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| 1 | Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy显示文摘技术开发总是是在生物医学的研究驾驶突破的力量之一。自从托马斯·摩根的时间起,一步一步地, Drosophilists 为操作并且机能上地把开发了强大的基因工具为改进这些技术并且开发新技术的果蝇染色体,而是房间仍然大,今天特别作为生物学家开始系统地学习不同模型有机体的功能的 genomics ,包括人,以一种高产量的方式。这里,我们报导,第一次在果蝇,为借助于改进抄写在很高的效率修改果蝇染色体的一个快速、容易、高度特定的方法像使活跃之物的受动器核酸酶(TALEN ) 策略。我们利用了最近发达的单位集会策略装配设计修改黄基因的二特定的 TALEN (在性染色体上) 并且新奇正染色体的基因。TALEN 的 mRNAs 随后被注入果蝇胚胎。从 31.2% 注射 F0 肥沃的苍蝇,我们检测了包含黄基因的可继承的修正。从到可继承的修正的察觉的特定的 TALEN 的建设的全部过程能在一个月以内被完成。在果蝇的这个调停 TALEN 的染色体修正方法的潜在的应用程序被讨论。 | Jiyong Liu Changqing Li Zhongsheng Yu Peng Huang Honggang Wu Chuanxian Wei Nannan Zhu Yan Shen Yixu Chen Bo Zhang Wu-Min Deng Renjie Jiao | 2012 | Journal of Genetics and Genomics2012，39，5： | 43 |
| 2 | Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system显示文摘 | Pengpeng Liu Lijiang Long Kai Xiong Bo Yu Nannan Chang Jing-Wei Xiong Zuoyan Zhu Dong Liu | 2014 | Cell Research2014，24，7： | 8 |
| 3 | Promoter methylation of Wnt/β-Catenin signal inhibitor TMEM88 is associated with unfavorable prognosis of nonsmall cell lung cancer显示文摘Objective:Recent research has indicated that altered promoter methylation of oncogenes and tumor suppressor genes is an important mechanism in lung cancer development and progression.In this study,we investigated the association between promoter methylation of TMEM88,a possible inhibitor of the Wnt/β-Catenin signaling,and the survival of patients with nonsmall cell lung cancer(NSCLC).Methods:Twelve pairs of tumor and adjacent non-tumor samples were used for microarray analyses of DNA methylation and gene expression.For validation,more than two hundred additional samples were analyzed for methylation using bisulfite pyrosequencing and for gene expression using q RT-PCR.Then the cell function were tested by wound healing,transwell,CCK8 and cell cycle assay.Results:Our analysis of patient specimens showed that TMEM88 methylation was higher in NSCLC tumors(82.2%±10.3,P<0.01)compared with the adjacent normal tissues(65.9%±7.2).The survival analysis revealed that patients with high TMEM88methylation had a shorter overall survival(46 months)compared with patients with low TMEM88 methylation(>56 months;P=0.021).In addition,we found that demethylation treatment could inhibit tumor cell proliferation,migration,and invasion,which was supportive of an association between methylation and survival.Conclusions:Based on these consistent observations,we concluded that TMEM88 may play an important role in NSCLC progression and that promoter methylation of TMEM88 may serve as a biomarker for NSCLC prognosis and treatment. | Rongna Ma Nannan Feng Xiao Yu Hongyan Lin Xiaohong Zhang Oumin Shi Huan Zhang Shuo Zhang Lei Li Min Zheng Ming Gao Herbert Yu Biyun Qian | 2017 | Cancer Biology & Medicine2017，14，4： | 6 |
| 4 | Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer显示文摘Objective: Long non-coding RNAs(lnc RNAs) are involved in numerous biological processes in lung cancer cells. In our previous studies, we identified a lnc RNA, ENST00000439577, which is highly expressed in lung carcinomas, and termed it lung cancer progression-associated transcript 1(LCPAT1). To characterize the role of LCPAT1 in lung cancer, we conducted the current study.Methods: Expression of LCPAT1 and autophagy-associated markers in tumor tissues and lung cancer cell lines was determined by real-time quantitative polymerase chain reaction(q PCR). Hematoxylin and eosin(HE) staining, q PCR, Western blot, and immunohistochemistry were performed to evaluate xenografted tumor tissues. Autophagy induced by rapamycin was detected by Western blot and immunofluorescence in lung cancer cell lines.Results: Expression of LCPAT1 and microtubule-associated protein 1 light chain 3 beta(LC3B) was positively correlated in lung cancer. Knockdown of LCPAT1 inhibited tumor growth and suppressed cell autophagy in vivo. Moreover, LCPAT1 knockdown in lung cancer cell lines resulted in decreased autophagy-associated gene expression and alleviated the cell autophagy induced by rapamycin.Conclusions: We speculate that LCPAT1 plays a crucial role in regulating autophagy in lung cancer. | Xiao Yu Xiaofei Ye Hongyan Lin Nannan Feng Sumeng Gao Xiaohong Zhang Yu Wang Herbert Yu Xiaobei Deng Biyun Qian | 2018 | Cancer Biology & Medicine2018，15，3： | 5 |
| 5 | Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor显示文摘 | Gong, Ben-Qiang Xue, Jiao Zhang, Nannan Xu, Lahong Yao, Xinran Yang, Qiu-Jiao Yu, Yang Wang, Hong-Bin Zhang, Dandan Li, Jian-Feng | 2017 | Molecular Plant2017，10，5： | 3 |
| 6 | Female Reproductive Cycles of Phrynocephalus przewalskii (Lacertilia:Agamidae) in the Tengger Desert,China显示文摘The timing of reproduction can significantly affect an offspring's fitness, thereby also influencing the fitness of the parents, especially in species inhabiting extreme environments, such as deserts. Female reproductive cycles in Phrynocephalus przewalskii were studied from April to September 2008. Significant cycles of gonadal volume were found in all studied populations and the cycles were similar among the various populations. Females began vitellogenesis in April and contained oviductal eggs form May to June. Gonad volume decreased significantly in July and reached minimum volume from August to September. The follicular growth was negatively correlated with increasing precipitation and temperature in all populations. Hatching occurs during summer and early fall, when most of the annual rainfall occurs. Mean clutch size based on all populations was 2.7 ± 0.9 SE(n = 71). | Wei ZHAO Nannan YU Yajuan WANG Weihong JI Naifa LIU | 2011 | Asian Herpetological Research2011，2，1： | 3 |
| 7 | A novel Cu-doped high entropy alloy with excellent comprehensive performances for marine application显示文摘High entropy alloy(HEA)has attracted great interests as one of the promising multifunctional materials in marine applications.However,Cu as an effective biocide tends to form segregation in HEA,which could deteriorate corrosion and induce brittle fracture.Herein,we report a strategy to tailor the existing form of Cu in HEA from undesired large-scale segregation to uniform distribution with dispersed nanoscale precipitation,while retaining the unique structure characteristics of HEA.Eliminating Cu segregation improves toughness and avoids serious corrosion in the grain boundary.Uniform distribution with dispersed nanoscale precipitation of Cu further enhances the antifouling and lubricating abilities of Cu-doped HEA.Tailored AlCoCrFeNiCu_(0.5)HEA in this work has excellent comprehensive properties combining good mechanical properties,outstanding antifouling abilities,superior resistance to corrosion and wear.Furthermore,the corresponded mechanisms are discussed in terms of Cu-segregation-eliminated,nanoscale-Cu-precipitate-forming and comprehensive properties. | Yuan Yu Nannan Xu Shengyu Zhu Zhuhui Qjao Jianbin Zhang Jun Yang Weimin Liu | 2021 | Journal of Materials Science & Technology2021，，10： | 3 |
| 8 | Geographic Variation in Clutch and Egg Size for the Lizard Phrynocephalus przewalskii(Squamata:Agamidae)显示文摘In order to tease apart proximate vs.ultimate sources of variation in reproductive strategy,studies have increasingly focused on populations rather than species as the unit of interest.The reproductive parameters of Phrynocephalus przewalskii(Agamidae)in different populations within the same phylogenetic clade were compared in this study.Female SVL,clutch size,egg volume and clutch volume varied significantly among populations.With increase in latitude,clutch size increased,while egg size decreased.Relatively fewer but larger eggs were produced with increasing of population density.Food availability had positive effects on clutch size,but no effect on egg size.Our result indicated that latitude,food availability and population density may be the proximate factors affecting the reproductive parameters of P.przewalskii. | Yajuan WANG Weihong JI Wei ZHAO Nannan YU Naifa LIU | 2011 | Asian Herpetological Research2011，2，2： | 2 |
| 9 | Nonplanar Perylene Monoimide-Based Fluorescent Film for Enhanced BTX Sensing显示文摘Film-based fluoresce nt sen sors have been adapted into portable devices for the vapor phase detecti on.The satisfactory sensing performs nee(e.g.,sen sitivity,selectivity,reusability)largely bene fits from fluorophores. | Meiling Zhang Nannan Ding Fayan Lai Congdi Shang Rong Miao Zhongshan Liu Yu Fang | 2021 | Chinese Journal of Chemistry2021，39，8： | 2 |
| 10 | Promoting nitric oxide electroreduction to ammonia over electron-rich Cu modulated by Ru doping显示文摘Electrocatalytic nitric oxide(NO)reduction is a promising strategy to produce ammonia.Developing a facile approach to synthesize efficient catalysts with enhanced NO electroreduction performance is highly desirable.Here,a series of Ru-doped Cu materials are constructed through in situ electroreduction of corresponding metal hydroxides.The optimized Ru_(0.05)Cu_(0.95)exhibits superior electrocatalytic performance for ammonia synthesis by using NO/Ar(1/4,n/n)as the feedstocks(Faradaic efficiency:64.9%,yield rate:17.68μmol cm^(-2)h^(-1)),obviously outperforming Cu counterpart(Faradaic efficiency:33.0%,yield rate:5.73μmol cm^(-2)h^(-1)).Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy and online differential electrochemical mass spectrometry(DEMS)are adopted to detect intermediates and unveil the possible reaction pathway.The downshift of the Cu d-band center induced by Ru doping facilitates the rate-limiting hydrogenation step and decreases the desorption energy of NH_(3),leading to high Faradaic efficiency and yield of ammonia. | Jiangwei Shi Changhong Wang Rong Yang Fanpeng Chen Nannan Meng Yifu Yu Bin Zhang | 2021 | Science China Chemistry2021，64，9： | 2 |
| 11 | Image features extraction and fusion based on joint sparse representation显示文摘 | Nannan Yu Tianshuang Qiu Feng Bi Aiqi Wang | | 0，，05： | 1 |
| 12 | Bifunctional photocatalysis of TiO 2 /Cu 2 O composite under visible light: Ti 3+ in organic pollutant degradation and water splitting显示文摘 | Liangbin Xiong Fan Yang Lili Yan Nannan Yan Xi Yang Mingqiang Qiu Ying Yu | 2011 | Journal of Physics and Chemistry of Solids2011，，： | 1 |
| 13 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 14 | Image features extraction and fusion based on joint sparse representation显示文摘 | YU Nannan QIU Yianshuang BI Feng | 2011 | IEEE Journal of Selected Topics in Signal Processing(S1932-4553)2011，5，5： | 1 |
| 15 | Image features extraction and fusion basedon joint sparse representation显示文摘 | Yu Nannan Qiu Tianshuang Bi Feng | 2011 | IEEE Journal of Selected Topics in Signal Processing2011，5，5： | 1 |
| 16 | Visuals to Text:A Comprehensive Review on Automatic Image Captioning显示文摘Image captioning refers to automatic generation of descriptive texts according to the visual content of images.It is a technique integrating multiple disciplines including the computer vision(CV),natural language processing(NLP)and artificial intelligence.In recent years,substantial research efforts have been devoted to generate image caption with impressive progress.To summarize the recent advances in image captioning,we present a comprehensive review on image captioning,covering both traditional methods and recent deep learning-based techniques.Specifically,we first briefly review the early traditional works based on the retrieval and template.Then deep learning-based image captioning researches are focused,which is categorized into the encoder-decoder framework,attention mechanism and training strategies on the basis of model structures and training manners for a detailed introduction.After that,we summarize the publicly available datasets,evaluation metrics and those proposed for specific requirements,and then compare the state of the art methods on the MS COCO dataset.Finally,we provide some discussions on open challenges and future research directions. | Yue Ming Nannan Hu Chunxiao Fan Fan Feng Jiangwan Zhou Hui Yu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，8： | 1 |
| 17 | Image features extraction and fusion based on joint sparse representation 显示文摘 | Yu Nannan Qiu Tianshuang Bi Feng | 2011 | IEEE Journal of Selected Topics in Signal Processing2011，5，5： | 1 |
| 18 | Transport Infrastruc- ture, Spatial Clusters and Regional Econom- ic Growth in China显示文摘 | Nannan Yu Martin Dejong Servaas Storm Jianning Mi | 2012 | Transport Reviews2012，32，1： | 1 |
| 19 | Spatial spiUover effects of transport infrastructure: evidence flora Chinese re- giom显示文摘 | Nannan Yu Martin de Jong Servaas Stormb Jianing Mi | 2013 | Joumal of Transport Geography2013，，28： | 1 |
| 20 | Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder显示文摘[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each group.The control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value. | Xiangpu LIU Jingping MU Xinhua YU Shun ZENG Nannan LIU Xiaohu ZHU | 2021 | Medicinal Plant2021，12，3： | 1 |
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