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| 1 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 2 | Effects of hypoxia on survival,behavior,and metabolism of Zhikong scallop Chlamys farreri Jones et Preston 1904显示文摘Hypoxia,a frequent occurring threat in coastal regions,often results in mass mortalities of marine organisms and brings a serious ecological problem.The commercially important Zhikong scallop Chlamys farreri is being under such a threat as the risks of eutrophication and hypoxia have risen in their culture areas.However,little information has been known concerning their tolerance to hypoxia and their strategy for survival.In the present study,a 20-day experiment was conducted to determine the ef fects of hypoxia on the survival,behavior,and metabolism of Zhikong scallop.With the LC_(50)for dissolved oxygen(DO)being estimated as 1.8 mg/L,the survival of Zhikong scallop can be greatly challenged even under the moderate hypoxic condition of around 2.0 mg/L DO.The survival rate ranged from 69%to 59%when DO dropped from 3.0 to 2.0 mg/L,and it was further reduced to 47%at 1.5 mg/L DO.In hypoxic conditions,the scallops became significantly active,which may be explained as escape attempts to avoid hypoxic water.To save energy,Zhikong scallop would depress their respiration.However,when DO dropped from 3.0 to 2.0 mg/L,the oxygen consumption rate hardly changed.The upregulation of lactate dehydrogenase activity and the unrepressed phosphofructokinase activity,which often result in the unbalanced cellular homeostasis and energy budget,may account for the observed increase in the mortality rate of Zhikong scallops.In general,Zhikong scallop is sensitive to hypoxia events,though possible escape attempts,depressed respiration,and oxaloacetate-pathway may increase their survival chance. | LI Qiao ZHANG Fang WANG Minxiao LI Mengna SUN Song | 2020 | Journal of Oceanology and Limnology2020，38，2： | 5 |
| 3 | Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia显示文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions. | Yuepeng PAN Mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang SUN Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 4 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 5 | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis显示文摘Postoperative endophthalmitis(POE)has been the most threatening complication after cataract surgery,which perhaps can be solved by the antibiotic-loaded intraocular lens(IOL).However,most drug-loaded IOLs demonstrate insufficient drug quantity,short release time,increased implantation-related difficulties or other noticeable drawbacks.To prevent POE and to address these deficiencies,a drug-loaded copolymer IOL,prepared from poly(urethane acrylate)prepolymer,isobornyl methacrylate(IBOMA),N-vinyl-2-pyrrolidone(NVP),Irgacure 819,RUVA-93,and gatifloxacin(GAT),was rapidly fabricated via photocuring and by using a 3D-printed mold.This composite displayed an outstanding and controllable GAT release behavior in vitro,a high light transmittance,and a moderate refractive index.Also,it demonstrated improved strain stress and elongation compared with the reference commercial acrylic IOL material.In vivo tests demonstrated satisfying released drug concentration at the early treatment stage.In vitro and in vivo studies further confirmed the remarkable bacterial inhibition and prevention of POE by the proposed IOL,which also displayed good biocompatibility.These findings suggested that the GAT-loaded IOL could be a promising implant to prevent and cure POE,also the proposed methods could inspire more designs for various medical applications. | Mengna Li Jing-Wei Xu Jiayong Li Wei Wang Chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao | 2023 | Bioactive Materials2023，，2： | 2 |
| 6 | A Method for Alpine Wetland Delineation and Features of Border: Zoigê Plateau, China显示文摘Accurate wetland delineation is the basis of wetland definition and mapping, and is of great importance for wetland management and research. The Zoigê Plateau on the Qinghai-Tibet Plateau was used as a research site for research on alpine wetland delineation. Several studies have analyzed the spatiotemporal pattern and dynamics of these alpine wetlands, but none have addressed the issues of wetland boundaries. The objective of this work was to discriminate the upper boundaries of alpine wetlands by coupling ecological methods and satellite observations. The combination of Landsat 8 images and supervised classification was an effective method for rapid identification of alpine wetlands in the Zoigê Plateau. Wet meadow was relatively stable compared with hydric soils and wetland hydrology and could be used as a primary indicator for discriminating the upper boundaries of alpine wetlands. A slope of less than 4.5° could be used as the threshold value for wetland delineation. The normalized difference vegetation index(NDVI) in 434 field sites showed that a threshold value of 0.3 could distinguish grasslands from emergent marsh and wet meadow in September. The median normalized difference water index(NDWI) of emergent marsh remained more stable than that of wet meadow and grasslands during the period from September until July of the following year. The index of mean density in wet meadow zones was higher than the emergent and upland zones. Over twice the number of species occurred in the wet meadow zone compared with the emergent zone, and close to the value of upland zone. Alpine wetlands in the three reserves in 2014 covered 1175.19 km2 with a classification accuracy of 75.6%. The combination of ecological methods and remote sensing technology will play an important role in wetland delineation at medium and small scales. The correct differentiation between wet meadow and grasslands is the key to improving the accuracy of future wetland delineation. | ZHENG Yaomin NIU Zhenguo GONG Peng LI Mengna HU Lile WANG Lei YANG Yuxiang GU Hai-jun MU Jinrong DOU Gejia XUE Hui WANG Lin LI Hua DOU Gejie DANG Zhicairang | 2017 | Chinese Geographical Science2017，27，5： | 2 |
| 7 | PVT1 affects ENIT and cell proliferation and migration via regulating p21 in triple-negative breast cancer cells cultured with mature adipogenic medium显示文摘Excessive adiposity has long been proved to be associated with greater incidence and mortality of breast cancer in post-menopausal women.However,the effects and underlying mechanisms of human adipocytes on breast cancer cells remain largely unknown.In recent years,several reports have revealed the oncogenic role of long non-coding RNA PVT1 in breast cancer.Here,we aimed to investigate the role and underlying mechanisms of PVT1 in triple-negative breast cancer (TNBC)cells cultured with mature adipogenic medium.At first,we successfully induced adipogenic differentiation from human adipose-derived mesenchymal stern cells and collected the mature adipogenic medium to mimic excessive adiposity.Our results demonstrated that the mature adipogenic medium promoted the epithelial-mesenchymal transition,enhanced the cell viability and migration potential of TNBC cells.In addition,we proved that mature adipogenic medium affected the PVT1 expression and inhibition of the PVT1 disturbed the role of mature adipogenic medium in TNBC cells.Finally,we illustrated that repression of p21 restored the phenotype caused by PVT1 knockdown in TNBC cells treated with mature adipogenic medium.Taken together,our results demonstrated that PVT1 affected the role of mature adipogenic medium in TNBC cells via modulating p21 expression. | Lingli Wang Ruirui Wang Zi Ye Yanyan Wang Xiao Li Weizhen Chen Mengna Zhang Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 2 |
| 8 | Alkyl-chain branched effect on the aggregation and photophysical behavior of polydiarylfluorenes toward stable deep-blue electroluminescence and efficient amplified spontaneous emission显示文摘The control of the condensed superstructure of light-emitting conjugated polymers(LCPs)is a crucial factor to obtain high performance and stable organic optoelectronic devices.Side-chain engineering strategy is an effective platform to tune inter chain aggregation and photophysical behaviour of LCPs.Herein,we systematically investigated the alkyl-chain branched effecton the conformational transition and photophysical behaviour of polydiarylfluorenes toward efficient blue optoelectronic devices.The branched side chain will improve materials solubility to inhibit interchain aggregation in solution according to DLS and optical analysis,which is useful to obtain high quality film.Therefore,our branched PEODPF,POYDPF pristine film present high luminance efficiency of 36.1%and 39.6%,enhanced about 20%relative to that of PODPF.Compared to the liner-type sides'chain,these branched chains also suppress chain planarization and improve film morphological stability effectively.Interestingly,the branched polymer also had excellent stable amplified spontaneous emission(ASE)behaviour with low threshold(4.72μJ/cm2)and a center peak of 465 nm,even thermal annealing at 220℃in the air atmosphere.Therefore,side-chain branched strategy for LCPs is an effective means to control interchain aggregation,film morphology and photophysical property of LCPs. | Lili Sun Ning Sun Lubing Bai Xiang An Bin Liu Chen Sun Lixiang Fan Chuanxin Wei Yamin Han Mengna Yu Jinyi Lin Dan Lu Ning Wang Linghai Xie Kang Shen Xinwen Zhang Yanan Xu Juan Cabanillas-Gonzalez Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 9 | Identification and characterization of endosymbiosis-related immune genes in deep-sea mussels Gigantidas platifrons显示文摘Deep-sea mussels of the subfamily Bathymodiolinae are common and numerically dominant species widely distributed in cold seeps and hydrothermal vents.During long-time evolution,deep-sea mussels have evolved to be well adapted to the local environment of cold seeps and hydrothermal vents by various ways,especially by establishing endosymbiosis with chemotrophic bacteria.However,biological processes underlying the establishment and maintenance of symbiosis between host mussels and symbionts are largely unclear.In the present study,Gigantidas platifrons genes possibly involved in the symbiosis with methane oxidation symbionts were identified and characterized by Lipopolysaccharide(LPS)pull-down and in situ hybridization.Five immune related proteins including Toll-like receptor 2(TLR2),integrin,vacuolar sorting protein(VSP),matrix metalloproteinase 1(MMP1),and leucine-rich repeat(LRR-1)were identified by LPS pull-down assay.These five proteins were all conserved in either molecular sequences or functional domains and known to be key molecules in host immune recognition,phagocytosis,and lysosome-mediated digestion.Furthermore,in situ hybridization of LRR-1,TLR2 and VSP genes was conducted to investigate their expression patterns in gill tissues of G.platifrons.Consequently,LRR-1,TLR2,and VSP genes were found expressed exclusively in the bacteriocytes of G.platifrons.Therefore,it was suggested that TLR2,integrin,VSP,MMP1,and LRR-1 might be crucial molecules in the symbiosis between G.platifrons and methane oxidation bacteria by participating in symbiosis-related immune processes. | LI Mengna CHEN Hao WANG Minxiao ZHONG Zhaoshan ZHOU Li LI Chaolun | 2020 | Journal of Oceanology and Limnology2020，38，4： | 1 |
| 10 | A telomere-to-telomere gap-free assembly of soybean genome显示文摘Dear Editor,Soybean(Glycine max),one of the world's most important crops,represents an indispensable source of edible oil and protein for both humans and livestock.The first soybean reference genome of the Williams 82 cultivar(Wm82)was assembled using a wholegenome shotgun approach integrated with physical and highdensity genetic maps in 2010(Schmutz et al.,2010).In addition to the first reference genome,de novo genome assemblies have been released recently for dozens of cultivated soybean accessions with the application of long-read sequencing technology(Li et al.,2014;Shen et al.,2018;Liu et al.,2020).Although those assemblies provide valuable resources for functional genomics and molecular breeding,there are still a number of unresolved gaps that impede the exploration of complex genomic regions such as centromeres and telomeres。 | Longfei Wang Mengzhu Zhang Mengna Li Xinyu Jiang Wu Jiao Qingxin Song | 2023 | Molecular Plant2023，16，11： | 1 |
| 11 | A web based tool to merge geometric morphometric data from multiple characters显示文摘Geometric morphometrics(GM) is an important method of shape analysis and increasingly used in a wide range of scientific disciplines.Presently,a single character comparison system of geometric morphometric data is used in almost all empirical studies,and this approach is sufficient for many scientific problems.However,the estimation of overall similarity among taxa or objects based on multiple characters is crucial in a variety of contexts(e.g.(semi-)automated identification,phenetic relationships,tracing of character evolution,phylogenetic reconstruction).Here we propose a new web-based tool for merging several geometric morphometrics data files from multiple characters into a single data file.Using this approach information from multiple characters can be compared in combination and an overall similarity estimate can be obtained in a convenient and geometrically rigorous manner.To illustrate our method,we provide an example analysis of 25 dung beetle species with seven Procrustes superimposed landmark data files representing the morphological variation of body features:the epipharynx,right mandible,pronotum,elytra,hindwing,and the metendosternite in dorsal and lateral view.All seven files were merged into a single one containing information on 649 landmark locations.The possible applications of such merged data files in different fields of science are discussed. | Ming Bai Jing Li Wencheng Wang Rolf G. Beutel Benjamin Wipfle Wangang Liu ShaLi Mengna Zhang Yuanyuan Lu Xingke Yang | 2017 | Zoological Systematics2017，42，1： | 1 |
| 12 | On the Development of a Model for the Prediction of Liquid Loading in Gas Wells with an Inclined Section显示文摘The ability to predict liquid loading in horizontal gas wells is of great importance for determining the time of drainage and optimizing the related production technology.In the present work,we describe the outcomes of experiments conducted using air-water mixtures in a horizontal well.The results show that the configuration with an inclined section is the most susceptible to liquid loading.Laboratory experiments in an inclined pipe were also conducted to analyze the variation of the critical gas flow rate under different angles,pressure and liquid volume(taking the equal liquid volume at inlet and outlet as the criterion for judging on the critical state).According to these results,the related angle of the inclined section ranges from 45°to 60°.Finally,a modified approach based on the Belfroid model has been used to predict the critical gas flow rate for the inclined section.After comparison with field data,this modified model shows an accuracy of 96%,indicating that it has better performances with respect to other models used in the past to predict liquid loading. | Mengna Liao Ruiquan Liao Jie Liu Shuangquan Liu Li Li Xiuwu Wang Yang Cheng | 2019 | Fluid Dynamics & Materials Processing2019，15，5： | 1 |
| 13 | A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation显示文摘Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor microbiosphere.Currently,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is unknown.Here,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench geomorphology.Microbial community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter availability.At lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different magnitude.Evidence is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic populations.Such depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere. | Jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-Smith Jonathan D.Todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 14 | Titanylphthalocyanine as hole transporting material for perovskite solar cells显示文摘Titanylphthalocyanine(TiOPc) as hole transporting material(HTM) was successfully synthesized by a simple process with low cost. Perovskite solar cells using the TiOPc as HTM were fabricated and characterized. TiOPc as HTM plays an important role in increasing the power conversion efficiency(PCE) by minimizing recombination losses at the perovskite/Au interface because TiOPc as HTM can extract photogenerated holes from the perovskite and then transport quickly these charges to the back metal electrode. In the research, the β-TiOPc gives a higher PCE than α-TiOPc for the devices due to sufficient transfer dynamics. The β-TiOPc was applied in perovskite solar cells without dopping to afford an impressive PCE of 5.05% under AM 1.5G illumination at the thickness of 40 nm which is competitive with spiro-OMe TAD at the same condition. The present work suggests a guideline for optimizing the photovoltaic properties of perovskite solar cells using the TiOPc as the HTM. | Mengna Sun Shirong Wang Yin Xiao Zhihao Song Xianggao Li | 2015 | Journal of Energy Chemistry2015，24，6： | 0 |
| 15 | Highly efficient quantum dot light-emitting diodes with the utilization of an organic emission layer显示文摘The relative balance of electron and hole injection is crucial for the achievement of highly efficient quantum dot(QD)lightemitting diodes(QLEDs).Here,an inverted red QLED with the utilization of an organic emitting layer(EML)was obtained,exhibiting peak current efficiency(CE)and external quantum efficiency(EQE)of 25.63 cd/A and 23.20%,respectively.In the proposed device,the organic EML,which is a blend of fac-tris(2-phenylpyridine)iridium(Ir(ppy)_(3))and 4,4’-bis(N-carbazolyl)-1,1’-biphenyl(CBP),works as an exciton harvester to capture the leaked electrons from QD layer and the injected holes from hole transporting layer(HTL),then affording energy transfer from organic EML to the adjacent QD layer so that the emission of QD is enhanced significantly.At the same time,according to the results of hole-only and electron-only devices,the insertion of organic EML promotes the hole injection,and eliminates excess electrons from QD to HTL,thus leading to a better match of hole and electron injection in the device.On the basis of the above benefits,the optimal QLED with a 10 nm organic EML offered~2-fold improvements of CE and EQE,respectively,relative to the control device.Furthermore,a better operational lifetime of QLEDs based on the organic EML was achieved. | Yang Li Dejiang Zhao Wei Huang Zhiqiang Jiao Lu Wang Qingyu Huang Peng Wang Mengna Sun Guangcai Yuan | 2023 | Nano Research2023，16，7： | 0 |
| 16 | Key microRNAs and target genes involved in regulating maturation in Lilium显示文摘Lilium is an ornamental bulb with a long juvenile stage,making its cultivation under natural conditions lengthy and costly.SQUAMOSA promoterbinding protein-like(SPL)transcription factors are related to plant growth and development,including phase transition.However,their role in phase transition in Lilium is not known.To explore the molecular mechanisms associated with the phase transition in Lilium,bulbs of Lilium Oriental Trumpet'Robina'were treated with lowered temperature to induce phase transition,and the small RNA and degradome were sequenced.A total of 161 miRNAs were identified as targets.Twenty-nine known miRNAs were differentially expressed,including 16 upregulated miRNAs and 13 down-regulated miRNAs.Lbr-miR156a was significantly down-regulated,and the target genes of Lbr-miR156a were identified as LbrSPL3 and LbrSPL16.Phylogenetic analysis showed that LbrSPL3 and LbrSPL16 had high homology with other plant SPLs.Subcellular localization and transcriptional activation experiments confirmed that LbrSPL3 and LbrSPL16 were mainly located in the nucleus and had transcriptional activity.The in situ hybridization results showed that the expression of LbrSPL3 and LbrSPL16 was increased following low-temperature treatment.Functional verification experiments of Arabidopsis transgenic plants showed that the overexpression of LbrSPL3 and LbrSPL16 could promote plant phase change,while the overexpression of Lbr-miR156a could inhibit this process.These results help elucidate the mechanism of phase transition regulation in Lilium and provide a reference for breeding research in other bulbous flowers. | Yao Chen Mengna Zhao Xiaoshan Wang Jinteng Cui Wei Ge Kezhong Zhang | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 17 | A Novel Imaging Method Based on Reweighted Total Variation for an Interferometer Array on Lunar Orbit显示文摘Ground-based radio observations below 30 MHz are susceptible to the ionosphere of the Earth and the radio frequency interference.Compared with other space mission concepts,making low frequency observations using an interferometer array on lunar orbit is one of the most feasible ones due to a number of technical and economic advantages.Different from traditional interferometer arrays,the interferometer array on lunar orbit faces some complications such as the three-dimensional distribution of baselines and the changing sky blockage by the Moon.Although the brute-force method based on the linear mapping relationship between the visibilities and the sky temperature can produce satisfactory results in general,there are still large residual errors on account of the loss of the edge information.To obtain the full-sky maps with higher accuracy,in this paper we propose a novel imaging method based on reweighted total variation(RTV)for a lunar orbit interferometer array.Meanwhile,a split Bregman iteration method is introduced to optimize the proposed RTV model so as to decrease the computation time.The simulation results show that,compared with the traditional brute-force method,the RTV regularization method can effectively reduce the reconstruction errors and obtain more accurate sky maps,which proves the effectiveness of the proposed method. | Xiaocheng Yang Mengna Wang Lin Wu Jingye Yan Junbao Zheng Li Deng | 2023 | Research in Astronomy and Astrophysics2023，23，12： | 0 |
| 18 | Microbial reduction and migration of As/Fe mediated by electron shuttle:Differences between incorporated and adsorbed As(V)显示文摘Metal-reducing bacteria play a central and important role in the biogeochemical cycle of arsenic(As)and iron(Fe).Research on As/Fe migration from arsenic-containing iron minerals mediated by electronic shuttles is of significance to groundwater protection and human health.Further,the redox activity and bioavailability of goethite with differing occurrence and distribution of arsenic have not been studied clearly.In this study,the function of electron shuttle AQDS in Fe(III)bioreduction was determined.It was found that acidic conditions were conducive to the growth and reproduction of strain D2201,which was beneficial to the reduction of As(V)/Fe(III).The OD600nm value of the bacteria at pH 6 exceeded twice that at pH 8.Then,three types of goethite,namely pure goethite(Gt),coprecipitated As(V)-goethite(Gt-As),and adsorbed arsenic-goethite(Gt*As),were compared for microbial reduction reactivity.X-ray photoelectron spectroscopy analysis illustrated the proportion of OH-content in Gt-As was much lower than that of Gt and Gt*As,indicating Gt-As carried more surface defects and had higher bioavailability.The Fe(II)content released from AQDS-mediated bioreduction of Gt-As was two-fold higher than that of Gt and Gt*As at pH 7.In addition,pH significantly affected goethite bioreduction efficiency and arsenic migration degree.The dissolved Fe(II)concentration for Gt-As was 0.98,0.133,and 0.139 mM at pH 6,7,and 8,respectively;corresponding to dissolved As(T)content of 3.51,1.48,and 1.31μM within 9 days of culture.This study highlights the significant influence of AQDS and mineral structure on the As/Fe biochemical cycle,which will help further develop the bioremediation of arsenic-contaminated sediments. | Jia Wang Zuoming Xie Yanxin Wang Yang Yang Mengna Chen | 2022 | Water Biology and Security2022，1，2： | 0 |
| 19 | Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma显示文摘In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are important.Immune checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on tumors.To date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some tumors.However,glioblastoma(GBM)still lacks an effective treatment.Recently,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to bevacizumab.Therefore,the use of immune checkpoints in the treatment of GBM still faces many challenges.First,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be determined.Second,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be addressed.All of these concerns require extensive basic research and clinical trials.In this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM. | Shaoping Shen Ling Chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi Uemura Qiyan Wu Xinguang Yu Tianyi Liu | 2020 | Cancer Biology & Medicine2020，17，3： | 0 |
| 20 | Application of phenonaphthazine derivatives as hole-transporting materials for perovskite solar cells显示文摘Two electron-rich,solution-processable phenonaphthazine derivatives,5,12-bis{N-[4,4'-bis-(phenyl)-aminophen-4''-yl]}-phenonaphthazine(BPZTPA) and 5,12-bis{N-[4,4'-bis(methoxy-phenyl)aminophen-4''-yl]}-phenonaphthazine(Me O-BPZTPA) have been designed and employed in the fabrication of perovskite solar cells.BPZTPA and Me O-BPZTPA exhibit excellent thermal stabilities,hole mobilities(~10-4cm^2/(V.s)) and suitable HOMO levels(-5.34 and-5.29 e V,respectively) relative to the valence band of the CH_3NH_3 Pb I_3 and Au work function,showing their potential as alternative hole-transporting materials(HTMs).Meanwhile,the corresponding mesoporous Ti O_2/CH_3NH_3 Pb I_3/HTM/Au devices are investigated,and the best power conversion efficiency of 10.36% has been achieved for Me O-BPZTPA without using p-type dopant. | Xueyuan Liu Fei Zhang Xicheng Liu Mengna Sun Shirong Wang Dongmei Li Qingbo Meng Xianggao Li | 2016 | Journal of Energy Chemistry2016，25，4： | 0 |
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