Zuoren Yang Maojun Wang Shuangxia Jin Guangda Wang Li Zhang Lingjian Wang Jianying Li Sumbul Saeed Shoupu He Zhi Wang Kun Wang Zhaosheng Kong Fuguang Li Xianlong Zhang Xiaoya Chen Yuxian Zhu | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 5 | Molecular dy-namics calculation of the fluorine ions' potential ener-gies in AlGaN/GaN heterostructures显示文摘 | Yuan Li Wang Maojun Chen K J | 2008 | Journaof Ap-plied Physics2008，104，116106： | 1 |
| 6 | Fluorine plasmaion implantation in AlGaN/GaN heterostructures : Amolecular dynamics simulation study 显示文摘 | Yuan Li Wang Maojun? Chen K J | 2008 | AppliedPhysics Letters2008，92，102109： | 1 |
| 7 | TMCO1是内质网钙离子过载激活的钙离子通道显示文摘钙信号是重要的细胞内离子信号,其在胞内的浓度必须被精确地调控,以达到信号传递的忠实性和准确性。内质网是细胞内的重要钙库,保持内质网(ER)中钙离子浓度的平衡对于触发准确的钙信号和行使正常的细胞功能至关重要。 | Qiao-Chu Wang Qiaoxia Zheng Haiyan Tan Bing Zhang Xiaoling Li Yuxiu Yang Jie Yu Yang Liu Hao Chai Xi Wang Zhongshuai Sun Jiu-Qiang Wang Shu Zhu Fengli Wang Maojun Yang Caixia Guo Heng Wang Qingyin Zheng Yang Li Quan Chen Aimin Zhou 唐铁山 | 2017 | 科学新闻2017，19，4： | 0 |
| 8 | Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index显示文摘Dear Editor,The selection of linkers and payloads plays a crucial role in determining the therapeutic indices of antibody–drug conjugates(ADCs).1 Valine–citrulline(Val–Cit)coupled with a self-immolativeρ-aminobenzyl(PAB)spacer as a cleavable dipeptide linker,designated as“VC linker”in this letter,has been popularly used in ADC conjugation.1 However,VC linker is highly hydrophobic2 and,together with hydrophobic payloads at high DARs(drug-toantibody ratios),may turn ADC molecules that have hydrophilic parts in their antibody portions,into aggregation-prone“surfactant-like”structures. | Ting Shao Tianzhi Chen Yuning Chen Xiaoyue Liu Yi-Li Chen Qi Wang Tong Zhu Maojun Guo Hui Li Dianwen Ju Chunhe Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 9 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity显示文摘The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including neurodegeneration.NAD-boosting agents can provide neuroprotective benefits.Here,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage pathway.We obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active site.The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming.Importantly,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt toxicity.These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline. | Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang | 2022 | Cell Research2022，32，6： | 0 |
| 10 | Multidimensional diversity of bird communities across spatial variation of land cover in Zoige on the eastern Qinghai-Tibetan Plateau显示文摘Background:Spatial variation of land cover can result in the changes of community similarities and biotic homog-enization,whereby the increasing similarity would reduce the adaptive capacity of biotic assemblages to further disturbance,and degenerate ecosystem services they offer.However,it remains scarce to integrate multidimensional diversity for unveiling how variations in land cover may influence the patterns and processes of biotic homogeniza-tion in the Anthropocene.In this study,we examined how spatial variation of land cover could alter taxonomic,phy-logenetic and functional homogenization of bird communities simultaneously in a compound ecosystem of Zoige Marsh on the eastern Qinghai-Tibetan Plateau.Acting as the largest alpine marsh and peatland in the world,Zoige Marsh has undergone great changes in the land cover pattern due to climate change and anthropogenic activities.Methods:We conducted transect surveys for bird communities over six years(2014‒2019)during breeding sea-sons in four main land cover types(meadow,woodland,village and marsh),representing the spatial variation of land covers in the study area.We compared multidimensional diversity(taxonomic,phylogenetic and functional diver-sity)among land covers to assess the effects of spatial variation in land cover type on bird communities,particularly whether this variation has homogenized biotic communities.Results:Bird communities during breeding seasons were different and complementary in the four land covers.Taxonomic,phylogenetic and functional similarities were significantly lower in meadow than in the other three types,i.e.woodland,village and marsh.However,when we controlled for the effects of taxonomic similarities,the pattern of phylogenetic similarities almost reversed,with the highest standardized effect size(SES)phylogenetic similarity in meadow;and we found no significant difference in SES functional similarity among land covers.Conclusions:Our results suggest that spatial variation of land cover can play a crucial role in regulating multiple dimensions of bird diversity in Zoige Marsh.The findings indicate that taxonomic,phylogenetic and functional homogenization of bird communities may differently response to the variation of land covers.It thus highlights not only the relative roles of different land covers in maintaining biodiversity and community structures of birds,but also the urgency of retarding ecosystem degradations on the eastern Qinghai-Tibetan Plateau. | Aichun Xu Maojun Zhong Ke Tang Xiaoyi Wang Chen Yang Haigen Xu Jianfeng Yi Wei Liu Chunlan Zhang Junhua Hu | 2021 | Avian Research2021，12，2： | 0 |
| 11 | Subarachnoid hemorrhage after surgery of the medulla oblongata hemangioblastoma:A case report显示文摘Objectives: To discuss the bleeding mechanisms after removing a medulla oblongata hemangioblastoma. Methods: A 42-year-old male patient was diagnosed with a medulla oblongata hemangioblastoma. Preoperative cranial magnetic resonance imaging, computed tomography angiography and post-surgery computed tomography were completed during clinical procedure. We also reviewed the related literatures. Results: The preoperative computed tomography angiography did not demonstrate any intracranial aneurysm. But, the patient had a fatal subarachnoid hemorrhage with ventricular hemorrhage 4 hours after surgery following the post-surgery computed tomography. Conclusions: Subarachnoid hemorrhage after surgery of the medulla oblongata hemangioblastoma is very rare. Delayed postoperative hemorrhage seems the most reasonable explanation of Subarachnoid hemorrhage in our case. | Xiang Yang Yuekang Zhang Xuesong Liu Maojun Chen | 2016 | Translational Neuroscience and Clinics2016，2，3： | 0 |
| 12 | Histone H3 lysine 27 trimethylation suppresses jasmonate biosynthesis and signaling to affect male fertility under high temperature in cotton显示文摘High-temperature(HT)stress causes male sterility in crops,thus decreasing yields.To explore the possible contribution of histone modifications to male fertility under HT conditions,we defined the histone methylation landscape for the marks histone H3 lysine 27 trimethylation(H3K27me3)and histone H3 lysine 4 trimethylation(H3K4me3)by chromatin immunoprecipitation sequencing(ChIP-seq)in two differing upland cotton(Gossypium hirsutum)varieties.We observed a global disruption in H3K4me3 and H3K27me3 modifications,especially H3K27me3,in cotton anthers subjected to HT.HT affected the bivalent H3K4me3–H3K27me3 modification more than either monovalent modification.We determined that removal of H3K27me3 at the promoters of jasmonate-related genes increased their expression,maintaining male fertility under HT in the HT-tolerant variety at the anther dehiscence stage.Modulating jasmonate homeostasis or signaling resulted in an anther indehiscence phenotype under HT.Chemical suppression of H3K27me3 deposition increased jasmonic acid contents and maintained male fertility under HT.In summary,our study provides new insights into the regulation of male fertility by histone modifications under HT and suggests a potential strategy for improving cotton HT tolerance. | Yanlong Li Miao Chen Aamir Hamid Khan Yizan Ma Xin He Jing Yang Rui Zhang Huanhuan Ma Chunyang Zuo Yawei Li Jie Kong Maojun Wang Longfu Zhu Xianlong Zhang Ling Min | 2023 | Plant Communications2023，4，6： | 0 |
| 13 | Exploration of Infection Prevention and Control Practice of Designated Hospitals in During Corona Virus Disease 2019 Epidemic Period显示文摘Corona Virus Disease 2019(COVID-19)is a new infectious disease that appeared in whan in December 2019 Since January23,the national health and fitmess commission has required hospitals to be designated in accordance with the principle of'concentrating patients,experts,resources and treatment'.Designated hospitals are often the strength of the general hospital and general hospital complex layers of various kinds of personnel,campus area is large,multi-channel,ordinary outpatient accepts people more,for emergency and severe cases treatment in patients with normal difficulty pressuure big,suspected/confirmed cases,combined with the COVID-19 occurred when the traditional holiday,the country launched the emergency response since,process reform faces a difficult labor,shortage of mampower,protective shortages,short time limit,and many other difficulties,hospital infection prevention and control is facing unprecedented pressure.In this paper,the West China-Guang'an Hospital,Sichuan University(Guang'an people's hospital)as a designated hospital,on the basis of the relevant scheme of the national health committee,epidemic prevention and control of the actual,combined with comprehensive hospital leadership,mampower allocation,protection,security,patient management,disinfection isolation,preview triage,preventive measures,training,monitoring,etc.,with practical experience summary for the COVID-19 diring the hospital infection prevention and control to improve the practice exploration. | Haiquan Luo Maojun Fu Xiantao Chen Yunliang Chen Yichuan Li Xiaochuan Liu Xiaolan Su Yanling Chen | 2020 | Journal of Clinical and Nursing Research2020，4，4： | 0 |
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