|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis显示文摘AIM:To study the expression of vascular endothelial growth factor C (VEGF-C) and chemokine receptor CCR7 in gastric carcinoma and to investigate their associations with lymph node metastasis of gastric carcinoma and their values in predicting lymph node metastasis.METHODS:The expression of VEGF-C and CCR7 in gastric carcinoma tissues obtained from 118 patients who underwent curative gastrectomy was examined by immunohistochemisty.Among these patients,39 patients underwent multi-slice spiral CT (MSCT) examination.RESULTS:VEGF-C and CCR7 were positively expressed in 52.5 and 53.4% of patients. VEGF-C expression was more frequently found in tumors with lymph node metastasis than those without it (P<0.001).VEGF-C expression was also closely related to lymphatic invasion (P<0.001), vascular invasion (P<0.01),and TNM stage (P<0.001). However,there was no significant correlation between VEGF-C expression and age at surgery, gender, tumor size, tumor location,Lauren classification,and depth of invasion. CCR7 expression was significantly higher in patients with lymph node metastasis compared with those without lymph node metastasis (P<0.001) and was also associated with tumorsize (P<0.01), depth of invasion (P<0.001), lymphatic invasion (P<0.001),and TNM stage (P<0.001).However,the presence of CCR7 had no correlation to age at surgery,gender, tumor location, Lauren classification,and vascular invasion. Among the 39 patients who underwent MSCT examination,only CCR7 expression was related to lymph node metastasis determined by MSCT (P<0.05).In the current retrospective study,the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of VEGF-C and CCR7 expression in the diagnosis of lymph node metastasis for patients with gastric carcinoma were 73.8%, 70.2%,72.6%,71.4% and 72.0%,and 82.0%,77.2%,79.4%,80.0% and 79.7%,respectively.After subdivision according to the combination of VEGF-C and CCR7 expression, receiver operating characteristic (ROC) analysis showed that the accuracy of the combined examination of VEGF-C and CCR7 expression in predicting lymph node metastasis was relatively high (area under ROC curve [Az]=0.83).CONCLUSION:The expression of VEGF-C and CCR7 is related to lymph node metastasis of gastric carcinoma and both of them may become new targets for the treatment of gastric carcinoma.Furthermore,the combined examination of VEGF-C and CCR7 expression in endoscopic biopsy specimens may be useful in predicting lymph node metastasis of gastric carcinoma and deciding the extent of surgical lymph node resection. | ChaoYan Zheng-GangZhu Ying-YanYu JunJi YiZhang Yu-BaoJi MinYan JunChen Bing-YaLin | 2004 | World Journal of Gastroenterology2004，10，6： | 54 |
| 2 | Comprehensive Evaluation of Ski Resort Development Conditions in Northern China显示文摘China′s bid for the 2022 Winter Olympic Games will promote rapid development of domestic ski tourism. More than 10 provinces in the northern China list ski tourism as a new source of growth in the tourism industry. Formulating a scientific evaluation system is an important foundation for ski resort development. By referring to the conditions of existing international ski resorts, a comprehensive index system for evaluating ski resort development was developed based on natural factors, human factors, athletic sports, and popular ski tourism. The system was composed of one target layer, two indices, seven sub-indices and twenty-five basic indices. Based on data collected during a field investigation in 2012 and on a statistical model, the development conditions of the following ski resorts were quantified: Yabuli Ski Resort in Heilongjiang Province and Beidahu Ski Resort in Jilin Province in Northeast China, Wanlong Ski Resort in Hebei Province and Nanshan Ski Resort in Beijing in the northern China, and Silk Road International Ski Resort in Uygur Autonomous Region of Xinjiang in the northwestern China. The resulting index values of development conditions at Beidahu, Yabuli, Wanlong, Nanshan, and Silk Road International Ski Resorts were 0.304, 0.278, 0.270, 0.214, and –0.025, respectively. Various natural and human factors exert positive and negative effects on the development potential of ski resorts. The development conditions of the five ski resorts were inferior to those of first-class international resorts. Therefore, the development conditions of the five ski resorts should be improved with future construction. | LI Yu ZHAO Minyan GUO Peng ZHENG Ji LI Zehong LI Fujia SHI Yuanyuan DONG Suocheng | 2016 | Chinese Geographical Science2016，26，3： | 10 |
| 3 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 4 | Incorporating S-shaped testing-effort functions into NHPP software reliability model with imperfect debugging显示文摘Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped varying trend of TE increasing rate more accurately, first, two S-shaped testing-effort functions(TEFs), i.e.,delayed S-shaped TEF(DS-TEF) and inflected S-shaped TEF(IS-TEF), are proposed. Then these two TEFs are incorporated into various types(exponential-type, delayed S-shaped and inflected S-shaped) of non-homogeneous Poisson process(NHPP)SRGMs with two forms of ID respectively for obtaining a series of new NHPP SRGMs which consider S-shaped TEFs as well as ID. Finally these new SRGMs and several comparison NHPP SRGMs are applied into four real failure data-sets respectively for investigating the fitting and prediction power of these new SRGMs.The experimental results show that:(i) the proposed IS-TEF is more suitable and flexible for describing the consumption of TE than the previous TEFs;(ii) incorporating TEFs into the inflected S-shaped NHPP SRGM may be more effective and appropriate compared with the exponential-type and the delayed S-shaped NHPP SRGMs;(iii) the inflected S-shaped NHPP SRGM considering both IS-TEF and ID yields the most accurate fitting and prediction results than the other comparison NHPP SRGMs. | Qiuying Li Haifeng Li Minyan Lu | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 7 |
| 5 | Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in Shanghai patients with arthropathy显示文摘AIM: The study was to screen the possible risk factors of adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs) in Shanghai patients with arthropathy. METHODS: The subjects were ran- domly selected from a database of outpatients with arthropathy from 9 main hospitals in Shanghai. A door to door retrospective epidemiological survey was used to collect demographic information about the patients, both indi- vidual and familial. This included data on their medical histories, lifestyle and dietary habits, history of smoking and alcohol consumption, history of drug therapy, quality of life (QOL) prior to NSAIDs intake, history of NSAIDs therapy and its ADR events, etc. Descriptive statistical methods and univariate analysis were also used to identify possible risk factors for ADRs induced by NSAIDs. RESULTS: Of the 1002 patients surveyed, the average length of NSAIDs intake was 2 years. ADR incidence from different NSAIDs was high, in a range from 46.7 %-66.2 %. In general, the candidate risk factors for ADRs were different for each NSAID. Each of the candidate risk factors were defined and studied in order to evaluate its role in the determination of ADRs from NSAIDs. “Family history of ADRs caused by NSAIDs” was found to be a significant risk factor for the four commonly used NSAIDs: meloxicam, diclofenac, nimesulide, and nabumetone. CONCLUSION: A retrospective epidemiological survey was useful in detecting the risk factors for ADRs caused by NSAIDs. The study found that different NSAIDs might have different risk factors and that there is no single risk factor universally applicable to all NSAIDs. | WenSHI Yong-mingWANG Shao-liLI MinYAN DuanLi Bin-yanCHEN Neng-nengCHENG | 2004 | Acta Pharmacologica Sinica2004，25，3： | 7 |
| 6 | Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates显示文摘Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity,which play a key role in the construction of natural products,pharmaceuticals,and manmade materials.Converting the normally highly stable fiuoroalkenes into silylated fluoroalkenes by selective defluorosilylation is a challenging task.Herein,we report a simple,inexpensive and robust defluorosilylation of a variety of fluoroalkenes with silylboronates in the presence of alkoxy base to directly synthesize various silylated fluoroalkenes.The protocol features mild and safe reaction conditions that avoid a catalyst,a transition metal,a ligand,and high reaction temperature and tolerates a wide scope of fluoroalkene substrates without compromising the efficiency.Density functional theory calculations show that transient silyl anion complex undergoes an SN2,or SNv substitution,which is responsible for this base-mediated defluorosilylation. | Pan Gao Guoqiang Wang Longlong Xi Minyan Wang Shuhua Li Zhuangzhi Shi | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 7 | Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal,intragastric and intravenous administration显示文摘The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate(TMPP)in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes:intranasal(i.n.),intragastric(i.g.)and intravenous(i.v.)administration.After i.n.,i.g.and i.v.administration of a single-dose at 10 mg/kg,cerebral cortex dialysates and plasma samples drawn from the carotid artery were collected at timed intervals.The concentration of TMPP in the samples was analyzed by HPLC.The area under the concentration-time curve(AUC)and the ratio of the AUCbrain to the AUCplasma(drug targeting efficiency,DTE)was calculated to evaluate the brain targeting efficiency of the drug via these different routes of administration.After i.n.administration,TMPP was rapidly absorbed to reach its peak plasma concentration within 5 min and showed a delayed uptake into cerebral cortex(t_(max)=15 min).The ratio of the AUCbrain dialysates value between i.n.route and i.v.injection was 0.68,which was greater than that obtained after i.g.administration(0.43).The systemic bioavailability obtained with i.n.administration was greater than that obtained by the i.g.route(86.33%vs.50.39%),whereas the DTE of the nasal route was 78.89%,close to that of oral administration(85.69%).These results indicate that TMPP is rapidly absorbed from the nasal mucosa into the systemic circulation,and then crosses the blood-brain barrier(BBB)to reach the cerebral cortex.Intranasal administration of TMPP could be a promising alternative to intravenous and oral approaches. | Dongmei Meng Haoyang Lu Shanshan Huang Minyan Wei Pingtian Ding Xianglin Xiao Yuehong Xu Chuanbin Wu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 5 |
| 8 | Physico-chemical characterization and source tracking of black carbon at a suburban site in Beijing显示文摘Particles from ambient air and combustion sources including vehicle emission, coal combustion and biomass burning were collected and chemically pretreated with the purpose of obtaining isolated BC(black carbon) samples. TEM(transmission electron microscopy)results indicate that BC from combustion sources shows various patterns, and airborne BC appears spherical and about 50 nm in diameter with a homogeneous surface and turbostratic structure. The BET(Barrett–Emmett–Teller) results suggest that the surface areas of these BC particles fall in the range of 3–23 m2/g, with a total pore volume of 0.03–0.05 cm3/g and a mean pore diameter of 7–53 nm. The nitrogen adsorption–desorption isotherms are indicative of the accumulation mode and uniform pore size. O2-TPO(temperature programmed oxidation)profiles suggest that the airborne BC oxidation could be classified as the oxidation of amorphous carbon, which falls in the range of 406–490°C with peaks at 418, 423 and 475°C,respectively. Generally, the BC characteristics and source analysis suggest that airborne BC most likely comes from diesel vehicle emission at this site. | Hailin Wang Lei Nie Dan Liu Meiping Gao Minyan Wang Zhengping Hao | 2015 | Journal of Environmental Sciences2015，27，7： | 4 |
| 9 | CRA-40/Atmosphere—The First-Generation Chinese Atmospheric Reanalysis(1979–2018):System Description and Performance Evaluation显示文摘Atmospheric reanalysis reproduces the past atmospheric conditions through assimilation of historical meteorological observations with fixed version of a numerical weather prediction(NWP)model and data assimilation(DA)system.It is widely used in weather,climate,and even business-related research and applications.This paper reports the development of CMA’s first-generation global atmospheric reanalysis(RA)covering 1979–2018(CRA-40;CRA refers to CMA-RA).CRA-40 is produced by using the Global Spectral Model(GSM)/Gridpoint Statistical Interpolation(GSI)at a 6-h time interval and a TL574 spectral(34-km)resolution with the model top at 0.27 hPa.A large number of reprocessed satellite data and widely collected conventional observations were assimilated during the reanalyzing process,including the reprocessed atmospheric motion vector(AMV)products from FY-2C/D/E/G satellites,dense conventional observations(at about 120 radiosonde and 2400 synoptic stations)over China,as well as MWHS-2 and GNSS-RO observations from FY-3C.The reanalysis fitting to observations is improved over time,especially for surface pressure with root-mean-square error reduced from 1.05 hPa in 1979 to 0.8 hPa,and for upper air temperature from 1.65 K in 1979 to 1.35 K,in 2018.The patterns of global analysis increments for temperature,specific humidity,and zonal wind are consistent with the changes in the observing system.Near surface temperature from the model’s 6-h forecast reflects the global warming trend reasonably.The CRA-40 precipitation pattern matches well with those of GPCP and other reanalyses.CRA-40 also successfully captures the QBO and its vertical and temporal development,hemispherical atmospheric circulation change,and moisture transport by the East Asian summer monsoon.CRA is now operationally running in near real time as a climate data assimilation system in CMA. | Zhiquan LIU Lipeng JIANG Chunxiang SHI Tao ZHANG Zijiang ZHOU Jie LIAO Shuang YAO Jingwei LIU Minyan WANG Huiying WANG Xiao LIANG Zhisen ZHANG Yan YAO Ting ZHU Zhe CHEN Wenhui XU Lijuan CAO Hui JIANG Kaixi HU | 2023 | Journal of Meteorological Research2023，37，1： | 4 |
| 10 | The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies显示文摘Terpenoids,including aromatic volatile monoterpenoids and sesquiterpenoids,function in defense against pathogens and herbivores.Phoebe trees are remarkable for their scented wood and decay resistance.Unlike other Lauraceae species investigated to date,Phoebe species predominantly accumulate sesquiterpenoids instead of monoterpenoids.Limited genomic data restrict the elucidation of terpenoid variation and functions.Here,we present a chromosome-scale genome assembly of a Lauraceae tree,Phoebe bournei,and identify 72 full-length terpene synthase(TPS)genes.Genome-level comparison shows pervasive lineage-specific duplication and contraction of TPS subfamilies,which have contributed to the extreme terpenoid variation within Lauraceae species.Although the TPS-a and TPS-b subfamilies were both expanded via tandem duplication in P.bournei,more TPS-a copies were retained and constitutively expressed,whereas more TPS-b copies were lost.The TPS-a genes on chromosome 8 functionally diverged to synthesize eight highly accumulated sesquiterpenes in P.bournei.The essential oil of P.bournei and its main component,b-caryophyllene,exhibited antifungal activities against the three most widespread canker pathogens of trees.The TPS-a and TPS-b subfamilies have experienced contrasting fates over the evolution of P.bournei.The abundant sesquiterpenoids produced by TPS-a proteins contribute to the excellent pathogen resistance of P.bournei trees.Overall,this study sheds light on the evolution and adaptation of terpenoids in Lauraceae and provides valuable resources for boosting plant immunity against pathogens in various trees and crops. | Xiao Han Junhong Zhang Shuang Han Sun Li Chong Guanliang Meng Minyan Song Yang Wang Shengcai Zhou Chengcheng Liu Luhuan Lou Xiongzhen Lou Longjun Cheng Erpei Lin Huahong Huang Qi Yang Zaikang Tong | 2022 | Plant Communications2022，3，6： | 3 |
| 11 | Model-based robustness testing for avionics-embedded software显示文摘Robustness testing for safety-critical embedded software is still a challenge in its nascent stages. In this paper, we propose a practical methodology and implement an environment by employing model-based robustness testing for embedded software systems. It is a system-level black-box testing approach in which the fault behaviors of embedded software is triggered with the aid of modelbased fault injection by the support of an executable model-driven hardware-in-loop (HIL) testing environment. The prototype implementation of the robustness testing environment based on the proposed approach is experimentally discussed and illustrated by industrial case studies based on several avionics-embedded software systems. The results show that our proposed and implemented robustness testing method and environment are effective to find more bugs, and reduce burdens of testing engineers to enhance efficiency of testing tasks, especially for testing complex embedded systems. | Yang Shunkun Liu Bin Wang Shihai Lu Minyan | 2013 | Chinese Journal of Aeronautics2013，26，3： | 3 |
| 12 | Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration显示文摘To establish an injectable hydrogel containing Prussian blue(PB) nanospheres for photothermal therapy against cancer, PB nanospheres were prepared by one-pot synthesis and the thermosensitive Pluronic F127 was used as the hydrogel matrix. The PB nanospheres and the hydrogel were characterized by shape, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation, as well as the rheological features. The effect of the PB nanospheres and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention,photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in a tumor-bearing mouse model. The PB nanospheres had a diameter of about 150 nm and exhibited satisfactory serum stability, photo-heat convert ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanospherecontaining hydrogel showed a phase transition at body temperature and, as a result, a long retention time in vivo. The photothermal agent-embedded hydrogel displayed promising photothermal therapeutic effects in the tumor-bearing mouse model with little-to-no systemic toxicity after peritumoral administration. | Jijun Fu Bo Wu Minyan Wei Yugang Huang Yi Zhou Qiang Zhang Lingran Du | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 13 | Spatial diversity and combination technology using amplitude and phase weighting method for phase-coherent underwater acoustic communications显示文摘 | LI Jilong HUANG Minyan CHENG Shuping TAN Qianlin FENG Haihong | 2018 | Chinese Journal of Acoustics2018，37，1： | 2 |
| 14 | A Modeling Language Based on UML for Modeling Simulation Testing System of Avionic Software显示文摘With direct expression of individual application domain patterns and ideas,domain-specific modeling language(DSML) is more and more frequently used to build models instead of using a combination of one or more general constructs.Based on the profile mechanism of unified modeling language(UML) 2.2,a kind of DSML is presented to model simulation testing systems of avionic software(STSAS).To define the syntax,semantics and notions of the DSML,the domain model of the STSAS from which we generalize the domain concepts and relationships among these concepts is given,and then,the domain model is mapped into a UML meta-model,named UML-STSAS profile.Assuming a flight control system(FCS) as system under test(SUT),we design the relevant STSAS.The results indicate that extending UML to the simulation testing domain can effectively and precisely model STSAS. | WANG Lize LIU Bin LU Minyan | 2011 | Chinese Journal of Aeronautics2011，24，2： | 2 |
| 15 | Design and control of a middle-vessel batch distillation for separating DMC–EMC–DEC mixture显示文摘In this paper, the mixture of dimethyl carbonate, ethyl methyl carbonate and diethyl carbonate was separated by middle-vessel batch distillation with feeding in middle-vessel and process control characteristics were researched. The steady state simulation results in Aspen Plus were exported to Aspen Dynamics. Then control effect of liquid level control with HighSelector, composition control(structure1, structure2) and temperature control(proportional action, proportional integration action) were proposed. Composition control structure 2 and temperature control with PI action were investigated to achieve a good control effect. | Minyan Zhu Yafei Hou Na Yu Mengqi Chen Zhanhua Ma Lanyi Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 2 |
| 16 | Detection of differentially expressed gertes in hepatocellar carcinoma using DNA microarray 显示文摘 | Li Yao Qiu Minyan Wu Chaoqun | 2001 | DNA Chip''s Application2001，，1： | 1 |
| 17 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 18 | Synthesis and properties of dendrimer liquid crystal based on ester and ether of gallic acid显示文摘 | Zheng Minyan Wei Yongsheng Gu Yuanzi | | 0，，： | 1 |
| 19 | MCSim-based occupational health risk assessment on benzene显示文摘 | LI Minyan HUANG Deyin LIU Mao | 2013 | Journal of Risk Analysis and Crisis Response2013，3，3： | 1 |
| 20 | Detection of differentially expressed genes in hepatocellar carcinoma using NDAmicroarray显示文摘 | Li Yao Qiu Minyan Wu Chaoqun | 2001 | DNA Chip''s Application2001，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员