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| 1 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 2 | Extraordinary simultaneous enhancement of the coercivity and remanence of dual alloy HRE-free Nd-Fe-B sintered magnets by post-sinter annealing显示文摘Post-sinter annealing process plays an important role in the microstructures and magnetic properties of the Nd-Fe-B sintered magnets.In this paper,systematically investigated are the magnetic properties and microstructures of the as-sintered and post-sinter annealed Nd-Fe-B magnets with Pr-Fe-Ga boundary addition.Two choice consecutive annealing methods are adopted at high and low temperatures,namely the 1 st annealing at 880℃ for 2 h and then the 2^(nd) annealing at 440℃ for 3 h.It is exceptional to find out that both the remanence and coercivity are improved after 2^(nd) annealing process for this type of magnet.The coercivity is hugely increased from 10.09 kOe for the as-sintered sample to 17.19 kOe for the 2^(nd) annealed magnet,with a significant increment of 70.37%in coercivity.The extraordinary magnetic properties of B_(r)=14.44 kGs,H_(cj)=17.19 kOe and(BH)_(max)=51.08 MGOe are obtained for the designated Nd-Fe-B sintered magnets without heavy rare earth(HRE)elements manufactured by dual alloy method.The Curie temperature is monotonically decreased from 634 K to 602 K while the c-axis alignment degree is optimized after annealing.Microstructural observation and analysis indicate that the elemental distribution patterns are altered after the 2^(nd) annealing.The diffusion of the aggregate(Pr,Nd,Cu,Ga)-rich phase from triple junctions into the grain boundary regions is ascribed to the formation of thin and continuous grain boundary layer,which is critical to improve the microstructures and magnetic properties. | Qingfang Huang Qingzheng Jiang Jifan Hu Sajjad Ur Rehman Gang Fu Qichen Quan Jixiang Huang Deqin Xu Dakun Chen Zhenchen Zhong | 2022 | Journal of Materials Science & Technology2022，，11： | 3 |
| 3 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 4 | Tissue inhibitor of metalloproteinase-1 counteracts glucolipotoxicity in the pancreatic β-cell line INS-1显示文摘背景 Glucolipotoxicity 可能在 metalloproteinase-1 ( TIMP-1 )的 2 diabetes.Tissue 禁止者禁止的联系肥胖的类型的发展期间在房间补偿不全阶段起一个重要作用矩阵 metalloproteinase ( MMP )活动并且调整许多房间类型的增长和 apoptosis ,包括胰腺的 -cells.In 现在的学习,我们调查了 TIMP-1 是否在胰腺的房间线 INS-1.Methods INS-1 房间抵抗 glucolipotoxicity 在正常 o | JIANG Hong-wei ZHU Han-yu WANG Jian-zhong FU Bo LU Yang HONG Quan XIE Yuan-sheng CHEN Xiang-mei | 2011 | Chinese Medical Journal2011，，2： | 2 |
| 5 | High-speed optical secure communication with an external noise source and an internal time-delayed feedback loop显示文摘We propose and experimentally demonstrate a novel physical layer encryption scheme for high-speed optical communication. A 10 Gb/s on-off keying signal is secretly transmitted over 100 km standard single-mode fiber.The intensity-modulated message is secured by the encryption mechanism, which is composed of an external noise source and an internal time-delayed feedback loop. The external noise serves as an entropy source with sufficient randomness. The feedback loop structure in the transmitter introduces a time-domain encryption key space, and a corresponding open-loop configuration at the receiver side is used for synchronization and decryption.Experiment results show the effectiveness of the proposed scheme. For a legitimate terminal, bit error rate below10-8 can be obtained. Decryption degradations with the mismatch of different hardware parameters are researched. The time delay in the feedback loop provides a sensitive encryption key. For other hardware parameters,the system is robust enough for synchronization. Meanwhile, the time-delay signature of the loop is able to be well concealed by the external noise. Moreover, the proposed scheme can support density wavelength division multiplexing transmission with a relatively simple structure. This work also provides a new concept to establish optical secure communication by combining a time-delayed feedback chaotic system and random noise. | YUDI FU MENGFAN CHENG XINGXING JIANG QUAN YU LINBOJIE HUANG LEI DENG DEMING LIU | 2019 | Photonics Research2019，7，11： | 2 |
| 6 | Increased CD34 + CD38 ? CD123 + cells in myelodysplastic syndrome displaying malignant features similar to those in AML显示文摘 | Li Juan Li Jing Lian Tao Rong Fu Hua Quan Wang Hui Juan Jiang Lan Zhu Yue Wei Zhang Hui Liu Zong Hong Shao | 2014 | International Journal of Hematology2014，，1： | 1 |
| 7 | Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK ‐dependent autophagy显示文摘 | Teng Jiang Jin‐Tai Yu Xi‐Chen Zhu Hui‐Fu Wang Meng‐Shan Tan Lei Cao Qiao‐Quan Zhang Li Gao Jian‐Quan Shi Ying‐Dong Zhang Lan Tan | 2014 | Br J Pharmacol2014，，13： | 1 |
| 8 | MicroRNA‐125b attenuates epithelial‐mesenchymal transitions and targets stem‐like liver cancer cells through small mothers against decapentaplegic 2 and 4显示文摘 | Jun‐Nian Zhou Quan Zeng Hai‐Yang Wang Biao Zhang Si‐Ting Li Xue Nan Ning Cao Chun‐Jiang Fu Xin‐Long Yan Ya‐Li Jia Jing‐Xue Wang Ai‐Hua Zhao Zhi‐Wei Li Yan‐Hua Li Xiao‐Yan Xie Xiao‐Mei Zhang Yan Dong Ying‐Chen Xu Li‐Juan He Wen Yue Xue‐Tao Pei | 2015 | Hepatology2015，，3： | 1 |
| 9 | Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26<ce:hsp sp='0.25'/>kDa GST plasmid DNA vaccine in mice显示文摘 | Feng Wei Quan Liu Shengyan Gao Limin Shang Yujia Zhai Jingtao Men Li Jiang Xing-Quan Zhu Zhiqiang Fu Yaojun Shi Zhiping Xia Jiaojiao Lin | 2008 | Vaccine2008，，33： | 1 |
| 10 | Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A2 Activating Protein显示文摘Ubiquitin (Ub) is an essential modifier conserved in all eukaryotes from yeast to human. Phospholipase A2 activating protein (PLAA), a mammalian homolog of yeast DOA1/UFD3, | Qing-Shan Fu #$ , Chen-Jie Zhou # , Hong-Chang Gao % , Ya-Jun Jiang #$ , Zi-Ren Zhou #$ , Jing Hong % , Wen-Ming Yao % , Ai-Xin Song # , Dong-Hai Lin %1 , and Hong-Yu Hu #1 # State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 China % Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China $ Graduate School of the Chinese Academy of Sciences, 19A Yu Quan Road, Beijing 100039, China | 2009 | 生物物理学报2009，25，S1： | 0 |
| 11 | Synthesis and preliminary biological evaluation of a technetium-99m labeled thymidine analog显示文摘The synthesis and labeling of ^(99m)Tc-N^3-(N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (^(99m)Tc-NHT) were studied.In the presence of sodium glucoheptonate(GH) and ethylene diamine tetraacetic acid(EDTA),^(99m)Tc-NHT was obtained by using bisaminoethanethiol(N_2S_2) as a bifunctional coupling agent.The radiochemical purity of the ^(99m)Tc-NHT was over 95%.Biodistribution of ^(99m)Tc-NHT was performed in hepatoma HepA tumor-bearing mice.At 2 h p.i.,the ratios of tumor-to-muscle,tumor-to-bone and tumor-to-blood were 4.41±0.32,2.45±0.24 and 1.51±0.18,respectively. | Chun Xiong Lu Zheng Wu Wang Quan Fu Jiang Jie Tang Cheng Tan Jian Kang-Zhang | 2011 | Chinese Chemical Letters2011，22，11： | 0 |
| 12 | Research status and development directions of intelligent drilling fluid technologies显示文摘By reviewing the current status of drilling fluid technologies with primary intelligence features at home and abroad,the development background and intelligent response mechanisms of drilling fluid technologies such as variable density,salt response,reversible emulsification,constant rheology,shape memory loss prevention and plugging,intelligent reservoir protection and in-situ rheology control are elaborated,current issues and future challenges are analyzed,and it is pointed out that intelligent material science,nanoscience and artificial intelligence theory are important methods for future research of intelligent drilling fluid technology of horizontal wells with more advanced intelligent features of'self-identification,self-tuning and self-adaptation'.Based on the aforementioned outline and integrated with the demands from the drilling fluid technology and intelligent drilling fluid theory,three development suggestions are put forward:(1)research and develop intelligent drilling fluids responding to variable formation pressure,variable formation lithology and fluid,variable reservoir characteristics,high temperature formation and complex ground environmental protection needs;(2)establish an expert system for intelligent drilling fluid design and management;and(3)establish a real-time intelligent check and maintenance processing network. | JIANG Guancheng DONG Tengfei CUI Kaixiao HE Yinbo QUAN Xiaohu YANG Lili FU Yue | 2022 | Petroleum Exploration and Development2022，49，3： | 0 |
| 13 | Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study显示文摘Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been limited.Objective:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,2020.Methods:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical records.Results:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were men.Hypertension(45.1%)was the most common comorbidity,while 59(36.4%)patients had no comorbidity.At admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate COVID-19.In total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical ventilation.Most patients received mechanical ventilation before ICU admission.Approximately 93.2%of the patients developed respiratory failure or acute respiratory distress syndrome.There were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal outcomes.The in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan. | Xianlong Zhou Guoyong Ding Qing Fang Jun Guo Luyu Yang Ping Wang Shou-Zhi Fu Ang Li Jian Xia Jiangtao Yu Jianyou Xia Min Ma Zhuanzhuan Hu Lei Huang Ruining Liu Cheng Jiang Shaoping Li Mingxia Yu Xizhu Xu Yan Zhao Quan Hu Weijia Xing Zhigang Zhao | 2022 | Emergency and Critical Care Medicine2022，2，3： | 0 |
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