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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Routing valley exciton emission of a WS_(2) monolayer via delocalized Bloch modes of in-plane inversion-symmetry-broken photonic crystal slabs显示文摘The valleys of two-dimensional transition metal dichalcogenides(TMDCs)offer a new degree of freedom for information processing.To take advantage of this valley degree of freedom,on the one hand,it is feasible to control valleys by utilizing different external stimuli,such as optical and electric fields.On the other hand,nanostructures are also used to separate the valleys by near-field coupling.However,for both of the above methods,either the required low-temperature environment or low degree of coherence properties limit their further applications.Here,we demonstrate that all-dielectric photonic crystal(PhC)slabs without in-plane inversion symmetry(C_(2) symmetry)can separate and route valley exciton emission of a WS2 monolayer at room temperature.Coupling with circularly polarized photonic Bloch modes of such PhC slabs,valley photons emitted by a WS_(2) monolayer are routed directionally and are efficiently separated in the far field.In addition,far-field emissions are directionally enhanced and have long-distance spatial coherence properties. | Jiajun Wang Han Li Yating Ma Maoxiong Zhao Wenzhe Liu Bo Wang Shiwei Wu Xiaohan Liu Lei Shi Tian Jiang Jian Zi | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 4 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 5 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 6 | Human bone marrow mesenchymal stem cell transplantation attenuates axonal injury in stroke rats显示文摘Previous studies have shown that transplantation of human bone marrow mesenchymal stem cells promotes neural functional recovery after stroke, but the neurorestorative mechanisms remain largely unknown. We hypothesized that functional recovery of myelinated axons may be one of underlying mechanisms. In this study, an ischemia/reperfusion rat model was established using the middle cerebral artery occlusion method. Rats were used to test the hypothesis that intravenous transplantation of human bone marrow mesenchymal stem cells through the femoral vein could exert neuroprotective effects against cerebral ischemia via a mechanism associated with the ability to attenuate axonal injury. The results of behavioral tests, infarction volume analysis and immunohistochemistry showed that cerebral ischemia caused severe damage to the myelin sheath and axons. After rats were intravenously transplanted with human bone marrow mesenchymal stem cells, the levels of axon and myelin sheath-related proteins, including microtubule-associated protein 2, myelin basic protein, and growth-associated protein 43, were elevated, infarct volume was decreased and neural function was improved in cerebral ischemic rats. These findings suggest that intravenously transplanted human bone marrow mesenchymal stem cells promote neural function. Possible mechanisms underlying these beneficial effects include resistance to demyelination after cerebral ischemia, prevention of axonal degeneration, and promotion of axonal regeneration. | Yi Xu Shiwei Du Xinguang Yu Xiao Han Jincai Hou Hao Guo | 2014 | Neural Regeneration Research2014，9，23： | 3 |
| 7 | A reduced-order method for parameter identification of a crystal plasticity model considering crystal symmetry显示文摘The focus of this paper is to identify the material parameters of a crystal plasticity model for Ni-base single crystal superalloys.To facilitate the stepwise calibration of the multistage flow rules, further decoupling and simplification are implemented without compromising its simulating capability. Reduced-order kinematics in crystal plasticity, which only comprise scalar components instead of their original tensors, are derived by considering the crystal symmetry and uniaxial loading condition. The relationships between components in elastic and plastic deformation gradient are established by explicitly accounting the control quantities, which is overall load in stress-controlled creep tests or displacement of gauge section in strain-controlled experiments,respectively. In addition, their approximate forms are also given by neglecting both elastic changes in volume and section area. A new objective function based on the shortest distance was introduced to correlate data from the simulations and experiments, and an integrated optimization process without finite element computation was developed into a commercial software package.Parameters in the crystal plasticity model are successfully calibrated by the efficient reduced-order method from the experimental data in such a sequence as: elastic, plastic, primary stage and secondary to tertiary stages creep laws. The multistage weak coupling flow rules can significantly reduce the non-uniqueness of the optimal solution under the circumstance of excessive parameters but insufficient experimental data. Finally, the optimized results with the reduced-order method have been validated by the finite element method. | HAN ShiWei YANG XiaoGuang SHI DuoQi HUANG Jia | 2019 | Science China(Technological Sciences)2019，62，3： | 2 |
| 8 | Towards Friction Stir Remanufacturing of High‑Strength Aluminum Components显示文摘Volumetric defects in high-strength aluminum alloy components were repaired via friction stir remanufacturing(FSR).Various consumable pins made of AA7075-T6 were designed.Top diameters of the consumable pins afected material fow,which ensured that the materials at the repairing interface were forged to metallurgical bonding.Conical angles determined load transfer besides material fow,which afected the fracture of the pins before the dwelling stage.Sound repaired components were achieved when the conical angle of the consumable pin was 1°larger than that of the volumetric defect.The ultimate tensile strength and elongation of the repaired components reached 445.9 MPa and 9.6%,respectively.The design criteria of the consumable pin in the FSR was established,which provided valuable references to repair volumetric defects in high-strength aluminum components. | Xiangchen Meng Yuming Xie Xiaotian Ma Mingyang Liang Xiaoyang Peng Shiwei Han Lei Kan Xin Wang Sihao Chen Yongxian Huang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，1： | 1 |
| 9 | Equilibria between Cerium or neodymium and oxygen in molten iron显示文摘 | Han Qiyong Liu Shiwei Niu Hongbing | 1981 | Metallurgical Transactions1981，21，4： | 1 |
| 10 | Propelling polysulfide redox by Fe_(3)C-FeN heterostructure@nitrogendoped carbon framework towards high-efficiency Li-S batteries显示文摘Lithium-sulfur(Li-S) batteries hold great promise in next-generation high-energy-density energy storage systems,but the intractable shuttle effect and the sluggish redox kinetics of polysulfides hinder the practical implementation of Li-S batteries.Here,heterostructured Fe_(3)C-FeN nanoparticles dotted in the threedimensional-ordered nitrogen-doped carbon framework(Fe_(3)C-FeN@NCF) were synthesized by molecular engineering combined with heterointerface engineering,and were applied to regulate the immobilization-diffusion-conversion behavior of polar polysulfides.It is experimentally and theoretically demonstrated that the heterointerface between Fe_(3)C and FeN exhibits high sulfiphilicity and high electronic/ionic conductivity,thus effectively capturing polysulfides and accelerating the bidirectional conversion of sulfur species.Meanwhile,the holey carbon framework functions as the scaffold to highly disperse binary nanoparticles,ensuring the sufficient exposure of active sites and the easy accessibility for lithium ions and electrons.By virtue of these synergistic merits,the Li-S batteries based on Fe_(3)CFeN@NCF-modified separators afford excellent electrochemical performances including a high rate capacity of 858 mA h g^(-1)at 2 C and a low capacity decay rate of 0.07% per cycle after 800 cycles at 1C This work provides inspiration for the design of heterostructured compounds and sheds light on the potential of heterostructure in high-efficiency Li-S batteries. | Mengdi Zhang Jiawei Mu Yanan Li Yuanyuan Pan Zhiliang Dong Bei Chen Shiwei Guo Wenhan Yuan Haiqiu Fang Han Hu Mingbo Wu | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 11 | Identification of Suitable Reference Genes for qPCR Analysis of Serum microRNA in Gastric Cancer Patients显示文摘 | Jianning Song Zhigang Bai Wei Han Jun Zhang Hua Meng Jintao Bi Xuemei Ma Shiwei Han Zhongtao Zhang | 2012 | Digestive Diseases and Sciences2012，，4： | 1 |
| 12 | High transmittance and grain-orientated alumina ceramics fabricated by adding fine template particles显示文摘Transparent Al_(2)O_(3) ceramics with grains aligned to the c-axis were prepared by adding platelets with a low aspect ratio into fine equiaxed particles.The mixed powders were formed into green bodies using spontaneous coagulation casting and sintered by pressureless sintering and hot-isostatic pressure sintering.Zeta potentials and rheological behavior of the slurries,relative densities of green bodies,and orientation and optical properties of sintered bodies were investigated and discussed.The platelet with a high aspect ratio suppressed densification more seriously during sintering than the one with a low aspect ratio.An excellent oriented structure was obtained when 5 wt%platelets with a low aspect ratio were added,and transparent Al_(2)O_(3) ceramics with grains aligned to c-axis were successfully prepared;the in-line transmittance was 78.4%at 600 nm,which is the highest one in the currently reported literature. | Han CHEN Jin ZHAO Shunzo SHIMAI Xiaojian MAO Jian ZHANG Guohong ZHOU Shiwei WANG Na GU Kai ZHENG | 2022 | Journal of Advanced Ceramics2022，11，4： | 1 |
| 13 | Kinetically accelerated and high-mass loaded lithium storage enabled by atomic iron embedded carbon nanofibers显示文摘Carbonaceous materials represent the dominant choice of materials for anodic lithium storage in many energy storage devices.Nevertheless,the nonpolar carbonaceous materials offer weak adsorption toward Li+that largely denies the high-rate Li+storage.Herein,the atomic Fe sites decorated carbon nanofibers(AICNFs)facilely produced by electrospinning are reported for kinetically accelerated Li+storage.Theoretical calculation reveals that the atomic Fe sites possess coordination unsaturated electronic configuration,enabling suitable bonding energy and facilitated diffusion path of Li+.As a result,the optimal structure displays a high capacitive contribution up to 95.9%at a scan rate of 2.0 mV·s^(−1).In addition,ultrahigh capacity retention of 97%is afforded after 5,000 cycles at a current density of 3 A·g^(−1).Moreover,the interlaced fiber structure enabled by electrospinning benefits structural stability and improved conductivity even at thick electrodes,thus allowing a high areal capacity of 1.76 mAh·cm−2 at a loading of 8 mg·cm−2.Because of these structure and performance merits,the lithium-ion capacitor containing the AICNF-based anode delivers a high energy density and large power density. | Qian Xu Yanan Li Chenghao Wu Xitong Sun Qiang Li Huabin Zhang Le Yu Yuanyuan Pan Yujuan Wang Shiwei Guo Mengdi Zhang Han Hu Mingbo Wu | 2022 | Nano Research2022，15，7： | 0 |
| 14 | Effects of Coal Metakaolin on the Mechanical Properties and Microstructure of High-belite Sulphoaluminate Cement显示文摘The effects of coal metakaolin on the mechanical properties of high-belite sulphoaluminate cement under compressive loading were investigated.The composition and microstructure of hydration products at different hydration times were analyzed by X-ray diffraction and scanning electronic microscopy.The hydration process of blended cement was studied via electrochemical impedance spectroscopy.In particular,replacing a part of cement with CMK(10%,20%,and 30%)was found to promote the hydration process,to refine the pore size,and to improve the compressive strength of the composite.The best compressive strength of the cement was achieved at a CMK content of 30%after 28 days hydration,being improved by 20.13 MPa,or1.44 times relative to that of undoped specimens.Furthermore,the compressive strength is shown to correlate with the impedance parameter R_(CCP),which allows the latter to be used for nondestructive assessment of the compressive strength of blended cement materials. | WANG Xingyi HAN Pengju NIU Shiwei HE Bin MA Fuli GUO Tiantian XU Jinchuan | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 0 |
| 15 | Influence of spiral anchor composite foundation on seismic vulnerability of raw soil structure显示文摘A typical single-layer raw soil structure in villages and towns in China is taken as the research object.In the probabilistic seismic demand analysis,the seismic demand model is obtained by the incremental dynamic time history analysis method.The seismic vulnerability analysis is carried out for the raw soil structure of nonfoundation,strip foundation,and spiral anchor composite foundation,respectively.The spiral anchor composite foundation can reduce the seismic response and failure state of raw soil structure,and the performance level of the structure is significantly improved.Structural requirements sample data with the same ground motion intensity are analyzed by linear regression statistics.Compared with the probabilistic seismic demand model under various working conditions,the seismic demand increases gradually with the increase of intensity.The seismic vulnerability curve is summarized for comparative analysis.With the gradual deepening of the limit state,the reduction effect of spiral anchor composite foundation on the exceedance probability becomes more and more obvious,which can reduce the probability of structural failure to a certain extent. | Shiwei Hou Guangliang Gao Hao Zhang Zhanwen Lai Junyan Han | 2022 | Earthquake Research Advances2022，2，4： | 0 |
| 16 | Performance of^(18)F‑DCFPyL PET/CT in Primary Prostate Cancer Diagnosis,Gleason Grading and D'Amico Classifcation:A Radiomics‑Based Study显示文摘This study aimed to investigate the performance of^(18)F-DCFPyL positron emission tomography/computerized tomography(PET/CT)models for predicting benign-vs-malignancy,high pathological grade(Gleason score>7),and clinical D'Amico classifcation with machine learning.The study included 138 patients with treatment-naïve prostate cancer presenting positive^(18)F-DCFPyL scans.The primary lesions were delineated on PET images,followed by the extraction of tumor-to-backgroundbased general and higher-order textural features by applying fve diferent binning approaches.Three layer-machine learning approaches were used to identify relevant in vivo features and patient characteristics and their relative weights for predicting high-risk malignant disease.The weighted features were integrated and implemented to establish individual predictive models for malignancy(Mm),high path-risk lesions(by Gleason score)(Mgs),and high clinical risk disease(by amico)(Mamico).The established models were validated in a Monte Carlo cross-validation scheme.In patients with all primary prostate cancer,the highest areas under the curve for our models were calculated.The performance of established models as revealed by the Monte Carlo cross-validation presenting as the area under the receiver operator characteristic curve(AUC):0.97 for Mm,AUC:0.73 for Mgs,AUC:0.82 for Mamico.Our study demonstrated the clinical potential of^(18)F-DCFPyL PET/CT radiomics in distinguishing malignant from benign prostate tumors,and high-risk tumors,without biopsy sampling.And in vivo^(18)F-DCFPyL PET/CT can be considered a noninvasive tool for virtual biopsy for personalized treatment management. | Yuekai Li Fengcai Li Shaoli Han Jing Ning Peng Su Jianfeng Liu Lili Qu Shuai Huang Shiwei Wang Xin Li Xiang Li | 2023 | Phenomics2023，3，6： | 0 |
| 17 | Implementing hardware primitives based on memristive spatiotemporal variability into cryptography applications显示文摘Implementing hardware primitives into cryptosystem has become a new trend in electronic community.Memristor,with intrinsic stochastic characteristics including the switching voltages,times and energies,as well as the fluctuations of the resistance state over time,could be a naturally good entropy source for cryptographic key generation.In this study,based on kinetic Monte Carlo Simula-tion,multiple Artificial Intelligence techniques,as well as kernel density map and time constant analysis,memristive spatiotemporal variability within graphene based conductive bridging RAM(CBRAM)have been synergistically analyzed to verify the inher-ent randomness of the memristive stochasticity.Moreover,the ran-dom number based on hardware primitives passed the Hamming Distance calculation with high randomness and uniqueness,and has been integrated into a Rivest-Shamir-Adleman(RSA)cryptosystem.The security of the holistic cryptosystem relies both the modular arithmetic algorithm and the intrinsic randomness of the hardware primitive(to be more reliable,the random num-ber could be as large as possible,better larger than 2048 bits as NIST suggested).The spatiotemporal-variability-based random number is highly random,physically unpredictable and machinelearningattack resilient,improving the robustness of the entire cryptosystem. | Bo Liu Yudi Zhao YinFeng Chang Han Hsiang Tai Hanyuan Liang Tsung-Cheng Chen Shiwei Feng Tuo-Hung Hou Chao-Sung Lai | 2023 | Chip2023，2，1： | 0 |
| 18 | Survival outcomes of conversion surgery for metastatic pancreatic ductal adenocarcinoma after neoadjuvant therapy显示文摘Objective:To evaluate the survival outcomes of patients who underwent conversion surgery for metastatic pancreatic ductal adenocarcinoma(mPDAC)after neoadjuvant therapy(NAT)and to identify potential candidates that may benefit from this treat-ment strategy.Background:The role and eligibility population of conversion surgery for mPDAC remains controversial in the era of NAT.Methods:A consecutive cohort of patients diagnosed with mPDAC and treated with NAT followed by conversion surgery be-tween 2019 and 2021 were confirmed from a prospective database maintained by the Department of Pancreatic Hepatobiliary Surgery of Changhai Hospital.In accordance with residual metastases and technical resectability after NAT,patients were classi-fied as the complete pathological response of metastases(ypM0)resection group,residual metastases(ypM1)resection group,and exploration group.Median overall survival(mOS)was calculated using the Kaplan-Meier method,uni-and multivariable cox regression was performed to identify clinicopathological predictors of OS.Results:A total of 244 patients with mPDAC were identified from the prospective database,with 19(7.8%)patients who un-derwent ypM0 resection,22(9.0%)underwent ypM1 resection,and 23(9.4%)underwent explorative laparotomy.The mOS was 32.6 months for ypM0 resected patients,15.1 months for ypM1 resected patients,and 13.4 months for those who underwent explorative laparotomy(P<.001).Univariable and multivariable Cox regression analyses confirmed that ypM0 resection,normal-ization of preoperative CA19-9 levels,and continued adjuvant therapy were independent prognostic factors of conversion surgery for mPDAC after NAT.Subgroup analyses revealed that oligometastases and continued adjuvant therapy were associated with improved prognosis in the ypM1 resection group.Conclusion:In patients with mPDAC who underwent NAT followed by conversion surgery,the complete pathological response of metastases,normalization of preoperative CA19-9 levels,and continued adjuvant therapy were independent risk factors for prognosis.Patients with residual oligometastases after treatment were expected to prolong survival through resection.These patients may benefit from conversion surgery and should be potential candidates for this treatment strategy. | Lingyu Zhu Suizhi Gao Xinqian Wu Bo Li Xiaohan Shi Xiaoyi Yin Huan Wang Meilong Shi Penghao Li Yikai Li Chaoliang Zhong Chuanqi Teng Jiawei Han Yiwei Ren Jian Wang Zhendong Fua Xinyu Liu Kailian Zheng Shiwei Guo Gang Jin | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 19 | High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors显示文摘Tonalid,an important fragrance ingredient with widespread applicatio n,was synthesized via two FriedelCrafts reactions,which were catalyzed by AlCl_(3).The traditional tonalid production was conducted in batch stirring tank reactors,suffering from low production capacity and the safety hazard of temperature runaway.To solve these problems,the continuous-flow technologies were developed for the highefficiency and intrinsically safe synthesis of tonalid in microreactors.Catalyst AlCl_(3)was neatly homogenized in proper solvents by forming complex with reactant,which was a necessary step for the continuous synthesis in microreactors.Several reaction conditions,including reactant molar ratio,catalyst concentration,temperature,and microchannel hydrodynamic diameter,were investigated for the two Friedel-Crafts reactions in micro reactors.At optimized conditions,the yields of the two Friedel-Crafts reactions were 44.15%and 97.55%,respectively.In comparison with the batch reactors,the reaction times of these two reactions could both be reduced by nearly two thirds in microreactors at the similar yield. | Yang Han Yuanyuan Liu Shiwei Wang Xuehui Ge Xiaoda Wang Ting Qiu | 2022 | Chinese Journal of Chemical Engineering2022，，12： | 0 |
| 20 | Calculation Model and Allocation Strategy of Network Usage Charge for Peer-to-peer and Community-based Energy Transaction Market显示文摘The emergence of prosumers in distribution systems has enabled competitive electricity markets to transition from traditional hierarchical structures to more decentralized models such as peer-to-peer(P2P)and community-based(CB)energy transaction markets.However,the network usage charge(NUC)that prosumers pay to the electric power utility for network services is not adjusted to suit these energy transactions,which causes a reduction in revenue streams of the utility.In this study,we propose an NUC calculation method for P2P and CB transactions to address holistically economic and technical issues in transactive energy markets and distribution system operations,respectively.Based on the Nash bargaining(NB)theory,we formulate an NB problem for P2P and CB transactions to solve the conflicts of interest among prosumers,where the problem is further decomposed into two convex subproblems of social welfare maximization and payment bargaining.We then build the NUC calculation model by coupling the NB model and AC optimal power flow model.We also employ the Shapley value to allocate the NUC to consumers fairly for the NUC model of CB transactions.Finally,numerical studies on IEEE 15-bus and 123-bus distribution systems demonstrate the effectiveness of the proposed NUC calculation method for P2P and CB transactions. | Dong Han Lei Wu Xijun Ren Shiwei Xia | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 0 |
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