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| 1 | Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth显示文摘发信号的调停肽的 cell-to-cell 在植物在细胞的功能的协作和定义有关键角色。肽受体匹配为理解位于调停肽的发信号下面的机制是重要的。这里,我们报导根分裂组织生长的指导结构的鉴定为植物开发重要的因素(RGF ) 受体。基于签名 ligand 识别,主题(Arg-x-Arg ) 在充满白氨酸的重复受体 kinases (LRR-RKs ) 的一个亚科保存了的试金识别了机能上地 uncharacterized LRR-RK At4g26540 作为 RGF1 (RGFR1 ) 的受体。我们进一步在 2.6 Å 的一个决定与 RGFR1 的 LRR 领域在建筑群解决了 RGF1 的水晶结构;,它表明 Arg-x-Gly-Gly (RxGG ) 主题为由 RGFR1 的 RGF1 的硫酸盐组的特定的识别负责。基于 RxGG 主题,我们识别了另外四 RGFR。在导致 RGF 的发信号的五 RGFR 的参予被生物化学、基因的数据支持。我们也提供证明 SERK 为 RGF 作为合作受体工作的证据。一起拿,我们的学习识别 RGF 受体,能连接 RGF 的合作受体与他们的下游的部件发信号并且为与他们的肽 ligands 的 LRR-RKs 的基于结构的匹配提供原则的一个证明。 | Wen Song Li Liu Jizong Wang Zhen Wu Heqiao Zhang Jiao Tang Guangzhong Lin Yichuan Wang Xing Wen Wenyang Li Zhifu Han Hongwei Guo Jijie Chai | 2016 | Cell Research2016，26，6： | 20 |
| 2 | State of the Art and Prospects in Metal-Organic Framework-Derived Microwave Absorption Materials显示文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed. | Shuning Ren Haojie Yu Li Wang Zhikun Huang Tengfei Lin Yudi Huang Jian Yang Yichuan Hong Jinyi Liu | 2022 | Nano-Micro Letters2022，14，4： | 6 |
| 3 | Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats显示文摘The idea of aromatherapy, using essential oils, has been considered as an alternative antidepressant treatment. In the present study, we investigated the effect of Roman chamomile essential oil inhalation for two weeks on depressive-like behaviors in Wistar-Kyoto(WKY) rats. We found that inhalation of either Roman chamomile or one of its main components α-pinene,attenuated depressive-like behavior in WKY rats in the forced swim test. Using isobaric tags for relative and absolute quantitation analysis(iTRAQ), we found that inhalation of α-pinene increased expression of proteins that are involved in oxidative phosphorylation, such as cytochrome c oxidase subunit 6C-2, cytochrome c oxidase subunit 7A2, ATPase inhibitor in the hippocampus, and cytochrome c oxidase subunit 6C-2, ATP synthase subunit e, Acyl carrier protein, and Cytochrome b-c1 complex subunit 6 in the PFC(prefrontal cortex). In addition, using the quantitative real-time polymerase chain reaction technique, we confirmed an increase of parvalbumin mRNA expression in the hippocampus, which was shown to be upregulated by 2.8-fold in iTRAQ analysis, in α-pinene treated WKY rats. These findings collectively suggest the involvement of mitochondrial functions and parvalbumin-related signaling in the antidepressant effect of α-pinene inhalation. | Yingying Kong Ting Wang Rong Wang Yichuan Ma Shanshan Song Juan Liu Weiwei Hu Shengtian Li | 2017 | Science China(Life Sciences)2017，60，6： | 6 |
| 4 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 5 | The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth显示文摘The molecular links between extracellular signals and the regulation of localized protein synthesis in plant cells are poorly understood.Here,we show that in Arabidopsis thaliana,the extracellular peptide RALF1 and its receptor,the FERONIA receptor kinase,promote root hair(RH)tip growth by modulating protein synthesis.We found that RALF1 promotes FERONIA-mediated phosphorylation of elF4E1,a eukaryotic translation initiation factor that plays a crucial role in the control of mRNA translation rate.Phosphorylated elF4E1 increases mRNA affinity and modulates mRNA translation and,thus,protein synthesis.The mRNAs targeted by the RALF1-FERONIA-elF4E1 module include ROP2 and RSL4,which are important regulators of RH cell polarity and growth.RALF1 and FERONIA are expressed in a polar manner in RHs,which facilitate elF4E1 polar丨ocalization and thus may control local f?OP2 translation.Moreover,we demonstrated that high-level accumulation of RSL4 exerts negative-feedback regulation of RALF1 expression by directly binding the RALF1 gene promoter,determining the final RH size.Our study reveals that the link between RALF1-FERONIA signaling and protein synthesis constitutes a novel component regulating cell expansion in these polar growing cells. | Sirui Zhu Jose Manuel Estevez Hongdong Liao Yonghua Zhu Tao Yang Chiyu Li Yichuan Wang Lan Li Xuanming Liu Javier Martinez Pacheco Hongwei Guo Feng Yu | 2020 | Molecular Plant2020，13，5： | 3 |
| 6 | Flexible and biocompatible nanopaper-based electrode arrays for neural activity recording显示文摘 | Yichuan Guo Zhiqiang Fang Mingde Du Long Yang Leihou Shao Xiaorui Zhang Li Li Jidong Shi Jinsong Tao Jinfen Wang Hongbian Li Ying Fang | 2018 | Nano Research2018，11，10： | 3 |
| 7 | User Association and Wireless Backhaul Bandwidth Allocation for 5G Heterogeneous Networks in the Millimeter-Wave Band显示文摘The user association and wireless backhaul bandwidth allocation for a two-tier heterogeneous network(Het Net) in the millimeter wave(mm Wave) band is proposed in this article. The two-tier Het Net is built up with a macro base station(MBS) and several small cell SBSs, where the MBS is assumed to be equipped with large-scale antenna arrays but the SBSs only have single-antenna capability and they rely on the wireless link to the MBS for backhaul. The sum of logarithmic user rate, which is established according to the result of multi-user Multiple Input Multiple Output(MIMO) downlink employing Zero-Force Beamforming(ZFBF), is chosen as the network utility for the objective function. And a distributed optimization algorithm based on primal and dual decomposition is used to jointly optimize the user association variable xj,i and the wireless backhaul bandwidth factor β. Simulation results reveal that the distributed optimization algorithm jointly optimizing two variables outperforms the conventional SINR-based user association strategies. | zhenxiang su bo ai yichuan lin danping he ke guan ning wang guoyu ma li niu | 2018 | China Communications2018，15，4： | 2 |
| 8 | Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis显示文摘Breast cancer bone metastasis poses significant challenge for therapeutic strategies.Inside the metastatic environment,osteoclasts and tumor cells interact synergistically to promote cancer progression.In this study,the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.Importantly,the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide(SPIO)nanoparticles.Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion,leading to alleviated osteolysis.Therefore,the bone targeting&furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis. | Yichuan Pang Li Su Yao Fu Fan Jia Chenxi Zhang Xiankun Cao Wenxin He Xueqian Kong Jiake Xu Jie Zhao An Qin | 2021 | Bioactive Materials2021，6，3： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | Growth asymmetry precedes differential auxin response during apical hook initiation in Arabidopsis显示文摘The development of a hook-like structure at the apical part of the soil-emerging organs has fascinated botanists for centuries,but how it is initiated remains unclear.Here,we demonstrate with highthroughput infrared imaging and 2-D clinostat treatment that,when gravity-induced root bending is absent,apical hook formation still takes place.In such scenarios,hook formation begins with a de novo growth asymmetry at the apical part of a straightly elongating hypocotyl.Remarkably,suchde novo asymmetric growth,but not the following hook enlargement,precedes the establishment of a detectable auxin response asymmetry,and is largely independent of auxin biosynthesis,transport and signaling.Moreover,we found that functional cortical microtubule array is essential for the following enlargement of hook curvature.When microtubule array was disrupted by oryzalin,the polar localization of PIN proteins and the formation of an auxin maximum became impaired at the to-be-hook region.Taken together,we propose a more comprehensive model for apical hook initiation,in which the microtubuledependent polar localization of PINs may mediate the instruction of growth asymmetry that is either stochastically taking place,induced by gravitropic response,or both,to generate a significant auxin gradient that drives the full development of the apical hook. | Yang Peng Dan Zhang Yuping Qiu Zhina Xiao Yusi Ji Wenyang Li Yiji Xia Yichuan Wang Hongwei Guo | 2022 | Journal of Integrative Plant Biology2022，64，1： | 1 |
| 11 | Vegetation and Soil Characteristics of Different Desertification Grasslands in Northwest Sichuan显示文摘[Objective]The paper was to study vegetation and soil characteristics of different desertification grasslands in northwest Sichuan. [Method]By taking different desertification grasslands as the research object,the characteristic factors of vegetation community,biomass,soil moisture content,volume weight and porosity were analyzed through scientific investigation,sampling and formula calculation to reveal the changes in vegetation and soil characteristics of different desertification grasslands in Northwest Sichuan. [Result]Community succession presented the pattern of ' hygrophyte-mesophyte-xerophyte' with the aggravation of grassland desertification. The height and coverage of community decreased,species richness was declined by 88%,and composition of dominant species also changed greatly. The diversity index of light-desertification grassland was the highest among tested grasslands. Total biomass was decreased by 90. 4%,and the underground biomass decreased far more than aboveground biomass. In desertification progress,both soil moisture content and water holding capacity decreased,while volume weight showed upward trend and porosity showed downward trend; soil characteristics had large variation in early stage of desertification,so restoration treatment of desertification grassland should be carried out in the early stage of desertification. [Conclusion]The study provided a theoretical basis for researches on causes and management programs of desertification grassland,having an important meaning for ecological restoration of regional grassland and maintenance of ecological security. | Wan Ting Tu Weiguo Xi Huan Li Yudong Tang Xuefang Yang Yichuan | 2014 | Animal Husbandry and Feed Science2014，6，2： | 1 |
| 12 | Does elevated asymmetrical dimethylarginine predict major adverse cardiac events and mortality in patients after percutaneous coronary intervention?显示文摘 | Yang Shao Yichuan Fan Jun Li Hui Cao Bing Liu Junpeng Wang Jun Yang Qiang Zhang Xinhua Hu | 2014 | International Journal of Cardiology2014，，： | 1 |
| 13 | Crystal plasticity finite element modelling of the extrusion texture of a magnesium alloy显示文摘 | Yichuan Shao Tao Tang Dayong Li Weiqin Tang Yinghong Peng | 2015 | Modelling and Simulation in Materials Science and Engineering2015，，： | 1 |
| 14 | Locality-Sensitive Task Allocation and Load Balancing in Networked Multiagent Systems:Talent versus Centrality显示文摘 | Jiang Yichuan Li Zhaofeng | | 0，，06： | 1 |
| 15 | Deep learning model improves radiologists'performance in detection and classification of breast lesions显示文摘Objective:Computer-aided diagnosis using deep learning algorithms has been initially applied in the field of mammography,but there is no large-scale clinical application.Methods:This study proposed to develop and verify an artificial intelligence model based on mammography.Firstly,mammograms retrospectively collected from six centers were randomized to a training dataset and a validation dataset for establishing the model.Secondly,the model was tested by comparing 12 radiologists’performance with and without it.Finally,prospectively enrolled women with mammograms from six centers were diagnosed by radiologists with the model.The detection and diagnostic capabilities were evaluated using the freeresponse receiver operating characteristic(FROC)curve and ROC curve.Results:The sensitivity of model for detecting lesions after matching was 0.908 for false positive rate of 0.25 in unilateral images.The area under ROC curve(AUC)to distinguish the benign lesions from malignant lesions was0.855[95%confidence interval(95%CI):0.830,0.880].The performance of 12 radiologists with the model was higher than that of radiologists alone(AUC:0.852 vs.0.805,P=0.005).The mean reading time of with the model was shorter than that of reading alone(80.18 s vs.62.28 s,P=0.032).In prospective application,the sensitivity of detection reached 0.887 at false positive rate of 0.25;the AUC of radiologists with the model was 0.983(95%CI:0.978,0.988),with sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of94.36%,98.07%,87.76%,and 99.09%,respectively.Conclusions:The artificial intelligence model exhibits high accuracy for detecting and diagnosing breast lesions,improves diagnostic accuracy and saves time. | Yingshi Sun Yuhong Qu Dong Wang Yi Li Lin Ye Jingbo Du Bing Xu Baoqing Li Xiaoting Li Kexin Zhang Yanjie Shi Ruijia Sun Yichuan Wang Rong Long Dengbo Chen Haijiao Li Liwei Wang Min Cao | 2021 | Chinese Journal of Cancer Research2021，33，6： | 1 |
| 16 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 17 | Genetic correlations between COVID-19 and a variety of traits and diseases显示文摘The ongoing coronavirus disease(COVID-19)outbreak has posed an extraordinary threat to global public health.Patients with certain underlying medical conditions,such as obesity,hypertension,and diabetes are at increased risk for poor outcome in COVID-19.1 Given the high genetic heritability of the aforementioned conditions,their shared genetic factors may play a crucial role in the severity of COVID-19.Indeed,a recent genome-wide association study(GWAS)of COVID-19 has reported two genomic loci associated with severe COVID-19,indicating a strong genetic influence on the severity of COVID-19. | Xiao Chang Yun Li Kenny Nguyen Huiqi Qu Yichuan Liu Joseph Glessner Patrick M.A.Sleiman Hakon Hakonarson | 2021 | The Innovation2021，2，2： | 0 |
| 18 | Progress in Research of Chinese Wetland Parks显示文摘There has been a rapid development in the construction of wetland parks in China in recent years.This paper discussed the progress in the research of Chinese wetland parks that covered the aspects of wetland resources,landscape and environment.The function of wetland parks,the evaluation of landscape and the exploiting of resources;the landscape concept and landscape planning and design;the plant environment,the water environment and the recreation environment were all reviewed.The research of Chinese wetland parks started later but developed rapidly,having remarkable achievements in practice and functional studies,and there are still some shortcomings in the researches to be improved.At last,the key points which should be researched urgently in the future were discussed. | ZHANG Yichuan LI Dongsheng WANG Shanshan | 2008 | Journal of Northeast Agricultural University(English Edition)2008，15，4： | 0 |
| 19 | Electrochemical Co-reduction of Bi(Ⅲ)and Y(Ⅲ)and Extracting Yttrium from Molten LiCl-KCl Using Liquid Bi as Cathode显示文摘The electrochemical reaction of Bi(Ⅲ)and co-reduction behaviour of Bi(Ⅲ)and Y(Ⅲ)ions were researched in molten LiCl-KCl on a ttmgsten(W)electrode employing a range of electrochemical teclmiques.Cyclic voltammetric and square-wave voltanunetric results revealed that the reduction of Bi(Ⅲ)was a one-step process,with the exchange of three electrons on a W electrode,and diffusion-controlled.The electrochemical curves showed two reduction peaks pertaining to the formation of Bi-Y alloy compounds,because of the co-reduction of Bi(Ⅲ)and Y(Ⅲ) by metallic Y deposited on the pre-deposited Bi-coated W electrode and reacting with Bi metal in molten LiCl-KCl. Furthermore,galvanostatic electrolysis was conducted using liquid Bi as cathode to extract yttrium at different current intensities,and the extractive products were analyzed by SEM,EDS and XRD.The results indicated that BiY intermetallic compotmd was formed in the molten LiCl-KCl-YCl3 system. | LI Mei LIU Yichuan SUN Zhongxuan HAN Wei ZHANG Milin YANG Xiaoguang SUN Yang | 2019 | Chemical Research in Chinese Universities2019，35，1： | 0 |
| 20 | Theoretical investigation on optical properties of Möbius carbon nanobelts in one-and two-photon absorption显示文摘The first successful synthesis of fully fused and fully conjugated Möbius carbon nanobelts(CNBs)has attracted considerable attention.However,theoretical calculations based on suchπ-conjugated Möbius CNB are still insufficient.Herein,we theoretically investigated molecular spectroscopy of Möbius CNBs without and with n-butoxy groups via visualization methods.The results show that the presence of n-butoxy groups can significantly affect Möbius CNBs’optical performance,changing electron-hole coherence and enhancing two-photon absorption cross-sections.Our work provides a deeper understanding of photophysical mechanisms of Möbius CNBs in one-and two-photon absorption and reveals possible applications on optoelectronic devices. | Zhiqiang Yang Yichuan Chen Jing Li Chen Lu Junfang Zhao Mengtao Sun | 2023 | Frontiers of physics2023，18，3： | 0 |
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