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| 1 | Graft-accelerated virus-induced gene silencing facilitates functional genomics in rose flowers显示文摘Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS', where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR_1, RhA G, and RhNUDX_1 in rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods. | Huijun Yan Shaochuan Shi Nan Ma Xiaoqian Cao Hao Zhang Xianqin qiu Qigang Wang Hongying Jian Ningning Zhou Zhao Zhang Kaixue Tang | 2018 | Journal of Integrative Plant Biology2018，60，1： | 11 |
| 2 | Inheritance of Perpetual Blooming in Rosa chinensis ‘Old Blush'显示文摘Perpetual blooming is one of the most important biological and economical traits in modern rose, while the genetic basis underlining the control of this trait is poorly investigated. With an aim in dissecting the genetic determinism of perpetual blooming, we developed six rose populations(OB, W, F1, F2, BC1 OB and BC1W) derived from a WOB population [interspecific diploid hybridization between Rosa chinensis ‘Old Blush'(OB) and R. wichuriana ‘Basye's Thornless'(W)]. Perpetual blooming is absent both in a F1 population with 296 individuals and a BC1 W population(W as the backcross parent) with 150 individuals. However, the perpetual blooming trait showed a typical 3︰1 segregation in a backcross population BC1 OB with OB as the backcross parent. In this population with 300 individuals, 83 plants had the perpetual blooming phenotype while the other 217 featured non-perpetual blooming, indicating that the perpetual blooming trait is very likely controlled by two recessive genes in R. chinensis(rpb1 and rpb2). These genetic data suggest that the inheritance of rose perpetual blooming may be controlled by a complex mechanism. | LI Shubin ZHOU Ningning ZHOU Qing YAN Huijun JIAN Hongying WANG Qigang CHEN Min QIU Xianqin ZHANG Hao WANG Shufang LI Shufa TANG Kaixue | 2015 | Horticultural Plant Journal2015，1，2： | 9 |
| 3 | Systematic Review and Meta-analysis of Efficacy of Banxia Xiexin Decoction for Treatment of Bile Reflux Gastritis显示文摘[Objectives]The purpose was to study the clinical efficacy and safety of Banxia Xiexin decoction in treating bile reflux gastritis(BRG).[Methods]Randomized controlled trial was adopted to conduct scientific and standardized assessment on the risk of bias in the included articles.With overall effect and epigastric pain relief as indices,meta-analysis was performed,and sensitivity and safety analysis was conducted on the included literature.[Results]A total of 13 articles were included,involving a total of 1478 patients.The results of meta-analysis show that the efficacy of Banxia Xiexin decoction alone and Banxia Xiexin decoction-Western medicine combination is better than that of Western medicine alone.[Conclusions]Banxia Xiexin decoction is safe and effective in treating bile reflux gastritis.However,as the 13 articles included are all low in quality and there is a certain degree of publication bias,the objectivity of the results is affected to some extent. | Ningning ZHAO Bing WEI Shiying TANG | 2020 | Medicinal Plant2020，11，3： | 3 |
| 4 | RICHARDSON EXTRAPOLATION AND DEFECT CORRECTION OF FINITE ELEMENT METHODS FOR OPTIMAL CONTROL PROBLEMS显示文摘在为到最佳的控制问题的一个班的双线性的有限元素近似的 H1 标准的 Asymptotic 错误扩大为矩形的网孔被导出。与矩形的网孔,二个不同计划和插值缺点修正的理查森推测能被使用。数字近似被用来产生的更高的顺序一以后|为有限元素近似的错误评估者。[从作者抽象] | Tang Liu Ningning Yan Shuhua Zhang | 2010 | Journal of Computational Mathematics2010，28，1： | 2 |
| 5 | Mechanism of Deca-BDE-induced apoptosis in Neuro-2a cells:Role of death-receptor pathway and reactive oxygen species-mediated mitochondrial pathway显示文摘Decabromodiphenyl ether(BDE-209) is a prevalent polybrominated diphenyl ether(PBDE)congener known to have neurotoxicity. Effects of BDE-209 on Neuro-2a cells were performed in the present study and the possible apoptotic pathway was discussed. Results indicated that BDE-209 induced Neuro-2a cell apoptosis, increased the protein expression of Fas and Fas-associated death domain-containing protein(FADD) and activated the caspase-8 and-3activities in a concentration-dependent manner, inferring the death-receptor pathway was involved in the apoptotic process. Meanwhile, BDE-209 exposure increased the Bax/Bcl-2 ratio and decreased the cellular mitochondrial membrane potential(MMP) which led to cytochrome C released to the cytoplasm. The intracellular caspase-9 was elevated simultaneously,which caused downstream caspase cascade and triggered cell apoptosis. Moreover, BDE-209 exposure increased cellular reactive oxygen species(ROS) level in a concentration-dependent manner and the addition of N-acetyl-L-cysteine(NAC), known as ROS scavengers, obviously reduced the apoptotic rate and a positive relationship was observed between the degree of apoptosis blocking and the loss of MMP and ROS production. We thus concluded that BDE-209 induced Neuro-2a cell apoptosis via the combination of the death-receptor signaling pathway and the mitochondrial signaling pathway. The elevated ROS production was considered to magnify the intracellular apoptosis signal and played a crucial role in apoptosis of Neuro-2a cells induced by BDE-209. | Hongmei Chen Xuexi Tang Bin Zhou Ningning Xu You Wang | 2016 | Journal of Environmental Sciences2016，28，8： | 2 |
| 6 | Effect of Cellulose Acetate Butyrate Microencapsulated Ammonium Polyphosphate on the Flame Re~cy, Mechanical, Elecmcal, and Thermal Properties of Intumescent Flame-Retardant Ethylene Vinyl Acetate Copolymer/Microencapsulated Ammonium Pol- yphosphate/Polyamide-6 Blends 显示文摘 | Wang Bibo Tang Qinbo Hong Ningning | 2011 | ACS Applied Matereri- al&Interfaces2011，3，9： | 1 |
| 7 | Using DGT to Assess Cadmium Bioavailability to Ryegrass as Influenced by Soil Properties显示文摘A generally accepted method for predicting the bioavailability and transfer of cadmium(Cd) from soil to plants has not yet been established. In this study, the diffusive gradients in thin films(DGT) and conventional extraction methods for metal fractions were used to investigate how effective these methods were at predicting Cd bioavailability to ryegrass(Lolium perenne) and to assess whether these holistic variables were independent of the soil property variables. The influences of soil properties on the predictive capabilities of the different methods were evaluated using multivariate statistics. The Cd concentrations in the shoots and roots of ryegrass correlated more closely with the effective Cd concentration measured by DGT(CE), compared with those with soil total Cd, pore water Cd, and ethylenediaminetetraacetic acid disodium salt(Na2EDTA)- and acetic acid(HOAc)-extractable Cd. When soil properties were included in a stepwise multiple linear regression, Cd transfer to L. perenne was negatively influenced by p H and positively influenced by organic matter(OM). The multivariate statistics showed that the adjusted correlation coefficients for the plots involving soil total Cd, pore water Cd, and Na2EDTA- and HOAc-extractable Cd had been significantly improved after considering the influences of soil properties, which suggested that these methods were p H and OM dependent. For CE, the relationship was p H independent or only dependent in strongly acidic soils. These results suggested that the main soil factors affecting bioavailability had the lowest impact on the DGT technique. Therefore, the DGT technique provided significant advantages over conventional methods when assessing Cd bioavailability. | SONG Ningning WANG Fangli MA Yibing TANG Shirong | 2015 | Pedosphere2015，25，6： | 1 |
| 8 | Effect of cellulose acetate butyrate microencapsulated ammonium polyphosphate on the flame retardancy,mechanical,electrical,and thermal properties of intumescent flame-retardant ethylene-vinyl acetate copolymer/microencapsulated ammonium polyphosphate/polyamide-6 blends显示文摘 | Bibo Wang Qinbo Tang Ningning Hong | 2011 | ACS Applied Materials&Interfaces2011，3，9： | 1 |
| 9 | Systematic Review and Meta-analysis of Tanshinone Capsule in the Treatment of Polycystic Ovary Syndrome显示文摘[Objectives]To study the efficacy and safety of tanshinone capsule in the treatment of polycystic ovary syndrome(PCOS).[Methods]A randomized controlled trial or semi-randomized controlled trial of tanshinone capsule in the treatment of polycystic ovary syndrome was included.Two researchers screened the retrieved literature,extracted the data,assessed the risk of bias of the included literature,and then carried out meta-analysis.[Results]A total of 5 articles were included,involving 350 patients.The results of meta-analysis showed that compared with the control group,tanshinone capsule could reduce total cholesterol[MD=-0.73,95%CI(-0.86,-0.60),P<0.00001],triglyceride[MD=-0.40,95%CI(-0.57,-0.23),P<0.00001],low density lipoprotein cholesterol[MD=-0.47,95%CI(-0.73,-0.53),P<0.00001],follicle stimulating hormone[MD=-0.63,95%CI(-0.73,-0.53),P<0.00001],increase high density lipoprotein cholesterol[MD=0.28,95%CI(0.20,0.35),P<0.00001],the effective rate(P=0.06)and luteinizing hormone(P=0.07)in the treatment of polycystic ovary syndrome.[Conclusions]Tanshinone capsule could effectively improve the level of lipid metabolism and follicle stimulating hormone in patients with polycystic ovary syndrome. | Bing WEI Yi ZHANG Ningning ZHAO Shiying TANG | 2020 | Medicinal Plant2020，11，2： | 1 |
| 10 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 11 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 12 | Reactive oxygen species accumulation patterns of alfalfa root nodules identified using an optimized method显示文摘ROS include superoxide anion radical (O2^-), hydrogen peroxide (H2O2), singlet oxygen (0-0), hydroxyl radical (OH ), and hydroxyl anion (OH-). O2^-, the radical with the highest oxidation compacity to produce H2O2, OH and OH^-, is a byproduct of aerobic respiration in organisms. Rhizobia and their legume hosts are aerobic organisms, and nitrogen-fixing nodules formed on legume roots are developed from their symbiotic in teractions. Therefore, ROS are generated in legume nodules through aerobic respiration by both symbiotic partners. | Liangliang Yu Leqi Huang Shuang Zeng Guirong Tang Sunjun Wang Ningning Li Junhui Yan Li Luo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 0 |
| 13 | A living cell-based fluorescent reporter for high-throughput screening of anti-tumor drugs显示文摘Suppression of cellular O-linkedβ-N-acetylglucosaminylation(O-Glc NAcylation)can repress proliferation and migration of various cancer cells,which opens a new avenue for cancer therapy.Based on the regulation of insulin gene transcription,we designed a cell-based fluorescent reporter capable of sensing cellular O-Glc NAcylation in HEK293 T cells.The fluorescent reporter mainly consists of a reporter(green fluorescent protein(GFP)),an internal reference(red fluorescent protein),and an operator(neuronal differentiation 1),which serves as a'sweet switch'to control GFP expression in response to cellular OGlc NAcylation changes.The fluorescent reporter can efficiently sense reduced levels of cellular OGlc NAcylation in several cell lines.Using the fluorescent reporter,we screened 120 natural products and obtained one compound,sesamin,which could markedly inhibit protein O-Glc NAcylation in He La and human colorectal carcinoma-116 cells and repress their migration in vitro.Altogether,the present study demonstrated the development of a novel strategy for anti-tumor drug screening,as well as for conducting gene transcription studies. | Ningning Tang Ling Li Fei Xie Ying Lu Zifan Zuo Hao Shan Quan Zhang Lianwen Zhang | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 0 |
| 14 | Complex granular flows of sticky-wet material on flip-flow screens:Calibration of discrete element simulations显示文摘Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow screens.However,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow screens.To achieve accurate simulations of the thick layer of sticky-wet particles on a flip-flow screen,firstly,the movement law of particle flow was studied,and a multi-regime combination cali-bration method based on characteristics of particle flow regimes was proposed.Based on the Plackett-Burman experiment,the curse of dimensionality caused by multi-state and multi-contact parameters was overcome.Subsequently,the lifting cylinder,rotating drum,and trampoline tests were carried out to obtain macroscopic reference values under various granular flow regimes.The calibration results were then determined using the response surface method and climbing algorithm.Finally,the calibration results were tested at both macroscopic and mesoscopic scales and compared with a commonly used calibration method.The results demonstrate that the calibration method,which considers the multi-state characteristics,improves simulation accuracy by 2%-10%and reduces the simulation error to less than 10%,thus meeting the requirements for engineering optimization of flip-flow screens. | Ningning Xu Sen Tang Dongdong Lin Runhui Geng Xinwen Wang Xihui Liang | 2024 | Particuology2024，84，1： | 0 |
| 15 | Comparative transcriptomic and metabonomic analysis revealed the relationships between biosynthesis of volatiles and flavonoid metabolites in Rosa rugosa显示文摘Rosa rugosa is not only cultivated as a landscaping plant,but also used in cosmetics,the medical and food industries.However,little information is currently available on the gene regulatory networks involved in its scent and color biosynthesis and metabolism.In this study,R.rugosa Thunb.f.rosea Rehd with red petals(RR)and its white petal variant(WR),were used to study the molecular mechanisms in flower color and scent.Sixty-five differential flavonoid metabolites and 15 volatiles were found to have significant differences between RR and WR.Correspondingly,the key regulators(MYB-bHLH-WD40)of anthocyanin synthesis pathway and their structural genes involved in flavonoid biosynthesis,benzenoid/phenylpropanoid biosynthesis,terpenoid biosynthesis pathways were also found to be differentially expressed by comparative transcriptome.Further,qPCR permitted the identification of some transcripts encoding proteins that were putatively associated with scent and color biosynthesis in roses.Particularly,the results showed that the ACT gene(encoding CoA geraniol/citronellol acetyltransferase,GeneID:112190420),which expressed lower in WR,was involved in three pathways:flavonoid biosynthesis,phenylpropanoid biosynthesis and terpenoid biosynthesis,however,GT5(anthocyanin glycosylation gene,GeneID:112186660),expressed higher in WR,was involved in both flavonoid and phenylpropanoid biosynthesis pathways.These results suggested that ACT and GT5 might play important roles in regulating the relationship of color pigmentation and volatile emission. | Dedang Feng Hao Zhang Xianqin Qiu Hongying Jian Qigang Wang Ningning Zhou Yu Ye Jun Lu Huijun Yan Kaixue Tang | 2021 | Ornamental Plant Research2021，1，1： | 0 |
| 16 | Genome-wide identification and evolutionary analysis of MLO gene family in Rosaceae plants显示文摘Mutants lacking wild-type MLO(Mildew resistance Locus O)proteins show broad-spectrum resistance to the powdery mildew fungus,and dysregulated cell death control,with spontaneous cell death in response to developmental or abiotic stimuli.In order to understand the evolution and divergence patterns of the MLO gene family in Rosaceae plants,we analysed systematically genome-wide data from Fragaria vesca,Prunus persica,Prunus mume,Malus domestica,Pyrus bretschneideri and Rubus occidentalis based on bioinformatics methods.Using three phylogenetic methods(the neighbour-joining,maximum likelihood,and Bayesian methods),we identified 117 MLO genes from 6 Rosaceae species.The results of all three phylogenetic analysis methods supported that these genes were divided into six clades.Conserved motif analysis found that only motif 2 was present in all MLO proteins and had 3 nearly invariant amino acid residues.The findings indicated that motif 2 might be shared by the MLO gene family.The structural features of these genes showed large variations in sequence length among different species,although the lengths and the numbers of exons exhibited high degrees of similarity.Selective pressure analysis showed extremely significant differences in all 6 clades,with 2,1,and 1 site(s)under significant positive selection detected in clades III,IV,and VI,respectively.These positive selection sites were important driving forces for the promotion of the functional differentiation of the MLO genes.Functional divergence analysis showed that the significantly divergent sites were located within the domains of the MLO genes.Functional distance analysis showed that the clade V had more conservative functions and might have retained more original functions during the evolutionary process.However,clade I may have undergone extensive altered functional constraints as a specialised functional role.Moreover,the most original function of the MLO genes in Rosaceae could be related to the evolution of their resistance to powdery mildew,which then gradually evolved into functions such as the regulation of flower development,the control of root morphology,and seed evolution due to the different evolutionary rates after gene duplication.These results provide a theoretical basis for further studies of the molecular evolutionary patterns of the plant MLO gene family. | Yongxian Tian Qigang Wang Hao Zhang Ningning Zhou Huijun Yan Hongying Jian Shubin Li Guisheng Xiang Kaixue Tang Xianqin Qiu | 2022 | Horticultural Plant Journal2022，8，1： | 0 |
| 17 | Identification of Sinorhizobium meliloti LsrB regulon显示文摘Redox homeostasis determines cell fate for both prokaryotes and eukaryotes.In bacteria,redox state depends on aerobic respiration and antioxidant protection.Superoxide anion radicals produced from aerobic respiration are catalyzed by superoxide dismutase(SOD)to hydrogen peroxide(H_(2)O_(2)). | Fang An Ningning Li Lanya Zhang Wenjia Zheng Shenghui Xing Guirong Tang Junhui Yan Liangliang Yu Li Luo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 0 |
| 18 | Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results显示文摘Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch time.We aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla MR-Linac.Methods: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled prospectively.The contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image registration.The physician then manually adjusted them,and dose recalculation was performed accordingly.GraphPad Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical analyses.Results: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI toxicities.The estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry analysis.Clinical trial registration Chinese Clinical Trial Registry ChiCTR2000033382. | Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song Shulian Wang Hui Fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu | 2024 | Chronic Diseases and Translational Medicine2024，10，1： | 0 |
| 19 | Systematic Review and Meta-analysis of Biyuanshu Oral Liquid in the Treatment of Chronic Rhinosinusitis显示文摘[Objectives]The objective was to study the clinical efficacy and safety of Biyuanshu oral liquid in the treatment of chronic rhinosinusitis(CRS).[Methods]Randomized controlled trial was adopted to conduct scientific and standardized assessment on the risk of bias in the included papers.With overall effect and incidence of adverse reactions as indices,meta-analysis was performed,and sensitivity and safety analysis was conducted on the included literature.[Results]A total of 15 papers were included,involving 1489 patients.The efficiency of Biyuanshu oral liquid combined with Western medicine was better than that of Western medicine alone.[Conclusions]Biyuanshu oral liquid is safe and effective in treating chronic rhinosinusitis,and is suitable for patients who are not convenient for surgery.However,as the 15 papers included are all low in quality and there is a certain degree of publication bias,the objectivity of the results is affected to some extent. | Ningning ZHAO Shiying TANG | 2020 | Medicinal Plant2020，11，5： | 0 |
| 20 | Low-content and highly effective zoned Rh and Pd three-way catalysts for gasoline particulate filter potentially meeting Euro 7显示文摘The next-generation Euro 7 standard proposed much lower pollutant limits from gasoline vehicles,specifically for CO and NO_(x),which would be challenging for the three-way catalysts(TWCs)utilized commercially to eliminate these pollutants.TWCs with reductive(Rh)and oxidative(Pd)active components on gasoline particulate filters(TWC on GPF)play importantly auxiliary roles in the remediation of CO and NO_(x)downstream the close coupled TWCs to meet their emission targets.Here,a low-content Rh-based TWC(0.17 wt%)zoned with a less expensive Pd-based TWC(0.29 wt%)for GPF applications(cGPF)is reported using improved colloidal deposition method.The supporting of Rh on Y-stabilized ZrO_(2)rather than on CeO_(2)-ZrO_(2)inhibits the formation of inactive Ce rhodate species,while Pd on CeO_(2)-ZrO_(2)not only guarantees the high oxygen storage capacity(OSC)but also enhances catalytic activity.The layout of the front one-fifth in volume being 0.29 wt%Pd on Ce_(0.43)Zr_(0.5)7O_(2)and the rear four-fifths being 0.17 wt%Rh on Zr_(0.85)Y_(0.15)O_(2)prevents the possible alloying of Rh with Pd.The highly effective zoned Rh and Pd TWCs show synergistic three-way activity before and after severe hydrothermal aging at 1000℃with 10%water for24 h,which could be potential choices for close coupled GPF application to satisfy the upcoming stringent emission standards,such as Euro 7 and China 6b. | Ying Xin Hanxue Zhang Pan Li Ningning Qu Ahui Tang Fuzhen Yang Dongxu Han Junxiu Jia Jin Wang Lirong Zheng Zhaoliang Zhang | 2023 | Journal of Rare Earths2023，41，6： | 0 |
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