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| 1 | Massive cranium from Harbin in northeastern China establishes a new Middle Pleistocene human lineage显示文摘It has recently become clear that several human lineages coexisted with Homo sapiens during the late Middle and Late Pleistocene.Here,we report an archaic human fossil that throws new light on debates concerning the diversification of the Homo genus and the origin of H.sapiens.The fossil was recovered in Harbin city in northeastern China,with a minimum uranium-series age of 146 ka.This cranium is one of the best preserved Middle Pleistocene human fossils.Its massive size,with a large cranial capacity(1,420 mL)falling in the range of modern humans,is combined with a mosaic of primitive and derived characters.It differs from all the other named Homo species by presenting a combination of features,such as long and low cranial vault,a wide and low face,large and almost square orbits,gently curved but massively developed supraorbital torus,flat and low cheekbones with a shallow canine fossa,and a shallow palate with thick alveolar bone supporting very large molars.The excellent preservation of the Harbin cranium advances our understanding of several less-complete late Middle Pleistocene fossils from China,which have been interpreted as local evolutionary intermediates between the earlier species Homo erectus and later H.sapiens.Phylogenetic analyses based on parsimony criteria and Bayesian tip-dating suggest that the Harbin cranium and some other Middle Pleistocene human fossils from China,such as those from Dali and Xiahe,form a third East Asian lineage,which is a part of the sister group of the H.sapiens lineage.Our analyses of such morphologically distinctive archaic human lineages from Asia,Europe,and Africa suggest that the diversification of the Homo genus may have had a much deeper timescale than previously presumed.Sympatric isolation of small populations combined with stochastic long-distance dispersals is the best fitting biogeographical model for interpreting the evolution of the Homo genus. | Xijun Ni Qiang Ji Wensheng Wu Qingfeng Shao Yannan Ji Chi Zhang Lei Liang Junyi Ge Zhen Guo Jinhua Li Qiang Li Rainer Grun Chris Stringer | 2021 | The Innovation2021，2，3： | 6 |
| 2 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 3 | Geochemical provenancing and direct dating of the Harbin archaic human cranium显示文摘As one of the most complete archaic human fossils,the Harbin cranium provides critical evidence for studying the diversification of the Homo genus and the origin of Homo sapiens.However,the unsystematic recovery of this cranium and a long and confused history since the discovery impede its accurate dating.Here,we carried out a series of geochemical analyses,including non-destructive X-ray fluorescence(XRF),rare earth elements(REE),and the Sr isotopes,to test the reported provenance of the Harbin cranium and get better stratigraphic constraints.The results show that the Harbin cranium has very similar XRF element distribution patterns,REE concentration patterns,and Sr isotopic compositions to those of the Middle Pleistocene-Holocene mammalian and human fossils recently recovered from the Harbin area.The sediments adhered in the nasal cavity of the Harbin cranium have a 87Sr/86Sr ratio of 0.711898,falling in the variation range measured in a core drilled near the Dongjiang Bridge,where the cranium was discovered during its reconstruction.The regional stratigraphic correlations indicate that the Harbin cranium was probably from the upper part of the Upper Huangshan Formation of the Harbin area,which has an optically stimulated luminescence dating constraint between 138 and 309 ka.U-series disequilibrium dating(n=10)directly on the cranium suggests that the cranium is older than 146 ka.The multiple lines of evidence from our experiments consistently support the theory that the Harbin cranium is from the late Middle Pleistocene of the Harbin area.Our study also shows that geochemical approaches can provide reliable evidence for locating and dating unsystematically recovered human fossils,and potentially can be applied to other human fossils without clear provenance and stratigraphy records. | Qingfeng Shao Junyi Ge Qiang Ji Jinhua Li Wensheng Wu Yannan Ji Tao Zhan Chi Zhang Qiang Li Rainer Grun Chris Stringer Xijun Ni | 2021 | The Innovation2021，2，3： | 3 |
| 4 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 5 | Efficient array & pointer bound checking against buffer overflow at- tacks via hardware/software显示文摘 | Shao Zili Xue Chun Zhuge Qingfeng | 2005 | Information Technology Coding and Computing2005，32，1： | 1 |
| 6 | Efficient assignment and scheduling for heterogeneous DSP systerns 显示文摘 | SHAO Zili ZHUGE Qingfeng SHA E H M | 2008 | IEEE Transactions on Parallel and Distributed Sys tems2008，16，6： | 1 |
| 7 | Ice-volume and insolation influences on hydroclimate changes in central eastern China during the antepenultimate glacial period显示文摘The rainfall changes in East Asian summer monsoon(EASM)regions on the orbital timescale remain controversial due to the lack of reliable rainfall records.Here,we present new multiproxy records(δ^(18)O,δ^(13)C,Sr/Ca and Mg/Ca)of a230Thdated stalagmite from Hulu Cave in central eastern China.Multiproxy records reconstruct a regional hydroclimate history from 340 to 261 kyr BP(thousand years before present),approximately covering the antepenultimate glacial period.Theδ^(18)O record is dominated by the precessional cycles,suggesting that EASM responds to changes in Northern Hemisphere summer insolation(NHSI)on the orbital timescale.Significant correlations amongst theδ^(13)C,Sr/Ca and Mg/Ca suggest that a common factor,i.e.,the local hydrological cycle,controlled their variability,and their leading principal component can be used as a proxy linked to regional rainfall.This composite record bears a good similarity to those from the Chinese Loess Plateau,showing a gradually decreasing rainfall during the antepenultimate glacial period,consistent with changes in global ice volume.Superimposed on the long-term trend,three relative wetter intervals were responding to the higher NHSI periods,suggesting that EASM rainfall variability was induced by integrated effects of global ice volume and NHSI.The increased ice sheets and lower NHSI resulted in an increased meridional temperature gradient and southward shift of the westerlies,which shortened the duration of Meiyu and midsummer rainfall.The differences between the rainfall record and the stalagmiteδ^(18)O record indicate that the latter represents the overall EASM intensity linked to monsoon circulation,but does not directly reflect the rainfall changes at the cave sites. | Quan WANG Shayue YUAN Yijia LIANG Kan ZHAO Qingfeng SHAO Zhenqiu ZHANG Junji ZHU Xinggong KONG Yongjin WANG Jianghu LAN Hai CHENG Chengwei XIA Yi LI | 2023 | Science China Earth Sciences2023，66，1： | 0 |
| 8 | Elementary discussion on construction technology of foundation treatment for water conservancy and hydropower projects显示文摘Human life is inseparable from water resources,and human development is inseparable from electric energy.Water conservancy and hydropower project plays a very important role in all stages of human development,whether it is power generation,irrigation,flood control or drainage,which can not be separated from the construction of water and hydropower projects.This paper briefly discusses and analyzes the basic treatment construction techniques for water conservancy and hydropower projects,giving full play to the key role of water conservancy and hydropower projects in the development of national economy. | Linjun Shao Qingfeng Wang Guiyun Qin Rongqiang Liu | 2018 | Smart Construction Research2018，2，1： | 0 |
| 9 | LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation显示文摘Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer. | Xiao Fan Fangzhou Liu Xiang Wang Ying Wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng Yan Jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 10 | Elementary discussion on construction technology of foundation treatment for water conservancy and hydropower projects显示文摘Human life is inseparable from water resources,and human development is inseparable from electric energy.Water conservancy and hydropower project plays a very important role in all stages of human development,whether it is power generation,irrigation,flood control or drainage,which can not be separated from the construction of water and hydropower projects.This paper briefly discusses and analyzes the basic treatment construction techniques for water conservancy and hydropower projects,giving full play to the key role of water conservancy and hydropower projects in the development of national economy. | Linjun Shao Qingfeng Wang Guiyun Qin Rongqiang Liu | 2018 | Smart Construction Research2018，2，3： | 0 |
| 11 | iHypoxia:An Integrative Database of Protein Expression Dynamics in Response to Hypoxia in Animals显示文摘Mammals have evolved mechanisms to sense hypoxia and induce hypoxic responses.Recently,high-throughput techniques have greatly promoted global studies of protein expression changes during hypoxia and the identification of candidate genes associated with hypoxiaadaptive evolution,which have contributed to the understanding of the complex regulatory networks of hypoxia.In this study,we developed an integrated resource for the expression dynamics of proteins in response to hypoxia(iHypoxia),and this database contains 2589 expression events of 1944 proteins identified by low-throughput experiments(LTEs)and 422,553 quantitative expression events of 33,559 proteins identified by high-throughput experiments from five mammals that exhibit a response to hypoxia.Various experimental details,such as the hypoxic experimental conditions,expression patterns,and sample types,were carefully collected and integrated.Furthermore,8788 candidate genes from diverse species inhabiting low-oxygen environments were also integrated.In addition,we conducted an orthologous search and computationally identified 394,141 proteins that may respond to hypoxia among 48 animals.An enrichment analysis of human proteins identified from LTEs shows that these proteins are enriched in certain drug targets and cancer genes.Annotation of known posttranslational modification(PTM)sites in the proteins identified by LTEs reveals that these proteins undergo extensive PTMs,particularly phosphorylation,ubiquitination,and acetylation.iHypoxia provides a convenient and user-friendly method for users to obtain hypoxia-related information of interest. | Ze-Xian Liu Panqin Wang Qingfeng Zhang Shihua Li Yuxin Zhang Yutong Guo Chongchong Jia Tian Shao Lin Li Han Cheng Zhenlong Wang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
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