|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Boschniakia rossica on expression of GSTP,p53 and p21^(ras)proteins in early stage of chemical hepatocarcinogenesis and its anti-inflammatory activities in rats显示文摘AIM To investigate the effect of Boschniakiarossica(BR)extract on expression of GST-P,p53 and p21rasproteins in early stage of chemicalhepatocarcinogenesis in rats and its anti-inflammatory activities.METHODS The expression of tumor marker-placental form glutathione S-transferase(GST-P),p53 and p21rasproteins were investigated byimmunohistochemical techniques and ABCmethod.Anti-inflammatory activities of BR werestudied by xylene and croton oil-induced mouseear edema,carrageenin,histamine and hotscald-induced rat pow edema,adjuvant-inducedrat arthritis and cotton pellet-induced mousegranuloma formation methods.RESULTS The 500 mg/kg of BR-H2O extractfractionated from BR-Methanol extract hadinhibitory effect on the formation of DEN-inducedGST-P-positive foci in rat liver(GST-P stainingwas 78% positive in DEN+AAF group vs 20%positive in DEN+AAF+BR group,P<0.05)andthe expression of mutant p53 and p21rasproteinwas lower than that of hepatic preneoplasticlesions(33% and 22% positive respectively inDEN+AAF group vs negative in DEN+AAF+BRgroup).Both CH2Cl2 and H2O extracts from BRhad anti-inflamatory effect in xylene and crotonoil-induced mouse ear edema(inhibitory rateswere 26%-29% and 35%-59%,respectively). BR-H2O extract exhibited inhibitory effect incarrageenin,histamine and hot scald-inducedhind paw edema and adjuvant-induced arthritis inrats and cotton pellet-induced granulomaformation in mice.CONCLUSION BR extract exhibited inhibitory effect on formation of preneoplastic hepatic foci in early stage of rat chemical hepato-carcinogenesis. Both CH2CI2 and H2O extracts from BR exerted anti-inflammatory effect in rats and mice. | Zong Zhu Yin Hai Ling Jin Xue Zhe Yin Tian Zhu Li Ji Shu Quan Zeng Nan Jin Institute for Cancer Research,Yanbian University College of Medicine,Yanji 133000,Jilin Province,China | 2000 | World Journal of Gastroenterology2000，6，6： | 33 |
| 2 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 3 | Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis显示文摘There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. | Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou | 2018 | Bone Research2018，6，4： | 13 |
| 4 | Recent progress in engineering near-infrared persistent luminescence nanoprobes for time-resolved biosensing/bioimaging显示文摘Persistent luminescence nanoprobes (PLNPs) can remain luminescent after ceasing excitation.Due to the ultra-long decay time of persistent luminescence (PersL),autofluorescence interference can be efficiently eliminated by collecting PersL signal after autofluorescence decays completely,thus the imaging contrast and sensing sensitivity can be significantly improved.Since near-infrared (NIR) light shows reduced scattering and absorption coefficient in penetrating biological organs or tissues,near-infrared persistent luminescence nanoprobes (NIR PLNPs) possess deep tissue penetration and offer a bright prospect in the areas of in vivo biosensing/bioimaging.In this review,we firstly summarize the design of different types of NIR PLNPs for biosensing/bioimaging,such as transition metal ions-doped NIR PLNPs,lanthanide ions-doped NIR PLNPs,organic molecules-based NIR PLNPs,and semiconducting polymer self-assembled NIR PLNPs.Notably,organic molecules-based NIR PLNPs and semiconductor self-assembled NIR PLNPs,for the first time,were introduced to the review of PLNPs.Secondly,the effects of different types of charge carriers on NIR PersL and luminescence decay of NIR PLNPs are significantly emphasized so as to build up an in-depth understanding of their luminescence mechanism.It includes the regulation of valence band and conduction band of different host materials,alteration of defect types,depth and concentration changes caused by ion doping,effective radiation transitions and energy transfer generated by different luminescence centers.Given the design and potential of NIR PLNPs as long-lived luminescent materials,the current challenges and future perspective in this rapidly growing field are also discussed. | Ling Liang Na Chen Yiyi Jia Qinqin Ma Jie Wang Quan Yuan Weihong Tan | 2019 | Nano Research2019，12，6： | 11 |
| 5 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 6 | LncRNA HOTAIR mediates TGF-β2-induced cell growth and epithelial-mesenchymal transition in human lens epithelial cells显示文摘 | Zhilin Zhang Huirong Zhu Yan Liu Fu Quan Xibo Zhang Ling Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 10 |
| 7 | Liquid crystal-templated chiral nanomaterials: from chiral plasmonics to circularly polarized luminescence显示文摘Chiral nanomaterials with intrinsic chirality or spatial asymmetry at the nanoscale are currently in the limelight of both fundamental research and diverse important technological applications due to their unprecedented physicochemical characteristics such as intense light-matter interactions, enhanced circular dichroism, and strong circularly polarized luminescence. Herein, we provide a comprehensive overview of the state-of-the-art advances in liquid crystal-templated chiral nanomaterials. The chiroptical properties of chiral nanomaterials are touched, and their fundamental design principles and bottom-up synthesis strategies are discussed. Different chiral functional nanomaterials based on liquid-crystalline soft templates, including chiral plasmonic nanomaterials and chiral luminescent nanomaterials, are systematically introduced, and their underlying mechanisms, properties, and potential applications are emphasized. This review concludes with a perspective on the emerging applications, challenges, and future opportunities of such fascinating chiral nanomaterials. This review can not only deepen our understanding of the fundamentals of soft-matter chirality, but also shine light on the development of advanced chiral functional nanomaterials toward their versatile applications in optics, biology, catalysis, electronics, and beyond. | Xuan Zhang Yiyi Xu Cristian Valenzuela Xinfang Zhang Ling Wang Wei Feng Quan Li | 2022 | Light(Science & Applications)2022，11，8： | 6 |
| 8 | Red/orange dual-emissive carbon dots for pH sensing and cell imaging显示文摘The dual-emissive N,S co-doped carbon dots (N,S-CDs) with a long emission wavelength were synthesized via solvothermal method.The N,S-CDs possess relatively high photoluminescence (PL) quantum yield (QY) (35.7%) towards near-infrared fluorescent peak up to 648 nm.With the advanced characterization techniques including X-ray photoelectron spectroscopy (XPS),Fourier transform infrared spectroscopy (FTIR),etc.It is found that the doped N,S elements play an important role in the formation of high QY CDs.The N,S-CDs exist distinct pH-sensitive feature with reversible fluorescence in a good linear relationship with pH values in the range of 1.0-13.0.What is more,N,S-CDs can be used as an ultrasensitive Ag+ probe sensor with the resolution up to 0.4 μM.This finding will expand the application of as prepared N,S-CDs in sensing and environmental fields. | Miaoran Zhang Rigu Su Jian Zhong Ling Fei Wei Cai Qingwen Guan Weijun Li Neng Li Yusheng Chen Lulu Cai Quan Xu | 2019 | Nano Research2019，12，4： | 6 |
| 9 | Stochastic stability of quasi-integrable Hamiltonian systems with time delay by using Lyapunov function method显示文摘The asymptotic Lyapunov stability of one quasi-integrable Hamiltonian system with time-delayed feedback control is studied by using Lyapunov functions and stochastic averaging method.First,a quasi-integrable Hamiltonian system with time-delayed feedback control subjected to Gaussian white noise excitation is approximated by a quasi-integrable Hamiltonian system without time delay.Then,stochastic averaging method for quasi-integrable Hamiltonian system is used to reduce the dimension of the original system,and after that the Lyapunov function of the averaged It equation is taken as the optimal linear combination of the corresponding independent first integrals in involution.Finally,the stability of the system is determined by using the largest eigenvalue of the linearized system.Two examples are used to illustrate the proposed procedure and the effects of delayed time on the Lyapunov stability are discussed as well. | LING Quan 1,JIN XiaoLing 1 &HUANG ZhiLong 2 1 Department of Mechanics,Zhejiang University,Hangzhou 310027,China 2 State Key Laboratory of Fluid Power Transmission and Control,Zhejiang University,Hangzhou 310027,China | 2010 | Science China(Technological Sciences)2010，53，3： | 5 |
| 10 | Cytokine?induced killer cell therapy for advanced pancreatic adenocarcinoma:A case report and review of the literature显示文摘 | Wei Li Lin Xu Ling Zhao Li Wang Yong Zhang Quan Gao Ling Mai | 2013 | Oncology Letters2013，，4： | 4 |
| 11 | Premature atherosclerosis in patients with acquired immunodeficiency syndrome显示文摘背景动脉粥样硬化的增加的风险与自从高度活跃的 antiretroviral 治疗(HAART ) ,病毒(HIV ) 感染进入了的人的免疫不全在病人被报导了使用。然而,没有在中国感染 HIV 的病人的早熟的动脉粥样硬化的清楚的证据。我们的学习被设计在中国感染 HIV 的 patients.Methods 决定在 HIV 感染和动脉粥样硬化之间的关系 145 个病人在这研究被注册。这些包括了 82 个感染 HIV 的病人(41HAART 对待和 41 antiretroviral 治疗(艺术) 天真的病人) 并且 43 个 HIV 否定的控制题目。传统的心血管的风险因素, HIV 感染参数,和治疗政体上的数据是镇定的。脉搏波浪速度(PWV ) 用一个脉搏压力分析器被决定作为动脉粥样硬化患者的指示物评估动脉的墙的功能脉管的 damage.Results A 更高的 PWV ((1358. | ZENG Yong YE Yi-cong LUO Ling QIU Zhi-feng HAN Yang LI Xiao-meng FANG Quan ZHANG Shu-yang LI Tai-sheng | 2010 | Chinese Medical Journal2010，，23： | 4 |
| 12 | MEF2C promotes M1 macrophage polarization and Th1 responses显示文摘The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammation and host defense;however,the underlying molecular mechanism remains unclear.Here,we show that myocyte enhancer factor 2 C(MEF2C)is essential for regulating M1 macrophage polarization in response to infection and inflammation.Global gene expression analysis demonstrated that MEF2C deficiency in macrophages downregulated the expression of M1 phenotypic markers and upregulated the expression of M2 phenotypic markers.MEF2C significantly promoted the expression of interleukin-12 p35 subunit(Il12a)and interleukin-12 p40 subunit(Il12b).Myeloid-specific Mef2c-knockout mice showed reduced IL-12 production and impaired Th1 responses,which led to susceptibility to Listeria monocytogenes infection and protected against DSS-induced IBD in vivo.Mechanistically,we showed that MEF2C directly activated the transcription of Il12a and Il12b.These findings reveal a new function of MEF2C in macrophage polarization and Th1 responses and identify MEF2C as a potential target for therapeutic intervention in inflammatory and autoimmune diseases. | Xibao Zhao Qianqian Di Han Liu Jiazheng Quan Jing Ling Zizhao Zhao Yue Xiao Han Wu Zherui Wu Wengang Song Huazhang An Weilin Chen | 2022 | Cellular & Molecular Immunology2022，19，4： | 4 |
| 13 | Impact of diabetes on the prognosis of hip fracture: a cohort study in the Chinese population显示文摘 | WANG Hong LV Yan-wei LAN Ling ZHANG Quan CHEN Hai-ling ZHANG Guo-ying DENG Li-li LI Ju-fen | 2013 | Chinese Medical Journal2013，，5： | 4 |
| 14 | Cytotoxicity of lambda-cyhalothrin on the macrophage cell line RAW 264.7显示文摘The wide use and wide-spectrum toxicity of synthetic pyrethroids (SPs) insecticides make them an emerging ecotoxicological concern. Some previous studies showed that SPs possessed cytotoxicity in some immune cells such as human lymphocytes and rat bone marrow. However, the cytotoxicity of SPs to macrophages, which are crucial to innate immunity, has not been explored. In the present report, we investigated a new pyrethroid insecticide, lambda-cyhalothrin (LCT), which may increase the generation of reactive oxygen species (ROS) and DNA damage levels and cause cytotoxicity in RAW 264.7 cells in dose- and time-dependent manners. The results for the first time implicated increased endogenous ROS and DNA damage as co-mediators of LCT-induced cytotoxicity in macrophages. Our results also suggested that macrophages were involved in synthetic pyrethroid-induced adverse immune effects. Considering the ubiquitous environmental presence of SPs, this study provided new information relative to the potential long-term physiological and immunological effects associated with chronic exposure to SPs. Hence, the potential immunotoxicity of SPs should be considered in assessing the safety of these compounds in sensitive environmental compartments. | Quan Zhang, Cui Wang, Liwei Sun, Ling Li, Meirong Zhao Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China. | 2010 | Journal of Environmental Sciences2010，22，3： | 3 |
| 15 | Influence of diet intake on liver function test显示文摘InfluenceofdietintakeonliverfunctiontestCHENGShuQuan,ZHANGJiFang,ZHANGZiFu,QIANMeiYan,GUOXiaoLing,SHANGWenZhangandLIDuo... | CHENG Shu Quan, ZHANG Ji Fang, ZHANG Zi Fu, QIAN Mei Yan, GUO Xiao Ling, SHANG Wen Zhang and LI Duo Jing Department of Medical Laboratory, The Central Hospital of Jiaozuo Coal Mine Administration, Jiaozuo 454150, Henan Province, China | 1997 | World Journal of Gastroenterology1997，3，4： | 3 |
| 16 | Experimental study of wind loads on gable roofs of low-rise buildings with overhangs显示文摘 | Peng HUANG Ling TAO Ming GU Yong QUAN | 2018 | Frontiers of Structural and Civil Engineering2018，12，3： | 3 |
| 17 | Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair显示文摘Directional axon regeneration and remyelination are crucial for repair of spinal cord injury(SCI),but existing treatments do not effectively promote those processes.Here,we propose a strategy for construction of niche-specific spinal white matter-like tissue(WMLT)using decellularized optic nerve(DON)loaded with neurotrophin-3(NT-3)-overexpressing oligodendrocyte precursor cells.A rat model with a white matter defect in the dorsal spinal cord of the T10 segment was used.The WMLT transplantation group showed significant improvement in coordinated motor functions compared with the control groups.WMLT transplants integrated well with host spinal cord white matter,effectively addressing several barriers to directional axonal regeneration and myelination during SCI repair.In WMLT,laminin was found to promote development of oligodendroglial lineage(OL)cells by binding to laminin receptors.Interestingly,laminin could also guide linear axon regeneration via interactions with specific integrins on the axon surface.The WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin,NT-3 and OL cells to achieve significant structural repair of SCI.Our protocol can help to promote research on repair of nerve injury and construction of neural tissues and organoids that form specific cell niches. | Bi-Qin Lai Yu-Rong Bai Wei-Tao Han Bao Zhang Shu Liu Jia-Hui Sun Jia-Lin Liu Ge Li Xiang Zeng Ying Ding Yuan-Huan Ma Ling Zhang Zheng-Hong Chen Jun Wang Yuan Xiong Jin-Hua Wu Qi Quan Ling-Yan Xing Hong-Bo Zhang Yuan-Shan Zeng | 2022 | Bioactive Materials2022，7，5： | 3 |
| 18 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 19 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 20 | Integrating morphological spatial pattern analysis and the minimal cumulative resistance model to optimize urban ecological networks: a case study in Shenzhen City, China显示文摘Background:With the increasing fragmentation of landscape induced by rapid urbanization,the construction of ecological networks is of great signifcance to alleviate the degradation of urban habitats and protect natural envi‑ronments.However,there is considerable uncertainty when constructing ecological networks,especially the difer‑ent approaches to selecting ecological sources.We used the southern Chinese city of Shenzhen as a study area to construct and optimize ecological networks using a coupling approach.Ecological source areas were extracted using morphological spatial pattern analysis(MSPA)and the landscape index method.Ecological networks were con‑structed using the minimal cumulative resistance(MCR)model and the gravity model.Stepping stones and ecological fault points were added in corridors to optimize the ecological network.Results:Ten core areas with maximum importance patch values were extracted by the landscape index method as ecological source areas according to MSPA,after which corridors between ecological sources were constructed based on the MCR model.The constructed ecological networks were optimized using 35 stepping stones and 17 ecologi‑cal fault points.The optimized ecological networks included 11 important corridors,34 general corridors,and seven potential corridors.The results of corridor landscape-type analysis showed that a suitable ecological corridor is 60 to 200 m wide.Conclusions:Overall,our results imply that ecological source areas can be identifed virtually,and that ecological networks can be signifcantly optimized by combining MSPA and MCR models.These results provide a methodologi‑cal reference for constructing ecological networks,and they will be useful for urban planning and biodiversity protec‑tion in Shenzhen and other similar regions around the world. | Yang‑Yang Li Yu‑Zhe Zhang Zhi‑Yun Jiang Cheng‑Xuan Guo Ming‑Yue Zhao Zhi‑Guang Yang Ming‑Yan Guo Bing‑Yue Wu Quan‑Ling Chen | 2021 | Ecological Processes2021，10，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员