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| 1 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 2 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 3 | Clinical features and radiological manifestations of COVID-19 disease显示文摘Coronavirus disease 2019(COVID-19)was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province(China).Coronavirus is a family of single-stranded RNA viruses.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted from person to person.Although asymptomatic individuals can transmit the virus,symptomatic patients are more contagious.The incubation period ranges from 3-7 d and symptoms are mainly respiratory,including pneumonia or pulmonary embolism in severe cases.Elevated serum levels of interleukins(IL)-2,IL-6,IL-7 indicate the presence of cytokine release syndrome,which is associated with disease severity.The disease has three main phases:Viral infection,pulmonary involvement,and hyperinflammation.To date,no treatment has proved to be safe or effective.Chest X-ray and computed tomography(CT)are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia,follow-up,and detection of complications.The main radiological findings are ground-glass opacification and areas of consolidation.The long-term clinical course is unknown,although some patients may develop pulmonary fibrosis.Positron emission tomography-computed tomography(PETCT)is useful to assess pulmonary involvement,to define the affected areas,and to assess treatment response.The pathophysiology and clinical course of COVID-19 infection remain poorly understood.However,patterns detected on CT and PETCT may help to diagnose and guide treatment.In this mini review,we analyze the clinical manifestations and radiological findings of COVID-19 infection. | Pedro Landete Carlos Andres Quezada Loaiza Beatriz Aldave-Orzaiz Susana Hernandez Muniz Antonio Maldonado Enrique Zamora Allan Charles Sam Cerna Elia del Cerro Raquel Cano Alonso Felipe Counago | 2020 | World Journal of Radiology2020，12，11： | 2 |
| 4 | Intelligent PV module for grid-connected PV systems 显示文摘 | Eduaro Raman Ricardo Alonso Pedro Ibanez | 2006 | IEEE2006，53，4： | 1 |
| 5 | RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy显示文摘 | Virginia Alonso-Espinaco Miriam Cuatrecasas Vicente Alonso Pilar Escudero Maribel Marmol Carlos Horndler Javier Ortego Rosa Gallego Jordi Codony-Servat Xabier Garcia-Albeniz Pedro Jares Antoni Castells Juan José Lozano Rafael Rosell Joan Maurel | 2014 | European Journal of Cancer2014，，： | 1 |
| 6 | Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients显示文摘 | Alejandro de la Sierra Josep Redon José R. Banegas Julián Segura Gianfranco Parati Manuel Gorostidi Juan J. de la Cruz Javier Sobrino José L. Llisterri Javier Alonso Ernest Vinyoles Vicente Pallarés Antonio Sarría Pedro Aranda Luis M. Ruilope | 2009 | Hypertension2009，，3： | 1 |
| 7 | Susceptibility for postmenopausal osteoporosis: interaction be- tween genetic, hormonal and lifestyle factors 显示文摘 | Pedro Mezquita-Raya Manuel Mufioz-Torres Guillermo Alonso | 2004 | Calcif Tissue Int2004，75，5： | 1 |
| 8 | Pervaporation of azeotropic mixtures ethanol/ethyl tert-butyl ether:influence of membrane conditioning and operation variables on pervaporation flux Original显示文摘 | Inmaculada Ortiz Pedro Alonso Ane Urtiaga | 2002 | Desalination2002，149，13： | 1 |
| 9 | The contribution of serum osteoprotegerin to bone mass and vertebral fractures in postmenopausal women显示文摘 | Pedro Mezquita-Raya Magdalena Higuera Diego Fernández García Guillermo Alonso María Estrella Ruiz-Requena Juan Dios Luna Fernando Escobar-Jiménez Manuel Mu?oz-Torres | 2005 | Osteoporosis International2005，，11： | 1 |
| 10 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 1 |
| 11 | Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study显示文摘 | Karen L Kotloff James P Nataro William C Blackwelder Dilruba Nasrin Tamer H Farag Sandra Panchalingam Yukun Wu Samba O Sow Dipika Sur Robert F Breiman Abu SG Faruque Anita KM Zaidi Debasish Saha Pedro L Alonso Boubou Tamboura Doh Sanogo Uma Onwuchekwa Byo | 2013 | The Lancet2013，，9888： | 1 |
| 12 | BALB/c Mice Vaccinated with Leishmania major Ribosomal Proteins Extracts Combined with CpG Oligodeoxynucleotides Become Resistant to Disease Caused by a Secondary Parasite Challenge显示文摘 | Laura Ramírez Salvador Iborra Jimena Cortés Pedro Bonay Carlos Alonso Manoel Barral-Netto Manuel Soto Jorge Morales-Montor | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 13 | Omega-3 fatty acids and blood pressure显示文摘 | Cabo Jorge Alonso Rodrigo Mata Pedro | 2012 | British Journal of Nutrition2012，，2： | 1 |
| 14 | Lipoprotein(a) levels in Familial Hipercholesterolaemia: an important predictor for cardiovascular disease independent of the type of LDL-receptor mutation显示文摘 | Rodrigo Alonso Eduardo Andres Nelva Mata Francisco Fuentes-Jiménez Lina Badimón José López-Miranda Teresa Padró Ovidio Mu?iz Jose Luis Díaz-Díaz Marta Mauri Jose María Ordovás Pedro Mata Rocío Aguado | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 15 | Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention显示文摘 | Borja Ibanez Carlos Macaya Vicente Sánchez-Brunete Gonzalo Pizarro Leticia Fernández-Friera Alonso Mateos Antonio Fernández-Ortiz José M. García-Ruiz Ana García-álvarez Andrés I?iguez Jesús Jiménez-Borreguero Pedro López-Romero Rodrigo Fernández-Jiménez J | 2013 | Circulation2013，，14： | 1 |
| 16 | Identification and Characterisation of Sources of PM10 in Madrid (Spain) by Statistical Methods显示文摘 | Pedro Salvador Begona Artinano Diana G Alonso | 2004 | Atmosphric Environment2004，38，3： | 1 |
| 17 | Identification and characterization of sources of PM10 in Madrid (Spain) by statistical methods 显示文摘 | Pedro Salvador Begona Artinano Diana G Alonso | 2004 | Atmospheric Environment2004，38，： | 1 |
| 18 | Intelligent PV moudule for grid-connected PV systems显示文摘 | Edurdo Roman Ricardo Alonso Pedro Ibanez Damian Goitia | | 0，，04： | 1 |
| 19 | Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants显示文摘 | Clara Menendez Elizeus Kahigwa Rosmarie Hirt Penelope Vounatsou John J Aponte Fidel Font Camilo J Acosta David M Schellenberg Claudia M Galindo John Kimario Honorathy Urassa Bernard Brabin Tom A Smith Andrew Y Kitua Marcel Tanner Pedro L Alonso | 1997 | The Lancet1997，，9081： | 1 |
| 20 | Development of lamellar gel phase emulsion containing baru oil(Dipteryx alata Vog.) as a prospective delivery system for cutaneous application显示文摘The rational design of emulsions requires study of the main factors that influence their formation, physicochemical properties and, consequently, stability and performance. The use of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive. Dipteryx alata Vogel(D. alata) is an oleaginous species native to Brazil. The seeds of this species contain highly unsaturated oil with significant amounts of tocopherols and phytosterols, representing an important source of agents capable of combatting oxidative processes. In this work, a lamellar gel phase emulsion using oil extracted from the seeds of D. alata(baru) was developed. The steps involved in the development of this research were as follows: 1) development of formulations and 2) in vitro assays by simulating the evaporation of the final product after application to the skin and Electron paramagnetic resonance spectroscopy(EPR) of fatty acid spin labels was used to investigate the profile of interaction of the dispersed systems with stratum corneum(SC) lipids. The results indicate that the developed system shows no signs of instability during the storage period. Moreover, EPR studies indicated that D. alata oil and especially the developed formulation were able to increase SC lipid fluidity and extract a fatty-acid spin label from the lipid domain structures of SC, demonstrating its potential to act as a drug or skin care vehicle. | Cristhianne Moraes Jorge L.V.Anjos Monica Maruno Antonio Alonso Pedro Rocha-Filho | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 0 |
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