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| 1 | Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis显示文摘AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria.On 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for EUS-FNA.RESULTS:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUSFNA.EUS-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic body-tail.Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP.No one met level 1 findings of IDCP,but 3 patients met level 2 findings of IDCP.Of 10 seronegative cases,2 cases were diagnosed with 'definitive type 1 AIP',and 3 cases were diagnosed with 'probable type 2 AIP' when considering both the level 2 histological findings and response to steroids.CONCLUSION:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases. | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 2 | Characteristic endoscopic findings and risk factors for cytomegalovirus-associated colitis in patients with active ulcerative colitis显示文摘AIM: To identify characteristic endoscopic findings and risk factors for cytomegalovirus(CMV)-associated colitis in patients with active ulcerative colitis(UC).METHODS: A total of 149 UC patients admitted to the Department of Gastroenterology, Nagoya University Hospital, from January 2004 to December 2013 with exacerbation of UC symptoms were enrolled in this retrospective study. All medical records, including colonoscopy results, were reviewed. CMV infection was determined by the presence of CMV antigen, CMV inclusion bodies in biopsy specimens, or positive specific immunohistochemical staining for CMV. Multivariate analysis was used to identify independent risk factors for CMV colitis.RESULTS: Multivariate analysis indicated independent associations with the extent of disease(pancolitis) anduse of > 400 mg corticosteroids for the previous 4 wk. In contrast, no association was seen with sex, age at UC diagnosis, immunomodulator use, or infliximab use. Punched-out ulceration was also significantly associated with CMV infection in patients with active UC(odds ratio = 12.672, 95%CI: 4.210-38.143).CONCLUSION: Identification of a total corticosteroid dose > 400 mg for 4 wk, extensive colitis and a specific endoscopic finding of punched-out ulcer might facilitate the more rapid diagnosis and timely initiation of antiviral therapy for CMV-associated colitis in patients with active UC. | Yutaka Hirayama Takafumi Ando Yoshiki Hirooka Osamu Watanabe Ryoji Miyahara Masanao Nakamura Takeshi Yamamura Hidemi Goto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，6： | 8 |
| 3 | In vivo histological diagnosis for gastric cancer using endocytoscopy显示文摘AIM To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric cancers.METHODS Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas(including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were compared.RESULTS The endocytoscopic images of the cancerous area were assessed as evaluable in 25(83.3%) and 27(90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28(93.3%) and 23(76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement(κ-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy. | Issei Tsurudome Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Masanobu Matsushita Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Osamu Watanabe Masato Nakaguro Akira Satou Yoshiki Hirooka Hidemi Goto | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 4 | Retrospective analysis of primary gastric diffuse large B cell lymphoma in the rituximab era: a multicenter study of 95 patients in Japan显示文摘 | Tsutomu Tanaka Kazuyuki Shimada Kazuhito Yamamoto Yoshiki Hirooka Yasumasa Niwa Isamu Sugiura Kunio Kitamura Hiroshi Kosugi Tomohiro Kinoshita Hidemi Goto Shigeo Nakamura | 2012 | Annals of Hematology2012，，3： | 3 |
| 5 | Colorectal endoscopic submucosal dissection in special locations显示文摘Colorectal endoscopic submucosal dissection(ESD) is considered one of the most challenging endoscopic procedures for novice endoscopists. When compared with the stomach, the colon and rectum have a narrower tubular lumen, greater angulation at the flexures, and a thinner muscle layer. These factors make endoscopic control and maneuverability difficult. ESD of the colorectum was considered more difficult than gastric and esophageal ESD. However, with learning from the experts, practicing, and selecting an appropriate technique,most of colorectal ESD could be performed successfully. Nevertheless, some colorectal locations are extremely specialized either from unique anatomy or given unstable scope position. Accordingly, the objective of this review was to provide endoscopists with an overview of the techniques and outcomes associated with ESD at these special colorectal locations. ESD at the discussed special locations of the ileo-colo-rectum was found to be feasible, and outcomes were comparable to those of ESD performed in non-special locations of the ileocolo-rectum. Practice for skill improvement and awareness of the unique characteristics of each special location is the key to performing successful ESD. | Uayporn Kaosombatwattana Takeshi Yamamura Masanao Nakamura Yoshiki Hirooka Hidemi Goto | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 3 |
| 6 | Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis显示文摘AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine responders.METHODS: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous infusion.All patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine therapy.Administration was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/mL.Clinical activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a response.Among responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of cyclosporine.Factors considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical course.RESULTS: Cyclosporine was not discontinued due to side effects in any patient.Nineteen(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of 'mucosal bleeding' and responsive cases.Fifteen(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of cyclosporine.Of the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine therapy.None of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical course.In contrast,a significant association was observed for maintenance therapy with azathioprine after cyclosporine therapy(P = 0.0014).CONCLUSION: Maintenance therapy with azathioprine might improve the long-term efficacy of continuously infused cyclosporine for severe steroid-refractory ulcerative colitis patients. | Nobuyuki Miyake Takafumi Ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 7 | Clinical utility of a new endoscopic scoring system for Crohn's disease显示文摘AIM:To evaluate the clinical value of the newly modified Simple Endoscopic Score for Crohn's disease(m SES-CD).METHODS:Seventy-six Crohn's disease(CD) patients who underwent transanal double balloon endoscopy(DBE) in our hospital between 2003 and 2012 were retrospectively reviewed. DBE is defined as small intestinal endoscopy using two attached balloons. We included patients with stenosis which hampered passage of the scope and those who underwent DBE with observation for at least 80 cm from the ileocecal valve. Our new m SES-CD assesses the endoscopic activity of two consecutive small intestinal segments located 0-40 cm and 40-80 cm from the ileocecal valve by DBE,in addition to the activity of four colorectal segments. To compare the usefulness of m SES-CD with SES-CD,we similarly divided the patients into two groups according to total m SES-CD score(low disease activity group,< 4; high disease activity group,≥ 4). The clinical value of m SES-CD in predicting clinical outcome in patients with CD was evaluated using the occurrence of surgery after DBE as an endpoint.RESULTS:Median age of the 76 CD patients was 36 years(range,16-71). Thirty-nine patients had stenosis which hampered passage of the DBE to 80 cm on the proximal side from the ileocecal valve. Median evaluable length of small intestine by DBE was 80 cm(range,3-200). A total of 74 patients had one or more small intestinal lesions detected by DBE,of which 62(83.8%) were within 80 cm of the ileocecal valve on the proximal side. Only two patients(2.7%) with proximal-side lesions more than 80 cm from the ileocecal valve did not have lesions within 80 cm. Patients with high m SES-CD scores showed significantly shorter surgeryfree survival than those with low scores(P < 0.05). In contrast,surgery-free survival did not significantly differ between the low and high SES-CD groups(P > 0.05). Multivariate analysis by a Cox proportional hazards model identified m SES-CD as an independent factor for surgery-free survival.CONCLUSION:m SES-CD is useful in evaluating the risk of surgery-free survival in patients with CD. | Kazuhiro Morise Takafumi Ando Osamu Watanabe Masanao Nakamura Ryoji Miyahara Osamu Maeda Kazuhiro Ishiguro Yoshiki Hirooka Hidemi Goto | 2015 | World Journal of Gastroenterology2015，21，34： | 2 |
| 8 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 9 | Shrinkage Behavior of High Performance Concrete at Different Elevated Temperatures under Different Sealing Conditions显示文摘The shrinkage behavior of high performance cement concrete made from Portland cement, ultra fine granulated blast furnace slag and pulverized fly ash with addition of superplasticizer at different temperatures from ambient temperature to 120 ℃ under different sealing conditions was investigated by means of length change measurement on cylindrical concrete specimens along with curing age. Results show that drying shrinkage deformations of titled concrete specimens increased rapidly as the curing temperature rose. The development of drying shrinkage deformation can be efficiently controlled with the aid of aluminum tape sealing as compared with the unsealed specimens, especially when the curing temperature is below 60℃, although it will increase dramatically when the curing temperature is elevated to above 90℃. Polymer coating on concrete specimens showed a similar effect on the control of drying shrinkage as the sealing operation with aluminum tape. | 潘志华 NAKAMURA Hidemi WEE Tionghuan | 2006 | Journal of Wuhan University of Technology(Materials Science)2006，21，3： | 2 |
| 10 | Smoking Increases the Treatment Failure for Helicobacter pylori Eradication显示文摘 | Takeshi Suzuki Keitaro Matsuo Hidemi Ito Akira Sawaki Kaoru Hirose Kenji Wakai Shigeki Sato Tsuneya Nakamura Kenji Yamao Ryuzo Ueda Kazuo Tajima | 2006 | The American Journal of Medicine2006，，3： | 2 |
| 11 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 12 | Peripancreatic vascular involvements of autoimmune pancreatitis显示文摘 | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Ryoji Miyahara Naoki Ohmiya Jyunichi Haruta Hidemi Goto Yoshiki Hirooka | 2012 | J Gastroenterol Hepatol2012，，12： | 1 |
| 13 | Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts显示文摘 | Masakazu Ishii Chika Koike Akira Igarashi Katsuyuki Yamanaka Haiou Pan Yukihito Higashi Hiroyuki Kawaguchi Masaru Sugiyama Nobuyuki Kamata Tomoyuki Iwata Takehiro Matsubara Kozo Nakamura Hidemi Kurihara Koichiro Tsuji Yukio Kato | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 14 | Clinical usefulness of novel tag‐less A gile patency capsule prior to capsule endoscopy for patients with suspected small bowel stenosis显示文摘 | Masanao Nakamura Yoshiki Hirooka Takeshi Yamamura Ryoji Miyahara Osamu Watanabe Takafumi Ando Naoki Ohmiya Hidemi Goto | 2015 | Digestive Endoscopy2015，，1： | 1 |
| 15 | Effective expansion of human adipose‐derived stromal cells and bone marrow‐derived mesenchymal stem cells cultured on a fragmin/protamine nanoparticles‐coated substratum with human platelet‐rich plasma显示文摘 | Satoko Kishimoto Masayuki Ishihara Yasutaka Mori Megumi Takikawa Hidemi Hattori Shingo Nakamura Toshinori Sato | 2013 | J Tissue Eng Regen Med2013，，12： | 1 |
| 16 | Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors显示文摘 | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hiroshi Matsubara Yuya Itoh Yosuke Nakamura Masanao Nakamura Ryoji Miyahara Kazuhiko Hayashi Masatoshi Ishigami Yoshiaki Katano Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 17 | Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy显示文摘 | Daigo Arakawa Naoki Ohmiya Masanao Nakamura Wataru Honda Osamu Shirai Akihiro Itoh Yoshiki Hirooka Yasumasa Niwa Osamu Maeda Takafumi Ando Hidemi Goto | 2009 | Gastrointestinal Endoscopy2009，，4： | 1 |
| 18 | Clinical oncology for pancreatic and biliary cancers:Advances and current limitations显示文摘In the early 2000s,the main stream of endoscopic ultrasonography(EUS)changed from a mechanical scanning method to electronic radial or linear scanning methods.Subsequently,useful applications in trans-abdominal ultrasonography came within reach of EUS.In particular,contrast-enhanced EUS(CE-EUS)and EUS-elastography became cutting-edge diagnostic modalities for pancreatic disorders.Each type of pancreatic disorder has characteristic hemodynamics.CE-EUS uses color Doppler flow imaging and harmonic imaging to classify pancreatic lesions.EUS-elastography can assess tissue hardness by measuring its elasticity.This parameter appears to correlate with the malignant potential of the lesions.Tissue elasticity studies can provide information on both its pattern and distribution.The former is the conventional method of morphological diagnosis,but it is restricted to observations made in a region of interest(ROI).The latter is an unbiased analysis that can be performed by image analysis software and is theoretically constant,regardless of the ROI.Though EUSfine needle aspiration(FNA)is also a very useful diagnostic tool,there are several limitations.Diagnostic EUS-FNA of pancreatic cystic lesions has marginal utility mainly due to low sensitivity.Therefore,in particular,endoscopists should keep this limitation in mind. | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Takuya Ishikawa Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Masatoshi Ishigami Yoshiaki Katano Hidemi Goto | 2011 | World Journal of Clinical Oncology2011，2，5： | 1 |
| 19 | Methtrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases显示文摘 | Masaru Kojima Hideaki Itoh Kaoru Hirabayashi Seiji Igarashi Yoshio Tamaki Kayoko Murayama Hidemi Ogura Ryuta Saitoh Kenji Kashiwabara Jyuro Takimoto Nobuhide Masawa Shigeo Nakamura | 2006 | Pathology - Research and Practice2006，，9： | 1 |
| 20 | Interleukin-1β stimulates galectin-9 expression in human astrocytes显示文摘 | Hidemi Yoshida Tadaatsu Imaizumi Mika Kumagai Kazuyuki Kimura Chikako Satoh Naoyuki Hanada Koji Fujimoto Nozomu Nishi Kunikazu Tanji Tomoh Matsumiya Fumiaki Mori Xue-Fan Cui Wakako Tamo Takeo Shibata Shingo Takanashi Ken Okumura Takanori Nakamura Koichi W | 2001 | Neuroreport2001，，17： | 1 |
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