|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunohistochemical study on p53,H-rasp21,c-erbB-2 protein and PCNA expression in HCC tissues of Hart and minority ethnic patients显示文摘AIM To find out the difference of humanprimary liver carcinogenesis between Han andminority ethnic patients in Xinjiang.METHODS Expression of p53,c-erbB-2,H-rasp21 protein and proliferating cell nuclearantigen(PCNA)in tumor tissues of 50 patients(Han 38,minority 12)with primary hepaticcarcinoma was detected byimmunohistochemistry(LSAB).RESULTS The positive frequency of p53,c-erbB-2,H-rasp21 and PCNA expression was46.0%(23/50),70.0%(35/50),68.0%(34/50)and 82.0%(41/50)in tumor tissues;4.0%(2/50),22.0%(11/50),64.0%(32/50)and 52.0%(26/ 50)in peritumors respectively and asignificant difference,except for H-rasp21,ofoncogene alteration was found(P<0.05)between tumor and non-tumorous tissues.Combined the three oncogenes alteration,26%(13/50)tumor tissues had positiveimmunoreactivity,but in peritumor and normallivers it was negative.The positive rate of p53,c-erbB-2 and H-rasp21 protein expression was39.5%(15/38),60.5%(23/38)and 39.5%(15/38)in tumors of Han patients;66.7%(8/12),100%(12/12)and 75.0%(9/12)in minoritiesrespectively,with statistical difference (P<0.05).CONCLUSION Overexpression of p53,c-erbB-2and H-rasp21 in human primary liver carcinoma isan important biomarker of genetic alteration.The different frequency of these oncogeneticchanges may reflect some environmental or/andethnic hereditary factors affecting the livercarcinogenesis.The special life style of Han,Uygur,Kazak and Mongolia nationalities inXinjiang may also be related to theetiopathogenesis of this disease. | Guo Yue Lin Zhao Lun Chen Cai Mo Lu Ying Li Xiao Jia Ping Rong Huang Department of Laboratory Medicine,Chinese PLA 474 Hospital,Urumqi 830011,Xinjiang Uygur Autonomic Region,China Department of Pathology,the 1st Teaching Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomic Region,China | 2000 | World Journal of Gastroenterology2000，6，2： | 40 |
| 2 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 3 | Typical atmospheric haze during crop harvest season in northeastern China:A case in the Changchun region显示文摘This study presents the mass concentrations of PM_(2.5),O_3,SO_2 and NOxat one urban,one suburban and two rural locations in the Changchun region from September 25 to October 272013. Major chemical components of PM_(2.5)at the four sites were daily sampled and analyzed. Most of daily concentrations of SO_2(7–82 μg/m^3),O_3(27–171 μg/m^3) and NOx(14–213 μg/m^3) were below the limits of the National Ambient Air Quality Standard(NAAQS)in China. However,PM_(2.5)concentrations(143–168 μg/m^3) were 2-fold higher than NAAQS.Higher PM_(2.5)concentrations(~ 150 μg/m^3) were measured during the pre-harvest and harvest at the urban site,while PM_(2.5)concentrations significantly increased from 250 to400 μg m^(-3) at suburban and rural sites with widespread biomass burning. At all sites,PM_(2.5)components were dominated by organic carbon(OC) and followed by soluble component sulfate(SO_4^(2-)),ammonium(NH_4^+) and nitrate(NO_3^-). Compared with rural sites,urban site had a higher mineral contribution and lower potassium(K^+and K) contribution to PM_(2.5).Severe atmospheric haze events that occurred from October 21 to 23 were attributed to strong source emissions(e.g.,biomass burning) and unfavorable air diffusion conditions.Furthermore,coal burning originating from winter heating supply beginning on October 18 increased the atmospheric pollutant emissions. For entire crop harvest period,the Positive Matrix Factorization(PMF) analysis indicated five important emission contributors in the Changchun region,as follows: secondary aerosol(39%),biomass burning(20%),supply heating(18%),soil/road dust(14%) and traffic(9%). | Wei Wei Chen Daniel Q.Tong Mo Dan Shi Chun Zhang Xue Lei Zhang Yue Peng Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 10 |
| 4 | Inhibition of choroidal neovascularization by lentivirusmediated PEDF gene transfer in rats显示文摘AIM: To evaluate the effects of lentivirus-mediated pigment epithelium-derived factor(PEDF) gene transfer performed in treatment of rats with established choroidal neovascularization(CNV), and investigates the mechanism by which PEDF inhibits CNV in rats.METHODS: Brown Norway(BN) rats(n =204) were induced by exposure to a laser, and then randomly assigned to 3 groups: no treatment; treatments with intravitreal injection of lentivirus-PEDF-green fluorescent protein(GFP) or lentivirus-control GFP(free fluorescent protein). Following induction and treatment,the CNV tissue was assessed for form, size and vessel leakage by fluorescein fundus angiography(FFA), optical coherence tomography(OCT), histopathology, and examination of choroidal flat mounts. VEGF, Flk-1, and PEDF expression were evaluated by real-time polymerase chain reaction(PCR) and Western blot.RESULTS: A stable laser-induced rat model of CNV was successfully established, and used to demonstrate lentivirus-mediated PEDG gene transfer by intravitreal injection. Expression of green fluorescence labelled PEDF was observed in the retina up to 28 d after injection. An intravitreal injection of lentivirus-PEDF-GFP at 7d led to a significant reduction in the size,thickness and area of CNV showed by FFA, OCT and choroidal flat mounts. PEDF was up-regulated while VEGF and Flk-1 were down-regulated in the lentivirus-PEDF-GFP group. The differences in VEGF and Flk-1 expression in the control and lentivirus-PEDF groups at 7, 14, 21 and 28 d after laser induction were all statistically significant. CONCLUSION: Lentivirus-mediated PEDF gene transfer is effective for use in treatment of laser-induced CNV, and PEDF exerts its therapeutic effects by inhibiting expression of VEGF and Flk-1. | Ya-Jie Yu Bin Mo Lu Liu Yan-Kun Yue Chang-Li Yue Wu Liu | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 9 |
| 5 | Pool boiling on the superhydrophilic surface with TiO_2 nanotube arrays显示文摘Surface with TiO2 nanotube arrays(TNTAs)is superhydrophilic and of great specific area.This paper investigates the pool boiling characteristics at the thermal interface with TNTAs.The results show that the TNTAs interface can enhance the pool boiling heat transfer compared to the pure Ti metal plate.The bubbles formed at the initial nucleation state are very small and released in higher frequency.The pool boiling heat transfer enhancement at the TNTAs interface may be attributed to the high density of nucleate site,high intrinsic heating area of nanotubes layer,superhydrophilicity and the vertically oriented nanotube structure. | CHEN Yue,MO DongChuan,ZHAO HongBin,DING Nan & LU ShuShen School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China | 2009 | Science China(Technological Sciences)2009，52，6： | 7 |
| 6 | Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice显示文摘OBJECTIVE:To observe the effect of Jiangtang Xiaoke(JTXK) granule on endoplasmic reticulum(ER)stress in high fat diet(HFD)-induced type 2 diabetes mellitus(T2 DM) KK-Ay mice.METHODS:KK-Ay mice were fed with HFD to induce the T2 DM model,while normal control C57 BL/6 J mice were given standard feed.Fasting blood glucose(FBG) in all mice was measured weekly and oral glucose tolerance tests(OGTTs) were performed at 4 and 10 weeks after start of treatment to determine glucose metabolism.Serum fasting insulin(FINS) and insulin sensitivity index(ISI) were measured to determine insulin sensitivity.m RNA expressions of eukaryotic initiation factor-2 alpha(e IF2α),glucose regulated protein 78(GRP78),activating transcription factor 4(ATF4),and C/EBP homology protein(CHOP) were assessed by reverse transcription polymerase chain reaction and the protein expressions of p-e IF2α,GRP78,and CHOP were assessed by Western blotting.RESULTS:JTXK granule significantly reduced FBG and free fatty acid levels and improved OGTT at the120 min of the 10-week treatment in T2 DM KK-Ay mice.FINS and Hb Alc levels were reduced and insulin sensitivities were increased in KK-Ay diabetic mice,which were improved with the treatment of JTXK granule,especially at the 7 and 3.5 g/kg doses.JTXK granule at the 3.5 g/kg dose was most effective in reducing both gene and protein expressions of e IF2α,GRP78,and CHOP.CONCLUSION:ER stress response is increased in T2 DM KK-Ay mice.Treatment with JTXK granule attenuates glucose disorders,improves insulin sensitivity,and reduces serum FFA in T2 DM KK-Ay mice.The mechanisms may be attributed to regulation of the signaling ER stress pathway via decreasing e IF2α phosphorylation and suppressing e IF2α-ATF4-CHOP activation. | Zhang Yi Mo Fangfang Zhang Dongwei Gao Sihua Zhao Dandan Yu Na Mu Qianqian Zuo Jiacheng Ma Yue | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 3 |
| 7 | Electroactive polymeric nanofibrous composite to drive in situ construction of lithiophilic SEI for stable lithium metal anodes显示文摘Uncontrolled lithium dendrite growth hinders the practical application of lithium metal batteries(LMBs).Herein,we report a novel Li^(+) flux distributor achieved by placing an electroactive polyvinylidene fluoride/polymethyl methacrylate(PVDF/PMMA)composite nanofiber interlayer on a current collector,inducing uniform lithium deposition to mitigate the dendrite problem.Specifically,the released PMMA reacts with Liþto form abundant C–O–Li bonds and generate in situ a stable lithiophilic PMMA-Li solid electrolyte interphase layer.Theoretical calculations reveal that polar C–F groups in the PVDF framework and lithiophilic PMMA-Li provide homo-dispersed Li^(+) migration pathways with low energy barriers.Consequently,uniform Li nucleation is achieved at the molecular level,resulting in ultrahigh cycling stability with dendrite-free Li deposition at 5 mA cm^(-2) and 5 mAh cm^(-2)for over 500 h.The PVDF/PMMA||Li||LiFePO_(4)(LFP)full cell presents an increased rate capacity of 110 mAh g^(-1) at 10 C.In addition,a soft-package battery demonstrates a high energy density of 289 Wh kg^(-1).This work provides a facile design for stable lithium metal anodes to promote the practical use of LMBs and other alkali metal batteries. | Ai-Long Chen Nan Shang Yue Ouyang Lulu Mo Chunyang Zhou Weng Weei Tjiu Feili Lai Yue-E Miao Tianxi Liu | 2022 | eScience2022，2，2： | 3 |
| 8 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 9 | Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs显示文摘The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels.However,using angiogenesis inhibitors alone does not meet the cancer treatment needs.Herein,we used the amphiphilic drug-drug conjugate(ADDC)strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together.With one-step esterification of hydrophilic floxuridine(FUDR)and hydrophobic pseudolaric acid B(PAB),the conjugate was synthesized.The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water.From further in vitro and in vivo experiments,this FUDR-PAB conjugate does not only have a high antitumor effect,but also shows efficient antianiogenesis property.These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together. | Mo Sun Qiuhui Qian Leilei Shi Li Xu Qunfang Liu Linzhu Zhou Xinyuan Zhu Jian-Min Yue Deyue Yan | 2020 | Science China Chemistry2020，63，1： | 3 |
| 10 | Methological Quality of Systematic Reviews and Meta-Analyses on Acupuncture for Stroke: A Review of Review显示文摘Objective: To assess the methodological quality of systematic reviews and meta-analyses regarding acupuncture intervention for stroke and the primary studies within them. Methods: Two researchers searched Pub Med, Cumulative index to Nursing and Allied Health Literature, Embase, ISI Web of Knowledge, Cochrane, Allied and Complementary Medicine, Ovid Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang and Traditional Chinese Medical Database to identify systematic reviews and meta-analyses about acupuncture for stroke published from the inception to December 2016. Review characteristics and the criteria for assessing the primary studies within reviews were extracted. The methodological quality of the reviews was assessed using adapted Oxman and Guyatt Scale. The methodological quality of primary studies was also assessed. Results: Thirty-two eligible reviews were identified, 15 in English and 17 in Chinese. The English reviews were scored higher than the Chinese reviews(P=0.025), especially in criteria for avoiding bias and the scope of search. All reviews used the quality criteria to evaluate the methodological quality of primary studies, but some criteria were not comprehensive. The primary studies, in particular the Chinese reviews, had problems with randomization, allocation concealment, blinding, dropouts and withdrawals, intent-to-treat analysis and adverse events. Conclusions: Important methodological flaws were found in Chinese systematic reviews and primary studies. It was necessary to improve the methodological quality and reporting quality of both the systematic reviews published in China and primary studies on acupuncture for stroke. | CHEN Xin-lin MO Chuan-wei LU Li-ya GAO Ri-yang XU Qian WU Min-feng ZHOU Qian-yi HU Yue ZHOU Xuan LI Xian-tao | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 2 |
| 11 | Acid modified carrier on catalytic oxidation of dichloromethane over CeO_(2)/HZSM-5 catalysts显示文摘In this study,a series of Hydrogen-Zeolite Socony Mobil-5-X(HZSM-5-X) catalysts were prepared by acid modification,then Ce/HZSM-5-X(X=0,0.2,0.4,1.0,2.0) catalysts were prepared by impregnation method.The catalytic performance of the catalysts on dichloromethane(DCM) oxidation was investigated.Through different characterizations,HZSM-5-X exhibit high specific surface area,good redox ability,rich acidity and much suitable acidic site distribution after acid treatment.Among them,Ce/HZSM-5-0.4 shows better catalytic activity with the lowest by-product and the best CO_(2) yield.Its T_(90) is 302℃ and the CO_(2) yield of T_(90) is more than 80 wt%,which demonstrates that the acid modification of carrier plays the positive effect on the catalytic capacity for DCM oxidation. | Mengxiang Li Jing Mo Xuanyu Gu Yue Zhou Mengjie Fan Shubao Shen Yingwen Chen | 2022 | Journal of Rare Earths2022，40，10： | 2 |
| 12 | Clinical features and an atypical WT1 mutant site in a child with incomplete Denys-Drash syndrome显示文摘 | Hai-Yan Wang Zhi-Hui Yue Liang-Zhong Sun Jia-Cong Mo Ying Mo Jun-Jie Sun | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 13 | Curing dynamics and network formation of cyanate ester resin / polyhedral oligomeric silsesquioxane nanocomposites显示文摘 | Lin Yue Jin Jie Song Mo | 2011 | Polymer2011，52，8： | 1 |
| 14 | MicroRNAome Com- parison between Intramuscular and Subcutaneous Vascular Stem Cell Adipogenesis显示文摘 | Guo Yunxue Mo Delin Zhang Yue | 2012 | PLO S One2012，7，9： | 1 |
| 15 | Experimental study on the absorption behaviors of gas phase bivalent mercury in Ca-based wet flue gas desulfurization slurry system显示文摘 | Yunjun Wang Yue Liu Zhongbiao Wu Jiansong Mo Bin Cheng | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 16 | Effect of thinning intensity on understory herbaceous diversity and biomass in mixed coniferous and broad-leaved forests of Changbai Mountain显示文摘Background:Herbs are an important part of the forest ecosystem,and their diversity and biomass can reflect the restoration of vegetation after forest thinning disturbances.Based on the near-mature secondary coniferous and broad-leaved mixed forest in Jilin Province Forestry Experimental Zone,this study analyzed seasonal changes of species diversity and biomass of the understory herb layer after different intensities of thinning.Results:The results showed that although the composition of herbaceous species and the ranking of importance values were affected by thinning intensity,they were mainly determined by seasonal changes.Across the entire growing season,the species with the highest importance values in thinning treatments included Carex pilosa,Aegopodium alpestre,Meehania urticifolia,and Filipendula palmata,which dominated the herb layer of the coniferous and broad-leaved mixed forest.The number of species,Margalef index,Shannon-Wiener index and Simpson index all had their highest values in May,and gradually decreased with months.Pielou index was roughly inverted“N”throughout the growing season.Thinning did not increase the species diversity.Thinning can promote the total biomass,above-and below-ground biomass.The number of plants per unit area and coverage were related to the total biomass,above-and below-ground biomass.The average height had a significantly positive correlation with herb biomass in May but not in July.However,it exerted a significantly negative correlation with herb biomass in September.The biomass in the same month increased with increasing thinning intensity.Total herb biomass,above-and below-ground biomass showed positive correlations with Shannon-Winner index,Simpson index and Pielou evenness index in May.Conclusions:Thinning mainly changed the light environment in the forest,which would improve the plant diversity and biomass of herb layer in a short time.And different thinning intensity had different effects on the diversity of understory herb layer.The findings provide theoretical basis and reference for reasonable thinning and tending in coniferous and broad-leaved mixed forests. | Gerong Wang Yue Sun Mo Zhou Naiqian Guan Yuwen Wang Runhua Jiang Zhiyu Liu Mengjia Wu Fucai Xia | 2021 | Forest Ecosystems2021，8，4： | 1 |
| 17 | The salt stress relief and growth promotion effect of Rs-5 on cotton显示文摘 | Haitao Yue Wenping Mo Chun Li Yuanyuan Zheng Hui Li | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 18 | Solution of non-linear thermal transient problems by a new adaptive time-step method in quenching process显示文摘 | Huiping Li Guoqun Zhao Lianfang He Yue Mo | 2007 | Applied Mathematical Modelling2007，，1： | 1 |
| 19 | Immune-inspired incremental feature selection technology to data streams 显示文摘 | YUE XUN MO HONGWEI CHI ZHONGXIAN | 2008 | Applied Soft Computing2008，8，2： | 1 |
| 20 | The salt stress relief and growth promotion effect of RS-5 on cotton显示文摘 | Yue H Mo W Li C | | 0，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员