|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 4 | Identification of stably expressed QTL for resistance to black shank disease in tobacco(Nicotiana tabacum L.) line Beinhart 1000-1显示文摘Cigar line Beinhart 1000-1 has effective durable resistance to black shank(BS) and is considered one of the most resistant sources in tobacco(Nicotiana tabacum L.). To investigate the inheritance and identification of stable quantitative trait loci(QTL) for BS response, F2,BC1 F2 individuals and BC1 F2:3 lines were produced from a cross between Beinhart 1000-1 and Xiaohuangjin 1025. Two major quantitative trait loci(M-QTL) named qBS7 and qBS17 were repeatedly detected under different conditions. QTL qBS7 was mapped to the region between PT30174 and PT60621 and explained 17.40%–25.60% of the phenotypic variance under different conditions. The other QTL qBS17 in interval PT61564–PT61538 of linkage group 17 was detected in a BC1 F2 population in the field and in BC1 F2:3 in both the field and at the seedling stage, explaining 6.90% to 11.60% of the phenotypic variance. The results improve our understanding of the inheritance of resistance to BS and provide information that can be used in marker-assisted breeding. | Yusheng Zhang Xuan Guo Xingxing Yan Min Ren Caihong Jiang Yazeng Cheng Liuying Wen Dan Liu Yu Zhang Mingming Sun Quanfu Feng Aiguo Yang Lirui Cheng | 2018 | The Crop Journal2018，6，3： | 4 |
| 5 | The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosisthrough inhibition of de novo lipogenesis in high-fructose-fed rats显示文摘 | Lu-Ping Ren Guang-Yao Song Zhi-Juan Hu Mingming Zhang Lanbo Peng Shu-Chun Chen Limin Wei Fan Li Wen Sun | 2013 | International Journal of Molecular Medicine2013，，： | 2 |
| 6 | Cyanostilbene-based near-infrared emissive platinum(Ⅱ) metallacycles for cancer theranostics显示文摘In this work,a near-infrared emissive dipyridyl ligand was synthesized and used to prepare three platinum(II)metallacycles with different shapes via metal-coordination-driven self-assembly with different platinum(II)precursors.These metallacycles were further used for both cell imaging and cancer therapy,offering a new type of theranostic agents towards cancer treatment. | Lingzhi Ma Tianfeng Yang Zeyuan Zhang Siping Yin Zhongxiao Song Wen Shi Dake Chu Yanmin Zhang Mingming Zhang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 7 | Reduced grapheme oxides: Light-weight and high efficiency electro- magnetic interference shielding at elevated temperatures显示文摘 | WEN 13o CAO Maosheng LU Mingming | 2014 | J Adv Mater2014，26，21： | 1 |
| 8 | Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice显示文摘 | Yuchan Wang Hongwei Kan Yanyan Yin Wangyang Wu Wen Hu Mingming Wang Weiping Li Weizu Li | 2014 | Pharmacology, Biochemistry and Behavior2014，，： | 1 |
| 9 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://gffzzdf7d528e3a264cb9hwwkxfwou9n5o6556.ffgz.tsg.suse.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 10 | Pretreatment with 13 -Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction : Role of eNOS Activation 显示文摘 | Wang Mingming Chen Minchun Wen Aidong | 2015 | Scientific Reports2015，5，15： | 1 |
| 11 | A STOCHASTIC TRUST-REGION FRAMEWORK FOR POLICY OPTIMIZATION显示文摘In this paper,we study a few challenging theoretical and numerical issues on the well known trust region policy optimization for deep reinforcement learning.The goal is to find a policy that maximizes the total expected reward when the agent acts according to the policy.The trust region subproblem is constructed with a surrogate function coherent to the total expected reward and a general distance constraint around the latest policy.We solve the subproblem using a preconditioned stochastic gradient method with a line search scheme to ensure that each step promotes the model function and stays in the trust region.To overcome the bias caused by sampling to the function estimations under the random settings,we add the empirical standard deviation of the total expected reward to the predicted increase in a ratio in order to update the trust region radius and decide whether the trial point is accepted.Moreover,for a Gaussian policy which is commonly used for continuous action space,the maximization with respect to the mean and covariance is performed separately to control the entropy loss.Our theoretical analysis shows that the deterministic version of the proposed algorithm tends to generate a monotonic improvement of the total expected reward and the global convergence is guaranteed under moderate assumptions.Comparisons with the state-of-the–art methods demonstrate the effectiveness and robustness of our method over robotic controls and game playings from OpenAI Gym. | Mingming Zhao Yongfeng Li Zaiwen Wen | 2022 | Journal of Computational Mathematics2022，40，6： | 0 |
| 12 | FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population显示文摘The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels. | Haoran Wei Mingming Zhao Man Huang Chenze Li Jianing Gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 13 | ABI5 promotes heat stress-induced chlorophyll degradation by modulating the stability of MYB44 in cucumber显示文摘The yellowing of leaves caused by the decomposition of chlorophyll(Chl)is a characteristic event during senescence,which can be induced by various environmental stresses.However,the molecular mechanisms of high temperature-induced Chl degradation in horticultural plants remain poorly understood.Here,we found that heat stress induced Chl degradation and the expression of ABI5 and MYB44 in cucumber.Silencing of ABI5 compromised heat stress-induced Chl degradation,and the transcription of pheophytinase(PPH)and pheophorbide a oxygenase(PAO),two key genes in Chl catabolic pathway,but silencing of MYB44 exhibited the opposite results.Furthermore,ABI5 interacted with MYB44 in vitro and in vivo.ABI5 positively regulated heat stress-induced Chl degradation through two pathways.ABI5 directly bound to PPH and PAO promoters to promote their expression,leading to accelerating Chl degradation.On the other hand,the interaction between ABI5 and MYB44 reduced the binding of MYB44 to PPH and PAO promoters and led to the ubiquitination-depended protein degradation of MYB44,thereby alleviating the transcription inhibitory effect of MYB44 on PPH and PAO.Taken together,our findings propose a new regulatory network for ABI5 in regulating heat stress-induced Chl degradation. | Weikang Liu Guangling Chen Mingming He Jianqiang Wu Wenxu Wen Qinsheng Gu Shirong Guo Yu Wang Jin Sun | 2023 | Horticulture Research2023，10，6： | 0 |
| 14 | Data processing of the Kuiyang-ST2000 deep-towed high-resolution multichannel seismic system and application to South China Sea data显示文摘The Kuiyang-ST2000 deep-towed high-resolution multichannel seismic system was designed by the First Institute of Oceanography,Ministry of Natural Resources(FIO,MNR).The system is mainly composed of a plasma spark source(source level:216 dB,main frequency:750 Hz,frequency bandwidth:150-1200 Hz)and a towed hydrophone streamer with 48 channels.Because the source and the towed hydrophone streamer are constantly moving according to the towing configuration,the accurate positioning of the towing hydrophone array and the moveout correction of deep-towed multichannel seismic data processing before imaging are challenging.Initially,according to the characteristics of the system and the towing streamer shape in deep water,travel-time positioning method was used to construct the hydrophone streamer shape,and the results were corrected by using the polynomial curve fitting method.Then,a new data-processing workflow for Kuiyang-ST2000 system data was introduced,mainly including float datum setting,residual static correction,phase-based moveout correction,which allows the imaging algorithms of conventional marine seismic data processing to extend to deep-towed seismic data.We successfully applied the Kuiyang-ST2000 system and methodology of data processing to a gas hydrate survey of the Qiongdongnan and Shenhu areas in the South China Sea,and the results show that the profile has very high vertical and lateral resolutions(0.5 m and 8 m,respectively),which can provide full and accurate details of gas hydrate-related and geohazard sedimentary and structural features in the South China Sea. | Yanliang PEI Mingming WEN Zhengrong WEI Baohua LIU Kai LIU Guangming KAN | 2023 | Journal of Oceanology and Limnology2023，41，2： | 0 |
| 15 | The genetic and molecular basis for improving heat stress tolerance in wheat显示文摘Wheat production requires at least-2.4%increase per year rate by 2050 globally to meet food demands.However,heat stress results in serious yield loss of wheat worldwide.Correspondingly,wheat has evolved genetic basis and molecular mechanisms to protect themselves from heat-induced damage.Thus,it is very urgent to understand the underlying genetic basis and molecular mechanisms responsive to elevated temperatures to provide important strategies for heat-tolerant varieties breeding.In this review,we focused on the impact of heat stress on morphology variation at adult stage in wheat breeding programs.We also summarize the recent studies of genetic and molecular factors regulating heat tolerance,including identification of heat stress tolerance related QTLs/genes,and the regulation pathway in response to heat stress.In addition,we discuss the potential ways to improve heat tolerance by developing new technologies such as genome editing.This review of wheat responses to heat stress may shed light on the understanding heat-responsive mechanisms,although the regu-latory network of heat tolerance is still ambiguous in wheat. | Lv Sun Jingjing Wen Huiru Peng Yingyin Yao Zhaorong Hu Zhongfu Ni Qixin Sun Mingming Xin | 2022 | aBIOTECH2022，3，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员