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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | SKOSCore:简约知识组织网络表述语言显示文摘简约知识组织表述语言(SKOS Core)以资源描述框架(RDF)为基础,是一种表述规范词表中的基本结构和概念表内容的格式语言。所谓概念表(Concept Scheme)是指某领域里所有概念及概念之间的语义关系的集合。SKOS Core由网络联盟(W3C)语义网(Semantic Web)下的最佳实践和应用工作小组(Best Practice andDeployment Working Group)出版并维护。本文的主要目的是为SKOS Core在都柏林元数据中结合使用提供一些基本的诠释。通过给出各种规范词表用SKOS Core表达的例子,该文介绍了SKOS Core的管理政策、SKOS Core与都柏林元数据、资源描述框架结构语言(RDF Schema)以及网络实用分类系统语言(Web Ontology Language,OWL)之间的关系。SKOS Core的发展仍处在初级阶段,本文的介绍希望能够起到一个抛砖引玉的作用,同时也能促进下一步的发展,与都柏林元数据词汇的使用结合起来。 | Alistair Miles Brian Matthews Michael Wilson Dan Brickley | 2006 | 现代图书情报技术2006，，1： | 5 |
| 3 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 4 | Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease显示文摘 | Sweta Tandra Matthew M. Yeh Elizabeth M. Brunt Raj Vuppalanchi Oscar W. Cummings Aynur ünalp-Arida Laura A. Wilson Naga Chalasani | 2011 | Journal of Hepatology2011，，3： | 3 |
| 5 | Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease显示文摘 | Kris V. Kowdley Patricia Belt Laura A. Wilson Matthew M. Yeh Brent A. Neuschwander‐Tetri Naga Chalasani Arun J. Sanyal James E. Nelson | 2011 | Hepatology2011，，： | 3 |
| 6 | A typology for the classification, description and valuation of ecosystem functions, goods and services显示文摘 | Rudolf S de Groot Matthew A Wilson Roelof M.J Boumans | 2002 | Ecological Economics2002，，3： | 3 |
| 7 | Pancreatic stents for prophylaxis against post-ERCP pancreatitis: a meta-analysis and systematic review显示文摘 | Abhishek Choudhary Matthew L. Bechtold Murtaza Arif Nicholas M. Szary Srinivas R. Puli Mohamed O. Othman Wilson P. Pais Mainor R. Antillon Praveen K. Roy | 2011 | Gastrointestinal Endoscopy2011，，2： | 3 |
| 8 | Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Jane W. Newburger Masato Takahashi Michael A. Gerber Michael H. Gewitz Lloyd Y. Tani Jane C. Burns Stanford T. Shulman Ann F. Bolger Patricia Ferrieri Robert S. Baltimore Walter R. Wilson Larry M. Baddour Matthew E. Levison Thomas J. Pallasch Donald A. Fa | 2004 | Circulation2004，，17： | 2 |
| 9 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 10 | National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary显示文摘 | Terry A. Jacobson Matthew K. Ito Kevin C. Maki Carl E. Orringer Harold E. Bays Peter H. Jones James M. McKenney Scott M. Grundy Edward A. Gill Robert A. Wild Don P. Wilson W. Virgil Brown | 2014 | Journal of Clinical Lipidology2014，，： | 2 |
| 11 | Economic and ecological concepts for valuing ecosystem services显示文摘 | Stephen C. Farber Robert Costanza Matthew A. Wilson | 2002 | Ecological Economics2002，，3： | 2 |
| 12 | Pancreatic stents for prophylaxis against post-ERCP pancreatitis: a meta-analysis and systematic review显示文摘 | Abhishek Choudhary Matthew L. Bechtold Murtaza Arif Nicholas M. Szary Srinivas R. Puli Mohamed O. Othman Wilson P. Pais Mainor R. Antillon Praveen K. Roy | 2011 | Gastrointestinal Endoscopy2011，，2： | 1 |
| 13 | Comparison of constructions of irregular Gallager codes 显示文摘 | MacKay D J C Wilson S T Matthew C D | 1999 | IEEE Trans Commun1999，47，10： | 1 |
| 14 | Shape-memory behavior of estimulated polyurethane for medical applications显示文摘 | Baer G Wilson T S Matthews D L | 2007 | Journal of Applied Polymer Science2007，103，6： | 1 |
| 15 | An eight-step kinetics mechanism for high temperature propane flames 显示文摘 | Kiehne T M Matthews R D Wilson D E | 1987 | Combustion Science and Technology1987，54，1： | 1 |
| 16 | Political Sophistication and Economic Voting in the American Electorate: a Theory of Heterogeneous Attribution显示文摘 | Gomez Brad T Matthew Wilson | 2001 | American Journal of Political Science2001，，4： | 1 |
| 17 | Plasma immersion ion implantation as a technique in duplex and hybrid processing显示文摘 | Matthews A Leyland A Wilson A | 2003 | Vacuum2003，68，： | 1 |
| 18 | The buih environment and location-based physical activity 显示文摘 | Troped PJ Wilson JS Matthews CE | 2010 | Am J Prey Med2010，38，4： | 1 |
| 19 | Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical in- tensive care unit patients显示文摘 | Matthews LR Ahmed Y Wilson KL | 2012 | Am J Surg2012，204，1： | 1 |
| 20 | The chemistry and behaviour of antimony in the soil environment with comparisons to arsenic: A critical review显示文摘 | Susan C. Wilson Peter V. Lockwood Paul M. Ashley Matthew Tighe | 2009 | Environmental Pollution2009，，5： | 1 |
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