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| 1 | Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage. | WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing | 2013 | Science China(Technological Sciences)2013，56，3： | 60 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Qingfei Xiaoyan Wan,a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa–induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways显示文摘Gram-negative pathogen–induced nosocomial infections and resistance are a most serious menace to global public health. Qingfei Xiaoyan Wan(QF), a traditional Chinese medicine(TCM)formula, has been used clinically in China for the treatment of upper respiratory tract infections, acute or chronic bronchitis and pulmonary infection. In this study, the effects of QF on Pseudomonas aeruginosa–induced acute pneumonia in mice were evaluated. The mechanisms by which four typical antiinflammatory ingredients from QF, arctigenin(ATG), cholic acid(CLA), chlorogenic acid(CGA) and sinapic acid(SPA), regulate anti-inflammatory signaling pathways and related targets were investigated using molecular biology and molecular docking techniques. The results showed that pretreatment with QF significantly inhibits the release of cytokines(TNF-α and IL-6) and chemokines(IL-8 and RANTES),reduces leukocytes recruitment into inflamed tissues and ameliorates pulmonary edema and necrosis. In addition, ATG was identified as the primary anti-inflammatory agent with action on the PI3K/AKT and Ras/MAPK pathways. CLA and CGA enhanced the actions of ATG and exhibited synergistic NF-κB inactivation effects possibly via the Ras/MAPK signaling pathway. Moreover, CLA is speculated to target FGFR and MEK firstly. Overall, QF regulated the PI3K/AKT and Ras/MAPK pathways to inhibit pathogenic bacterial infections effectively. | Yuanyuan Hou Yan Nie Binfeng Cheng Jin Tao Xiaoyao Ma Min Jiang Jie Gao Gang Bai | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 17 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Investigation of dielectric barrier discharge plasma flow control显示文摘Effects of plasma flow control are researched on the basis of plasma exciting flow experiments and numerical simulations. Turbulent model is more effective than laminar model in plasma numerical simulation as results showed. Both plasma exciting effects of acceleration and flow separation suppression are investigated through experiments carried on the flat plate and the compressor cascades. The results demonstrate that boundary layer characteristic is modified by plasma exciting. Distributions of total pressure and velocity in the wake are improved notably for 20 m/s coming velocity and the effect of plasma can still be observed while velocity is increased to 50 m/s. For low velocity flow, plasma exciting is effective in flow separation suppression. | NIE ChaoQun LI Gang ZHU JunQiang ZHANG Yi LI YuTong | 2008 | Science China(Technological Sciences)2008，51，7： | 9 |
| 6 | Application of 3D-computed tomography angiography technology in large meningioma resection显示文摘Objective:To discuss the role of 3D-computed tomography angiography(3D-CTA) technology in reducing injuries of large meningioma surgery.Methods:3D-CTA preoperative examinations were done in 473 patients with large meningioma(simulated group).The images were analyzed by 30 post-processing workstation.By observing the major intracranial blood vessels,venous sinus,and the compression and invasion pattern in the nerve region,assessing risk level of the surgery,simulating the surgical procedures,the surgical removal plan,surgical routes and tumor blood-supplying artery embolisation plan were performed.Two hundred and fifty seven large meningioma patients who didn’t underwent 3D-CTA preoperative examination served as control group.The incidence of postoperative complications,intraoperative blood transfusion and the operation time were compared between these two groups.Results:Compared with the control group,the Simpson’s grade 1 and 11 resection rate was 80.3%(380/473),similar with that of the control(81.3%,209/257).The incidence of postoperative complications in 3D-CTA simulated group was 37.0%which was significantly lower than that(48.2%) of the control(P<0.01). The intraoperative blood supply for simulated group and the control was(523.4±208.1) mL and (592.0±263.3) mL,respectively,with significant difference between two groups(P<0.01).And the operation time[(314.8±106.3)]min was significantly lower in simulated group than that in the control[(358.4±147.9) min](P<0.01).Conclusions:Application of 3D-CTA imaging technology in risk level assessment before large-scaled meningioma resection could assist in the rational planning of tumor resectin,surgical routes,and is helpful in reducing injuries and complications and enhancing the prognosis of the patients. | Jian-Qiang Chen Yin Guan Gang Li Xiao-Hua Li Yue-Fu Zhan Xiang-Yin Li Liu Nie Xiang-Jun Han | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 9 |
| 7 | Molecular mapping of QTLs for root response to phosphorus deficiency at seedling stage in wheat (Triticum aestivum L.)显示文摘Phosphorus (P) deficiency in the soil is one of the major abiotic stresses that limit plant growth and crop productivity throughout the world. Development of cultivars with improved P-deficiency tolerance is an efficient strategy for sustainable agriculture. Plant roots play an important role in crop growth and development, especially in nutrient uptake and improvement of P-efficiency. Mapping quantitative trait loci (QTLs) for root traits and their response to low P stress at seedling stage will facilitate the development of P-efficient wheat cultivars. In this study, 30 QTLs (LOD>2.0) were mapped for the three root traits, such as root length, root number and root dry matter under different P supply conditions and their response to P-stress. These QTLs were distributed on 14 chromosomes, with each of the 5 QTLs explaining more than 10% phenotype variance. Analyses showed that root traits and their response to P-deficiency were controlled by different QTLs. In addition, alleles with positive effects were separated on both parents, and wheat cultivars with improved P-efficiency could be developed by accumulating these positive effect alleles together. | Li Zhenxing Ni Zhongfu Peng Huiru Liu Zhiyong Nie Xiuling Xu Shengbao Liu Gang Sun Qixin | 2007 | Progress in Natural Science:Materials International2007，17，10： | 8 |
| 8 | Orthogonal M-ary code shift keying spread spectrum underwater acoustic communication显示文摘M-ary and code shift keying(CSK)spread spectrum is generally applied to overcoming the spreading gain versus data rate limitation in underwater acoustic(UWA)communications.In addition,the concept of orthogonal M-ary CSK is introduced to UWA communication to gain higher rates.We propose a scheme employing dual-orthogonal-channel M-ary and CSK spread spectrum UWA communication based on Gold sequences owing large code set and good self and cross correlation.The modulation and demodulation scheme of the orthogonal M-ary CSK is derived algebraically and the factors critical to its performance are discussed.Furthermore,its bit error rate(BER)curve is evaluated via simulations and compared with the dual-channel M-ary CSK.Finally,the validity of the simulations is verified in tank experiments.1096.8 bps data rate of the proposed communication scheme is realized for 10 kbits data volume with no error.Overall through deduction,numerical simulation,and experiment,it is shown that the proposed method offers significantly improved performance. | YU Yang ZHOU Feng QIAO Gang NIE Donghu | 2014 | Chinese Journal of Acoustics2014，33，3： | 6 |
| 9 | TOOTH CONTACT ANALYSIS OF CONICAL INVOLUTE GEARS显示文摘圆锥形的复杂齿轮的数学模型基于传动和产生机制的理论被开发。牙齿接触分析(TCA ) 被执行用交叉并且交叉的轴检验圆锥形的复杂齿轮对的协调并且适用的接触。另外,齿轮表面的主要方向和弯曲被调查,交配牙齿表面的接触椭圆也被学习。最后,数字解说性的例子被提供表明计算结果,测试齿轮被成为忍受 fortooth 测试,并且结论被验证理论有适用性。 | HE Jingliang WU Xutang CUI Yahui NIE Gang | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 6 |
| 10 | Dynamic analysis of a flameless combustion model combustor显示文摘Flameless combustion is a new technology with the following advantages:1)Ultra-low emissions of both NOX and CO;2)fuel flexibility,from liquid fuels,natural gas to hydrogen-rich syngas;3)lower possibility of flashback and thermoacoustic oscillations.In this paper,we focus on the dynamic characteristics of a flameless model combustor.Experimental results show that flameless combustion can lower emissions while maintaining combustion stability.However,combining a pilot flame with flameless combustion may excite thermoacoustic instability. | CUI YuFeng 1* ,LüXuan 1,2 ,XU Gang 1 &NIE ChaoQun 1 1 Institute of Engineering Thermophysics,Chinese Academy of Sciences,Beijing 100190,China 2Graduate School of the Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Technological Sciences)2010，53，8： | 5 |
| 11 | Recombinant adenovirus with human indoleamine-2,3- dioxygenase and hepatitis B virus preS was constructed and expressed in HepG2 cells显示文摘背景 Indoleamine-2,3-dioxygenase (伊多语) 被证明压制伊多语的特定的有免疫力的反应和弄空可以是的肝炎 B 病毒(HBV ) 为 HBV 的一条有用途径治疗。测试这个概念,我们与人的伊多语和 HBV preS 构造了 recombinant 侵入人体气管粘膜的病菌,它将在人的伊多语和 HBV preS cDNA 的碎片是的 vivo experiments.Methods 为未来形成基础 subcloned 进在包含二 cytomegalovirus (CMV ) 的一个 adenoviral 向量系统的多重克隆的地点倡导者。再结合在 Escherichia coli BJ5183 被进行。包含 hlDO 基因和 HBVpreS 基因的 recombinant 侵入人体气管粘膜的病菌在 293 被包装并且放大 cells.Integration 被聚合酶链反应象病毒的 titers 的 quantification 一样证实。HepG2 房间感染 recombinant 侵入人体气管粘膜的病菌和 mRNA 和为 hlDO 特定的蛋白质, HBVpreS 被 RT-PCR 和西方的弄污 respectively.Results 检测 recombinant 侵入人体气管粘膜的病菌成功地被生产。它的 titer 是 2.5x109 efu/ml。象编码蛋白质一样的伊多语和 HBVpreS mRNA 能在 transfected HepG2 房间,然而并非在有双倡导者 adenoviral 向量的 hlDO-HBVpreS 的转移是的控制 HepG2 cells.Conclusion 被发现有效。有 hlDO 和 HBVpreS 的 recombinant 侵入人体气管粘膜的病菌将为未来研究提供试验性的基础。 | CHEN Yong-bing SHI Xian-jie LU Gang NIE Hong-feng SHEN Xiao-qing YU Cong-hui GONG Jian-ping | 2011 | Chinese Medical Journal2011，，19： | 5 |
| 12 | Study on the α-cyclodextrin/poly(ethylene glycol) self-assembly supramolecular nanoparticles for drug delivery显示文摘This paper reports the synthesis and drug delivery properties of a novel supramolecular nanoparticle.α-Cyclodextrins(α-CD) were threaded on cinnamic acid modified poly(ethylene glycol) to form inclusion complex nanoparticles by supramolecular self-assemble.The anti-tumor drug doxorubicin was loaded in the nanoparticles and released in vitro to study the drug release behavior and the anti-tumor effects.The structure and morphology of the nanoparticles were characterized by nuclear magnetic resonance,X-ray diffraction,ultraviolet absorbance,dynamic laser scattering,scanning electronic microscopy,transmission electron microscopy and atom force microscopy.The distribution of the drug loaded nanoparticles in cells and the anti-tumor effects were studied by confocal laser microscopy.The results demonstrate that the supramolecular nanoparticle is biocompatible and it is a promising carrier for drug delivery systems. | LI Yuan,JI Li,WANG Gang,SONG LiQing,HE Bin,LI Li,NIE Yu,WU Yao & GU ZhongWei National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China | 2010 | Science China Chemistry2010，53，3： | 5 |
| 13 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 14 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
| 15 | Control of endwall secondary flow in a compressor cascade with dielectric barrier discharge plasma actuation显示文摘Three dielectric barrier discharge plasma actuators were mounted at the positions of 20%,40%and 60%of chord length on the endwall in a compressor cascade.The downstream flow field of the cascade has been measured with a mini five-hole pressure probe with and without the plasma actuation.The measured results show that the plasma actuation most effectively reduces total pressure loss and flow blockage when the actuators are operated simultaneously.As each of the actuators is operated independently,the actuator at the position of 20%of chord length most effectively reduces flow blockage, and the actuator at the position of 60%of chord length fairly reduces total pressure loss.However, negative pressure loss reduction occurs with the plasma actuator at the position of 40%of chord length.In brief,the plasma actuation placed on the endwall in the cascade apparently influences the endwall secondary flow,and the optimal locations and strength of actuation are critical for the control of endwall secondary flow in a compressor cascade with the plasma actuators. | LI Gang XU YanJi LIN Bin ZHU JunQiang NIE ChaoQun MA HongWei WANG ZhaoFeng | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 16 | Non-equilibrium Plasma Assisted Combustion of Low Heating Value Fuels显示文摘This paper describes the effects of non-equilibrium air plasma generated by a dielectric barrier discharge (DBD) on the combustion of low heating value fuels. The experimental results indicate that addition of a very small amount of energy to the air flow in the form of DBD significantly improves the flame stability. Moreover, main combustion characteristics such as flame propagation speed, combustion intensity and lean blow-off limits are also enhanced by the effect of plasma. Some active radicals such as excited O atom and excited N2 molecule are observed by spectrograph in the discharge area. Based on the results of numerical investigation we can conclude that these active radicals generated in discharge area can accelerate the production rate of active OH radical which plays a key role in the oxidation process of low heating value fuel, and thus the whole combustion process is accelerated. | Hongbin Hu Quanbin Song Yanji Xu Gang Li Chaoqun Nie | 2013 | Journal of Thermal Science2013，22，3： | 4 |
| 17 | Transcription Factors:Potential Cell Death Markers in Parkinson's Disease显示文摘Parkinson's disease(PD) is a neurodegenerative disease with a long preclinical phase. The continuous loss of dopaminergic(DA) neurons is one of the pathogenic hallmarks of PD. Diagnosis largely depends on clinical observation, but motor dysfunctions do not emerge until70%–80% of the nigrostriatal nerve terminals have been destroyed. Therefore, a biomarker that indicates the degeneration of DA neurons is urgently needed. Transcription factors are sequence-specific DNA-binding proteins that regulate RNA synthesis from a DNA template. The precise control of gene expression plays a critical role in the development, maintenance, and survival of cells,including DA neurons. Deficiency of certain transcription factors has been associated with DA neuron loss and PD. In this review, we focus on some transcription factors and discuss their structure, function, mechanisms of neuroprotection, and their potential for use as biomarkers indicating the degeneration of DA neurons. | Ronglin Wang Shaosong Yang Tiejian Nie Gang Zhu Dayun Feng Qian Yang | 2017 | Neuroscience Bulletin2017，33，5： | 4 |
| 18 | Curcumin protects against acetaminophen-induced apoptosis in hepatic injury显示文摘AIM:To explore the effects of curcumin(CMN)on hepatic injury induced by acetaminophen(APAP)in vivo.METHODS:Male mice were randomly divided into three groups:groupⅠ(control)mice received the equivalent volumes of phosphate-buffered saline(PBS)intraperitoneally(ip);GroupⅡ[APAP+carboxymethylcellulose(CMC)]mice received 1%CMC(vehicle)2h before APAP injection;GroupⅢ(APAP+CMN)mice received curcumin(10 or 20 mg/kg,ip)2 h before before or after APAP challenge.In GroupsⅡandⅢ,APAP was dissolved in pyrogen-free PBS and injected at a single dose of 300 mg/kg.CMN was dissolved in 1%CMC.Mice were sacrificed 16 h after the APAP injection to determine alanine aminotransferase(ALT)levels in serum and malondialdehyde(MDA)accumulation,superoxide dismutase(SOD)activity and hepatocyte apoptosis in liver tissues.RESULTS:Both pre-and post-treatment with curcumin resulted in a significant decrease in serum ALT compared with APAP treatment group(10 mg/kg:801.46±661.34 U/L;20 mg/kg:99.68±86.48 U/L vs 5406.80±1785.75 U/L,P<0.001,respectively).The incidence of liver necrosis was significantly lowered in CMN treated animals.MDA contents were significantly reduced in 20 mg/kg CMN pretreatment group,but increased in APAP treated group(10.96±0.87 nmol/mg protein vs 16.03±2.58 nmol/mg protein,P<0.05).The decrease of SOD activity in APAP treatment group and the increase of SOD in 20 mg/kg CMN pretreatment group were also detected(24.54±4.95 U/mg protein vs 50.21±1.93 U/mg protein,P<0.05).Furthermore,CMN treatment efficiently protected against APAPinduced apoptosis via increasing Bcl-2/Bax ratio.CONCLUSION:CMN has significant therapeutic potential in both APAP-induced hepatotoxicity and other types of liver diseases. | Gang Li Jun-Bao Chen Chao Wang Zhi Xu Hao Nie Xiao-Yan Qin Xiao-Mei Chen Quan Gong | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 19 | Source models for the 2016 Mw6.0 Hutubi earthquake, Xinjiang,China: A possible reverse event显示文摘South and north-dipping nodal planes from the U.S. Geological Survey moment tensor solution were used to invert global teleseismic body waves to reveal the source rupture process of the December 8,2016, Mw6.0 Hutubi earthquake. The results show that a compact pattern is the main feature of this event for only one main slip zone located at the hypocenter for both models. The slip distributions are dominated by a nearly pure-thrust fault, and there is no apparent surface rupture. The inversion revealed that the slip zone extends 10 km along strike and 12 km along dip. The released total seismic moment was about 9.0 × 10^(17) Nm, corresponding to a magnitude of Mw6.0. It is difficult to solve for a best-fit rupture plane due to the sample slip pattern without obvious rupture directivity. This makes the farfield teleseismic data not sensitive enough to determine the fault geometric parameters. The source model of the reverse north-dipping plane fits well with the observed waveforms, and the results of the aftershock relocation outline a trend of north-dipping profiles, indicating the possibility of a reverse event. The inverted normal fault beneath the Qigu fold, interpreted by geological and seismic studies,may be the seismogenic fault for this reverse event. | Gang Liu Xuejun Qiao Wei Xiong Yu Zhou Zhaosheng Nie Chuanjia Xia | 2017 | Geodesy and Geodynamics2017，8，5： | 4 |
| 20 | 3D brain glioma segmentation in MRI through integrating multiple densely connected 2D convolutional neural networks显示文摘To overcome the computational burden of processing three-dimensional(3 D)medical scans and the lack of spatial information in two-dimensional(2 D)medical scans,a novel segmentation method was proposed that integrates the segmentation results of three densely connected 2 D convolutional neural networks(2 D-CNNs).In order to combine the lowlevel features and high-level features,we added densely connected blocks in the network structure design so that the low-level features will not be missed as the network layer increases during the learning process.Further,in order to resolve the problems of the blurred boundary of the glioma edema area,we superimposed and fused the T2-weighted fluid-attenuated inversion recovery(FLAIR)modal image and the T2-weighted(T2)modal image to enhance the edema section.For the loss function of network training,we improved the cross-entropy loss function to effectively avoid network over-fitting.On the Multimodal Brain Tumor Image Segmentation Challenge(BraTS)datasets,our method achieves dice similarity coefficient values of 0.84,0.82,and 0.83 on the BraTS2018 training;0.82,0.85,and 0.83 on the BraTS2018 validation;and 0.81,0.78,and 0.83 on the BraTS2013 testing in terms of whole tumors,tumor cores,and enhancing cores,respectively.Experimental results showed that the proposed method achieved promising accuracy and fast processing,demonstrating good potential for clinical medicine. | Xiaobing ZHANG Yin HU Wen CHEN Gang HUANG Shengdong NIE | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
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