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| 1 | Tracking shallow marine red beds through geological time as exemplified by the lower Telychian (Silurian) in the Upper Yangtze Region,South China显示文摘Marine red beds occur frequently in China through geological time.Despite their complex environments,the red beds are found in three depositional settings:1) oceanic,deep water,as in the Upper Cretaceous of southern Tibet;2) outer shelf,deeper water,as in the Lower-Middle Ordovician of South China;and 3) inner shelf,shallow water,as in the Silurian and Triassic in South China.The Silurian marine red beds are recurrent in the lower Telychian,upper Telychian,and upper Ludlow.This paper is to document the marine nature of the lower Telychian red beds (LRBs) in the Upper Yangtze Region and to discuss the spatial and temporal distribution of the LRBs and their depositional environments.The LRBs are best developed on the north side of the Cathaysian Oldland,which can be interpreted as the source area.It is inferred that they were deposited during a marine regression,characterized by the lack of upwelling,low nutrition and organic productivity with a decrease of biodiversity and a high rate of sedimentation.The iron-rich sediments may have been transported by rivers on the oldland into the Upper Yangtze Sea,as rates of deposition were rapid enough to counteract normal reducing effect around sediment-water interface.The LRBs are different from the off-shore,deeper water red beds of lower Telychian in Avalonia and Baltica and further from the oceanic,deep water red beds of Upper Cretaceous in southern Tibet chiefly in palaeogeographic settings,biotic assemblages and marine environments. | RONG JiaYu WANG Yi ZHANG XiaoLe | 2012 | Science China Earth Sciences2012，55，5： | 25 |
| 2 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 3 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 4 | Overview of current targeted therapy in gallbladder cancer显示文摘Gallbladder cancer(GBC)is rare,but is the most malignant type of biliary tract tumor.Unfortunately,only a small population of cancer patients is acceptable for the surgical resection,the current effective regimen;thus,the high mortality rate has been static for decades.To substantially circumvent the stagnant scenario,a number of therapeutic approaches owing to the creation of advanced technologic measures(e.g.,next-generation sequencing,transcriptomics,proteomics)have been intensively innovated,which include targeted therapy,immunotherapy,and nanoparticle-based delivery systems.In the current review,we primarily focus on the targeted therapy capable of specifically inhibiting individual key molecules that govern aberrant signaling cascades in GBC.Global clinical trials of targeted therapy in GBC are updated and may offer great value for novel pathologic and therapeutic insights of this deadly disease,ultimately improving the efficacy of treatment. | Xiaoling Song Yunping Hu Yongsheng Li Rong Shao Fatao Liu Yingbin Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 5 | Population-standardized genetic risk score: the SNP-based method of choice for inherited risk assessment of prostate cancer显示文摘几条不同途径对为决定前列腺癌症(PCa ) 风险的临床医生可得到。利用单个核苷酸多型性(SNP ) 的各种各样的 PCa 风险评价方法的临床的有效性被建立了;然而,这些基于 SNP 的方法没被比较。这研究的目的是为 PCa 风险评价比较三个最通常使用的基于 SNP 的方法。参加者是人(n = 1654 ) 在 PCa 开发的未来的研究注册了。59 PCa 联系风险的 SNP 的遗传型在这个队是可得到的。精明的基于 SNP 的基因风险分数(GRS ) 的三个方法被用于象风险等位基因计数那样的单个疾病风险的评估(GRS 皇家装甲兵) ,加权的风险等位基因计数(GRS-wRAC ) ,和标准化人口的基因风险得分(GRS-PS ) 。吝啬的 GRS 被计算,并且表演在操作典型曲线(AUC ) 和积极预兆的价值(PPV ) 的接收装置下面用区域被比较。所有基于 SNP 的方法被发现独立地与 PCa 被联系(所有 P <0.05;因此他们的临床的有效性) 。分别地,在人与或没有 GRS 皇家装甲兵使用的 PCa 的吝啬的 GRS 用 GRS-wRAC 是 55.15 和 53.46 分别地,是 7.42 和 6.97,使用的 GRS-PS 是 1.12 和 0.84,分别地(所有 P <0.05 为病人与或没有 PCa 之间的差别) 。在基于 AUC 从 non-PCa 区别 PCa 并且在预言 PCa 同样执行的所有三个基于 SNP 的方法基于 PPV 冒险(所有 P >0.05 为在三个方法之间的比较) ,并且所有三个基于 SNP 的方法比家庭历史有显著地更高的 AUC (所有 P <0.05 ) 。从这研究的结果建议当三个大多数通常使用了时, 基于SNP 的方法在在人口水平从 non-PCa 区别 PCa 同样表现了,因为, GRS-PS 是为在单个水平的风险评价的选择的方法它的价值(在 1.0 代表平均人口风险的地方)能容易不管在计算使用的联系风险的 SNP 的数字被解释。 | Carly A Conran Rong Na Haitao Chen Deke Jiang Xiaoling Lin S Lilly Zheng Charles B Brendler Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 4 |
| 6 | Subcellular chemical imaging of structurally similar acridine drugs by near-field laser desorption/laser postionization mass spectrometry显示文摘Insights into the pharmacologic effect on cellular processes and the potential toxicological effects are vital to new drug development and evaluation,yet research on these subjects remains a great challenge due to the lack of information regarding the spatiotemporal distribution of drugs and metabolites within a single cell.Mass spectrometry imaging(MSI)has proven to be a label-free and high-throughput approach for visualizing drug distribution in spatial and temporal domains.However,single-cell drug imaging has been limited so far by detection sensitivity and microscale lateral resolution.Herein,we report near-field laser desorption/laser postionization mass spectrometry(NDPI-MS)for single-cell imaging of two structurally similar drugs,proflavine and ethacridine,and subcellular distributions of proflavine at different drug concentrations were investigated.The NDPI-MS imaging results indicate that proflavine was accumulated in lysosomes,which was verified by laser scanning confocal microscopy(LSCM).Additionally,a distinguished subcellular distribution pattern of ethacridine from proflavine could be visualized,highlighting the complexity of the interaction between the drugs and biological environment even though these two drugs possess similar structures.Taken together,the present results demonstrate the great potential of the integrated single-cell MSI platform for characterizing the drug distribution and its phenotype changes within individual cells,expediting the identification and evaluation of newly developed drugs. | Xiaoling Cheng Zhibin Yin Liu Rong Wei Hang | 2020 | Nano Research2020，13，3： | 3 |
| 7 | Silurian integrative stratigraphy and timescale of China显示文摘Silurian is a period with the shortest duration in Phanerozoic except for the Neogene and Quaternary. It represents an important and unique interval when the biotic diversity recovered quickly after the end-Ordovician mass extinction, different paleoplates or terranes conjoined, big oceans disappeared or narrowed, climate and sea level changed frequently, global biotic provincialism became weaker, some primitive plants started to occupy the land. Silurian is also the first system of which all the chronostratigraphic stratotypes(i.e. the GSSPs) including four series and seven stages were established by the International Subcommission on Silurian Stratigraphy(ISSS). Nonetheless, during the post-GSSP studies conducted by ISSS in the middle1980 s, some Silurian GSSPs were found to have some congenital defects such as no index fossils available that hinder the high resolution subdivision and correlation on a regional or global scale. In this paper, based on the latest development of Silurian study in China, the progress in biostratigraphy, chronostratigraphy, event stratigraphy(such as facies differentiation, heterochrony of black shales, marine red beds, carbonate rocks and reefs), chemostratigraphy, and tectonic stratigraphy(e.g., widespread of the late Silurian rocks in South China and its tectonic implication) are systematically summarized. Some existing problems and the areas to be focused in future work are also discussed. It is suitable for chronostratigraphic study to concentrate not only on the boundary but also doing multidisciplinary analysis on the biotic, chemical, magnetic, environmental, and chronologic aspects, in order to enhance the reliability and the potential for regional and global correlation of a certain GSSP.Some important achievements are expected in these areas in the Silurian study in China:(1) ecostratigraphy and basin analysis of the Llandovery, and the correlation of integrative stratigraphy with a high resolution;(2) establishment of the Wenlock to Pridoli chronostratigraphic framework;(3) the chemo-and magnetic stratigraphy and the age of some key intervals and horizons;(4)further investigation on paleogeography and plate tectonics; and(5) origin and early evolution of the terrestrial ecosystem. Some new breakthroughs might occur in the restudy on some of those problematic GSSPs of some particular series and stages. | Jiayu RONG Yi WANG Renbin ZHAN Junxuan FAN Bing HUANG Peng TANG Yue LI Xiaole ZHANG Rongchang WU Guangxu WANG Xin WEI | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 8 | Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth显示文摘 | Hailin Tang Xiaoping Liu Zeyou Wang Xiaoling She Xi Zeng Min Deng Qianjin Liao Xiaofang Guo Rong Wang Xiaoling Li Fang Zeng Minghua Wu Guiyuan Li | 2011 | Brain Research2011，，： | 1 |
| 9 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 10 | Preparation and properties of ZnO nano-whiskers显示文摘By a novel controlled combustion synthesis method, a large amount of ZnO nano-whiskers with different morphologies like nanotetrapods, long-leg nanotetrapod and multipods, were prepared without any catalysts and additives in open air at high temperature. Their morphologies, structures and optical properties were in-vestigated by using SEM, XRD and PL spectrum. The possible growth mechanisms on the ZnO nano-whiskers were proposed in this paper. | SHI XiaoLing CAO MaoSheng ZHAO YuNa SONG WeiLi RONG JiLi | 2008 | Science China(Technological Sciences)2008，51，9： | 1 |
| 11 | The effects of training intensities on motor recovery and gait symmetry in a rat model of ischemia显示文摘 | Le Li Wei Rong Zheng Ke Xiaoling Hu Kai-yu Tong | 2013 | Brain Injury2013，，4： | 1 |
| 12 | OSMRβmutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients显示文摘Dear Editor,Primary localized cutaneous amyloidosis(PLCA)is a skinlimited disorder characterized by deposition of amyloid material in the superficial dermis.According to clinical characteristics,PLCA is divided into lichen,macular,and nodular amyloidosis.PLCA is found worldwide but has a higher incidence in South America and Southeast Asia,such as in Brazil and China(Chang et al.,2014;Tey et al.,2016). | Jun Liu Junchen ChenYadan Zhong Xiaoling Yu Ping Lu Jianqi Feng Xin Zhang Shufeng Ma Chao Yang Bin Yang Zhili Rong | 2021 | Protein & Cell2021，12，8： | 1 |
| 13 | Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells显示文摘 | Yefei Rong Wenchuan Wu Xiaoling Ni Tiantao Kuang Dayong Jin Dansong Wang Wenhui Lou | 2013 | Tumor Biology2013，，： | 1 |
| 14 | Race-specific genetic risk score is more accurate than nonrace-specific genetic risk score for predicting prostate cancer and high-grade diseases显示文摘基因风险分数(GRS ) 基于疾病联系风险的单个核苷酸多型性(SNP ) 是能被用来除了家庭历史为特定的疾病提供继承信息的一个增进知识的工具。然而,当计算 GRS 时,在一个特定的种族组被含有的 SNP 是否仅仅应该被使用,仍然是未知的。学习是为在 1338 个病人之中预言前列腺癌症(PCa ) 比较赛跑特定的 GRS 和 nonrace 特定的 GRS 的表演的这的目的在上海经历了前列腺活体检视,中国。赛跑特定的 GRS 与七 PCa 联系风险的 SNP 被计算在东方亚洲人(GRS7 ) 含有,并且 nonrace 特定的 GRS 基于 76 PCa 联系风险的 SNP 是计算的在至少一个种族组(GRS76 ) 含有。分别地, GRS7 和 GRS76 的工具在学习人口是 1.19 和 1.85。更高的 GRS7 和 GRS76 在 univariate 和 multivariate 分析是为 PCa 和高级 PCa 的独立预言者。GRS7 为区别 PCa (0.602 对 0.573 ) 和高级 PCa (0.603 对 0.575 ) 比 GRS76 在操作接收装置的曲线(AUC ) 下面有一个更好的区域但是没到达统计意义。有的 GRS7 一更好(多达 13% 在不同截止) 积极预兆的价值(PPV ) 比 GRS76。在结论,赛跑特定的 GRS 是更柔韧的并且当比用没被显示与东方亚洲人被联系的 SNP 计算的 GRS 在东方亚洲人预言 PCa 时,有更好的表演。 | Rong Na Dingwei Ye Jun Qi Fang Liu Xiaoling Lin Brian T Helfand Charles B Brendler Carly Conran Jian Gong Yishuo Wu Xu Gao Yaqing Chen S Lilly Zheng Zengnan Mo Qiang Ding Yinghao Sun Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 1 |
| 15 | Assistive control system using continuous myoelectric signal in robotaided arm training for patients after stroke显示文摘 | Song Rong Tong Kaiyu Hu Xiaoling | 2008 | IEEE Transaction on Neural Systems and Rehabilitation Engineering2008，16，4： | 1 |
| 16 | Magnetic field induced pearlite transformation in Fe–0.47C–2.31Si–3.15Mn steel above the eutectoid temperature显示文摘 | Xiaoling Zhou Rong Zhou Pengxiang Zhang Yehua Jiang Zeng Li Hui Zhao | 2009 | Materials Science & Engineering A2009，，1： | 1 |
| 17 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 18 | Assistive control system using continuous myoelectric signal in robot-aided arm training for patients after Stroke显示文摘 | Rong S Kai-yu T Xiaoling H | 2008 | IEEE T Neur Sys Reh2008，16，4： | 1 |
| 19 | Therapeutic effect of Qinghuayin(清化饮)against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β signaling pathway显示文摘OBJECTIVE:To examine the efficacy of Qinghuayin(清化饮,QHY)in rat chronic atrophic gastritis(CAG)models and explored the molecular mechanism of QHY in treating CAG.METHODS:In total,65 Wistar rats were randomly divided into the control(n=10)and CAG groups(n=55).CAG model rats were further divided into five groups:model(n=10),vitacoenzyme(n=10),low-dose QHY(n=10),medium-dose QHY(n=10),and high-dose QHY groups(n=10).We analyzed histopathological changes using hematoxylin and eosin staining and measured interleukin(IL)-6 and IL-8 levels in serum using enzyme-linked immunosorbent assay(ELISA)(Boster Bio,Pleasanton,USA).In addition,gastrin(GAS),pepsinogen I(PGI),and PGII expressions were evaluated using ELISA.The protein and m RNA expression of toll-like receptor 4(TLR4)and toll or interleukin-1 receptor domaincontaining adaptor inducing interferon-β(TRIF)was detected by Western blotting and quantitative reverse transcription-polymerase chain reaction,respectively.RESULTS:Our results revealed that histopathological changes in CAG model rates could be restored by low-,medium-,and high-dose QHY.The changes in GAS and PGI/II expression demonstrated that QHY improved CAG.Serum IL-6 and IL-levels were decreased by QHY administration.TLR4 and TRIF were upregulated at the m RNA and protein levels in the model group but downregulated by QHY administration.CONCLUSION:We concluded that QHY could effectively improve the histopathological changes of the gastric mucosa induced by CAG in rats.The therapeutic mechanism of QHY may be related to inhibition of the inflammatory factors IL-6 and IL-8 and suppression of TLR4/TRIF m RNA and protein expression. | HE Youcheng YAO Xiaoling LI Sihan ZHOU Hongjian XU Ruoying ZHENG Rong XIAO Wendi SU Ning LIN Ping HUANG Minghan | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
| 20 | A theoretical study of the influence of dopants on the dehydrogenation properties of VH_2显示文摘Using the plane wave ultrasoft pseudopotential method based on the first-principles density functional theory(DFT),the influence on the electronic structure and dehydrogenation properties of VH2 doped with Zr,Cu and Zn has been studied.The results show that the negative heat of formation increases and the valence electron number at the Fermi level EF,N(EF) decreases in the Zr-doped model,indicating the higher stability of VH2 after Zr alloying.On the other hand,the negative heat of formation of VH2 decreases and the N(EF) increases in Cu-or Zn-doped systems,suggesting the lower stability of VH2 after Cu or Zn alloying.The calculated overlap populations and electron densities of the V-H bond demonstrate that the bonding is strengthened by Zr doping and weakened by Cu or Zn doping.The results predict that the maximum capacity to absorb and desorb hydrogen can be raised by the introduction of Zr and reduced by the introduction of Cu or Zn,while the dehydrogenation properties will be poorer in Zr-doped systems and enhanced in Cu-or Zn-doped systems.These predictions are consistent with the experimental results.Mulliken populations were also calculated and it was found that the Mulliken population of the V 3d orbitals decreased as a result of Zr doping,and increased after Cu or Zn doping. | LI Rong LUO XiaoLing LIANG GuoMing FU WenSheng | 2011 | Science China Chemistry2011，54，9： | 0 |
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