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| 1 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 4 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 5 | Roles of Smad3 and Smad7 in rat pancreatic stellate cells activated by transforming growth factor-beta 1显示文摘BACKGROUND:Pancreatic stellate cells(PSCs) play a major role in promoting pancreatic fibrosis.Transforming growth factor beta 1(TGF-β1) is a critical mediator of this process.This study aimed to determine the expression of the Smad3 and Smad7 genes in the process of PSC activation,and explore the mechanisms of chronic pancreatitis.METHODS:The expressions of Smad3 and Smad7 in PSCs before and after TGF-β1 treatment were detected by reverse transcription-polymerase chain reaction and Western blotting analysis.Smad3 expression was detected in PSCs after treatment with 5 ng/ml of TGF-β1 for 24 hours.RESULTS:Smad7 expression was decreased in TGF-β1-activated PSCs(P<0.05) in a dose-dependent manner.When TGF-β1 concentration reached 10 ng/ml,the expression of p-Smad3 Smad3,and Smad7 was inhibited(P<0.05).CONCLUSIONS:TGF-β1 promotes the expression of Smad3 and inhibits the expression of Smad7 during the activation of PSCs.In contrast,high-dose TGF-β1 downregulates the expression of Smad3 in completely activated PSCs. | Qian, Zhu-Yin Peng, Quan Zhang, Zheng-Wei Thou, Long-An Miao, Yi | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 13 |
| 6 | Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats显示文摘Dissolving microneedles carried drug molecules can effectively penetrate the stratum corneum of skin to improve the transdermal drug delivery. The traditional Chinese medicine acupuncture is based on the needle stimulation at a specific location(acupoint) to generate and transmit biochemical and physiological signals which alter the pathophysiological state of patients. However, the pain associated with conventional acupuncture needles and the requirement of highly trained professionals limit the development of acupuncture in non-Asian countries. The purpose of this study is to investigate whether the dissolving microneedles can be utilized as a self-administered painless replacement for acupuncture and locally released drug molecules can achieve expected therapeutic outcomes. Immunosuppressive rats were treated with acupuncture at Zusanli(ST36) acupoint using microneedles containing thymopentin.The immune functions and psychological mood of the immunosuppressed animals were examined. The proliferation of splenocytes was examined by CCK-8 assay. CD4 and CD8 expression patterns in spleen cells were detected by flow cytometry. The current study showed that use of either microneedles containing thymopentin or conventional acupuncture both resulted in immune cell proliferation, which was confirmed by flow cytometry. Furthermore, either conventional acupuncture or microneedles were able to effectively mitigate the anxiety caused by immune-suppression when applied on the ST36. | Qian Zhang Chuncao Xu Shiqi Lin Huanbin Zhou Gangtao Yao Hu Liu Lili Wang Xin Pan Guilan Quan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 9 |
| 7 | Synthesis and application of a hydrophobic hypercrosslinked polymeric resin for removing VOCs from humid gas stream显示文摘恐水病的亢奋的 crosslinked 聚合树脂 LC-1 被准备并且描绘。LC-1 树脂的性质与商业亢奋的 crosslinked 聚合物 NDA-201 树脂的那些相比。另外, trichloroethylene (TCE ) 的动态吸附被调查到在在 303 K 的干燥、潮湿的条件下面的 LC-1 上, LC-1 拥有的结果表演高恐水病的性质和罐头把 TCE 从气体移开没有高湿度的效果,高效地流。 | Peng Liu Chao Long Hong Ming Qian Ying Li Ai Min Li Quan Xing Zhang | 2009 | Chinese Chemical Letters2009，20，4： | 7 |
| 8 | Immunosuppressive terpenoids from Tripterygium wilfordii显示文摘二新萜烯, triptobenzene P (1 ) 和 wilforone (2 ) 从 Tripterygium wilfordii,以及 10 已知的萜烯被孤立。他们的结构被分光镜的方法阐明。加重 2 4, 8, 10,和 11 项显示出的重要抑制免疫力的活动。 | Qian Shen ZhiYao Yoshihisa Takaishi Yan Wen Zhang Hong Quan Duan | 2008 | Chinese Chemical Letters2008，19，4： | 7 |
| 9 | Inactivated Sendai Virus Induces ROS-dependent Apoptosis and Autophagy in Human Prostate Cancer Cells显示文摘Objective The current study aims to investigate the effect of Hemagglutinating virus of Japan envelope(HVJ-E) on induction of apoptosis and autophagy in human prostate cancer PC3 cells, and the underlying mechanisms. Methods PC3 cells were treated with HVJ-E at various multiplicity of infection(MOI), and the generated reactive oxygen species(ROS), cell viability, apoptosis, and autophagy were detected, respectively. Next, the role of ROS played in the regulation of HVJ-E-induced apoptosis and autuphagy in PC3 cells were analysed. In the end, the relationship between HVJ-E-induced apoptosis and autuophagy was investigated by using rapamycin and chloroquine. Results Flow cytometry assay revealed that HVJ-E treatment induced dose-dependent apoptosis and that the JNK and p38 MAPK signaling pathways were involved in HVJ-E-induced apoptosis in PC3 cells. In addition, HVJ-E was able to induce autophagy in PC3 cells via the class III PI3 K/beclin-1 pathway. The data also implyed that HVJ-E-triggered autophagy and apoptosis were ROS dependent. When ROS was blocked with N-acetylcysteine(NAC), HVJ-E-induced LC3-II conversion and apoptosis were reversed. Interestingly, HVJ-E-induced apoptosis was significantly increased by an inducer of autophagy, rapamycin pretreatment, both in vitro and in vivo. Conclusion HVJ-E exerts anticancer effects via autophagic cell death in prostate cancer cells. | QIAN Miao TAN Hai Ming YU Ning WANG Tao ZHANG Quan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 6 |
| 10 | Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats显示文摘背景肺的动脉的高血压(哼) 被压制 apoptosis 并且在脉管的墙中提高房间增长描绘。导致肺的动脉光滑的肌肉房间(PASMC ) apoptosis 被认为是一条治疗学的途径为哼。Oridonin 能在许多房间线引起 apoptosis,当很少被做了在三十只男 Sprague-Dawley 老鼠随机被分到三个组的 PASMC.Methods 上评估它的效果时:正常控制(NC ) ;组织缺氧血碳酸过多症(HH ) ;组织缺氧血碳酸过多症 + oridonin (HHO ) 。公寓暴露于组织缺氧血碳酸过多症四个星期。有教养的人的 PASMC (HPASMC ) 被分到三个组:normoxia (没有) ;组织缺氧(HY ) ;hypoxia+ oridonin (惊讶) 。吝啬的肺的动脉压力,在加中隔(RV/( LV+S ))的左室上的正确的室的集体比率,到脉管的外部直径(WT%)的肺的小动脉墙的厚度的比率和到全部的区域(WA%)的容器墙区域的比率被测量。肺的动脉的词法变化在光和电子显微镜下面被观察。在 vitro 并且在 vivo 的 apoptotic 特征被检测。mPAP, RV/(LV+S ) , WT% ,和在 HH 的 WA% 组织的结果比在 NC 的那些显著地大(P < 0.01 ) 并且 HHO 组(P < 0.01 ) ;caspase-3 和 caspase-9 的活动,和在组 HH 的 Bex, cyt-C 和 apoptotic 索引(AI ) 的表情是在 NC 和 HHO 组的不到那些;并且在组 HH 的 Bcl-2 的表示在 NC 和 HHO 组比那大。在组的 HPASMC mitochondrial 膜潜力惊讶比在组 HY 低( P < 0.01 ),并且在在 HO 组的细胞质, AI ,和 caspase-9 的 cyt-C 在 HY 组比那大( P < 0.01 ),但是在 HO 组的 Bcl-2 的表示是不到那在 HY 组( P < 0.05 )。结果建议那个 oridonin 罐头的结论有效地降低肺的动脉压力,并且禁止肺的动脉由经由一条线粒体依赖者小径导致光滑的房间 apoptosis 的结构的改变。 | WANG Liang-xing SUN Yu CHEN Chan HUANG Xiao-ying LIN Quan QIAN Guo-qing DONG Wei CHEN Yan-fan | 2009 | Chinese Medical Journal2009，，12： | 6 |
| 11 | Emerging insights into heterotrimeric G protein signaling in plants显示文摘Heterotrimeric guanine nucleotide-binding protein(G protein) signaling is an evolutionary conserved mechanism in diverse eukaryotic organisms.In plants,the repertoire of the heterotrimeric G protein complex,which is composed of the Gα,Gβ,and Gγ subunits,is much simpler than that in metazoans,and the identity of typical G protein-coupled receptors(GPCRs) together with their ligands still remains unclear.Comparative phenotypic analysis in Arabidopsis and rice plants using gain- and loss-of-function mutants of G protein components revealed that heterotrimeric G protein signaling plays important roles in a wide variety of plant growth and developmental processes.Grain yield is a complex trait determined by quantitative trait loci(QTL) and is influenced by soil nitrogen availability and environmental changes.Recent studies have shown that the manipulation of two non-canonical Gy subunits,GS3(GRAIN SIZE 3)and DEP1(DENSE AND ERECT PANICLE 1),represents new strategies to simultaneously increase grain yield and nitrogen use efficiency in rice.This review discusses the latest advances in our understanding of the heterotrimeric G protein signal transduction pathway and its application in improving yield and stress tolerance in crops. | Quan Xu Mingzhu Zhao Kun Wu Xiangdong Fu Qian Liu | 2016 | Journal of Genetics and Genomics2016，43，8： | 6 |
| 12 | Porous LaFeO3 nanofiber with oxygen vacancies as an efficient electrocatalyst for N2 conversion to NH3 under ambient conditions显示文摘Electrocatalytic N2 reduction to NH3 under ambient conditions is an eco-friendly and sustainable alternative to the traditional Haber-Bosch process. However, inhibited by the high activation barrier of N2, this process needs efficient electrocatalysts to adsorb and activate the N2, enabling the N2 reduction reaction(NRR). Herein, we report that porous LaFeO3 nanofiber with oxygen vacancies acts as an efficient NRR electrocatalyst with abundant active sites to enhance the adsorption and activation of N2. When tested in 0.1 M HCl, such electrocatalyst achieves a high Faradaic efficiency of 8.77% and a large NH3 yield rate of 18.59 μg h–1 mgcat–1.at-0.55 V versus reversible hydrogen electrode. This catalyst also shows high long-term electrochemical stability and excellent selectivity for NH3 formation. Density functional theory calculations reveal that, by introducing oxygen vacancy on LaFeO3, the subsurface metallic ions are exposed with newly localized electronic states near the Fermi level, which facilitates the adsorption and activation of N2 molecules as well as the subsequent hydrogenation reactions. | Chengbo Li Dongwei Ma Shiyong Mou Yongsong Luo Benyuan Ma Siyu Lu Guanwei Cui Quan Li Qian Liu Xuping Sun | 2020 | Journal of Energy Chemistry2020，29，11： | 6 |
| 13 | Food Frequency Questionnaire for Chinese Children Aged 12-17 Years: Validity and Reliability显示文摘Objective The primary objective of this study was to examine the validity and reliability of a semi-quantitative food frequency questionnaire(FFQ) among Chinese children aged 12-17 years. Methods A semi-quantitative 72-food item FFQ was developed for children aged 12-17 years. The reliability and validity of this FFQ were evaluated against 24-h dietary recalls(24 h DRs) to measure the consumption of foods and nutrients. We administered two FFQs and three DRs to children(N = 160) over a period of 1 month to evaluate the reliability and validity. Reliability was examined by quartile agreement and intraclass correlation coefficients(ICCs), and validity was examined by quartile agreement, Bland-Altman plots and correlation with DRs. Results For reliability, the ICCs between the two FFQs ranged from 0.21 to 0.76 for foods and nutrients, and the quartile agreement ranged from 70.0% to 95.0% in the same or adjacent quartiles. Spearman’s correlation coefficients of foods and nutrients between the second FFQ and the 24 h DRs ranged from-0.04 to 0.59. The Bland-Altman plots demonstrated good agreement across the range of intakes among nutrients. The quartile agreement ranged from 50.0% to 100.0%, with infrequent misclassification. Conclusion The FFQ assessment of dietary intakes demonstrated acceptable relative validity and high reproducibility for Chinese children aged 12-17 years. | LIU Dan JU La Hong YANG Zhen Yu ZHANG Qian GAO Jian Fen GONG Di Ping GUO Dan Dan LUO Shu Quan ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，7： | 6 |
| 14 | Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution显示文摘Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases. | Weimin Lin Qiwen Li Danting Zhang Xiaohan Zhang Xingying Qi Qian Wang Yaqian Chen Caojie Liu Hanwen Li Shiwen Zhang Yuan Wang Bin Shao Li Zhang Quan Yuan | 2021 | Bone Research2021，9，1： | 6 |
| 15 | Artificial periosteum in bone defect repair--A review显示文摘Periosteum is a thin membrane that encases the surfaces of most bones.It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells(MSCs)and osteogenic progenitor cells.Periosteum has a function of regulating cell and collagen arrangement,which is important to the integrity,modelling and remodelling of bone,particularly during bone defect repair.Apart from autograft and allograft,artificial periosteum,or tissue-engineered periosteum mimicking native periosteum in structure or function,made up of small intestinal submucosa,acellular dermis,induced membrane,cell sheets,and polymeric scaffolds,and so on,has been developed to be used in bone defect repair.In this review,we classify the artificial periosteum into three approaches based on the material source,that is,native tissues,scaffoldfree cell sheets and scaffold-cell composites.Mechanisms,methods and efficacy of each approach are provided.Existing obstacles and enabling technologies for future directions are also discussed. | Quan Wang Jianxiang Xu Haiming Jin Wenhao Zheng Xiaolei Zhang Yixing Huang Zhiyong Qian | 2017 | Chinese Chemical Letters2017，28，9： | 6 |
| 16 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 17 | The Impact of Relative Humidity and Atmospheric Pressure on Mortality in Guangzhou, China显示文摘Objective Although many studies have examined the effects of ambient temperatures on mortality, little evidence is on health impacts of atmospheric pressure and relative humidity. This study aimed to assess the impacts of atmospheric pressure and relative humidity on mortality in Guangzhou, China. Methods This study included 213,737 registered deaths during 2003-2011 in Guangzhou, China. A quasi-Poisson regression with a distributed lag non-linear model was used to assess the effects of atmospheric pressure/relative humidity. Results We found significant effect of low atmospheric pressure/relative humidity on mortality. There was a 1.79%(95% confidence interval: 0.38%-3.22%) increase in non-accidental mortality and a 2.27%(0.07%-4.51%) increase in cardiovascular mortality comparing the 5th and 25 th percentile of atmospheric pressure. A 3.97%(0.67%-7.39%) increase in cardiovascular mortality was also observed comparing the 5th and 25 th percentile of relative humidity. Women were more vulnerable to decrease in atmospheric pressure and relative humidity than men. Age and education attainment were also potential effect modifiers. Furthermore, low atmospheric pressure and relative humidity increased temperature-related mortality. Conclusion Both low atmospheric pressure and relative humidity are important risk factors of mortality. Our findings would be helpful to develop health risk assessment and climate policy interventions that would better protect vulnerable subgroups of the population. | OU Chun Quan YANG Jun OU Qiao Qun LIU Hua Zhang LIN Guo Zhen CHEN Ping Yan QIAN Jun GUO Yu Ming | 2014 | Biomedical and Environmental Sciences2014，27，12： | 5 |
| 18 | Background-free latent fingerprint imaging based on nanocrystals with long-lived luminescence and pH-guided recognition显示文摘Latent fingerprints (LFPs)are highly specific to individuals,and LFP imaging has played an important role in areas such as forensic investigation and law enforcement.Presently,LFP imaging still faces considerable problems,including background interference and destructive and complex operations.Herein,we have designed a background-free,nondestructive,and easy-to-perform method for LFP imaging based on pH-mediated recognition of LFPs by carboxyl group- functionalized Zn2GeO4:Mn (ZGO:Mn-COOH)persistent luminescence nanorods (PLNRs).By simply adjusting the pH of the ZGO:Mn-COOH colloid dispersion to a certain acidic range,the negatively charged ZGO:Mn-COOH readily binds to protonated fingerprint ridges via electrostatic attraction.The ZGO:Mn-COOH colloid dispersion can be stored in portable commercial spray bottles,and the LFPs have been easily detected in situ by simply dropping the colloid dispersion on the LFPs.Moreover,since the ZGO:Mn-COOH can remain luminescent after excitation ceases,background color and background fluorescence interference were efficiently removed by simply capturing the luminescent LFP images after the excitation ceased.The entire LFP imaging process can be easily conducted without any destructive or complex operations.Due to the great versatility of the developed method for LFP imaging,clear LFP images with well-resolved ridge patterns were obtained.The designed background-free,nondestructive,and easy-to-perform LFP imaging strategy has great potential for future applications, such as forensic investigations and law enforcement. | Zhiheng Li Qian Wang Yingqian Wang Qinqin Ma Jie Wang Zhihao Li Yingxue Li Xiaobo Lv Wei Wei Lang Chen Quan Yuan | 2018 | Nano Research2018，11，12： | 5 |
| 19 | First-principles calculations of electronic structure and optical properties of strained Mg_2Si显示文摘A detailed theoretical study on structural,electronic and optical properties of Mg2Si under the isotropic lattice deformation was performed based on the first-principles pseudopotential method.The results show that the isotropic lattice deformation results in a linear decrease in the energy gap for the directΓ15-Γ1 and indirectΓ15-L1 transitions from 93%to 113%,while the indirect band gapΓ15-X1 increases from 93%to 104%and then reduces over 104%.When the crystal lattice is 93%compressed and 113% stretched,the magnesium silicide is a zero-gap semiconductor.Furthermore,the isotropic lattice deformation makes the dielectric function shift and the static dielectric constant change. | CHEN Qian XIE Quan ZHAO FengJuan CUI DongMeng LI XuZhen | 2010 | Chinese Science Bulletin2010，55，21： | 4 |
| 20 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
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