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| 1 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 2 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 3 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，： | 2 |
| 4 | Hydrogen sulphide regulates intra- cellular pH in vascular smooth muscle cells显示文摘 | Shiau Wei Lee Yvonne Cheng Philip K Moore | 2007 | Biochem Biophys Res Commun2007，358，4： | 1 |
| 5 | Antidepressants and Anticonvulsants for Diabetic Neuropathy and Postherpetic Neuralgia显示文摘 | Sally L Collins R.Andrew Moore Henry J McQuay Philip Wiffen | 2000 | Journal of Pain and Symptom Management2000，，6： | 1 |
| 6 | Fatigue,sleep restriction and driving performance显示文摘 | Pierre Philip Patricia Sagaspe Nicholas Moore ect | 2005 | Accident Analysis and Prevertion2005，37，2005： | 1 |
| 7 | GPS applications in power systems Part 1 Introduction to GPS 显示文摘 | Philip Moore Peter Crossley | 2001 | Power Engineering Journal2001，13，1： | 1 |
| 8 | A practical control strategy for servo-pneumatic actuator systems显示文摘 | Jihong Wang Junsheng Pu Philip Moore | 1999 | Control Engineering Practice1999，，7： | 1 |
| 9 | Traditional and Modern Technology Assessment: Toward a Tool kit 显示文摘 | Jan Van Den Ende Karel Mulder Marjolijin Knot Ellen Moors Philip Vergaragt | 1998 | Technological Forecasting and Social Change1998，58，： | 1 |
| 10 | 显示文摘 | Philip L H Barry L J Gary O M Paul L A Jon M Moore | 1999 | Journal of Power Sources1999，80，： | 1 |
| 11 | Hydrogen sulfide:a novel mediator inflam- mation显示文摘 | Li Ling Madhav Bhatia Philip K Moore | 2006 | Curr Opin Pharmacol2006，6，2： | 1 |
| 12 | Traditional and Modern Technology Assessment:Toward a Toolkit 显示文摘 | Jan Van Den Ende Karel Mulder Marjolijn Knot Ellen Moors Philip Vergragt | 1998 | Technological Forecasting and Social Change1998，，58： | 1 |
| 13 | Integrating diverse methods to understand climate–land interactions in East Africa显示文摘 | Jennifer M. Olson Gopal Alagarswamy Jeffrey A. Andresen David J. Campbell Amelie Y. Davis Jianjun Ge Marianne Huebner Brent M. Lofgren David P. Lusch Nathan J. Moore Bryan C. Pijanowski Jiaguo Qi Philip K. Thornton Nathan M. Torbick Jing Wang | 2007 | Geoforum2007，，： | 1 |
| 14 | Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation显示文摘 | Rajamanickam Baskar Anna Sparatore Piero Del Soldato Philip Keith Moore | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 15 | Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction—a pilot study显示文摘 | Balasubramanian Srilatha P. Ganesan Adaikan Philip K. Moore | 2006 | European Journal of Pharmacology2006，，1： | 1 |
| 16 | Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats显示文摘 | Balasubramanian Srilatha Paulpandi Muthulakshmi P. Ganesan Adaikan Philip K. Moore | 2012 | The Aging Male2012，，3： | 1 |
| 17 | Adequacy of 1-cm Distal Margin After Restorative Rectal Cancer Resection With Sharp Mesorectal Excision and Preoperative Combined-Modality Therapy显示文摘 | Harvey G. Moore Elyn Riedel Bruce D. Minsky Leonard Saltz Philip Paty Douglas Wong Alfred M. Cohen Jose G. Guillem | 2003 | Annals of Surgical Oncology2003，，1： | 1 |
| 18 | Luck in the Vocabulary of Motives of Professional Ice Hockey 显示文摘 | Philip Moore | 2006 | Anthropological Note- hooks2006，12，2： | 1 |
| 19 | Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia显示文摘 | Sagiraju Sowmya Yada Swathi Ai Ling Yeo Mei Leng Shoon Philip Keith Moore Madhav Bhatia | 2010 | Vascular Pharmacology2010，，3： | 1 |
| 20 | Rate of Pathologic Complete Response With Increased Interval Between Preoperative Combined Modality Therapy and Rectal Cancer Resection显示文摘 | Harvey G. Moore M.D. Alicia E. Gittleman M.D. Bruce D. Minsky M.D. Douglas Wong M.D. Philip B. Paty M.D. Martin Weiser M.D. Larissa Temple M.D. Leonard Saltz M.D. Jinru Shia M.D. Jose G. Guillem M.D. M.P.H | 2004 | Diseases of the Colon & Rectum2004，，3： | 1 |
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