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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Investigations of the superlubricity of sapphire against ruby under phosphoric acid lubrication显示文摘In this study,we address the superlubricity behavior of sapphire against ruby(or sapphire against itself)under phosphoric acid solution lubrication.An ultra-low friction coefficient of 0.004 was obtained under a very high contact pressure,with a virgin contact pressure up to 2.57 GPa.Related experiments have indicated that the load,sliding speed,and humidity of the test environment can affect superlubricity to some degree,so we tested variations in these conditions.When superlubricity appears in this study a thin film is present,consisting of a hydrogen bond network of phosphoric acid and water molecules adsorbed on the two friction surfaces,which accounts for the ultra-low friction.Most significantly,the wear rate of the sapphire and ruby in the friction process is very slow and the superlubricity state is very stable,providing favorable conditions for future technological applications. | Jinjin LI Chenhui ZHANG Mingming DENG Jianbin LUO | 2014 | Friction2014，2，2： | 13 |
| 3 | Hydrodynamic effect on the superlubricity of phosphoric acid between ceramic and sapphire显示文摘In this work,a super-low friction coefficient of 0.003 was found between a silicon nitride ball and a sapphire plate lubricated by phosphoric acid solution.The wear mainly occurred in the running-in period and disappeared after superlubricity was achieved.The friction coefficient was effectively reduced from 0.3 to 0.003 at a constant speed of 0.076 m/s,accompanied by a 12-nm-thickness film.The lubrication regime was indicated to change from boundary lubrication in the running-in period to elastohydrodynamic lubrication in the superlubricity period,which is also supported by the results of the friction coefficient versus sliding speed.In addition,the experimental results showed good agreement with theoretical calculations based on the elastohydrodynamic lubrication theory,suggesting a significant hydrodynamic effect of phosphoric acid on superlubricity. | Mingming DENG Chenhui ZHANG Jinjin LI Liran MA Jianbin LUO | 2014 | Friction2014，2，2： | 11 |
| 4 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 5 | Recent progress on nanoparticle-based drug delivery systems for cancer therapy显示文摘The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. | Yanru Xin Mingming Yin Liyuan Zhao Fanling Meng Liang Luo | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 6 | Effects of proper drilling control to reduce respirable dust during roof bolting operations显示文摘 | Mingming Li Yi Luo Hua Jiang | 2016 | International Journal of Coal Science & Technology2016，3，4： | 6 |
| 7 | Dissipation of polycyclic aromatic hydrocarbons and microbial activity in a field soil planted with perennial ryegrass显示文摘 | Dengqiang FU Ying TENG Yuanyuan SHEN Mingming SUN Chen TU Yongming LUO Zhengao LI Peter CHRISTIE | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 6 |
| 8 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 9 | Surface Flood and Underground Flood in Xiangxi River Karst Basin: Characteristics, Models, and Comparisons显示文摘Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of surface and subsurface floods in this karst basin, utilizing a one-parameter Darcian model and the traditional exponential model. The observed hydrographs and inferred water components are strikingly similar for surface and subsurface floods. The Darcian model and the exponential model are based on different views of the flood generation process, with the former fitting the entire hydrograph with a single time constant, and the latter fitting only the recession limb with multiple time constants. Due to the anisotropy and heterogeneity of karst media, a combination of physical and chemical techniques including the use of 3S(remote sensing, geographical information system, global positioning system) method is proposed for an enhanced hydrological investigation to assess and characterize karst water resources in mountainous areas. | Mingming Luo Zhihua Chen Dechao Yin Hamza Jakada He Huang Hong Zhou Tao Wang | 2016 | Journal of Earth Science2016，27，1： | 4 |
| 10 | A strongly interactive adatom/substrate interface for dendrite-free and high-rate Li metal anodes显示文摘Lithium (Li) metal is considered as one of the most promising anode materials to build next-generation high-energy–density batteries. Nonetheless, dendritic Li deposition has dramatically hindered the practical applications of Li metal batteries (LMBs). Uniformizing Li deposition is a prerequisite to achieve safe and practical LMBs. Herein, an underpotential deposition (UPD) process is first proposed to alter the kinetic and uniformity of Li deposition morphology. Based on the strong interaction between the Li adatoms and manganese (Mn) based substrate, a competition between the UPD and bulk Li deposition is observed, on which the predominance of the UPD scenario tends to uniformize Li nucleation and deposition by the surface coverage of Li monolayers at potentials that are more positive than the Nernst potential of Li metal. Inspired by this process, an advanced hybrid Mn-graphene oxide structure is developed for Li protection, not only enabling dendrite-free Li anodes for high-capacity and -current density cycling, but also improving the interfacial kinetic of Li metal anodes at subzero temperatures, showing potential applicability in low temperature conditions. | Shun Li Zhendong Li Liyuan Huai Mingming Ma Kailin Luo Jiahe Chen Deyu Wang Zhe Peng | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 11 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 12 | Design and achieving of multicolor upconversion emission based on rare-earth doped tellurite显示文摘 | Mingming XING Yunbei MA Xixian LUO Yao FU Tao JIANG Hong WANG Xiaolong DUAN | 2014 | Journal of Rare Earths2014，，5： | 1 |
| 13 | Preparation and luminescence properties of monodisperse silica/aminosilane-coated Y_2O_3:Yb,Ho upconversion nanoparticles显示文摘Monodisperse silica/aminosilane-coated Y 2 O 3:Yb,Ho nanoparticles are prepared via homogenous precipitation combined with a polyvinylpyrrolidone-assisted ammoniation method.The factors that contribute to the success of the coating are examined,and the procedure is optimized.Compared with uncoated nanoparticles,coated nanoparticles exhibit an increased ratio of green to red emission intensity,which can mainly be attributed to the decreased number of surface defects induced by the surface coating. | PANG Tao CAO WangHe XING MingMing LUO XiXian XU ShuJing | 2011 | Chinese Science Bulletin2011，56，2： | 1 |
| 14 | Tran-sition from Cassie-Baxter to Wenzel States on Microline-Formed PDMS Surfaces Induced by Evaporation or Press-ing of Water Droplets 显示文摘 | Luo Cheng Xiang Mingming Liu Xinchuan | 2011 | Microfluid Nanofluid2011，10，4： | 1 |
| 15 | A Stable Inter-mediate Wetting State after a Water Drop Contacts theBottom of a MicroChannel or Is Placed on a Single Corner显示文摘 | Luo Cheng Xiang Mingming Heng Xin | 2012 | Langmuir2012，28，25： | 1 |
| 16 | Particle dispersion and circulation patterns in a 3D spouted bed with or without draft tube显示文摘 | LUO Kun YANG Shiliang FANG Mingming | 2013 | Industrial & Engineer- ing Chemistry Research2013，52，28： | 1 |
| 17 | Statistical Linearization on 2 DOFs Hydropneumatic Suspension with Asymmetric Non-linear Stiffness显示文摘Most references on hydropneumatic suspension analysis regard it as harden Duffing spring and take the white noise as the system input, which is quite different from real physical model. It will introduce considerable errors to the analytical result compared with the numerical simulation which makes it impossible to give a good depiction of the hydropneumatic suspension dynamics. In this paper, the dynamic response of the hydropneumatic suspension is worked out using statistical linearization based on 2 DOFs nonlinear suspension model. The damping of the suspension and the tire stiffness are both regarded as linear components and the real road roughness spectrum is used to work out the system input. The explicit analytical equivalent stiffness, dynamic mean value offset from statistic equilibrium position and the sprung acceleration varied with parameters of hydropneumatic spring, road roughness and vehicle velocity are worked out by substituting the nonlinear stiffness of hydropneumatic spring with its first three terms Tyler series at the static equilibrium position using James formula. The comparison of the numerical simulation and analytical result both on statistical parameters and distribution shows the validity of the analysis. The explicit form provides a concise and valid method on hydropneumatic suspension design and optimization. | DONG Mingming LUO Zhenxing | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 1 |
| 18 | The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children显示文摘School-age children are in a specific development stage corresponding to juvenility,when the white matter of the brain experiences ongoing maturation.Dffusion-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in vivo.In the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference space.Using tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial normalization.However,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain development.Here,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 years.With an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific templates.Compared with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult template.Although similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial normalization.Looking forward,the SACT template could contribute to future studies of white matter development in both healthy and clinical populations.The SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283). | Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei Men Shuping Tan Jia-Hong Gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao | 2022 | Neuroscience Bulletin2022，38，6： | 1 |
| 19 | Preparation of Nano Y2O2S: Eu phosphor by ethanol assisted combustion synthesis method 显示文摘 | Luo Xixian Cao Wanghe Xing Mingming | 2006 | Journal of Rare Earth2006，24，1： | 1 |
| 20 | Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo显示文摘 | Yongbo Zhao Peng Luo Qindong Guo Sanzhong Li Lei Zhang Mingming Zhao Haoxiang Xu Yuefan Yang Waisang Poon Zhou Fei | 2012 | Experimental Neurology2012，，2： | 1 |
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