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| 1 | Effect of age on aortic atherosclerosis显示文摘Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness calculated.Wall/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×100.Results In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis. | Michael A. Chen Miwa Kawakubo Patrick M. Colletti Dongxiang Xu Laurie LaBree Dustin Robert Detrano Stanley P Azen Nathan D. Wong Xue-Qiao Zhao | 2013 | Journal of Geriatric Cardiology2013，10，2： | 6 |
| 2 | ^(125)I-labeled anti-b FGF monoclonal antibody inhibits growth of hepatocellular carcinoma显示文摘AIM: To investigate the inhibitory efficacy of ^(125)I-labeled anti-basic fibroblast growth factor(b FGF) monoclonal antibody(m Ab) in hepatocellular carcinoma(HCC).METHODS: b FGF m Ab was prepared by using the 1G9B9 hybridoma cell line with hybridization technology and extracted from ascites fluid through a Protein G Sepharose affinity column. After labeling with ^(125)I through the chloramine-T method, b FGF m Ab was further purified by a Sephadex G-25 column. Gamma radiation counter GC-1200 detected radioactivity of ^(125)I-b FGF m Ab. The murine H22 HCC xenograft model was established and randomized to interventions with control(phosphate-buffered saline), ^(125)I-b FGF m Ab,^(125)I plus b FGF m Ab, b FGF m Ab, or ^(125)I. The ratios of tumor inhibition were then calculated. Expression of b FGF, fibroblast growth factor receptor(FGFR), plateletderived growth factor, and vascular endothelial growth factor(VEGF) m RNA was determined by quantitative reverse transcriptase real-time polymerase chain reaction. RESULTS: The purified b FGF m Ab solution was 8.145 mg/m L with a titer of 1:2560000 and was stored at-20 ℃. After coupling, ^(125)I-b FGF m Ab was used at a 1: 1280000 dilution, stored at 4 ℃, and its specific radioactivity was 37 MBq/mg. The corresponding tumor weight in the control, ^(125)I, b FGF m Ab, ^(125)I plus b FGF m Ab, and ^(125)I-b FGF m Ab groups was 1.88 ± 0.25, 1.625 ± 0.21, 1.5 ± 0.18, 1.41 ± 0.16, and 0.98 ± 0.11 g, respectively. The tumor inhibition ratio in the ^(125)I, b FGF m Ab, ^(125)I plus b FGF m Ab, and ^(125)I-b FGF m Ab groups was 13.6%, 20.2%, 25.1%, and 47.9%, respectively. Growth of HCC xenografts was inhibited significantly more in the ^(125)I-b FGF m Ab group than in the other groups(P < 0.05). Expression of b FGF and FGFR m RNA in the ^(125)I-b FGF m Ab group was significantly decreased in comparison with other groups(P < 0.05). Groups under interventions revealed increased expression of VEGF m RNA(except for ^(125)I group) compared with the control group.CONCLUSION: ^(125)I-b FGF m Ab inhibits growth of HCC xenografts. The coupling effect of ^(125)I-b FGF m Ab is more effective than the concomitant use of ^(125)I and b FGF m Ab. | Peng-Hui Hu Lan-Hong Pan Patrick Ting-Yat Wong Wen-Hui Chen Yan-Qing Yang Hong Wang Jun-Jian Xiang Meng Xu | 2016 | World Journal of Gastroenterology2016，22，21： | 4 |
| 3 | Laser pattern-induced unidirectional lubricant flow for lubrication track replenishment显示文摘Effective oil replenishment to the lubrication track of a running bearing is crucial to its sustainable operation.Reliable practical solutions are rare despite numerous theoretical studies were conducted in the last few decades.This paper proposes the use of surface effect,wettability gradient,to achieve the goal.This method is simple and can be nicely implemented using femtosecond laser ablation.A periodic comb-tooth-shaped pattern with anisotropic wetting capability is devised and its effect on the anisotropic spreading behaviour of an oil droplet is studied.Results show that the comb-tooth-shaped pattern enables the rearrangement of oil distribution,thereby escalating oil replenishment to the lubrication track.The effect is due to the unbalanced interfacial force created by the surface pattern.The influence of the shape and the pitch of teeth,which are the two governing factors,on oil transport is also reported.The effects of the newly devised surface pattern on lubrication are experimentally evaluated under the conditions of limited lubricant supply.These results are promising,demonstrating the reduction in bearing friction and the increase in lubricating film thickness. | Chenglong LIU Feng GUO Patrick WONG Xinming LI | 2022 | Friction2022，10，8： | 4 |
| 4 | Role of MicroRNA-214 in ginsenoside-Rg1-induced angiogenesis显示文摘 | Lai-Sheung Chan Patrick Ying-Kit Yue Nai-Ki Mak Ricky Ngok-Shun Wong | 2009 | European Journal of Pharmaceutical Sciences2009，，4： | 3 |
| 5 | MicroRNA-15b contributes to ginsenoside-Rg 1 -induced angiogenesis through increased expression of VEGFR-2显示文摘 | L.S. Chan Patrick Y.K. Yue Y.Y. Wong Ricky N.S. Wong | 2013 | Biochemical Pharmacology2013，，3： | 2 |
| 6 | Single incision laparoscopic right hemicolectomy: different approaches显示文摘 | WONG Tak-man DAY Weida KWOK Shu-yan LAU Ying-yu Patrick YIP Wai-chun Andrew | 2013 | Chinese Medical Journal2013，，2： | 2 |
| 7 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 8 | Appadtion of the NAC Transcription Factors Predates the Emergence of Land Plants显示文摘 | Aude Maugarny-Cales Beatriz Gonqalves Stefan Jouannic Michael Melkonian Gane Ka-Shu Wonge Patrick Laufs | 2016 | Molecular Plant2016，9，9： | 2 |
| 9 | Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression显示文摘 | Theodore H. Lindsay Beth M. Jonas Molly A. Sevcik Kazufumi Kubota Kyle G. Halvorson Joseph R. Ghilardi Michael A. Kuskowski Edward B. Stelow Pinku Mukherjee Sandra J. Gendler Gilbert Y. Wong Patrick W. Mantyh | 2006 | Pain2006，，1： | 2 |
| 10 | GI endoscopes显示文摘 | Shyam Varadarajulu Subhas Banerjee Bradley A. Barth David J. Desilets Vivek Kaul Sripathi R. Kethu Marcos C. Pedrosa Patrick R. Pfau Jeffrey L. Tokar Amy Wang Louis-Michel Wong Kee Song Sarah A. Rodriguez | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 11 | Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis显示文摘 | Lok Yung Chan Hoi Hin Kwok Renee Wan Yi Chan Malik Joseph Sriyal Peiris Nai Ki Mak Ricky Ngok Shun Wong Michael Chi Wai Chan Patrick Ying Kit Yue | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 12 | Compaction localization in porous sandstones: spatial evolution of damage and acoustic emission activity显示文摘 | Patrick Baud Emmanuelle Klein Teng-fong Wong | 2003 | Journal of Structural Geology2003，，4： | 1 |
| 13 | The angiosuppressive effects of 20(R)- ginsenoside Rg 3显示文摘 | Patrick Y.K. Yue Daisy Y.L. Wong P.K. Wu P.Y. Leung N.K. Mak H.W. Yeung L. Liu Zongwei Cai Zhi-Hong Jiang T.P.D. Fan Ricky N.S. Wong | 2006 | Biochemical Pharmacology2006，，4： | 1 |
| 14 | Compaction localization in porous sandstones:spatial evolution of damage and acoustic emission activity显示文摘 | Emmanuelle Klein Teng-fong Wong | 2004 | Journal of Structural Geology2004，26，： | 1 |
| 15 | Endoscopic simulators显示文摘 | David J. Desilets Subhas Banerjee Bradley A. Barth Vivek Kaul Sripathi R. Kethu Marcos C. Pedrosa Patrick R. Pfau Jeffrey L. Tokar Shyam Varadarajulu Amy Wang Louis-Michel Wong Kee Song Sarah A. Rodriguez | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 16 | Web-based surveillance and global Salmonella distribution ,2000- 2002 显示文摘 | Galanis E Lo Fo Wong DM Patrick ME | 2006 | Emerg Infect Dis2006，12，3： | 1 |
| 17 | The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells 显示文摘 | Patrick T W L Wong C H Stephen K W T | 2005 | J Gen Virol2005，86，： | 1 |
| 18 | Physical modeling of spiral inductors on silicon 显示文摘 | Yue C Patrick and S Simon Wong | 2000 | IEEE Transactions on Electron Devices2000，47，3： | 1 |
| 19 | Web-based surveil- lance and global Sahnonella distribution, 2000-2002显示文摘 | GALANIS E WONG DM PATRICK ME | 2006 | Emerg Infect Dis2006，12，3： | 1 |
| 20 | Altered Gene Expression in Normal Colonic Mucosa of Individuals With Polyps of the Colon显示文摘 | Chun-Yi Hao Dan?H. Moore Yanek?S.?Y. Chiu Patrick Wong James?L. Bennington Andrew?P. Smith Ling-Chun Chen Nancy?M. Lee | 2005 | Diseases of the Colon & Rectum2005，，12： | 1 |
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