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| 1 | Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells显示文摘AIM: To understand the role and significance of side population (SP) cells from hepatocellular carcinoma (HCC) in hepatocarcinogenesis, development, relapse and metastasis, we simulated the denutrition conditions that cancer cells experience in clinical therapy, observed the different anti-apoptosis ability of SP cells and non-SP cells under such conditions, and established the possible effects of P53, Bcl-2 and Bax on survival of SP cells. METHODS: We used ? ow cytometry to analyze and sort the SP and non-SP cells in established HCC lines MHCC97 and hHCC. We evaluated cell proliferation by methyl thiazolyl tetrazolium (MTT) assay and investigated the expression of p53, bcl-2 and bax genes during denutrition, by RT-PCR and immuno? uorescence staining. RESULTS: The percentage of SP cells in the two established HCC lines was 0.25% and 0.5%, respectively. SP cells had greater anti-apoptosis and proliferation ability than non-SP cells. Expression of Bcl-2 and Bax in SP and non-SP cells differed during denutrition. The former was up-regulated in SP cells, and the latter was up-regulated in non-SP cells. CONCLUSION: It may be that different upstream molecules acted and led to different expression levels of Bcl-2 and Bax in these two cell lines. There was a direct relationship between up-regulation of Bcl-2 and down-regulation of Bax and higher anti-apoptosis ability in SP cells. It may be that the existence and activity of SP cells are partly responsible for some of the clinical phenomena which are seen in HCC, such as relapse or metastasis. Further research on SP cells may have potential applications in the f ield of anticancer therapy. | Jing Fan Ren Li Rui Zhang Hai-Liang Liu Ning Zhang Fu-Qing Zhang Ke-Feng Dou | 2007 | World Journal of Gastroenterology2007，13，45： | 27 |
| 2 | Size distribution of chemical elements and their source apportionment in ambient coarse, fine, and ultrafine particles in Shanghai urban summer atmosphere显示文摘Ambient coarse particles (diameter 1.8-10 μm), fine particles (diameter 0.1-1.8 μm), and ultrafine particles (diameter < 0.1 μm) in the atmosphere of the city of Shanghai were sampled during the summer of 2008 (from Aug 27 to Sep 08). Microscopic characterization of the particles was investigated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDX). Mass concentrations of Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb in the size-resolved particles were quantified by using synchrotron radiation X-ray fluorescence (SRXRF). Source apportionment of the chemical elements was analyzed by means of an enrichment factor method. Our results showed that the average mass concentrations of coarse particles, fine particles and ultrafine particles in the summer air were 9.38 ± 2.18, 8.82 ± 3.52, and 2.02 ± 0.41 μg/m3, respectively. The mass percentage of the fine particles accounted for 51.47% in the total mass of PM10, indicating that fine particles are the major component in the Shanghai ambient particles. SEM/EDX results showed that the coarse particles were dominated by minerals, fine particles by soot aggregates and fly ashes, and ultrafine particles by soot particles and unidentified particles. SRXRF results demonstrated that crustal elements were mainly distributed in the coarse particles, while heavy metals were in higher proportions in the fine particles. Source apportionment revealed that Si, K, Ca, Fe, Mn, Rb, and Sr were from crustal sources, and S, Cl, Cu, Zn, As, Se, Br, and Pb from anthropogenic sources. Levels of P, V, Cr, and Ni in particles might be contributed from multi-sources, and need further investigation. | Senlin Lu Rui Zhang Zhenkun Yao Fei Yi Jingjing Ren Minghong Wu Man Feng Qingyue Wang | 2012 | Journal of Environmental Sciences2012，24，5： | 22 |
| 3 | Diagnostic value of tumor marker pro-gastrin-releasing peptide in patients with small cell lung cancer: a systematic review显示文摘背景肺癌症是在世界上的最普通的恶意之一并且导致死亡的领先的癌症之一。这研究的目的是与怀疑的小房间肺癌症( SCLC )作为在病人标准的引用评估并且比较浆液肿瘤标记 pro-gastrin-releasing 肽 31-98 ( ProGRP31-98 )的诊断的值到病理学的诊断直盖住 1978 到 2009 的 .Methods 文学搜索在 Pubmed 被执行,奥维德, MEDLINE , EMbase , Cancerlit ,中国知识基础结构( CNKI ),和用钥匙的 CBM 寻找词;“小房间肺癌症”,“肿瘤标记”,“ ProGRP31-98 ”和“诊断测试”,“ ELISA ”,“ EIA ”和“诊断精确性”。研究被收集,数据分析了与病理相比为 SCLC 的诊断评估浆液 ProGRP31-98 层次的诊断价值。为在分析的包括的资格标准为屏蔽的 Cochrane 和诊断测试方法组(SDTMG ) 出版的诊断研究基于标准。包括的文章的特征被估价,数据用评论经理 4.2 软件为学习异质的进一步统计的分析从原来的文章被提取。基于学习异质分析,合适的“效果”模型被选择由元分析计算分享的敏感和特性。在曲线(AUC ) 下面操作特征(SROC ) 曲线和区域的概括接收装置被产生, 22 篇文章全部的敏感分析 conducted.Results A 被进入这元评论,包括 11 英语有在水平 C 的质量的文章。总共,研究包含了 6759 个题目, 1470 被与 non-SCLC (NSCLC ) 诊断的病理,和 5289 个题目与 SCLC 诊断。元分析证明在研究之中的异质高(P=0.00001,(I2 )=86.8%) 。与 ELISA,分享的敏感是 0.72 (0.70 ~ 0.75 在 95% Cl ) 并且分享的特性是 0.93 (0.92to 0.94 在 95% Cl ) ;SROC 和 AUC 是 0.8817。这些数据建议那 ProGRP31-98 错过的诊断(28%) 的相对高的率,而是错误诊断(7%) 的相对低的率从元分析的 .Conclusion,我们断定浆液 ProGRP31-98 是有为有到病理的类似的诊断精确性的 SCLC 的诊断的高特性的一个珍贵标记。 | TANG Jian-hua ZHANG Xiu-long ZHANG Zhi-hua WANG Rui ZHANG He-ming ZHANG Zhi-lin WANG Jing-hui REN Wei-dong | 2011 | Chinese Medical Journal2011，，10： | 21 |
| 4 | A Reducing Iteration Orthogonal Matching Pursuit Algorithm for Compressive Sensing显示文摘In recent years, Compressed Sensing(CS) has been a hot research topic. It has a wide range of applications, such as image processing and speech signal processing owing to its characteristic of removing redundant information by reducing the sampling rate. The disadvantage of CS is that the number of iterations in a greedy algorithm such as Orthogonal Matching Pursuit(OMP) is fixed, thus limiting reconstruction precision.Therefore, in this study, we present a novel Reducing Iteration Orthogonal Matching Pursuit(RIOMP) algorithm that calculates the correlation of the residual value and measurement matrix to reduce the number of iterations.The conditions for successful signal reconstruction are derived on the basis of detailed mathematical analyses.When compared with the OMP algorithm, the RIOMP algorithm has a smaller reconstruction error. Moreover, the proposed algorithm can accurately reconstruct signals in a shorter running time. | Rui Wang Jinglei Zhang Suli Ren Qingjuan Li | 2016 | Tsinghua Science and Technology2016，21，1： | 17 |
| 5 | Fatigue behavior of Ti-6Al-4V cellular structures fabricated by additive manufacturing technique显示文摘Porous titanium and its alloys have been considered as promising replacement for dense implants, as they possess low elastic modulus comparable to that of compact human bones and are capable of providing space for in-growth of bony tissues to achieve a better fixation. Recently, the additive manufacturing(AM) method has been successfully applied to the fabrication of Ti-6 Al-4 V cellular meshes and foams.Comparing to traditional fabrication methods, the AM method offers advantages of accurate control of complex cell shapes and internal pore architectures, thus attracting extensive attention. Considering the long-term safety in the human body, the metallic cellular structures should possess high fatigue strength.In this paper, the recent progress on the fatigue properties of Ti-6 Al-4 V cellular structures fabricated by the AM technique is reviewed. The various design factors including cell shapes, surface properties, post treatments and graded porosity distribution affecting the fatigue properties of additive manufactured Ti-6 Al-4 V cellular structures were introduced and future development trends were also discussed. | Dechun Ren Shujun Li Hao Wang Wentao Hou Yulin Hao Wei Jin Rui Yang R.Devesh K.Misra Lawrence E.Murr | 2019 | Journal of Materials Science & Technology2019，35，2： | 15 |
| 6 | Prostate cancer research in China显示文摘在中国的前列腺癌症(PCa ) 研究在最近的年里的一个飞速上升的趋势上。在中国的第一染色体宽的协会研究(GWAS ) 鉴别二新 PCa 风险联系了单个核苷酸多型性(SNP ) 。下一代定序正在开始被过去常,产出新奇调查结果:基因熔化,长非编码的 RNA 和另外的变化。当各种各样的诊断 biomarkers 广泛地被调查了时, PCa 前进的机制被说明了。个性化的治疗基于基因因素, nano 药和繁体中文药是为 PCa 的试验性的治疗学的研究的焦点。这评论打算在中国在 PCa 研究在最近的进步之上打开灯并且以后指出可能的突破。 | Shan-Cheng Ren Rui Chen Ying-Hao Sun | 2013 | Asian Journal of Andrology2013，15，3： | 15 |
| 7 | Effective solutions to a global 3D visual system in networking environments显示文摘The development of Web-based global 3D visual system has made progresses. However, there exist few mature and effective ways for managing, transmitting and visualizing massive spatial data. Based on the related work, the paper illustrates the ellipsoidal quadtree technique for rapid access multi-scale and multiple level geographical data, integrates the streaming with level-of-detail rendering method for transmitting the data on the network, and im-plements large-scale terrain surface simplification using M-band wavelet transforms and mul-tiresolution triangulations. We fulfil a web-based global terrain visual system using COM com-ponents on the basis of the above techniques. The system has a good prospect in the military simulation and city plans. | ZHANG Liqiang1,2, ZHANG Yan3, YANG Chongjun2, LIU Suhong1, REN Yingchao2, RUI Xiaoping2 & LIU Donglin2 1. State Key Laboratory of Remote Sensing Sciences, School of Geography and Remote Sensing, Beijing Normal University, Beijing 100875, China 2. State Key Laboratory of Remote Sensing Sciences, Institute of Remote Sensing Applications, Chinese Academy of Sciences, Beijing 101001, China 3. Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 101001, China | 2005 | Science China Earth Sciences2005，48，11： | 13 |
| 8 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 9 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 10 | Spatial and temporal variation of haze in China from 1961 to 2012显示文摘The purpose of this study is to analyze the climatic characteristics and long-term spatial and temporal variations of haze occurrence in China. The impact factors of haze trends are also discussed. Meteorological data from 1961 to 2012 and daily PM10 concentrations from2003 to 2012 were employed in this study. The results indicate that the annual-average hazy days at all stations have been increasing rapidly from 4 days in 1961 to 18 days in 2012. The maximum number of haze days occur in winter(41.1%) while the minimum occur in summer(10.4%). During 1961-2012, the high occurrence areas of haze shifted from central to south and east regions of China. The Beijing-Tianjin-Hebei(Jing-Jin-Ji) region, Shanxi,Shaanxi, and Henan Province are the high occurrence areas for haze, while the Yangtze River Delta(YRD) and the Pearl River Delta(PRD) have become regions with high haze occurrences in the last 25 years. Temperature and pressure are positively correlated with the number of haze days. However, wind, relative humidity, precipitation, and sunshine duration are negatively correlated with the number of haze days. The key meteorological factors affecting the formation and dissipation of haze vary for high and low altitudes, and are closely related to anthropogenic activities. In recent years, anthropogenic activities have played a more important role in haze occurrences compared with meteorological factors. | Rui Han Shuxiao Wang Wenhai Shen Jiandong Wang Kang Wu Zhihua Ren Mingnong Feng | 2016 | Journal of Environmental Sciences2016，28，8： | 11 |
| 11 | Using borehole core analysis to reveal Late Quaternary paleoearthquakes along the Nankou-Sunhe Fault,Beijing显示文摘The Nankou-Sunhe Fault is a buried active normal fault that traverses the urban area of Beijing.Its seismic risks have caused considerable concerns.This paper studies paleoearthquakes along this fault by analyzing and correlating bore-hole cores obtained from triple-tube coring,incorporating experience acquired from trenching.As a result,a model for identifying earthquake-derived colluvium by sediment-core analysis is proposed.Triple-tube coring technique is useful to collect continuous undis-turbed soil core near the Nankou-Sunhe Fault.By identifying fault-scarp colluviums,determining cumulative displacement,and analysing stratum thickening on the hanging wall,we are able to establish a preliminary paleoearthquake sequence consisting of 13 surface-rupturing events since 60 ka.The seismic history can be divided into three periods based on different recurrence intervals.Between 60 and 40 ka,three earthquakes occurred with recurrence interval of ~10 ka.From 40 to 25 ka,there were six earthquakes with the recurrence interval of about 2.5 ka.In the last 25 ka,four earthquakes have taken place with the recurrence interval varying considerably.The recurrence interval between the last three events is ~5 ka.Smaller recurrence intervals correspond to stages of faster fault slip.The coseismic displacement of a single event is 0.8 to 2.2 m,average 1.4 m,largely equivalent to moment magnitudes 6.7-7.1.This study demonstrates the feasibility of bore-hole drilling in investigating paleoearthquakes along normal faults.It also suggests that closely spaced boreholes with continuous undisturbed cores are essential for reconstructing the complete paleoearthquake sequence. | ZHANG ShiMin WANG DanDan LIU XuDong ZHANG GuoHong ZHAO JunXiang LUO MingHui REN JunJie WANG Rui ZHANG YingLi | 2008 | Science China Earth Sciences2008，51，8： | 11 |
| 12 | Fine Mapping and Candidate Gene Analysis of Resistance Gene R_(SC3Q) to Soybean mosaic virus in Qihuang 1显示文摘Soybean mosaic virus(SMV) disease is one of the most destructive viral diseases in soybean(Glycine max(L.) Merr.). SMV strain SC3 is the major prevalent strain in Huang-Huai and Yangtze valleys, China. The soybean cultivar Qihuang 1 is of a rich resistance spectrum and has a wide range of application in breeding programs in China. In this study, F1, F2 and F2:3 from Qihuang 1×Nannong 1138-2 were used to study inheritance and linkage mapping of the SC3 resistance gene in Qihuang 1. The secondary F2 population and near isogenic lines(NILs) derived from residual heterozygous lines(RHLs) of Qihuang 1×Nannong 1138-2 were separatively used in the fine mapping and candidate gene analysis of the resistance gene. Results indicated that a single dominant gene(designated RSC3Q) controls resistance, which was located on chromosome 13. Two genomic-simple sequence repeat(SSR) markers BARCSOYSSR_13_1114 and BARCSOYSSR_13_1136 were found flanking the two sides of the RSC3 Q. The interval between the two markers was 651 kb. Qu antitative real-time PCR analysis of the candidate genes sho wed that five genes(Glyma13g25730, 25750, 25950, 25970 and 26000) were likely involved in soybean SMV resistance. These results would have utility in cloning of RSC3 Q resistance candidate gene and marker-assisted selection(MAS) in resistance breeding to SMV. | ZHENG Gui-jie YANG Yong-qing MA Ying YANG Xiao-feng CHEN Shan-yu REN Rui WANG Da-gang YANG Zhong-lu ZHI Hai-jian | 2014 | Journal of Integrative Agriculture2014，13，12： | 11 |
| 13 | Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml^-1显示文摘 | Rui Chen Li-Qun Zhou Xiao-Bing Cai Li-Ping Xie Yi-Ran Huang Da-Lin He Xu Gao Chuan-Liang Xu Qiang Ding Qiang wei Chang-Jun Yin Shan-Cheng Ren Fu-Bo Wang Ye Tian Zhong-Quan Sun Qiang Fu Lu-Lin Ma Jun-Hua Zheng Zhang-Qun Ye Ding-Wei Ye Dan-Feng Xu Jian-Quan Hou Ke-Xin Xu Jian-Lin Yuan Xin Gao Chun-Xiao Liu Tie-Jun Pan Ying-Hao Sun | 2015 | Asian Journal of Andrology2015，17，6： | 10 |
| 14 | Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy显示文摘A copper-bearing Ti-6AI-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure,antibacterial performance,and cytocompatibility.Characterization of microstructure revealed that the solution treated alloy consisted of α phase,α' phase and(3 phase,while besides these phases,the aged alloy also contained the precipitations of intermetallic Ti_2Cu compound.The solution treated alloy showed better antibacterial performance with increasing the solution temperature.The Cu ions released from Ti—6AI—4V—5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy,and do not induce any cytotoxicity.The optimal heat treatment for Ti-6Al-4V-5Cu alloy was solution treated at 930 C,at which it could exhibit both promising antibacterial performance and no cytotoxicity. | Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra | 2015 | Journal of Materials Science & Technology2015，31，7： | 10 |
| 15 | Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy显示文摘(PCA3 ) 前列腺癌症抗原 3 是为诊断在白种人人口识别的前列腺癌症(PCa ) 的 biomarker。我们在在经历起始的前列腺活体检视的 500 个人预言活体检视结果评估了尿 PCA3 的有效性。PCA3 分数的预兆的力量在操作特征(巨鸟) 曲线(AUC ) 的接收装置下面并且由决定曲线分析由区域被评估。PCA3 分数足够了区别从否定前列腺活体检视结果积极但是没与 PCa 的攻击性被相关。巨鸟分析比 % fPSA 为 PCA3 分数显示出更高的 AUC (0.750 对 0.622, P = 0.046 ) 在有 4.0-10.0 ng 的 PSA 的病人, ml-1,而是基于 PCA3 的模型不比基础模型显著地好。决定曲线分析显示基于 PCA3 的模型比有为几乎所有阀值可能性的一个更高的网络好处的基础模型优异,在有 4.0-10.0 ng ml-1 的 PSA 的病人的 25%-40% 的特别阀值可能性。然而, PCA3 分数(0.712 ) 的 AUC 不在有 PSA 的病人比 % fPSA (0.698 ) 或 PSAD (0.773 ) 优异 > 10.0 ng ml-1。我们的结果证实 RT-PCR-based PCA3 测试中等在与 4.0-10.0 ng ml-1 的 PSA 经历第一前列腺活体检视的中国病人改进了诊断精确性。 | Fu-Bo Wang Rui Chen Shan-Cheng Ren Xiao-Lei Shi Ya-Sheng Zhu Wei Zhang Tai-Le Jing Chao Zhang Xu Gao Jian-Guo Hou Chuan-Liang Xu Ying-Hao Sun | 2017 | Asian Journal of Andrology2017，19，2： | 10 |
| 16 | Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells显示文摘In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc, bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of CNE2 cells including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the “ladder pattern” revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner.The number of TUNEL-positive cells was dramatically increased to 33.6±1.2% from 2.8±0.3% by treat ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2,bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations.These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes. | LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI HUA XIONG, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China | 2001 | Cell Research2001，11，4： | 9 |
| 17 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 18 | Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Xufu Wei Cui Tan Chengyong Tang Guosheng Ren Tingxiu Xiang Zhu Qiu Rui Liu Zhongjun Wu | 2013 | Cellular Signalling2013，，5： | 8 |
| 19 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 20 | 【原创论文】组蛋白甲基转移化酶基因SETDB1促进前列腺癌细胞的增殖、迁徙和侵袭显示文摘SETDB1已在部分人类肿瘤中被确立为癌基因。本研究的目的是检测艇珏坫J基因及蛋白在人前列腺癌组织、细胞系、前列腺增生组织、前列腺上皮细胞中的表达。并研究SETDB1基因对前列腺癌细胞在体外的增殖、迁徙、侵袭的作用。方法:应用实时定量聚合酶链反应(Real-timeqPCR)免疫组化检测SETDB1基因及蛋白在人前列腺癌组织、细胞系、前列腺增生组织、前列腺上皮细胞中的表达。借助siRNA下调SETDB1在前列腺癌细胞系的表达,分别应用细胞计数实验、细胞克隆形成实验、流式细胞技术;细胞划痕实验、细胞小室侵袭实验对SETDB1下调后的细胞进行检测。结果:SETDB1在人前列腺组织、细胞中高表达,下调SETDB1在前列腺癌细胞系的表达后,前列癌细胞的增殖、迁徙、侵袭能力降低。结论:SETDB1可以作为前列腺癌的癌基因进一步研究。 | Yi Sun Min Wei Shan-Cheng Ren Rui Chen Wei-Dong Xu Fu-Bo Wang Ji Lu Jian Shen Yong-Wei Yu Jian-Guo Hou Chuan-Liang Xu Jiao-Ti Huang Ying-Hao Sun | 2014 | Asian Journal of Andrology2014，16，2： | 7 |
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