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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 3 | MILP-aided bit-based division property for ARX ciphers显示文摘Division property,which was proposed by Todo [1] at EUROCRYPT 2015,is a new technique to detect integral property.It could explicitly depict the hidden properties between the traditional ALL and BALANCE properties in integral cryptanalysis [2],which made it an effective method to search integral distinguishers.The definition is given as follows. | Ling SUN Wei WANG Ru LIU Meiqin WANG | 2018 | Science China(Information Sciences)2018，61，11： | 4 |
| 4 | Diatoms from the southwestern continental slope,South China Sea,and their paleoenvironmental significance since the last glacial times显示文摘A quantitative study was undertaken on diatoms from cores(SA08-34) obtained from the southwestern continental slope of the South China Sea(SCS).A total of 165 diatom species belonging to 45 genera were identified.We constructed a stratigraphic subdivision and correlation according to the characteristics of diatom assemblages together with 14C dating and carbonate analysis.We also discuss the sedimentary environment in the sea area since the last glacial times.The research shows that the diatom assemblages coincide with inter-glacial and glacial times,and changes in diatom abundance reflect the instability of the climate in the southern part of the SCS,such that shortterm,temperature descending events correlate with the interglacial interval.The abundance of diatoms is relevant to interglacial and glacial times,since high abundance values were associated with an interglacial interval,and low abundance values with the last glacial maximum.We assume that strong upwelling developed in the interglacial interval,the development of which was influenced by variations of monsoons in the East Asian region. | Meiqin Sun Dongzhao Lan Zhimin Cao | 2009 | Progress in Natural Science:Materials International2009，19，10： | 4 |
| 5 | Toward a further understanding of bit-based division property显示文摘The division property of a multiset,which is a generalization of the integral property,was proposed by Todo[1]at EUROCRYPT 2015.Since division property can precisely depict the implicit properties between ALL and BALANCE properties,it allows us to efficiently construct integral distinguisher even if the round function of the block cipher is non-bijective,bit-oriented,and low-degree. | Ling SUN Meiqin WANG | 2017 | Science China(Information Sciences)2017，60，12： | 3 |
| 6 | China' s energy development strategy under the low - carbon economy显示文摘 | Jiang Bing Sun Zhenqing Liu Meiqin | 2010 | Energy2010，35，11： | 1 |
| 7 | China’s energy development strategy under the low-carbon economy显示文摘 | Bing Jiang Zhenqing Sun Meiqin Liu | 2010 | Energy2010，，11： | 1 |
| 8 | Dispersion properties of a water-soluble phenol-formaldehyde resin显示文摘 | Sun Limei Li Mingyuan Lin Meiqin | 2009 | Journal of Dispersion Science and Technology2009，30，5： | 1 |
| 9 | Electrodeposition in organic system and properties of NiO electrochromic films显示文摘By electrodeposition in organic system,NiO films with reversible electrochromic property were fabricated.Fluorine-doped tin oxide glass slices were used as substrates,i.e.cathodes.Cyclic voltammetry and ultraviolet-visible transmission spectroscopy were adopted to study the electrochromic properties of the films.High resolution transmission electron microscopy(HRTEM) was employed to analyze the composition and structure of the films.It is found that the films are composed of fine NiO crystal grains of a few nanometers in diameter,endowing them with large visible light transmittance variation,rapid switch rate(i.e.rapid response time) between the bleached and colored states.Their cycling durability reached 6000 cycles. | SU Ge SONG MeiQin SUN WuZhu CAO LiXin LIU Wei MA DeWen CHEN Na ZHAO LiLi WANG Jing LIU XiaoYun | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 10 | China's energy develop- ment strategy under the low-carbon economy显示文摘 | Jiang Bing Zhenqing Sun Meiqin Liu | 2011 | Energy2011，35，11： | 1 |
| 11 | A Coverage Optimization Algorithm for Underwater Acoustic Sensor Networks based on Dijkstra Method显示文摘Dear Editor,This letter presents a coverage optimization algorithm for underwater acoustic sensor networks(UASN)based on Dijkstra method.Due to the particularity of underwater environment,the multipath effect and channel are easily disturbed,resulting in more node energy consumption.Once the energy is exhausted,the network transmission stability and network connectivity will be affected. | Meiqin Tang Jiawen Sheng Shaoyan Sun | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，8： | 1 |
| 12 | China's energy development strategy under the low-carbon economy 显示文摘 | Jiang Bing Zhenqing Sun Meiqin Liu | 2011 | Energy2011，35，11： | 1 |
| 13 | China's energy development strategy under the low-carbon economy 显示文摘 | Bing Jiang Zhenqing Sun Meiqin Liu | 2010 | Energy2010，，35： | 1 |
| 14 | Systematic study of the transfer of amino acids across the water/1,2-dichloroethane interface facilitated by dibenzo-18-crown-6显示文摘Facilitated ion transfer reactions of 20 amino acids with dibenzo-18-crown-6 (DB18C6) at the water/1,2-dichloroethane (W/DCE) interfaces supported at the tips of micro- and nano-pipets were investigated systematically using cyclic voltammetry. It was found that there were only 10 amino acids, that is, Leu, Val, Ile, Phe, Trp, Met, Ala, Gly, Cys, Gln (in brief), whose protonated forms as cations can give well-defined facilitated ion transfer voltammograms within the potential window, and the reaction pathway was proven to be consistent with the transfer by interfacial complexation/dissociation (TIC/TID) mechanisms. The association constants of DB 18C6 with different amino acids in the DCE (β0), and the kinetic parameters of reaction were evaluated based on the steady-state voltammetry of micro- or nano-pipets, respectively. The experimental results demonstrated that the selectivity of complexation of protonated amino acid by DB18C6 compared with that of alkali metal cations was low, which can be attributed to the vicinal effect arising from steric hindrance introduced by their side group and the steric bulk effect by lipophilic stabilization. Moreover, the association constants and the standard rate constants for different amino acids showed good correlations with their hydrophobicity (π), except Gly and Met, which inferred that the selectivity of such heterogeneous complex reaction for different amino acids with DB18C6, was not only affected by discrimination in binding these ions to the crown ether macro-cycle, but also significantly modified by the ion transfer Gibbs energy which was closely related to the structure of the transferred ions, protonated amino acids. | CHEN Yong, YUAN Yi, ZHANG Meiqin, LI Fei, SUN Peng, GAO Zhao & SHAO YuanhuaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China | 2004 | Science China Chemistry2004，47，1： | 0 |
| 15 | Study of ionizable drugs transfer across the water/1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system显示文摘The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ioni-zable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard par-tition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The ob-tained results have been summarized in ionic partition dia-grams, which are a useful tool for predicting and interpret-ing the transfer mechanisms of ionizable drugs at the liq-uid/liquid interfaces and biological membranes. | ZHANG Meiqin SUN Peng CHEN Yong LI Fei GAO Zhao SHAO Yuanhua | 2003 | Chinese Science Bulletin2003，48，12： | 0 |
| 16 | Dispersing SnO_2 nanocrystals in amorphous carbon as a cyclic durable anode material for lithium ion batteries显示文摘We demonstrate a facile route for the massive production of SnCb/carbon nanocomposite used as high-capacity anode materials of nextgeneration lithium-ion batteries.The nanocomposite had a unique structure of ultrafine SnO_2 nanocrystals(~5 nm,80 wt%) homogeneously dispersed in amorphous carbon matrix.This structure design can well accommodate the volume change of Li^+ insertion/desertion in SnO_2,and prevent the aggregation of the nanosized active materials during cycling,leading to superior cycle performance with stable reversible capacity of 400 mAh/g at a high current rate of 3.3 A/g. | Renzong Hu Wei Sun Meiqin Zeng Min Zhu | 2014 | Journal of Energy Chemistry2014，23，3： | 0 |
| 17 | Human IFT-A complex structures provide molecular insights into ciliary transport显示文摘Intraflagellar transport(IFT)complexes,IFT-A and IFT-B,form bidirectional trains that move along the axonemal microtubules and are essential for assembling and maintaining cilia.Mutations in IFT subunits lead to numerous ciliopathies involving multiple tissues.However,how IFT complexes assemble and mediate cargo transport lacks mechanistic understanding due to missing highresolution structural information of the holo-complexes.Here we report cryo-EM structures of human IFT-A complexes in the presence and absence of TULP3 at overall resolutions of 3.0–3.9Å.IFT-A adopts a“lariat”shape with interconnected core and peripheral subunits linked by structurally vital zinc-binding domains.TULP3,the cargo adapter,interacts with IFT-A through its N-terminal region,and interface mutations disrupt cargo transport.We also determine the molecular impacts of disease mutations on complex formation and ciliary transport.Our work reveals IFT-A architecture,sheds light on ciliary transport and IFT train formation,and enables the rationalization of disease mutations in ciliopathies. | Meiqin Jiang Vivek Reddy Palicharla Darcie Miller Sun-Hee Hwang Hanwen Zhu Patricia Hixson Saikat Mukhopadhyay Ji Sun | 2023 | Cell Research2023，33，4： | 0 |
| 18 | The Concept and Nature of Northern Ethnic Dynasties from the Historical View on the Chinese Nation显示文摘In recent years,the concept'northern ethnic dynasties'has been widely used when referring to dynasties established by ethnic groups from northern China,including Liao,Jin,Yuan,and Qing dynasty.When it comes to the prolonged debates on the relation between ethnic groups and state,the traditional narrative of the dynastic history of Central Plains,which holds'sinicization'as its principal line,has been challenged;and the academia has been focusing on how to elaborate features and state forms of these northern ethnic dynasties.This article argues that,only by returning to the dynasty-based narrative of the evolvement of northern ethnic regimes,can we break the shackle of western-style'nation state'narrative;can we understand the fact that dynasticity transcends ethnicity in Chinese history;and can we thereby establish the correct view of history on the Chinese nation. | Meiqin QI Jun CHEN Jie JI Yue SUN Li LIU | 2023 | Journal of the Chinese Nation Studies2023，2，2： | 0 |
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