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| 1 | Mechanism of the reconstruction of aqueous outflow drainage显示文摘Glaucoma is the leading cause of irreversible blindness worldwide. The reconstruction of aqueous outflow drainage (RAOD) has recently been proposed to aid in restoring aqueous outflow drainage in primary open-angle glaucoma. However, the mechanism of RAOD remains to be fully understood. Based on literature review and research studies, the potential mechanisms of RAOD are the following: (i) Circumferential dilation of the Schlemm’s canal (SC) and surrounding collector channels. (ii) Instant formation of microcracks through RAOD procedures. (iii) Formation of more pores, and local detachment between the SC endothelium (SCE) and basement membrane. (iv) Activation of stem cells by constant mechanical stress caused by the tensional suture placed at the anterior part of the SC. (v) Reversal of trabecular meshwork (TM) herniation. (vi) Mobilization of the reserve of the aqueous drainage. (vii) Change of SCE phenotype. (viii) Mechanosensing and mechanotransducing of TM. | Chen Xin Ning Tian Meng Li Huaizhou Wang Ningli Wang | 2018 | Science China(Life Sciences)2018，61，5： | 13 |
| 2 | Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study显示文摘To determine the interdependence of intracranial pressure(ICP) and intraocular pressure(IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure(LCP), optic nerve subarachnoid space pressure(ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP(via shunting cerebrospinal fluid(CSF) from the ventricle) were recorded. At baseline, all examined pressures were different(ICP>LCP>ONSP), but correlated(P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient(TLPG) remained stable(ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined(ICP-IOP independent zone). The optic nerve pressure gradient(ONPG) and trans-optic nerve pressure gradient(TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma. | Ruowu Hou Zheng Zhang Diya Yang Huaizhou Wang Weiwei Chen Zhen Li Jinghong Sang Sumeng Liu Yiwen Cao Xiaobin Xie Ruojing Ren Yazhuo Zhang Bernhard A. Sabel Ningli Wang | 2016 | Science China(Life Sciences)2016，59，5： | 11 |
| 3 | Burden of pancreatitis and associated risk factors in China,1990 to 2019:a systematic analysis for the Global Burden of Disease Study 2019显示文摘Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.Methods: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.Results: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.Conclusions: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years. | Ke Han Shimin Chen Yang Song Chen Du Fei Gao Shaohua Liu Yao He Ningli Chai Enqiang Linghu Miao Liu | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 4 | A Lectin from Chinese Mistletoe Increases γδ T Cell-mediated Cytotoxicity through Induction of Caspase-dependent Apoptosis显示文摘在这研究,槲寄生凝集素(ML ) 在 cytokine 网络的人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和调整上从中国槲寄生和这 60 kDa 汉语 ML 的效果被净化被学习。 8 个 T 房间的细胞毒素的性质被使用 51Cr 版本测试评估并且采用了排序的激活荧光的房间和 enzyme-linkedimmunosorbent 试金分析确定房间 membranephospholipid 的 translocation , phosphatidylserine 和原子 DNA 破碎在 apoptosis.It 期间被发现那:(i) ML 有效地在剂量刺激了鲸鱼群妈三角洲 T 房间增长--并且时间依赖者举止;( i i ) ML 增加了鲸鱼群妈三角洲 T 房间 cytotoxicity ;( iii ) ML 能由增加以一种 支持inflammatory 方式调制 lipopolysaccharide-inducedcytokine 版本肿瘤坏死因素( TNF ) -alpharelease 并且禁止反煽动性的白介素( IL )的版本以caspase依赖、CD95独立的方式的-10;(iv) ML inducedapoptosis 。结果显示 ML 是到人的鲸鱼群妈三角洲 T 房间 cytotoxicity, apoptosis 和 cytokine 生产的 potentimmunomodulator。 | Fang GONG Yanhui MA Anlun MA Qiwen YU Jiying ZHANG Hong NIE Xuehua CHEN Baihua SHEN Ningli LI Dongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 2 |
| 5 | Long-term follow-up of optic neuropathy in chronic low cerebrospinal fluid pressure monkeys: the Beijing Intracranial and Intraocular Pressure(iCOP) Study显示文摘Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness. | Jing Li Diya Yang Jacky MKKwong Jidi Fu Ruowu Hou Jost BJonas Huaizhou Wang Zheng Zhang Weiwei Chen Zhen Li Jinghong Sang Xiaobin Xie Ruojin Ren Robert NWeinreb Ningli Wang | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 6 | Silver nanoparticle labeled immunoresonance scattering spectral assay for trace fibrinogen显示文摘Silver nanoparticles in size of 8.0 nm was prepared by the trisodium citrate and used to label goat anti-human fibrinogen. In the pH 5.8 Na2HPO4-NaH2O4 buffer solution (PBS) and in the presence of polyethylene glycol (PEG) and KCl, the immune reaction between silver-labeled goat anti-human fibrinogen and fibrinogen took place and led the resonance scattering intensity at 465 nm (I465) to decreasing. The I465 decreased intensity was linear to the fibrinogen concentration in the range from 0.067 to 1.67 μg/mL, with a detection limit of 0.024 μg/mL. This method was applied to determination of fibrinogen in human plasma, with satisfactory results. | JIANG ZhiLiang CHEN YuanYuan LIANG AiHui TAO HuiLin TANG NingLi ZHONG FuXin | 2007 | Science China Chemistry2007，50，3： | 2 |
| 7 | Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study显示文摘 | Zhang Qing Li Sizhen Liang Yuanbo Wang Fenghua Chen Weiwei Wang Ningli | 2014 | Chinese Medical Journal2014，，9： | 1 |
| 8 | IL-21 regulates Th17 cells in rheumatoid arthritis显示文摘 | Xiaoyin Niu Dongyi He Xin Zhang Tao Yue Ningli Li Jingwu Z. Zhang Chen Dong Guangjie Chen | 2010 | Human Immunology2010，，4： | 1 |
| 9 | Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma显示文摘The blood circulatory system is the largest system of fluid flow in the human body,and it has been widely studied and well understood.Pulsation characterizes the blood circulatory system and results in three essentials,including(i)pressure fluctuations attributed to pumping of the heart,(ii)the self-regulatory,elastic cardiac muscle,which is sensitive to pressure variance and controls the output volume of the heart,and(iii)valves controlling the one-way flow. | Shen Wu Chen Xin Wei Zhu Yue Wan Qing Sang Rong Du Jian Wu Jin Wang Ningli Wang | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 10 | Scallop ice shape characteristics of swept wing based on large-scale icing wind tunnel experiment显示文摘Scallop ice is a special phenomenon that occurs during swept wing aircraft passing through icing clouds.It poses a great challenge for the icing safety assessment that the complex scallop ice shape feature and its mechanism are still unclear.In this work,a large-scale icing wind tunnel experiment of swept wing designed by NACA0012 airfoil is conducted in the Icing Wind Tunnel of China Aerodynamics Research and Development Center.The detailed three-dimensional ice shapes under 0°,15°,30°and 45°swept angles are obtained by laser scanning technology.The experimental results show that with the swept angle increasing from 0°to 45°,the 2D double ice horn structures show certain spanwise variation,and finally transform into complete scallop ice with ice thickness greatly enhanced in the stagnation line region.The empirical mode decomposition of the spanwise ice curve captures the high-frequency fluctuation on the scallop ice caused by the small-scale roughness element,while the trend with low frequency is not obvious.Based on the experimental data,a new complete scallop ice geometric model,named 5Points-5Lines-2Arcs(5P-5L-2A)model,is proposed,which can provide important basis for the quantitative description of complex scallop ice shape. | Qiang WANG Ningli CHEN Yuanbo WANG Weihao LI Yu LIU Xian YI | 2023 | Chinese Journal of Aeronautics2023，36，12： | 0 |
| 11 | Outcomes of super minimally invasive surgery vs.esophagectomy for superficial esophageal squamous cell carcinoma:a single-center study based on propensity score matching显示文摘Super minimally invasive surgery(SMIS)is a new concept proposed in 2016,which is defined as“curing the disease while preserving the integrity of human organ anatomy.”[1]Its concept has been accepted by the World Endoscopy Organization and Chinese Society of Digestive Endoscopy.The obvious advantage of SMIS is to cure diseases without damaging the structure and function of organs.For cancer patients,it can ensure a normal survival time and postoperative quality of life(QoL). | Jiancong Feng Ningli Chai Enqiang Linghu Xiuxue Feng Longsong Li Chen Du Wengang Zhang Qingzhen Wu | 2022 | Chinese Medical Journal2022，135，20： | 0 |
| 12 | An Efficient Trap Passivator for Perovskite Solar Cells:Poly(propylene glycol)bis(2‑aminopropyl ether)显示文摘Perovskite solar cells(PSCs)are regarded as promising candidates for future renewable energy production.High-density defects in the perovskite films,however,lead to unsatisfactory device performances.Here,poly(propylene glycol)bis(2-aminopropyl ether)(PEA)additive is utilized to passivate the trap states in perovskite.The PEA molecules chemically interact with lead ions in perovskite,considerably passivate surface and bulk defects,which is in favor of charge transfer and extraction.Furthermore,the PEA additive can efficiently block moisture and oxygen to prolong the device lifetime.As a result,PEA-treated MAPbI3(MA:CH3NH3)solar cells show increased power conversion efficiency(PCE)(from 17.18 to 18.87%)and good longterm stability.When PEA is introduced to(FAPbI3)1-x(MAPbBr3)x(FA:HC(NH2)2)solar cells,the PCE is enhanced from 19.66 to 21.60%.For both perovskites,their severe device hysteresis is efficiently relieved by PEA. | Ningli Chen Xiaohui Yi Jing Zhuang Yuanzhi Wei Yanyan Zhang Fuyi Wang Shaokui Cao Cheng Li Jizheng Wang | 2020 | Nano-Micro Letters2020，12，12： | 0 |
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