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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer显示文摘Studies have shown cell-free microRNA(miRNA) circulating in the serum and plasma with specific expression in cancer,indicating the potential of using miRNAs as biomarkers for cancer diagnosis and therapy.This study was to investigate whether plasma miRNA-21(miR-21) can be used as a biomarker for the early detection of non-small cell lung cancer(NSCLC) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.We used real-time RT-PCR to investigate the expression of miR-21 in the plasma of 63 NSCLC patients and 30 healthy controls and correlated the findings with early diagnosis,pathologic parameters,and treatment.Thirty-five patients(stages IIIB and IV) were evaluable for chemotherapeutic responses:11 had partial response(PR);24 had stable and progressive disease(SD+PD).Plasma miR-21 was significantly higher in NSCLC patients than in age-and sex-matched controls(P<0.001).miR-21 was related to TNM stage(P<0.001),but not related to age,sex,smoking status,histological classification,lymph node status,and metastasis(all P>0.05).This marker yielded a receiver operating characteristic(ROC) curve area of 0.775(95% CI:0.681-0.868) with 76.2% sensitivity and 70.0% specificity.Importantly,miR-21 plasma levels in PR samples were several folds lower than that in SD plus PD samples(P=0.049),and were close to that in healthy controls(P=0.130).Plasma miR-21 can serve as a circulating tumor biomarker for the early diagnosis of NSCLC and is related to the sensitivity to platinum-base chemotherapy. | Juan Wei Wen Gao Cheng-Jun Zhu Yi-Qian Liu Zhu Mei Ting Cheng Yong-Qian Shu | 2011 | Chinese Journal of Cancer2011，30，6： | 63 |
| 3 | The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients显示文摘Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications.This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion,including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).All subjects were evaluated with a number of accepted cognitive function tests,including themini‐mental status examination (MMSE).The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated,likewise with the correlation between MODD and MMSE.Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age,sex,glycemic control,hypertension,smoking,or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients.Elevated glucose excursion decreased the MMSE score,which reflects general cognitive function.Thus,therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients. | ZHONG Yuan ZHANG Xiao Yan MIAO Ya ZHU Jie Hua YAN Hong WANG Bei Yun JIN Jun HU Ting Jun JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 34 |
| 4 | Photo-curing 3D printing technique and its challenges显示文摘In recent ten years,3D printing technology has been developed rapidly.As an advanced technology,3D printing has been used to fabricate complex and high-precision objects in many fields.3D printing has several technologies.Among these technologies,photo-curing 3D printing was the earliest and most mature technology.In 1988,the first 3D printing machine which was based on photo-curing and called Stereo lithography Appearance(SLA)technology was produced by 3D system Corp.After 30 years of development,many new technologies based on photocuring mechanism emerged.Based on the different principle of pattern formation and character of printing technology,numerous photocuring 3D printing techniques,such as SLA,DLP,LCD,CLIP,MJP,twophoton 3D printing,holographic 3D printing and so on,have been developed.Photo-curing 3D printing has many advantages,such as high precision,smooth surface of printing objects,rapid printing speed and so on.Here,we would introduce five industrial photocuring 3D printing technologies,which are SLA,DLP,LCD,CLIP and MJP.The characters of the materials and the progress of the application of the technique in the biomedical field is also overviewed.At last,the difficulties and challenges of photo-curing 3D printing are also discussed. | Haoyuan Quan Ting Zhang Hang Xu Shen Luo Jun Nie Xiaoqun Zhu | 2020 | Bioactive Materials2020，5，1： | 33 |
| 5 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 6 | Herbal prescription Chang'an Ⅱ repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome显示文摘 | Feng-yun WANG Min SU Yong-qiu ZHENG Xiao-ge WANG Nan KANG Ting CHEN En-lin ZHU Zhao-xiang BIAN Xu-dong TANG | 2015 | Acta Pharmacologica Sinica2015，36，6： | 28 |
| 7 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 8 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 9 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 10 | Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome: the role of hyperglycemia and obesity显示文摘clopidogrel 的证明好处联合了的 BackgroundDespite 为冠的动脉疾病(CAD ) 的阿司匹林治疗,有新陈代谢的症候群(MS ) 的 CAD 病人仍然趋于有冠的 thrombotic 事件。我们试图与经历经皮的冠的干预(一种总线标准) 的 CAD 在病人在 clopidogrel 治疗的功效上调查新陈代谢的风险因素的影响有冠的 angiography (CAG ) 识别的 CAD 的 168 MS 和 168 个非 MS 题目的 .MethodsCohorts 在我们的学习被注册。MS 被修改成年治疗面板 III 标准定义。所有题目服 100 mg 阿司匹林和 75 mg clopidogrel 日报超过 1 个月了,并且管理装载 600 mg clopidogrel 和 300 mg 的剂量在一种总线标准前的阿司匹林。血样品在 clopidogrel 和阿司匹林的装载剂量以后被花 24 h。血小板聚集用轻发射度 aggregometry (LTA ) 和 thrombelastography (两岁的羊) 被测量。Clopidogrel 抵抗是定义 as 超过 50% 腺苷 diphosphate (自动数据处理) 导致了由自动数据处理由 TEG.ResultsPlatelet 聚集抑制率测量了的血小板聚集在有由两岁的羊测量了两个的 MS 的病人是显著地更低的(55%±31% 对 68%±32% ;P <0.001 ) 并且 LTA (29%±23% 对 42%±29% ;P <0.001 ) 。在 multivariate 分析,老[或(95% CI ) :1.483 (1.047-6.248 ) ;P = 0.002 ] ,肥胖[或(95% CI ) :3.608 (1.241-10.488 ) ;P = 0.018 ] ,高 fasting 血浆葡萄糖水平[或(95% CI ) :2.717 (1.176-6.277 ) ;P = 0.019 ] 并且 hyperuricemia [或(95% CI ) :2.583 (1.095-6.094 ) ;P = 0.030 ] 都统计上为 clopidogrel 抵抗冒险因素。有糖尿病和肥胖的 CAD 病人是更可能的没有糖尿病和肥胖,比 CAD 病人有 clopidogrel 抵抗[75%(61/81 ) 对 43%(67/156 ) ;P <0.001 ] 没有 MS,有 MS 的 .ConclusionsCAD 病人看起来与那些相比有更差的 antiplatelet 反应到 clopidogrel。肥胖,糖尿病和 hyperuricemia 都显著地与 clopidogrel 抵抗被联系。 | Zhao-Ke WU Jing-Jing WANG Ting WANG Shen-Shen ZHU Xi-Ling CHEN Chao LIU Wei-Guo ZHANG | 2015 | Journal of Geriatric Cardiology2015，12，4： | 21 |
| 11 | Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives显示文摘Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of gem-difluoromethylenated chrysin derivatives had higher anticancer activity than chrysin. | Xing ZHENG Jian Guo CAO Duan Fang LIAO Bing Yang ZHU Hui Ting LIU | 2006 | Chinese Chemical Letters2006，17，11： | 20 |
| 12 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 13 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 14 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 15 | Isolation and Identification of a Di-(2-Ethylhexyl)Phthalate-Degrading Bacterium and Its Role in the Bioremediation of a Contaminated Soil显示文摘Di-(2-ethylhexyl) phthalate(DEHP) is a high-molecular-weight phthalate ester(PAE) that has been widely used in the manufacture of polyvinylchloride and contributes to environmental pollution.The objectives of the present study were to isolate a DEHP degrader that can utilize DEHP as a carbon source and to investigate its capacity to biodegrade DEHP in both liquid culture and soil.A bacterial strain WJ4 was isolated from an intensively managed vegetable soil,which was contaminated with PAEs.The strain WJ4 was affiliated to the genus Rhodococcus and was able to remove DEHP from soil effectively.A period of only 7 d was required to degrade about 96.4%of DEHP(200 mg L^(-1)) in the liquid culture,and more than 55%of DEHP(1.0 g kg^(-1)) in the artificially contaminated soil was removed within 21 d.Furthermore,Rhodococcus sp.strain WJ4 had a strong ability to degrade DEHP without additional nutrients in liquid minimal medium culture and DEHP-contaminated soil and to degrade the homologue of DEHP in both liquid culture and soil.Strain WJ4 represents a novel tool for removing PAEs from contaminated soils and it may have great potential for application in the remediation of environmental pollution by PAEs. | WANG Jun ZHANG Man-Yun CHEN Ting ZHU Ye TENG Ying LUO Yong-Ming Peter CHRISTIE | 2015 | Pedosphere2015，25，2： | 18 |
| 16 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 17 | Friction and Wear Behavior of Resin/Graphite Composite under Dry Sliding显示文摘The friction and wear behavior of resin/graphite composite has been investigated using a pin-on-disc configuration under dry sliding condition. The results showed that the resin/graphite composite exhibited much better mechanical and tribological properties compared with the unimpregnated graphite. The friction coefficient was reduced by addition of furan resin, which could also prevent the'dusting' wear at loads more than 15 MPa. The steady and lubricated transfer film was easily formed on the counterpart surface due to the interaction of furan resin and wear debris of graphite, which was useful to reduce the wear rate of the resin/graphite composite. The composite is highly promising for mechanical sealing application and can be used at high load for long time sliding. | Zhenguo Zhu Shuo Bai Junfeng Wu Li Xu Ting Li Yong Ren Chang Liu | 2015 | Journal of Materials Science & Technology2015，31，3： | 14 |
| 18 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 19 | Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs显示文摘Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality pork.However, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal mucosa.Results: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa meal.Conclusions: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety. | Jiawei Wang Chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 12 |
| 20 | Preparation of high-affinity rabbit monoclonal antibodies for ciprofloxacin and development of an indirect competitive ELISA for residues in milk显示文摘A convenient competitive enzyme-linked immunosorbent assay(ELISA) for ciprofloxacin(CPFX) was developed by using rabbit monoclonal antibodies(RabMAbs) against a hapten-protein conjugate of CPFX-bovine serum albumin(BSA).The indirect competitive ELISA of CPFX had a concentration at 50% inhibition(IC50) of 1.47 ng/ml and a limit of detection(LOD) of 0.095 ng/ml.The mAb exhibited some cross-reactivity,however,not so high with enrofloxacin(28.8%),ofloxacin(13.1%),norfloxacin(11.0%),fleroxacin(22.6%),and pefloxacin(20.4%).And it showed almost no cross-reactivity with other antibiotics or sulfonamides evaluated in this study.The competitive ELISA kit developed here could be used as a screening tool to detect and control illegal addition of CPFX in food products.This kit had been applied to milk detection and the recovery rates from samples spiked by CPFX were in a range of 63.02%-84.60%,with coefficients of variation of less than 12.2%. | Bin HUANG Yun YIN Lei LU Hai DING Lin WANG Ting YU Jia-jin ZHU Xiao-dong ZHENG Yan-zhen ZHANG | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，10： | 11 |
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