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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 3 | A high-sensitivity H2S gas sensor based on optimized ZnO-ZnS nano-heterojunction sensing material显示文摘This paper reports a high-performance H2S gas sensing material that is made of ZnO nanowires(NWs)modified by an optimal amount of ZnS to form nano-hete rojunctions.Compared with the intrinsic ZnONWs,the three differently modified nano-heterostructure material ZnO-ZnS-x(x=5,10,15)shows significant improvement in sensing performance to H2S at the working temperatures of 100-400℃,especially in the low temperature range(<300℃).The chemiresistive sensor with ZnO-ZnS-10 sensingmaterial exhibits the largest response signal to H2S among all the other ZnO-ZnS-x(x=5,10,15,20)sensors.Its response signal to 5 ppm H2S at 150℃is about 2.7 times to that of the ZnO-NWs sensor.Besides,the ZnO-ZnS-10 sensor also features satisfactory selectivity and repeatability at 150℃.With the technical advantage attributed to the reduction of the redesigned band gap at the interface between ZnO and ZnS,the ZnO-ZnS hete ro structure sensor rather than the traditional ZnO-NWs sensor can be used for high-sensitivity application at low working temperature. | Pei Ding Dongsheng Xu Nan Dong Ying Chen Pengcheng Xu Dan Zheng Xinxin Li | 2020 | Chinese Chemical Letters2020，31，8： | 5 |
| 4 | Characteristics of Eddy Current Attenuation and Thickness Measurement of Metallic Plate显示文摘In eddy current testing, the law of attenuation of eddy current(EC) is of great concern. In conductive half space under the excitation of uniform magnetic field, the EC density decreases exponentially in the depth direction. However, in conductor with finite thickness tested by coil, the distribution of EC in the depth direction is more complicated. This paper studies the characteristics of EC attenuation in metallic plate of finite thickness. Simulation results show that there is an EC reflection at the bottom of plate, which changes the law of EC attenuation. A new concept, namely the equivalent attenuation coefficient, is proposed to quantify the speed of EC attenuation. The characteristics of EC attenuation are utilized to explain the nonmonotonic relation between coil voltage and plate thickness. Procedure of selecting frequency is discussed. Thereafter, measurement of plate thickness is carried out and accurate result is obtained. | Zhiwei Zeng Pengcheng Ding Jiayi Li Shaoni Jiao Junming Lin Yonghong Dai | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 2 |
| 5 | High performance organic transistors and phototransistors based on diketopyrrolopyrrole-quaterthiophene copolymer thin films fabricated via low-concentration solution processing显示文摘Conjugated polymers have received considerable attentions over the past years due to their large-area potential applications via low-cost solution processing.Improving crystallinity of conjugated polymer molecules in solution-processed thin films is crucial for their efficient charge transport and thus high performance optoelectronic devices.Herein,with diketopyrrolopyrrole-quaterthiophene(PDQT)copolymer as an example,it is found that by simply reducing the solution concentration for spincoating meanwhile with the assistance of post-annealing,significantly enhanced film crystallinity with formation of typical single crystalline domains is obtained,which benefits from the enough space for better molecular assembly especially at the semiconductor/dielectric interface.High performance polymer transistors and phototransistors were finally constructed based on the optimal lowconcentration(2 mg/mL)spin-coated PDQT films(12 nm),which giving a high charge carrier mobility of 2.28 cm^2V^(-1)s^(-1)and a photoresponse on/off ratio of 2.1×10~7at V_G=0 V under white light irradiation of6 mW/cm^2.The results suggest that the bright future of PDQT crystalline films for large-area flexible integrated optoelectronic devices and the application of effective low-concentration processing approach in solution-processed organic electronics with reduced material waste. | Pengcheng Gu Mengxiao Hu Shang Ding Guangyao Zhao Yifan Yao Feng Liu Xiaotao Zhang Huanli Dong Xiangke Wang Wenping Hu | 2018 | Chinese Chemical Letters2018，29，11： | 2 |
| 6 | Osteosarcoma metastasis: prospective role of ezrin显示文摘 | Yuanjin Zhang Ling Zhang Guofu Zhang Songbai Li Jun Duan Jie Cheng Guozhen Ding Chibing Zhou Jie Zhang Pengcheng Luo Dongbing Cai Lianghong Kuang Yichun Zhou Liqun Tong Xiangdong Yu Lifang Zhang Lijun Xu Li Yu Xiaomei Shi Aihong Ke | 2014 | Tumor Biology2014，，6： | 1 |
| 7 | Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer显示文摘Nucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment(TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely reduce the therapeutic efficacy. Herein, we have developed a lightcontrollable charge-reversal nanoparticle(LCCN) with controlled release of polyinosinic-polycytidylic acid [Poly(I:C)] to treat triple negative breast cancer(TNBC) by enhanced photodynamic immunotherapy. The nanoparticles keep suitably positive charge for stable loading of Poly(I:C), while rapidly reverse to negative charge after near-infrared light irradiation to release Poly(I:C). LCCN-Poly(I:C) nanoparticles trigger effective phototoxicity and immunogenic cell death on 4 T1 tumor cells, elevate antitumor immune responses and inhibit the growth of primary and abscopal 4 T1 tumors in mice. The approach provides a promising strategy for controlled release of various nucleic acid-based immune modulators, which may enhance the efficacy of photodynamic immunotherapy against TNBC. | Lei Fang Zitong Zhao Jue Wang Ping Xiao Xiangshi Sun Yaping Ding Pengcheng Zhang Dangge Wang Yaping Li | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 8 | On-line Testing Equipment of PVT Properties of Polymers Based on an Injection Molding Machine显示文摘 | Wang Jian Xie Pengcheng Ding Yumei et at | 2009 | Polymer Testing2009，28，： | 1 |
| 9 | p21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade显示文摘 | Yong Ding Yucai Wang Jun Chen Yunsheng Hu Zhuo Cao Pengcheng Ren Yong Zhang | 2014 | Tumor Biology2014，，4： | 1 |
| 10 | Ex-perimental research on geothermal heat pump system with non-azeotropic working fluids显示文摘 | ZHAO Pengcheng ZHAO Li DING Guoliang | 2002 | Applied Thermal Engineering2002，22，： | 1 |
| 11 | Prime editing-mediated precise knockin of protein tag sequences in the rice genome显示文摘Dear Editor,Accurately labeling proteins in living plant cells has long been a challenge and can be addressed by targeted insertion of tag sequences in a given locus.Recent optimized plant prime editors(PEs)enable efficient programmable installation of small insertions or deletions,including insertions of short sequences(Li et al.,2022a,2022b;Jiang et al.,2022;Xu et al.,2022;Zong et al.,2022;Zou et al.,2022).To investigate whether prime editing can be used to tag endogenous proteins in rice,we made use of the enpPE2 system described in our previous report(Li et al.,2022b). | Juan Li Jian Ding Jingyan Zhu Rongfang Xu Dongfang Gu Xiaoshuang Liu Jing Liang Chunhong Qiu Huanhuan Wang Min Li Ruiying Qin Pengcheng Wei | 2023 | Plant Communications2023，4，3： | 1 |
| 12 | ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling显示文摘ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and dystonia.ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli signaling.Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal cord.We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo.Our data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes. | Pengcheng Ma Ning-Ning Song Xiaoning Cheng Liang Zhu Qiong Zhang Long long Zhang Xiangcai Yang Huishan Wang Qinghua Kong Deli Shi Yu-Qiang Ding Bingyu Mao | 2020 | Journal of Molecular Cell Biology2020，12，5： | 1 |
| 13 | Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes显示文摘To investigate the circuit-level neural mechanisms of behavior,simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired.Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals.However,implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the equipment.Here,we present TINIscope,a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design.With its compact and lightweight design of 0.43 g,TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in mice.Proof-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions.Moreover,we explored potential multi-modal experimental designs by integrating additional modules for optogenetics,electrical stimulation or local field potential recordings.Overall,TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors. | Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang Mingzhai Sun Pak-Ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi | 2024 | National Science Review2024，11，1： | 0 |
| 14 | Constructing ultrastable electrode/electrolyte interface for rapid potassium ion storage capability via salt chemistry and interfacial engineering显示文摘Conversion/alloying anode materials exhibiting high K storage capacities suffer from large volume variations and unstable electrode/electrolyte interfaces upon cycling.Herein,taking SnS/reduced graphene oxide(SnS/rGO)anodes as an example,the electrochemical performance of SnS/rGO could significantly be improved via employing potassium bis(fluorosulfonyl)imide(KFSI)salt in electrolytes and ultrathin TiO_(2) coating.KF-rich inorganic layer was demonstrated to help form robust SEI layer,which could suppress the side reactions to increase the Coulombic efficiency.The formed potassiated K_(x)TiO_(2) coating layer was constructed to boost charge transfer capability and K-ion diffusion kinetics.The as-prepared SnS/rGO@TiO_(2)-20 electrode in KFSI electrolyte delivers the high CE of 99.1%and 424 mAh·g^(−1) after 200 cycles with an ultrahigh capacity retention of 98.5%. | Sheng Wen Xin Gu Xiangwei Ding Li Zhang Pengcheng Dai Liangjun Li Dandan Liu Wenchao Zhang Xuebo Zhao Zaiping Guo | 2022 | Nano Research2022，15，3： | 0 |
| 15 | Development of an Agrobacterium-mediated CRISPR/Cas9 system in pea(Pisum sativum L.)显示文摘Pea(Pisum sativum L.)is an annual cool-season legume crop.Owing to its role in sustainable agriculture as both a rotation and a cash crop,its global market is expanding and increased production is urgently needed.For both technical and regulatory reasons,neither conventional nor transgenic breeding techniques can keep pace with the demand for increased production.In answer to this challenge,CRISPR/Cas9 genome editing technology has been gaining traction in plant biology and crop breeding in recent years.However,there are currently no reports of the successful application of the CRISPR/Cas9 genome editing technology in pea.We developed a transient transformation system of hairy roots,mediated by Agrobacterium rhizogenes strain K599,to validate the efficiency of a CRISPR/Cas9 system.Further optimization resulted in an efficient vector,PsU6.3-tRNA-PsPDS3-en35S-PsCas9.We used this optimized CRISPR/Cas9 system to edit the pea phytoene desaturase(PsPDS)gene,causing albinism,by Agrobacterium-mediated genetic transformation.This is the first report of successful generation of gene-edited pea plants by this route. | Guan Li Rong Liu Rongfang Xu Rajeev KVarshney Hanfeng Ding Mengwei Li Xin Yan Shuxian Huang Juan Li Dong Wang Yishan Ji Chenyu Wang Junguang He Yingfeng Luo Shenghan Gao Pengcheng Wei Xuxiao Zong Tao Yang | 2023 | The Crop Journal2023，11，1： | 0 |
| 16 | Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine显示文摘Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes.However,real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored.Herein,based on the combination of scanning tunneling microscopy imaging and density functional theory modeling,we report the impact of the presence of melamine(M)on the formation and chirality of guanine(G)-tetrads on Au(111).Although M can interact with G by double hydrogen bonding,the Hoogsteen base pairing of G is not compromised,forming identical individual G-tetrads as would have happened without the presence of M.G-tetrads coexist with M on the surface not only in separate domains,but also within the mixture network of G-tetrads and M-dimers.Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles,all G-tetrads in the network keep the same chirality,emphasizing the high preference of homochirality in such biochemical systems. | Yanghan Chen Chong Chen Pengcheng Ding Guoqiang Shi Ye Sun Lev N.Kantorovich Flemming Besenbacher Miao Yu | 2020 | Nano Research2020，13，9： | 0 |
| 17 | Silicon nonlinear switch as a conditional circulator for monostatic LiDAR systems显示文摘All-optical silicon-photonics-based LiDAR systems allow for desirable features in scanning resolution and speed,as well as leverage other advantages such as size, weight, and cost. Implementing optical circulators in silicon photonics enables bidirectional use of the light path for both transmitters and receivers, which simplifies the system configuration and thereby promises low system cost. In this work, to the best of our knowledge, we present the first experimental verification of all-passive silicon photonics conditional circulators for monostatic LiDAR systems using a nonlinear switch. The proposed silicon nonlinear interferometer is realized by controlling signal power distribution with power-splitting circuits, allowing the LiDAR transmitter and receiver to share the same optical path. Unlike the traditional concept requiring a permanent magnet, the present device is implemented by using common silicon photonic waveguides and a standard foundry-compatible fabrication process. With several additional phase shifters, the demonstrated device exhibits considerable flexibility using a single chip, which can be more attractive for integration with photodetector arrays in LiDAR systems. | Mingfei Ding Yiwei Xie Hao Yan Abu Naim R.Ahmed Reza Safian Swapnajit Chakravarty Leimeng Zhuang Pengcheng Jiao Huan Li Liu Liu Daoxin Dai | 2022 | Photonics Research2022，10，2： | 0 |
| 18 | In-pile Test of Vanadium Self-powered Detector显示文摘In 2017,CARR operation studio of Division of Reactor Engineering Technology Research Division has taken on a scientific research project,in-pile test of vanadium self-powered detectors,published by Shanghai Nuclear Engineering Research&Design Institute(SNERDI).The development of vanadium self-powered detectors is a sub-item of CAP1400engineering design verification and relevant test,which is | DING Li XU Pengcheng NING Bo RAN Huaichang | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 19 | An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma显示文摘Despite exciting achievements with some malignancies,immunotherapy for hypoimmunogenic cancers,especially glioblastoma(GBM),remains a formidable clinical challenge.Poor immunogenicity and deficient immune infiltrates are two major limitations to an effective cancer-specific immune response.Herein,we propose that an injectable signal-amplifying nanocomposite/hydrogel system consisting of granulocyte-macrophage colony-stimulating factor and imiquimod-loaded antigen-capturing nanoparticles can simultaneously amplify the chemotactic signal of antigen-presenting cells and the'danger'signal of GBM.We demonstrated the feasibility of this strategy in two scenarios of GBM.In the first scenario,we showed that this simultaneous amplification system,in conjunction with local chemotherapy,enhanced both the immunogenicity and immune infiltrates in a recurrent GBM model;thus,ultimately making a cold GBM hot and suppressing postoperative relapse.Encouraged by excellent efficacy,we further exploited this signal-amplifying system to improve the efficiency of vaccine lysate in the treatment of refractory multiple GBM,a disease with limited clinical treatment options.In general,this biomaterial-based immune signal amplification system represents a unique approach to restore GBM-specific immunity and may provide a beneficial preliminary treatment for other clinically refractorymalignancies. | Qiujun Qiu Sunhui Chen Huining He Jixiang Chen Xinyi Ding Dongdong Wang Jiangang Yang Pengcheng Guo Yang Li Jisu Kim Jianyong Sheng Chao Gao Bo Yin Shihao Zheng Jianxin Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 20 | A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication显示文摘The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves.Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory,such as long-term potentiation and long-term depression.In this study,we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types,cell lineage and molecular features.Using the transcriptomes of 105057 nuclei from the hippocampus of a Beagle dog,we identified 26 cell clusters and a putative trajectory of oligodendrocyte development.Comparative analysis revealed a significant convergence between dog differentially expressed genes(DEGs)and putative positively selected genes(PSGs).Forty putative PSGs were DEGs in glutamatergic neurons,especially in Cluster 14,which is related to the regulation of nervous system development.In summary,this study provides a blueprint to understand the cellular mechanism of dog domestication. | Qi-Jun Zhou Xingyan Liu Longlong Zhang Rong Wang Tingting Yin Xiaolu Li Guimei Li Yuqi He Zhaoli Ding Pengcheng Ma Shi-Zhi Wang Bingyu Mao Shihua Zhang Guo-Dong Wang | 2022 | National Science Review2022，9，11： | 0 |
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