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| 1 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 2 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | Lessons from look-back in acute liver failure? A single centre experience of 3300 patients显示文摘 | William Bernal Anna Hyyrylainen Amit Gera Vinod K. Audimoolam Mark J.W. McPhail Georg Auzinger Mohammed Rela Nigel Heaton John G. O’Grady Julia Wendon Roger Williams | 2013 | Journal of Hepatology2013，，1： | 2 |
| 4 | Trace and minor elements in sphalerite: A LA-ICPMS study显示文摘 | Nigel J. Cook Cristiana L. Ciobanu Allan Pring William Skinner Masaaki Shimizu Leonid Danyushevsky Bernhardt Saini-Eidukat Frank Melcher | 2009 | Geochimica et Cosmochimica Acta2009，，16： | 1 |
| 5 | An Investigation into the Emissions Reduction Performance of an SCR System Over Two Years' In-Use Heavy-Duty Vehicle Operation 显示文摘 | Michael Block William Miller Nigel Clark etc | 2005 | SAE2005，，： | 1 |
| 6 | Alkaline phosphatase is involved in the control of adipogenesis in the murine preadipocyte cell line, 3T3-L1显示文摘 | Aus Tariq Ali Clem B. Penny Janice E. Paiker Chantal van Niekerk Aletta Smit William F. Ferris Nigel J. Crowther | 2004 | Clinica Chimica Acta2004，，1： | 1 |
| 7 | Nucleotide sequence of the Escherichia coli polAgene and primary structure of DNA polymerase Ⅰ显示文摘 | Catherine MJ William SK Nigel DFG | 1982 | J Bio Chem1982，257，： | 1 |
| 8 | Decomposition of Total Factor Productivity Change in the U.S. Hog Industry显示文摘 | Key Nigel McBride William Mosheim Roberto | 2008 | Journal of Agricultural and Applied Economics2008，，： | 1 |
| 9 | Crowd influence on decisions in association football显示文摘 | Alan Nevill Nigel Balmer Mark Williams | 1999 | The Lancet1999，，9162： | 1 |
| 10 | Relationship between the humidity and temperature of inspired gas and the function of the airway mucosa显示文摘 | Robin Williams Nigel Rankin Tony Smith David Galler Paul Seakins | 1996 | Critical Care Medicine1996，，： | 1 |
| 11 | Expression of the pea metallothionein-like gene PsMT A in Escherichia coli and Arabidopsis thaliana and analysis of trace metal ion accumulation: Implications for PsMT A function显示文摘 | Katherine M. Evans John A. Gatehouse William P. Lindsay Jianguo Shi Andrew M. Tommey Nigel J. Robinson | 1992 | Plant Molecular Biology1992，，6： | 1 |
| 12 | Increased model for end‐stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs显示文摘 | Matthew R. Foxton Mohammad A. B. Al‐Freah Andrew J. Portal Elizabeth Sizer William Bernal Georg Auzinger Mohamed Rela Julia A. Wendon Nigel D. Heaton John G. O’Grady Michael A. Heneghan | 2010 | Liver Transpl2010，，5： | 1 |
| 13 | CLINICAL CHARACTERISTICS AFFECTING THE OUTCOME OF LIVER RETRANSPLANTATION显示文摘 | Terence Wong John Devlin Nancy Rolando Nigel Heaton Roger Williams | 1997 | Transplantation1997，，6： | 1 |
| 14 | Assessment and Assimilation of FY-3 Humidity Sounders and Imager in the UK Met Office Global Model显示文摘China's Feng Yun 3(FY-3) polar orbiting satellites are set to become an important source of observational data for numerical weather prediction(NWP),atmospheric reanalyses,and climate monitoring studies over the next two decades.As part of the Climate Science for Service Partnership China(CSSP China) program,FY-3 B Microwave Humidity Sounder 1(MWHS-1) and FY-3 C MWHS-2 observations have been thoroughly assessed and prepared for operational assimilation.This represents the first time observations from China's polar orbiting satellites have been used in the UK's global NWP model.Since 2016,continuous data quality monitoring has shown occasional bias changes found to be correlated to changes in the energy supply scheme regulating the platform heating system and other transient anomalies.Nonetheless,MWHS-1 and MWHS-2 significantly contribute to the 24-h forecast error reduction by 0.3% and 0.6%,respectively,and the combination of both instruments is shown to improve the fit to the model background of independent sounders by up to 1%.The observations from the Microwave Radiation Imager(MWRI) also are a potentially significant source of benefits for NWP models,but a solar-dependent bias observed in the instrument half-orbits has prevented their assimilation.This paper presents the bases of a correction scheme developed at the Met Office for the purpose of a future assimilation of MWRI data. | Fabien CARMINATI Brett CANDY William BELL Nigel ATKINSON | 2018 | Advances in Atmospheric Sciences2018，35，8： | 1 |
| 15 | Graft dysfunction mimicking autoimmune hepatitis following liver transplantation in adults显示文摘 | Michael A. Heneghan Bernard C. Portmann Suzanne M. Norris Roger Williams Paolo Muiesan Mohamed Rela Nigel D. Heaton John G. O’Grady | 2001 | Hepatology2001，，3： | 1 |
| 16 | Manometric asymmetry in the anal canal in controls and patients with fecal incontinence显示文摘 | Nigel Williams Ch.M. F.R.C.S. Josephine Barlow M.Sc. Anthony Hobson B.Sc. Nigel Scott M.D. F.R.C.S. Prof. Miles Irving M.D. F.R.C.S | 1995 | Diseases of the Colon & Rectum1995，，12： | 1 |
| 17 | Project management maturity in the age of big data显示文摘 | NIGEL WILLIAMS NICOLE P FERDIN ROBIN CROFT | 2014 | In- ternational Journal of Managing Projects in Business2014，7，2： | 1 |
| 18 | The Alzheimer’s Disease Neuroimaging Initiative: Progress report and future plans显示文摘 | Michael W. Weiner Paul S. Aisen Clifford R. Jack William J. Jagust John Q. Trojanowski Leslie Shaw Andrew J. Saykin John C. Morris Nigel Cairns Laurel A. Beckett Arthur Toga Robert Green Sarah Walter Holly Soares Peter Snyder Eric Siemers William Potter P | 2010 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2010，，3： | 1 |
| 19 | Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer显示文摘 | Jian-Guo Wang Julia E. Geddings Maria M. Aleman Jessica C. Cardenas Pichika Chantrathammachart Julie C. Williams Daniel Kirchhofer Vladimir Y. Bogdanov Ronald R. Bach Janusz Rak Frank C. Church Alisa S. Wolberg Rafal Pawlinski Nigel S. Key Jen Jen Yeh Nig | 2012 | Blood2012，，23： | 1 |
| 20 | Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection显示文摘 | Giles O. Elliott Ian T. Johnson Jane Scarll Jack Dainty Elizabeth A. Williams D. Garg Amanda Coupe David M. Bradburn John C. Mathers Nigel J. Belshaw | 2013 | International Journal of Colorectal Disease2013，，1： | 1 |
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