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| 1 | Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis显示文摘 | Iris M. Otani Arjun A. Anilkumar Robert O. Newbury Monica Bhagat Lisa Y. Beppu Ranjan Dohil David H. Broide Seema S. Aceves | 2013 | The Journal of Allergy and Clinical Immunology2013，，6： | 3 |
| 2 | Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function显示文摘 | Sebastiaan A. Kleijn Wessel P. Brouwer Mohamed F.A. Aly Iris K. Rüssel Gerben J. de Roest Aernout M. Beek Albert C. van Rossum Otto Kamp | 2012 | European Heart Journal – Cardiovascular Imaging2012，，10： | 2 |
| 3 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 4 | Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells and the extracellular milieu显示文摘 | Chandan Kumar-Sinha Iris Wei Diane M. Simeone | 2012 | Current Opinion in Gastroenterology2012，，5： | 1 |
| 5 | Stable transformation of Pleurotus ostreatus to hygromycin B resistance using Lentinus edodes GPD expression signals显示文摘 | T. Irie Y. Honda T. Hirano T. Sato H. Enei T. Watanabe M. Kuwahara | 2001 | Applied Microbiology and Biotechnology (-)2001，，5： | 1 |
| 6 | Carboxin resistance transformation of the homobasidiomycete fungus Pleurotus ostreatus显示文摘 | Y. Honda T. Matsuyama T. Irie T. Watanabe M. Kuwahara | 2000 | Current Genetics2000，，3： | 1 |
| 7 | The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid显示文摘 | John M. Manners Iris A.M.A. Penninckx Katrien Vermaere Kemal Kazan Rebecca L. Brown Andrew Morgan Donald J. Maclean Mark D. Curtis Bruno P.A. Cammue Willem F. Broekaert | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 8 | Prostaglandin E2 Prevents Helicobacter -Induced Gastric Preneoplasia and Facilitates Persistent Infection in a Mouse Model显示文摘 | Isabella M. Toller Iris Hitzler Ayca Sayi Anne Mueller | 2010 | Gastroenterology2010，，4： | 1 |
| 9 | Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab显示文摘 | Jolien Tol Jeroen R. Dijkstra Marjolein Klomp Steven Teerenstra Martin Dommerholt M. Elisa Vink-B?rger Patricia H. van Cleef J. Han van Krieken Cornelis J.A. Punt Iris D. Nagtegaal | 2010 | European Journal of Cancer2010，，11： | 1 |
| 10 | Lymph Node Retrieval in Rectal Cancer is Dependent on Many Factors—the Role of the Tumor, the Patient, the Surgeon, the Radiotherapist, and the Pathologist显示文摘 | Leonie J.M. Mekenkamp Johan H. J. M. van Krieken Corrie A. M. Marijnen Cornelis J. H. van de Velde Iris D. Nagtegaal | 2009 | The American Journal of Surgical Pathology2009，，： | 1 |
| 11 | Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation显示文摘 | Linda Heijmen Edwin E. G. W. Voert Iris D. Nagtegaal Paul Span Johan Bussink Cornelis J. A. Punt Johannes H. W. Wilt Fred C. G. J. Sweep Arend Heerschap Hanneke W. M. Laarhoven | 2013 | European Radiology2013，，3： | 1 |
| 12 | A Shape‐Persistent Quadruply Interlocked Giant Cage Catenane with Two Distinct Pores in the Solid State显示文摘 | Gang Zhang Oliver Presly Fraser White Iris M. Oppel Michael Mastalerz | 2014 | Chem2014，，20： | 1 |
| 13 | TORC1‐dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice显示文摘 | Elisabeth Abs Susanna M. I. Goorden Jadwiga Schreiber Iris E. Overwater Marianne Hoogeveen‐Westerveld Caroline F. Bruinsma Elvedin Aganovi? Nils Z. Borgesius Mark Nellist Ype Elgersma | 2013 | Ann Neurol2013，，4： | 1 |
| 14 | A System of Classifying Microvascular Invasion to Predict Outcome After Resection in Patients With Hepatocellular Carcinoma显示文摘 | Sasan Roayaie Iris N. Blume Swan N. Thung Maria Guido Maria–Isabel Fiel Spiros Hiotis Daniel M. Labow Josep M. Llovet Myron E. Schwartz | 2009 | Gastroenterology2009，，3： | 1 |
| 15 | Pouch Inflammation Is Associated With a Decrease in Specific Bacterial Taxa显示文摘 | Leah Reshef Amir Kovacs Amos Ofer Lior Yahav Nitsan Maharshak Nirit Keren Fred M. Konikoff Hagit Tulchinsky Uri Gophna Iris Dotan | 2015 | Gastroenterology2015，，： | 1 |
| 16 | Extraction of Rare Earth Metals Using Liquid Surfactant Membranes in a Mixco Extractor显示文摘 | K. Uezu S. Irie O. Yoshimura M. Goto F. Nakashio | 1997 | Chemical Engineering Research and Design1997，，5： | 1 |
| 17 | The economical and environmental performance of miscanthus and switchgrass production and supply chains in a European setting显示文摘 | Edward M.W. Smeets Iris M. Lewandowski André P.C. Faaij | 2008 | Renewable and Sustainable Energy Reviews2008，，6： | 1 |
| 18 | Correlation between Degree of Neointimal Hyperplasia and Incidence and Characteristics of Neoatherosclerosis as Assessed by Optical Coherence Tomography显示文摘 | Rocco Vergallo Taishi Yonetsu Shiro Uemura Seung-Jung Park Stephen Lee Koji Kato Haibo Jia Farhad Abtahian Jinwei Tian Sining Hu Hang Lee Iris McNulty Abhiram Prasad Bo Yu Shaosong Zhang Italo Porto Luigi M. Biasucci Filippo Crea Ik-Kyung Jang | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 19 | Adipose tissue and adipocytes support tumorigenesis and metastasis显示文摘 | Kristin M. Nieman Iris L. Romero Bennett Van Houten Ernst Lengyel | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 1 |
| 20 | Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring显示文摘 | Ingrid P. C. Krapels Iris A. L. M. Rooij Marga C. Ocké Brigitte A. G. L. Cleef Anne-Marie M. Kuijpers-Jagtman Régine P. M. Steegers-Theunissen MD PhD | 2004 | European Journal of Nutrition2004，，1： | 1 |
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