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| 1 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | Raman lasing and soliton mode-locking in lithium niobate microresonators显示文摘The recent advancement in lithium-niobite-on-insulator(LNOI)technology is opening up new opportunities in optoelectronics,as devices with better performance,lower power consumption and a smaller footprint can be realised due to the high optical confinement in the structures.The LNOI platform offers both largeχ(2)andχ(3)nonlinearities along with the power of dispersion engineering,enabling brand new nonlinear photonic devices and applications for the next generation of integrated photonic circuits.However,Raman scattering and its interaction with other nonlinear processes have not been extensively studied in dispersion-engineered LNOI nanodevices.In this work,we characterise the Raman radiation spectra in a monolithic lithium niobate(LN)microresonator via selective excitation of Raman-active phonon modes.The dominant mode for the Raman oscillation is observed in the backward direction for a continuous-wave pump threshold power of 20mW with a high differential quantum efficiency of 46%.We explore the effects of Raman scattering on Kerr optical frequency comb generation.We achieve mode-locked states in an X-cut LNOI chip through sufficient suppression of the Raman effect via cavity geometry control.Our analysis of the Raman effect provides guidance for the development of future chip-based photonic devices on the LNOI platform. | Mengjie Yu Yoshitomo Okawachi Rebecca Cheng Cheng Wang Mian Zhang Alexander L.Gaeta Marko Loncar | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 3 | CRISPR/Cas9-based tools for targeted genome editing and replication control of HBV显示文摘Hepatitis B virus(HBV) infection remains a major global health problem because current therapies rarely eliminate HBV infections to achieve a complete cure. A different treatment paradigm to effectively clear HBV infection and eradicate latent viral reservoirs is urgently required. In recent years, the development of a new RNA-guided gene-editing tool, the CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9) system, has greatly facilitated site-specific mutagenesis and represents a very promising potential therapeutic tool for diseases, including for eradication of invasive pathogens such as HBV. Here, we review recent advances in the use of CRISPR/Cas9, which is designed to target HBV specific DNA sequences to inhibit HBV replication and to induce viral genome mutation, in cell lines or animal models. Advantages, limitations and possible solutions, and proposed directions for future research are discussed to highlight the opportunities and challenges of CRISPR/Cas9 as a new, potentially curative therapy for chronic hepatitis B infection. | Cheng Peng Mengji Lu Dongliang Yang | 2015 | Virologica Sinica2015，30，5： | 2 |
| 4 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 5 | Achieving simultaneous Cu particles anchoring in meso-porous TiO_(2) nanofabrication for enhancing photo-catalytic CO_(2) reduction through rapid charge separation显示文摘A facile solvo-thermal approach was successfully employed to prepare titanium oxide (TiO_(2)) nano-aggregates with simultaneous copper particles anchoring. The as-synthesized composite could convert CO_(2) into CH_(4) and CO products under simulated solar irradiation. The impact of copper loading amounts on the photo-reduction capability was evaluated. It was found proper amount of Cu loading could enhance the activity of CO_(2) photo-reduction. As a result, the optimal composite (TiO_(2)^(-)Cu-5%) consisting of TiO_(2) supported with 5% (mole ratio) Cu exhibits 2.2 times higher CH_(4) yield and 3 times higher CO yield compared with pure TiO_(2). Conduction band calculated from the band gap and valence X-ray photoelectron spectroscopy (XPS) indicated TiO_(2) nano-aggregates have suitable band edge alignment with respect to the CO_(2)/CH_(4) and CO_(2)/CO redox potential. Furthermore, with involving of Cu particles, an efficient separation of photo-generated charges was achieved on the basis of photocurrent response and photoluminescence spectra results, which contributed to the improved photo-catalytic performance. The present work suggested that the Cu-decorated TiO_(2) could serve as an efficient photo-catalyst for solar-driven CO_(2) photo-reduction. | Jinyan Xiong Mengmeng Zhang Mengjie Lu Kai Zhao Chao Han Gang Cheng Zhipan Wen | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 6 | Preparation of quaternarized N-halamine-grafted graphene oxide nanocomposites and synergetic antibacterial properties显示文摘At present,frequent outbreaks of bacteria and viruses have seriously affected people's normal lives.Therefore,the study of broad-spectrum antibacterial nanocomposites is very promising.However,most antibacterial materials have some disadvantages,such as single bactericidal mechanisms and unrepeatable use.Based on the current situation,a kind of nanocomposite with three structures of graphene oxide(GO),quaternary ammonium salt(QAs)and N-halamine was prepared,which showed synergistic effect to improve antibacterial activity and combined with a variety of sterilization mechanisms.Meanwhile,GO can provide richer ways of sterilization and high specific surface area,which is conducive to the grafting of quaternarized N-halamine.The advantages of physical sterilization of GO,charge adsorption of QAs,reuse of N-halamine and efficient sterilization are fully utilized.The results showed that the quaternarized N-halamine-grafted GO was obtained successfully.GO grafted with quaternarized N-halamine polymer showed strong speedy bactericidal activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)(99%).It had good storage and regeneration properties. | Danlin Bu Yu Zhou Chang Yang Hengyu Feng Chunxia Cheng Mengjie Zhang Zice Xu Linghan Xiao Yujing Liu Zhenai Jin | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 7 | Multifunctional modification of Fe_(3)O_(4) nanoparticles for diagnosis and treatment of diseases:A review显示文摘With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good biocompatibility and super-paramagnetic property are usually used as contrast agent for diagnosis of diseases inmagnetic resonance imaging(MRI).Currently,the combination of multiple imagingtechnologies has been considered as new tendency in diagnosis and treatment ofdiseases,which could enhance the accuracy and reliability of disease diagnosis andprovide new strategies for disease treatment.Therefore,novel contrast agents used formultifunctional imaging are urgently needed.Fe_(3)O_(4) MNPs are believed to be a potentialcandidate for construction of multifunctional platform in diagnosis and treatment ofdiseases.In recent years,there are a plethora of studies concerning the construction ofmultifunctional platform presented based on Fe_(3)O_(4) MNPs.In this review,we introducefabrication methods and modification strategies of Fe_(3)O_(4) MNPs,expecting greatimprovements for diagnosis and treatment of diseases in the future. | Miao QIN Mengjie XU Lulu NIU Yizhu CHENG Xiaolian NIU Jinlong KONG Xiumei ZHANG Yan WEI Di HUANG | 2021 | Frontiers of Materials Science2021，15，1： | 1 |
| 8 | Metabolic features of the tumor microenvironment of gastric cancer and the link to the systemic macroenvironment显示文摘 | Jiye Aa Lianzhen Yu Min Sun Linsheng Liu Mengjie Li Bei Cao Jan Shi Jin Xu Liping Cheng Jun Zhou Tian Zheng Xinwen Wang Chunyan Zhao Rongrong Gu Fengyi Zhang Ruihua Shi Guangji Wang | 2012 | Metabolomics2012，，1： | 1 |
| 9 | 查看详情显示文摘 | Cheng Rumei Ou Sbengju Li Mengjie | | 0，，： | 1 |
| 10 | A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse显示文摘Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience,and hardbor safety and hygiene.In this study,we fabricated a carbomer-based contraceptive gel consisting of three agents:tenofovir,gossypol acetate,and nitroglycerin(TGN),with pH adjusted to 4.5(to be compatible with the vagina).In vitro,the gossypol component of the contraceptive gel proved to be an effective spermicide.When the concentration of gossypol acetate was 10 mg/ml,the spermicidal ability reached 100%after 30 s.In addition,tenofovir in the gel significantly inhibited lentiviral transfection efficiency in cell-containing media.In 6 pairs of rats,the gel successfully prevented all females from conceiving after successful mating.Moreover,increased sexual frequency and enhanced erection,which were promoted by the nitroglycerin in the components,were observed in male rats that had the gel applied to their penises.This novel TGN contraceptive gel yielded a higher contraceptive success rate than that of the commercial contraceptive gel(Contragel®).In addition,it has the added benefits to prevent sexually transmitted diseases and improve male libido and erectile function during sexual intercourse.Combining three FDA-approved and marketed agents together,our trifunctional TGN gel has a great potential for further translation and commercialization. | Mengjie Xie Junlang Li Sichen Zhang Dashuai Zhu Xuan Mei Zhenzhen Wang Xiao Cheng Zhenhua Li Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，6： | 1 |
| 11 | Filamentation initiated by Cas2 and its association with the acquisition process in cells显示文摘Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive immunity.The process is critical for the ecology of the oral microflora and oral health.Although molecular mechanisms for spacer acquisition are known,it has never been established if this process is associated with the morphological changes of bacteria.In this study,we demonstrated a novel Cas2-induced filamentation phenotype in E.coli that was regulated by co-expression of the Cas1 protein.A 30 amino acid motif at the carboxyl terminus of Cas2 is necessary for this function.By imaging analysis,we provided evidence to argue that Cas-induced filamentation is a step coupled with new spacer acquisition during which filaments are characterised by polyploidy with asymmetric cell division.This work may open new opportunities to investigate the adaptive immune response and microbial balance for oral health. | Lei Wang Xin Yu Mengjie Li Guiqin Sun Lin Zou Tiansheng Li Linlin Hou Yameng Guo Danfeng Shen Di Qu Xunjia Cheng Li Chen | 2019 | International Journal of Oral Science2019，11，4： | 0 |
| 12 | Immigration,transformation,and emission control of sulfur and nitrogen during gasification of MSW:Fundamental and engineering review显示文摘This paper proposes a comprehensive summary and analysis of an important issue during municipal solid waste(MSW)gasification-sulfur and nitrogen pollution.It provides an overview of the fundamentals of MSW and the basic aspects of nitrogen and sulfur elements.Their characteristics of immigration,transformation and distribution during gasification with control solutions in realized or potential engineering are also concluded.The analysis indicates that the complete scenario of the occurrence form of sulfur and nitrogen elements in MSW is difficult to obtain,owing to the diverse sources and complicated compositions.However,with the assistance of advanced characterization and quantification methods(XPS,XRD,TG-FTIR,et al.),the common sulfur-and nitrogen-containing compounds in both organic and inorganic states can be detected.Adjustment of gasification conditions can regulate the transformation of these elements for emission control.The multiple pollutants including H_(2)S,SO_(x),COS,NH_(3),HCN and NO_(x)cannot be eliminated by one-step treatment but a combination of adsorption and catalytic treatments may realize the control goal.This research aims to benefit meeting emission standards during MSW gasification and to provide a reference for other processes such as incineration,pyrolysis and other feedstocks like biomass and refuse derived fuel(RDF). | Shuchao Cheng Xueyu Ding Xinxin Dong Mengjie Zhang Xinqi Tian Yang Liu Yaji Huang Baosheng Jin | 2023 | Carbon Resources Conversion2023，6，3： | 0 |
| 13 | Male parent birds exert more effort to reproduce in two desert passerines显示文摘Background:Parental investment by birds is limited by the habitat environment,and a male parent increases its effort to reproduce in birds that live in high-altitude areas.Methods:A study of the reproductive behaviour of the Saxaul Sparrow(Passer ammodendri)and the Isabelline Shrike(Lanius isabellinus)was carried out at the Gansu An’xi Extremely Arid Desert National Nature Reserve in northwest China to determine the reproductive input of passerine species in desert habitats.Results:In Saxaul Sparrows,compared to the female parent,the male parent exhibited a significantly higher fre-quency of nest-defense behaviour(chirping and warning)during nesting,hatching and feeding periods.In addition,in comparison to the female parent,the male parent exhibited almost equal frequencies of nesting and incubation but fed nestlings significantly more times.Similar to the male sparrows,the feeding rates of the male Isabelline Shrikes were significantly higher than those of the females.The hatching rate and fledging rate of the Saxaul Sparrow on aver-age in this study were 81.99 and 91.92%,respectively,while those of the shrike were 69.00 and 96.53%,respectively.Conclusions:These two different passerine species living in the same desert environment exhibited the same trend in their reproductive investments.Adapting to desert environments is a strategy that may have evolved in passerines where male parent birds put more effort than females into reproduction to ensure high reproductive output. | Donghui Ma Mengjie Lu Zhichang Cheng Xingnan Du Xiaoyu Zou Xingxing Yao Xinkang Bao | 2021 | Avian Research2021，12，3： | 0 |
| 14 | Screening of rootstocks with resistance to chilling and continuous cropping but without compromising fruit quality for protected watermelon production显示文摘Chilling stress and continuous cropping obstacles limit sustainable production of watermelons under controlled environments.Grafting of watermelon scions onto resistant rootstocks is an effective strategy currently used to overcome these environment limitations.However,currently used commercial rootstocks adversely affect watermelon fruit quality.The chilling tolerance and Fusarium oxysporum f.sp.niveum race 1(FON1)resistance of seven Cucurbit germplasms,including four watermelon germplasms(M08,TC,YL,and MY),two muskmelon cultivars(JT1 and JSM),and one commercial Cucurbita rootstock(QZ1)of watermelon,were explored in the current study.The effects of the rootstocks of these germplasms on watermelon resistance to chilling stress and continuous cropping obstacles were evaluated.TC rootstock showed the highest chilling tolerance and increased chilling tolerance of watermelon scion.All Cucurbit germplasms showed higher resistance to FON1 than watermelon cultivar N5(control).Watermelons grafted onto QZ1 showed the lowest wilt incidence and highest fruit yield but had the worst fruit quality after planting on soils continuously cropped for 11 years.Watermelons grafted onto TC showed higher resistance and yield and the best fruit quality.These findings indicate that TC has a large potential for use in grafting watermelon planted in continuously cropped soils(<10 years).TC can also be used as breeding rootstocks to improve watermelon resistance against continuous cropping obstacles without compromising fruit quality. | Kai Xu Zhixiang Lan Qing Liu Yuxing Xue Jingyi Yan Zhuangzhuang Su Mengjie Cheng Feishi Luan Xian Zhang Hao Li | 2022 | Vegetable Research2022，2，1： | 0 |
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