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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Application of Smith Predictor Based on Single Neural Network in Cold Rolling Shape Control显示文摘Flatness is one of the most important criterion factors to evaluate the quality of the steel strip. To improve the strip’s flatness quality, the most frequently used methodology is to employ the closed-loop automatic shape control system. However, in the shape control system, the shape-meter is always installed at the down way of the exit of the cold rolling mill and can not sense the changes of the strip flatness in the rolling gap directly. This kind of installation results in the delay of the feedback in the control system. Therefore, the stability and response performance of the system are strongly affected by the delay. At present, there is still no mature way to design controllers for systems with time delay. Although the conventional PID controller used in most practical applications has the capability to compensate the delay, the effect of the compensation is limited, especially for the systems with long time delay. Smith predictor, as a compensator for solving this problem, is now widely used in industry systems. However, the request of highly precise model of the system and the poor adaptive performance to the changes of related parameters limit the application of the Smith predictor in practice. In order to overcome the drawbacks of the Smith predictor, a new Smith predictor based on single neural network PID (SNN-PID) is proposed. Because the single neural network is employed into the Smith predictor to improve the controller’s self-adaptability, the adaptive capability to the varying parameters of the system is improved. Meanwhile, for the purpose of solving the problems such as time-consuming and complicated calculation of the neural networks in real time, the learning coefficient of neural network is divided into several stages as usually done in expert control system. Therefore, the control system can obtain fast response due to the improved calculation speed of the neural networks. In order to validate the performance of the proposed controller, the experiment is conducted on the shape control system in a 300 mm four-high reversing cold rolling mill. The experimental results show that the SNN-PID with Smith predictor controller can effectively compensate the delay effects and achieve better control performance than the conventional PID controller. | WANG Yiqun SUN FD LIU Jian SUN Menghui XIE Yihan | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 14 |
| 3 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 4 | An overview of laser-based multiple metallic material additive manufacturing: from macro- to micro-scales显示文摘Additive manufacturing(AM)is an emerging customized three-dimensional(3D)functional product fabrication technology.It provides a higher degree of design freedom,reduces manufacturing steps,cost and production cycles.However,existing metallic component 3D printing techniques are mainly for the manufacture of single material components.With the increasing commercial applications of AM technologies,the need for 3D printing of more than one type of dissimilar materials in a single component increases.Therefore,investigations on multi-material AM(MMAM)emerge over the past decade.Lasers are currently widely used for the AM of metallic components where high temperatures are involved.Here we report the progress and trend in laser-based macro-and micro-scale AM of multiple metallic components.The methods covered in this paper include laser powder bed fusion,laser powder directed energy deposition,and laser-induced forward transfer for MMAM applications.The principles and process/material characteristics are described.Potential applications and challenges are discussed.Finally,future research directions and prospects are proposed. | Chao Wei Zhizhou Zhang Dongxu Cheng Zhe Sun Menghui Zhu Lin Li | 2021 | International Journal of Extreme Manufacturing2021，3，1： | 7 |
| 5 | INCREASING RETURNS TO SCALE,DYNAMICS OF INDUSTRIAL STRUCTURE AND SIZE DISTRIBUTION OF FIRMS显示文摘A multi-agent model is presented to discuss the market dynamics and the size distribution of firms. The model emphasizes the effects of increasing returns to scale and gives the description of the born and death of adaptive producers. The evolution of market structure and its behavior under the technological shocks are investigated. Its dynamical results are in good agreement with some empirical “stylized facts” of industrial evolution. With the diversity of demand and adaptive growth strategies of firms, the firm size in the generalized model obeys the power-law distribution. Three factors mainly determine the competitive dynamics and the skewed size distributions of firms: 1. Self-reinforcing mechanism; 2. Adaptive firm growing strategies; 3. Demand diversity or widespread heterogeneity in the technological capabilities of firms. | Ying FAN Menghui LI Zengru DI | 2006 | Journal of Systems Science and Systems Engineering2006，15，1： | 5 |
| 6 | PhieCBEs:Plant High-Efficiency Cytidine Base Editors with Expanded Target Range显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-mediated genome editing can efficiently produce gene-knockout mutants.On the other hand,CRISPR/Cas-derived base editors offer the ability to induce precise nucleotide substitutions(Komor et al.,2016).Cytidine base editors(CBEs)consist of a cytidine deaminase fused with a Cas9-nickase variant(Cas9n,with a D10A substitu-tion)and can achieve site-specific C-to-T substitution.Similarly,adenine base editors use an adenine deaminase forA-to-G substi-tution.These systems have been used in various organisms(Mishra et al.,2019).However,the Cas9 complex requires target sites containing NGG protospacer adjacent motifs(PAMs),thus restricting selection of potential targets.A number of CBEs have been developed using Cas9 variants(mostly Cas9n),cytidine deaminases(such as rAPOBEC1 and PmCDA1),and uracil glycosylase inhibitor(UGI)domains.These CBEs of the first generation(BE1,rAPOBEC1-dCas9),second generation(BE2,rAPOBEC1-dCas9-UGI),and third generation(BE3,rAPOBEC1-Cas9n-UGI)have moderate editing efficiencies in mammalians(Komor etal.,2016). | Dongchang Zeng Taoli Liu Jiantao Tan Yaling Zhang Zhiye Zheng Bin Wang Degui Zhou Xianrong Xie Menghui Guo Yao-Guang Liu Qinlong Zhu | 2020 | Molecular Plant2020，13，12： | 5 |
| 7 | Improved Relief Grinding Method of Gear Hob with Equal Relief Angle显示文摘The regrinding error is the main factor affecting the eligible length of hob tooth,how to decrease the regrinding error is a hot issue in the research area of hob grinding.At present,researches focus on changing the trajectory of relief moving,because of no unified relief grinding path planning method,the research result is restricted in the practical application.For solving the problem,the calculation model of the hob relief angle is established with the Archimedes relieving motion to analyze the interaction between the increasing relief angle of the hob and the accelerating tooth profile errors.Based on it,the improved relief grinding method of gear hob is proposed with equal relief angle(ERA).Furthermore,the relief grinding method with ERA is developed with the following two steps.Firstly,the convergence numerical solution algorithm of the tooth top curve is designed to form the wheel motion path which is compared with that of traditional grinding.The second step is to establish the solution model of ERA grinding wheel.In order to verify the effect of the method,hob grinding simulation system of 3D solid was built under the AutoCAD environment.The regrinding errors is analyzed by intercepting the hob axial profiles of the various regrinding angles with Boolean operations and further converting it to basic rack tooth,then the simulation example of zero rake straight flute hob is used to compare the regrinding errors between ERA grinding and traditional grinding.Finally,the experiments were implemented on the five-axis CNC relief grinder with the relief motion of ERA grinding driven by cam.The results of experiments show that the method can effectively reduce the regrinding errors of hob and grind expediently gear hob of AA rank and over.This research provide an effective model of relief moving path plan reducing regrinding error,and have practicable value in CNC relief grinder. | LI Guolong SUN Menghui LI Xianguang LIU Fei HUANG Chao | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 4 |
| 8 | Pressure control strategy for pump motor energy transfer unit显示文摘Multi-level pressure source system is a novel hydraulic system with distinct advantage of energy saving. In order to balance each pressure level of the multi-level pressure source system, a pump motor energy transfer unit is usually equipped. However, the pump motor energy transfer has the characteristics of poor starting and low response, which cause long time of pressure adjustment and large pressure jitter when the transformer is switched to system suddenly and the motor-side pressure has pressure impact when rail of the pump-side is switched. To address these problems, this paper proposes a compound control strategy of feedforward compensation control with Fuzzy-PID to improve the controllability of the multi-level pressure source system. A test rig of the pump motor energy transfer unit is built and the controllability of compound controller and PID controller are compared. The experiment results show that, compared with the traditional PID, the adjustment time and the pressure impact are reduced by 20% and 25% with the proposed compound control strategy. Therefore, the presented compound control strategy can be used to improve starting performance and robustness of the pump motor energy transfer unit control system. | 姚静 Zhang Wei Cao Xiaoming Zhao Guichun Sun Menghui | 2019 | High Technology Letters2019，25，3： | 2 |
| 9 | Advanced Noncarbon Materials as Catalyst Supports and Non‑noble Electrocatalysts for Fuel Cells and Metal–Air Batteries显示文摘Electrochemical energy systems such as fuel cells and metal–air batteries can be used as clean power sources in the field of electric transportation and possess great potential in the reduction of various energy and environmental issues.In these systems,the oxygen reduction reaction(ORR)at the cathode is the rate-determining factor for overall system performance,and up to now,platinum group metals supported on carbon materials,especially Pt,remain the highest performing and the most practical ORR electrocatalysts.However,corresponding carbonaceous catalyst supports are extremely susceptible to corrosion under electrochemical operation,and therefore,the extensive exploration of alternative stable materials for ORR electrocatalysts with both high electrochemical stability and catalytic performance is essential.Here,noncarbon materials with high corrosion resistance have been explored to substitute traditional carbon supports or even act directly as low-cost non-noble metal electrocatalysts,and based on this,this review will present a comprehensive overview and deep analysis of the recent progress in noncarbon materials,including metals,oxides,nitrides,carbides,sulfides,and so on.Overall,general attributes associated with noncarbon materials include high corrosion resistance,strong metal–support interaction,and impressive porous structure retention.However,major drawbacks include low electrical conductivity,insufficient chemical stability in acidic or alkaline media,and poor electrochemical stability at ORR electrode potentials.To overcome these challenges,this review will also summarize efficient strategies such as combining with highly conductive materials,introducing dopants and forming vacancies to result in promising electrocatalytic ORR performances.Finally,this review will propose possible research directions to facilitate future research and development toward the practical application of noncarbon-based ORR electrocatalysts. | Shiming Zhang Menghui Chen Xiao Zhao Jialin Cai Wei Yan Joey Chung Yen Shengli Chen Yan Yu Jiujun Zhang | 2021 | Electrochemical Energy Reviews2021，4，2： | 2 |
| 10 | Engineered exosomes from different sources for cancertargeted therapy显示文摘Exosome is a subgroup of extracellular vesicles,which has been serving as an efficient therapeutic tool for various diseases.Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.After appropriate modification,engineered exosomes are able to deliver antitumor drugs to tumor sites efficiently and precisely with fewer treatment-related adverse effects.However,there still exist many challenges for the clinical translation of engineered exosomes.For instance,what sources and modification strategies could endow exosomes with the most efficient antitumor activity is still poorly understood.Additionally,how to choose appropriately engineered exosomes in different antitumor therapies is another unresolved problem.In this review,we summarized the characteristics of engineered exosomes,especially the spatial and temporal properties.Additionally,we concluded the recent advances in engineered exosomes in the cancer fields,including the sources,isolation technologies,modification strategies,and labeling and imaging methods of engineered exosomes.Furthermore,the applications of engineered exosomes in different antitumor therapies were summarized,such as photodynamic therapy,gene therapy,and immunotherapy.Consequently,the above provides the cancer researchers in this community with the latest ideas on engineered exosome modification and new direction of new drug development,which is prospective to accelerate the clinical translation of engineered exosomes for cancer-targeted therapy. | Menghui Zhang Shengyun Hu Lin Liu Pengyuan Dang Yang Liu Zhenqiang Sun Bingbing Qiao Chengzeng Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 11 | Highly sensitive integrated flexible tactile sensors with piezoresistive Ge2Sb2Te5 thin films显示文摘Flexible tactile sensor has been extensively investigated as a key component for emerging electronics applications such as robotics,wearable devices,computer hardware,and security systems.Tactile sensors based on various one-dimensional materials have been widely explored.However,precise control of the direction and distribution of these nanomaterials remains a great challenge,and it has been difficult to scale down the device.Here,we introduce highly sensitive integrated flexible tactile sensors based on uniform phase-change Ge_(2)Sb_(2)Te_(5)(GST)thin films that can scale device size down,at least,to micrometer range.Significant piezoresistive effect has been observed in GST-based sensors,showing a giant gauge factor of 338.A proof of concept 5×5 sensor array functioning as a touch panel has been demonstrated.Also,the flexible GST tactile sensor has been utilized for monitoring of radial artery pulse.In addition to the well-known tunable electrical and optical properties,the piezoresistive GST films provide a versatile platform for the integration of sensing,recording,and displaying functions. | Zhiguang Wang Cunzheng Dong Xinjun Wang Menghui Li Tianxiang Nan Xianfeng Liang Huaihao Chen Yuyi Wei Haomiao Zhou Mohsen Zaeimbashi Syd Cash Nian-Xiang Sun | 2018 | npj Flexible Electronics2018，2，1： | 2 |
| 12 | Restoring force correction based on online discrete tangent stiffness estimation method for real-time hybrid simulation显示文摘In real-time hybrid simulation(RTHS), it is difficult if not impossible to completely erase the error in restoring force due to actuator response delay using existing displacement-based compensation methods. This paper proposes a new force correction method based on online discrete tangent stiffness estimation(online DTSE) to provide accurate online estimation of the instantaneous stiffness of the physical substructure. Following the discrete curve parameter recognition theory, the online DTSE method estimates the instantaneous stiffness mainly through adaptively building a fuzzy segment with the latest measurements, constructing several strict bounding lines of the segment and calculating the slope of the strict bounding lines, which significantly improves the calculation efficiency and accuracy for the instantaneous stiffness estimation. The results of both computational simulation and real-time hybrid simulation show that:(1) the online DTSE method has high calculation efficiency, of which the relatively short computation time will not interrupt RTHS; and(2) the online DTSE method provides better estimation for the instantaneous stiffness, compared with other existing estimation methods. Due to the quick and accurate estimation of instantaneous stiffness, the online DTSE method therefore provides a promising technique to correct restoring forces in RTHS. | Huang Liang Guo Tong Chen Cheng Chen Menghui | 2018 | Earthquake Engineering and Engineering Vibration2018，17，4： | 2 |
| 13 | Systemic Vasculitis:An Important and Underestimated Cause of Malignant Hypertension显示文摘Objectives:Malignant hypertension(MHT)is defi ned as severe hypertension accompanied by ischemic failure of one or more organs.The aims of this study were to evaluate the current clinical and etiologic profi les of MHT.Methods:As a retrospective study,we selected all patients admitted to our center from January 2013 to December 2016.Seventy patients with MHT were included.Results:The average age of the patients was 40 years,and more than half of the patients were male(78.57%).There were 24 patients with essential hypertension,accounting for 34.29%of the patients,and 46 with secondary hypertension,accounting for 65.71%of the patients.For secondary MHT,systemic vasculitis(25.57%)was the most common cause,followed by severe obstructive sleep apnea syndrome(15.71%),primary renal parenchymal hypertension(11.43%),primary aldosteronism(7.14%),and Cushing syndrome(1.43%)and nutcracker phenomenon(1.43%).Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing severity.The levels of white blood cells,hypersensitive C-reactive protein,serum creatinine,and 24-hour urinary protein were above their normal range.Conclusion:Systemic vasculitis may be one of the main causes of MHT,and has been underestimated in the past.In future clinical work,clinicians need to pay more attention to patients with systemic vasculitis. | Qing Zhu Shasha Liu Mulalibieke Heizhati Xiaoguang Yao Menghui Wang Qin Luo Lei Wang Delian Zhang Guijuan Chang Nanfang Li | 2019 | Cardiovascular Innovations and Applications2019，，B07： | 2 |
| 14 | Weighted networks of scientific communication:the measurement and topological role of weight显示文摘 | LI Menghui FAN Ying CHEN Jiawei | 2005 | Physics A2005，350，： | 1 |
| 15 | Weighted net- works of scientific communication: The measurement and topological role of weight 显示文摘 | LI MENGHUI FAN YING CHEN JIAWEI | 2005 | Physica A: Statistical Mechanics and its Applica- tions2005，350，234： | 1 |
| 16 | Densities and vapor pressures of mixed-solvent desiccant systems containing{glycol(diethylene,or triethylene,or tetraethylene glycol)+salt(magnesium chloride)+water}显示文摘 | Chen Shangyi Allan N Soriano Li Menghui | 2010 | The Journal of Chemical Thermodynamics2010，42，9： | 1 |
| 17 | Cotton flavonoid structural genes related to the pigmentation in brown fibers显示文摘 | Xiao Yuehua Zhang Zhengsheng Yin Menghui | | 0，，1： | 1 |
| 18 | The analysis and dissimilarity comparison of community st ructure 显示文摘 | Zhang Peng Li Menghui Wu Jinshan | 2006 | Physica A2006，367，： | 1 |
| 19 | The community structure of scientific collaboration network显示文摘 | Zhang Peng Li Menghui Wu Jinshan | 2006 | Physica A2006，367，： | 1 |
| 20 | Accuracy and precision of methods for community identification in weightednetworks显示文摘 | Fan Yin Li Menghui Zhang Peng | 2007 | Physica A2007，377，： | 1 |
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