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| 1 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 2 | Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation显示文摘Dear Editor,Lipid droplets(LDs)are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and protect cells from lipotoxicity(Ohsaki et al.,2006).Disrupted LD and fat storage homeostasis has been linked to metabolic diseases such as atherosclerosis,obesity,and type II diabetes(Levin et al.,2001).Structurally,the core of neutral lipids in LDs is surroun ded by a phospholipid mono layer and coated with specific proteins(Storey et al.,2011).Perilipin family of proteins are the predominant LD-associated proteins. | Jianxi Zhu Mingyang Xu Yi Liu Lisha Zhuang Kejun Ying Feng Liu Dan Liu Wenbin Ma Zhou Songyang | 2019 | Protein & Cell2019，10，5： | 7 |
| 3 | Integrated transcriptome and proteome analysis provides insight into chilling-induced dormancy breaking in Chimonanthus praecox显示文摘Chilling has a critical role in the growth and development of perennial plants.The chilling requirement(CR)for dormancy breaking largely depends on the species.However,global warming is expected to negatively affect chilling accumulation and dormancy release in a wide range of perennial plants.Here,we used Chimonanthus praecox as a model to investigate the CR for dormancy breaking under natural and artificial conditions.We determined the minimum CR(570 chill units,CU)needed for chilling-induced dormancy breaking and analyzed the transcriptomes and proteomes of flowering and non-flowering flower buds(FBs,anther and ovary differentiation completed)with different CRs.The concentrations of ABA and GA3 in the FBs were also determined using HPLC.The results indicate that chilling induced an upregulation of ABA levels and significant downregulation of SHORT VEGETATIVE PHASE(SVP)and FLOWERING LOCUS T(FT)homologs at the transcript level in FBs when the accumulated CR reached 570 CU(IB570)compared to FBs in November(FB.Nov,CK)and nF16(non-flowering FBs after treatment at 16℃for−300 CU),which suggested that dormancy breaking of FBs could be regulated by the ABA-mediated SVP-FT module.Overexpression in Arabidopsis was used to confirm the function of candidate genes,and early flowering was induced in 35S::CpFT1 transgenic lines.Our data provide insight into the minimum CR(570 CU)needed for chilling-induced dormancy breaking and its underlying regulatory mechanism in C.praecox,which provides a new tool for the artificial regulation of flowering time and a rich gene resource for controlling chilling-induced blooming. | Zhineng Li Ning Liu Wei Zhang Chunyu Wu Yingjie Jiang Jing Ma Mingyang Li Shunzhao Sui | 2020 | Horticulture Research2020，7，1： | 6 |
| 4 | Precise robust motion control of cell puncture mechanism driven by piezoelectric actuators with fractional-order nonsingular terminal slidingmode control显示文摘A novel robust controller is proposed in this study to realize the precise motion control of a cell puncture mechanism(CPM)driven by piezoelectric ceramics(PEAs).The entire dynamic model of CPM is constructed based on the Bouc–Wen model,and the nonlinear part of the dynamic model is optimized locally to facilitate the construction of a robust controller.A model-based,nonlinear robust controller is constructed using time-delay estimation(TDE)and fractional-order nonsingular terminal sliding mode(FONTSM).The proposed controller does not require prior knowledge of unknown disturbances due to its real-time online estimation and compensation of unknown terms by using the TDE technology.The controller also has finite-time convergence and high-precision trajectory tracking capabilities due to FONTSM manifold and fast terminal sliding mode-type reaching law.The stability of the closed-loop system is proved by Lyapunov stability theory.Computer simulation and hardware-in-loop simulation experiments of CPM verify that the proposed controller outperforms traditional terminal sliding mode controllers,such as the integer-order or model-free controller.The proposed controller can also continuously output without chattering and has high control accuracy.Zebrafish embryo is used as a verification target to complete the cell puncture experiment.From the engineering application perspective,the proposed control strategy can be effectively applied in a PEA-driven CPM. | Shengdong Yu Hongtao Wu Mingyang Xie Haiping Lin Jinyu Ma | 2020 | Bio-Design and Manufacturing2020，3，4： | 2 |
| 5 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 6 | Detrital Zircon U-Pb Geochronology and Provenance of the Hebukesaier Formation in the Shaerbuerti Mountains,Northern West Junggar:Implication for Devonian Subduction of the Junggar–Balkhash Ocean显示文摘Limited Devonian magmatic record in northern West Junggar leads to contrasting models on its tectonic evolution.In this study,we conducted LA-ICP-MS U-Pb dating on detrital zircons of two sandstones from the Hebukesaier Formation in the Shaerbuerti Mountains.Detrital zircons with oscillatory zoning are characterized by high Th/U(>0.3)and low La/Yb(<0.15),indicating their magmatic origin.The youngest zircon ages of two samples are 402±2 Ma and 406±2 Ma,respectively,suggesting that the Hebukesaier Formation was deposited at the Early Devonian.Detrital zircon age patterns show single peaks(at ca.424 Ma,n=157),which indicates that these clastics were likely proximal accumulation after short distance transportation.Provenance of the Hebukesaier Formation was the Xiemisitai and Shaerbuerti Mountains.Detrital zircon ages range from 481 Ma to 395 Ma,which indicates that there was relatively continuous Early Paleozoic magmatism in the Xiemisitai and Shaerbuerti Mountains since the Early Ordovician.Age spectrums of sampled detrital zircons are distinct from those of Lower Devonian strata either in southern West Junggar or in East Junggar,which implies for individual tectonic evolution of northern West Junggar.We favor that Lower Devonian Hebukesaier Formation was developed in a fore–arc setting due to the northward subduction of the Junggar–Balkhash Ocean. | LIANG Hao CHEN Jiafu MA Xu YANG Hongzhang XIN Mingyang | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 7 | Anomalies in mid-high-temperature linear thermal expansion coefficient of the closed-cell aluminum foam显示文摘Low-density closed-cell aluminum foam is promising to be used as load-bearing and thermal insulation components. It is necessary to systematically study its thermal expansion performance. In this work, linear thermal expansion coefficient(LTEC) of the closed-cell aluminum foam of different density was measured in the temperature range of 100–500 °C. X-ray fluorescence was used to analyze elemental composition of the cell wall material. Phase transition characteristics were analyzed with X-ray diffraction and differential scanning calorimetry. LTEC of the closed-cell aluminum foam was found to be dominated by its cell wall property and independent of its density. Particularly, two anomalies were found and experimentally analyzed. Due to the release of the residual tensile stress, the LTEC declined and even exhibited negative values. After several thermal cycles, the residual stress vanished. With temperature higher than 300 °C,instantaneous LTEC showed hysteresis, which should result from the redistribution of some residual hydrogen in the Ti2Al20 Ca lattice. | Hong Ye Mingyang Ma Jilin Yu | 2014 | Chinese Science Bulletin2014，59，28： | 2 |
| 8 | Energetic particles’fluxes and dose in the Radiation Gene Box measured by space radiation detector onboard SJ-10 satellite显示文摘Background To evaluate the hazard of space radiation posing to the tissues,it is important to obtain exact fluxes of different radiation particles.The Radiation Gene Box(RGB)onboard SJ-10 spacecraft was an instrument designed to investigate the effects of space environment on the mESCs and drosophila.To derive the dose received by the tissues inside the RGB,the Space Radiation Detector(SRD)was installed inside it.Purpose The SRD was designed to derive the fluxes of electron,proton,hellion and gamma rays around it.If the type of the particles,the energies,the fluxes and the conversion coefficients are known,the dose received by the tissues could be evaluated.Methods The SRDwas designed as a △E-E solid-state telescope.By measuring the energy deposited in the three subdetectors,the particles’type and their energies could be discriminated.The data of SRDwere divided into 15 bins by the types of particles and their energy ranges.Results The gamma ray flux was higher than any other particle flux inside the RGB,and the electron was the most intense charge particle,while the helium ion was the most harmful radiation to the cells inside the RGB.Conclusion The dose rate inside the Radiation Gene Box was much higher than in the ground,but the integral dose of 12 days inside the RGB was about 2.13 mSv.It seemed unlikely to have obvious biological effects on the tissues of mice and drosophila. | Xingzhu Cui Yaqing Liu Wenxi Peng Jinzhou Wang Min Gao Dongya Guo Xiaohua Liang Ruirui Fan Huanyu Wang Yunlong Zhang Zhongjian Ma Mingyang Yan Hong Xiao Yuanda Jiang Haiying Hang | 2018 | Radiation Detection Technology and Methods2018，2，2： | 2 |
| 9 | Radiation shielding for the first optics enclosure at the High Energy Photon Source beamlines显示文摘Purpose The High Energy Photon Source(HEPS)is currently under construction in China and will be the brightest synchrotron radiation facility in the world.To solve the gas bremsstrahlung and synchrotron radiation hazard at HEPS beamlines,a comprehensive radiation study is performed.Method The Monte Carlo method is used to analyze the radiation field in the first optics enclosure at HEPS beamlines.First,the radiation sources including gas bremsstrahlung and synchrotron radiation are estimated.Then,the distribution of the radiation field in the hutch is calculated.Conservative parameters and a typical beamline geometry are used in the calculations.Finally,the shielding recommendations are summarized.Results and Conclusion In this paper,the considerations and bulk shielding design of the first optics enclosure at HEPS beamlines are described.The design satisfies the requirements of the radiation safety principles. | Pingcheng Liu Qiongyao Liu Zhongjian Ma Huijie Zhang Mingyang Yan Qingbin Wang | 2021 | Radiation Detection Technology and Methods2021，5，2： | 2 |
| 10 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 11 | The mitigation effects of exogenous melatonin on salinity‐induced stress in Malus hupehensis显示文摘 | Chao Li Ping Wang Zhiwei Wei Dong Liang Changhai Liu Lihua Yin Dongfeng Jia Mingyang Fu Fengwang Ma | 2012 | Journal of Pineal Research2012，，3： | 1 |
| 12 | Towards Friction Stir Remanufacturing of High‑Strength Aluminum Components显示文摘Volumetric defects in high-strength aluminum alloy components were repaired via friction stir remanufacturing(FSR).Various consumable pins made of AA7075-T6 were designed.Top diameters of the consumable pins afected material fow,which ensured that the materials at the repairing interface were forged to metallurgical bonding.Conical angles determined load transfer besides material fow,which afected the fracture of the pins before the dwelling stage.Sound repaired components were achieved when the conical angle of the consumable pin was 1°larger than that of the volumetric defect.The ultimate tensile strength and elongation of the repaired components reached 445.9 MPa and 9.6%,respectively.The design criteria of the consumable pin in the FSR was established,which provided valuable references to repair volumetric defects in high-strength aluminum components. | Xiangchen Meng Yuming Xie Xiaotian Ma Mingyang Liang Xiaoyang Peng Shiwei Han Lei Kan Xin Wang Sihao Chen Yongxian Huang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，1： | 1 |
| 13 | NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma显示文摘 | Shangwen Liu Xin Ma Qing Ai Qingbo Huang Taoping Shi Mingyang Zhu Baojun Wang Xu Zhang | 2013 | Urologic Oncology: Seminars and Original Investigations2013，，6： | 1 |
| 14 | Comtruction of novel cytokine by fusion of chicken IL-2 signal peptide to mature chicken IL-15 and comparison of the adjuvant effects by DNA immunization against Eimeria challenge 显示文摘 | Dexing Ma Mingyang GanJie Li | 2013 | Vet Im- munol Immunopathol2013，156，12： | 1 |
| 15 | Characterization of the genetic relationships among biotypes of Malus prunifolia using simple sequence repeat marker显示文摘 | Mingyang Fu Fengwang Ma | 2012 | Scientia Horticulturae2012，，： | 1 |
| 16 | Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients in industrial crystallization显示文摘Solubility has been widely regarded as a fundamental property of small molecule drugs and drug candidates,as it has a profound impact on the crystallization process.Solubility prediction,as an alternative to experiments which can reduce waste and improve crystallization process efficiency,has attracted increasing attention.However,there are still many urgent challenges thus far.Herein we used seven descriptors based on understanding dissolution behavior to establish two solubility prediction models by machine learning algorithms.The solubility data of 120 active pharmaceutical ingredients(APIs)in ethanol were considered in the prediction models,which were constructed by random decision forests and artificial neural network with optimized data structure and model accuracy.Furthermore,a comparison with traditional prediction methods including the modified solubility equation and the quantitative structure-property relationships model was carried out.The highest accuracy shown by the testing set proves that the ML models have the best solubility prediction ability.Multiple linear regression and stepwise regression were used to further investigate the critical factor in determining solubility value.The results revealed that the API properties and the solute-solvent interaction both provide a nonnegligible contribution to the solubility value. | Yiming Ma Zhenguo Gao Peng Shi Mingyang Chen Songgu Wu Chao Yang Jing-Kang Wang Jingcai Cheng Junbo Gong | 2022 | Frontiers of Chemical Science and Engineering2022，16，4： | 1 |
| 17 | Generation and Analysis of Expressed Sequence Tags from Chimonanthus praecox (Wintersweet) Flowers for Discovering Stress-Responsive and Floral Development-Related Genes显示文摘 | Shunzhao Sui Jianghui Luo Jing Ma Qinlong Zhu Xinghua Lei Mingyang Li Jinfa Zhang | 2012 | Comparative and Functional Genomics2012，，： | 1 |
| 18 | The mitigation effects of exogenous melatonin on salinity‐induced stress in Malus hupehensis显示文摘 | Chao Li Ping Wang Zhiwei Wei Dong Liang Changhai Liu Lihua Yin Dongfeng Jia Mingyang Fu Fengwang Ma | 2012 | Journal of Pineal Research2012，，3： | 1 |
| 19 | Identification and Expression of TOP3αin Gerbera hybrida显示文摘Meiotic recombination and the resulting novel allele combinations are fundamental to plant breeding and the identification of superior hybrids.However,the rate of meiotic crossovers is naturally suppressed below its potential ability,which prevents plant breeding efficiency.Nine suppressors of meiotic recombination have been identified in the model plant Arabidopsis and in other crop species.Mutations in these genes can lead to increased recombination frequency and could therefore potentially be used to create hyper-recombinant lines for ornamental breeding.In Gerbera hybrida,the anti-crossover factors remain elusive.In this study,we isolated and cloned TOP3αfrom flower buds of G.hybrida,and it encoded 935 amino acids with three conserved domains TOPRIM,TOP1Ac and zf-GR.Moreover,TOP3αwas the highest expressed at the flower bud stage,which coincided with the occurrence of meiotic recombination,suggesting that TOP3αis associated with the regulation of meiotic recombination in G.hybrida. | Shenchong Li Ying Cheng Dan Sun Lulin Ma Mingyang Li Fan Li | 2021 | Horticultural Plant Journal2021，7，2： | 1 |
| 20 | Electrophysiologic Mechanism and Radiofrequency Catheter Ablation of Incessent Atrioventricular Reentrant Tachycardi显示文摘Objective\ To study electrophysiologic mechanism and radiofrequency catheter ablation of incessent atrioventricular reentrant tachycardia. Methods\ In this report, 17 cases of incessant atrioventricular reentrant tachycardia (IAVRT) were presented. There were twelve men and five women. The average age was (46±17) years. Mean duration of persistent tachycardia was (36±76) days. Mean ventricular rate was (180±17) min\+\{-1\} during tachycardia. Five patients had cardiac dysfunction and four had tachycardia induced dilated cardiomyopathy. Results\ All the 17 patients underwent successful radiofrequency catheter ablation. There were eleven accessory pathways(APs) in the left side posteroseptal position, three in the left free wall, two in the right free wall and one in the right side posteroseptal position. Two Aps had decremental conduction characteristics. Four patients had longer than normal atrioventricular conduction time, mean AH interval being (161±6) ms. Six patients had posteroseptal AP with RP≥PR during tachycardia on the surface ECG. All patients were free of symptomatic tachycardia during follow up period of 1 38 months. Five patients with heart dysfunction ameliorated one week after tachycardia ablated. Four tachycardia induced dilated cardiomyopathies were followed for mean of 12 months, the size and function of the heart returned normal in three patients, and the heart size became smaller in one. Conclusion\ It was concluded that electrophysiologic mechanism of IAVRT could be related to the following factors: ①Position of the AP, posteroseptal AP had the highest incidence of IAVRT; ②Characteristics of AP, AP with RP≥PR during tachycardia on the surface ECG and the decremental conduction was liable to IAVRT; ③Longer atrioventricular conduction time. As previously described, one or more factors can lead to IAVRT. Radiofrequency catheter ablation could eradicate IAVRT and cure IAVRT induced dilated cardiomyopathy. | Shan Qijun(单其俊) Cao Kejiang(曹克将) Liao Mingyang(廖铭扬) Zou Jiangang(邹建刚) Li Wenqi(李闻奇) Huang Yuanzhu(黄元铸) Ma Wenzhu(马文珠) Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R | 2000 | Journal of Nanjing Medical University2000，14，1： | 0 |
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