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| 1 | Highly efficient generation of arbitrary vector beams with tunable polarization, phase, and amplitude显示文摘We propose an efficient and robust method to generate tunable vector beams by employing a single phasetype spatial light modulator(SLM). With this method, a linearly polarized Gaussian beam can be converted into a vector beam with arbitrarily controllable polarization state, phase, and amplitude. The energy loss during the conversion is greatly reduced and depends mainly on the reflectivity of the SLM. We experimentally demonstrate that conversion efficiency of about 47% is achieved by using an SLM with reflectivity of 62%.Several typical vector beams, including cylindrical vector beams, vector beams on higher order Poincaré spheres,and arbitrary vector beams attached with phases and with tunable amplitude, are generated and verified experimentally. This method is also expected to create high-power vector beams and play important roles in optical fabrication and light trapping. | SHENG LIU SHUXIA QI YI ZHANG PENG LI DONGJING WU LEI RAN JIANLIN ZHAO | 2018 | Photonics Research2018，6，4： | 23 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | Sorafenib extends the survival time of patients with multiple recurrences of hepatocellular carcinoma after liver transplantation显示文摘 | Wei-feng TAN Zhi-quan QIU Yong YU Rong-zheng RAN Bing YI Wan-yee LAU Chen LIU Ying-he QIU Fei-ling FENG Jing-han WANG Pei-ning YAN Bai-he ZHANG Meng-chao WU Xiang-ji LUO Xiao-qing JIANG | 2010 | Acta Pharmacologica Sinica2010，31，12： | 11 |
| 4 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 5 | Study of enzyme biosensor based on carbon nanotubes modified electrode for detection of pesticides residue显示文摘纸描述可控制的 layer-by-layer ( LBL )自己组装向玻璃化炭黑电极( GCE )的多围的碳 nanotubes ( MWNT )并且 poly 的修正技术( diallyldimethylammonium 氯化物)( PDDA ), Acetylcholinesterase (疼痛)被 LBL 直接使不能调动到修改 GCE 自己组装方法,疼痛的活动价值被使用它检测技术基于修改 Ellman 方法。然后,酉维因的作文被酶电极与 0.01U 活动价值检测,酉维因的检测极限是 10 ? 12 g L ? 1 酶生物传感器因此为杀虫剂显示出好性质残余察觉。 | Shu Ping Zhang Lian Gang Shan Zhen Ran Tian Yi Zheng Li Yi Shi Deng Song Zhang | 2008 | Chinese Chemical Letters2008，19，5： | 8 |
| 6 | Progress of intravoxel incoherent motion diffusion-weighted imaging in liver diseases显示文摘Traditional magnetic resonance(MR)diffusion-weighted imaging(DWI)uses a single exponential model to obtain the apparent diffusion coefficient to quantitatively reflect the diffusion motion of water molecules in living tissues,but it is affected by blood perfusion.Intravoxel incoherent motion(IVIM)-DWI utilizes a double-exponential model to obtain information on pure water molecule diffusion and microcirculatory perfusion-related diffusion,which compensates for the insufficiency of traditional DWI.In recent years,research on the application of IVIM-DWI in the diagnosis and treatment of hepatic diseases has gradually increased and has achieved considerable progress.This study mainly reviews the basic principles of IVIM-DWI and related research progress in the diagnosis and treatment of hepatic diseases. | Yun-Yun Tao Yi Zhou Ran Wang Xue-Qin Gong Jing Zheng Cui Yang Lin Yang Xiao-Ming Zhang | 2020 | World Journal of Clinical Cases2020，8，15： | 6 |
| 7 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 8 | Communication-less harmonic compensation in a multi-bus microgrid through autonomous control of distributed generation grid-interfacing converters显示文摘This paper proposes a novel approach to compensate buses voltage and current harmonics through distributed generation(DG)interfacing converter in a multibus microgrid.The control approach of each individual DG unit was designed to use only feedback variables of the converter itself that can be measured locally.In the proposed approach,the adjacent bus voltage is indirectly derived from the measured DG converter output voltage,DG line current and line impedance.A voltage closed-loop controller and a current closed-loop controller are designed to achieve both functions of DG real power generation and harmonics compensation.Therefore,the traditional harmonic measurement devices installed at the bus as well as the long distance communication between the bus and the DG converter are not required.The proposed approach can compensate the current harmonics,mitigate the buses voltage distortion and enable the customer devices to be operated in normal conditions within the multi-bus microgrid,and meanwhile relieve the burden of power quality regulator installed at the point of common coupling.Matlab simulations and experimental results are presented to show the operational effectiveness of the proposed approach. | Guangqian DING Ran WEI Ke ZHOU Feng GAO Yi TANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 5 |
| 9 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 10 | Detection of siderotic nodules in the liver with susceptibility weighted imaging: correlations to serum ferritin, Child-Pugh grade and hyaluronic acid levels显示文摘 | TAO Ran YOU Zhong-lan ZHANG Jiu-quan DAI Yong-ming ZHOU Dai-quan CAI Ping FAN Yi CUI Jin-guo WANG Jian | 2012 | Chinese Medical Journal2012，，17： | 5 |
| 11 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 12 | The Role of ROS in Hydroquinone-induced Inhibition of K562 Cell Erythroid Differentiation显示文摘The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated.After K562 cells were treated with hydroquinone for 24 h,and hemin was later added to induce erythroid differentiation for 48 h,hydroquinone inhibited hemin-induced | YU Chun Hong Suriguga LI Yang LI Yi Ran TANG Ke Ya JIANG Liang YI Zong Chun | 2014 | Biomedical and Environmental Sciences2014，27，3： | 5 |
| 13 | Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity显示文摘 | F. Ann Ran Patrick D. Hsu Chie-Yu Lin Jonathan S. Gootenberg Silvana Konermann Alexandro E. Trevino David A. Scott Azusa Inoue Shogo Matoba Yi Zhang Feng Zhang | 2013 | Cell2013，，2： | 4 |
| 14 | Bioinspired Unidirectional Liquid Transport Micro-nano Structures:A Review显示文摘Unidirectional liquid transport without any need of external energy has drawn worldwide attention for its potential applications in various fields such as microfluidics,biomedicine and mechanical engineering.In nature,numerous creatures have evolved such extraordinary unidirectional liquid transport ability such as spider sik,Sarracenia's trichomes,and Nepenthes alata's peristome,etc.This review summarizes the current progresses of natural unidirectional liquid transport on 1-Dimensional(1D)linear structure and 2-Dimensional(2D)surface stucture.The driving force of unidirectional liquid transport which is determined by unique structure exist distinct differences in physics.The fundamental understanding of 1D and 2D unidirectionaliquid transport especially about hierarchical structural characteristics and their transport mechanism were concentrated,and various bioinspired fabrication methods are also introduced.The applications of bioinspired directional liquid transport are demonstrated especially in fields of microfluidies,biomedical devices and anti-icing surfaces.With newly developed smart materials,various liquid transport regulation strategies are also summarized for the control of transport speed,direction guiding,etc.Finally,we provide new insights and future perspectives of the directional transport materials. | Liwen Zhang Guang Liu Huawei Chen Xiaolin Liu Tong Ran Yi Zhang Yang Gan Deyuan Zhang | 2021 | Journal of Bionic Engineering2021，18，1： | 4 |
| 15 | Experimental study on the partial discharge and AC breakdown properties of C_(4)F_(7)N/CO_(2)mixture显示文摘As an environmental friendly insulating medium,C_(4)F_(7)N has received extensive attention in the past two years.In this study,the partial discharge(PD)and breakdown characteristics of C_(4)F_(7)N/CO_(2)gas mixture were investigated using the gas insulation performance test platform.The influence of gas pressure and mixing ratio on the PD initial voltage(PDIV)and breakdown voltage of C_(4)F_(7)N/CO_(2)gas mixture in different electric fields was tested.It was found that the PDIV and breakdown voltage of gas mixture with 2-8%C_(4)F_(7)N in the highly non-uniform field showed a linear saturation increasing trend with the change of gas pressure and mixing ratio.The breakdown voltage of gas mixture increases linearly with gas pressure in the quasi-uniform electric field.The relative breakdown voltage of gas mixture in the highly non-uniform field under high-pressure conditions is inferior to those of low-pressure conditions.The C_(4)F_(7)N/CO_(2)gas mixture containing 2-8%C_(4)F_(7)N is sensitive to the non-uniformity of electric field.According to the PD and breakdown tests results,C_(4)F_(7)N/CO_(2)gas mixture with 2-8%C_(4)F_(7)N has the potential to replace SF6 using in gas-insulated equipment. | Yi Li Xiaoxing Zhang Ji Zhang Mingli Fu Ran Zhuo Yi Luo Dachang Chen Song Xiao | 2019 | High Voltage2019，4，1： | 4 |
| 16 | De Novo and Inherited SETD1A Variants in Early-onset Epilepsy显示文摘Early-onset epilepsy is a neurological abnormality in childhood, and it is especially common in the first2 years after birth. Seizures in early life mostly result from structural or metabolic disorders in the brain, and the genetic causes of idiopathic seizures have been extensively investigated. In this study, we identified four missense mutations in the SETD1 A gene(SET domain-containing 1 A, histone lysine methyltransferase): three de novo mutations in three individuals and one inherited mutation in a four-generation family. Whole-exome sequencing indicated that all four of these mutations were responsible for the seizures. Mutations of SETD1 A have been implicated in schizophrenia and developmental disorders, so we examined the role of the four mutations(R913 C, Q269 R, G1369 R, and R1392 H) in neural development. We found that their expression in mouse primary cortical neurons affected excitatory synapse development. Moreover, expression of the R913 C mutation also affected the migration of cortical neurons in the mouse brain.We further identified two common genes(Neurl4 and Usp39) affected by mutations of SETD1 A. These results suggested that the mutations of SETD1 A play a fundamental role in abnormal synaptic function and the development of neurons, so they may be pathogenic factors for neurodevelopmental disorders. | Xiuya Yu Lin Yang Jin Li Wanxing Li Dongzhi Li Ran Wang Kai Wu Wenhao Chen Yi Zhang Zilong Qiu Wenhao Zhou | 2019 | Neuroscience Bulletin2019，35，6： | 4 |
| 17 | First record of the little fire ant,Wasmannia auropunctata(Hymenoptera:Formicidae),in Chinese mainland显示文摘In January 2022,we received ant specimens collected from three field colonies from Shantou City,Guangdong Province,China.They were identified as the little fire ant,Wasmannia auropunctata,through morphological and molecular analyses.Wasmannia auropunctata is listed as one of the 100 most dangerous invasive species by the International Union for Conservation of Nature(IUCN)and has spread from its native range in South America to every continent except Antarctica.DNA analysis of mitochondrial cytochrome c oxidase subunit I(COI)in nine specimens of W.auropunctata found that they had a close genetic relationship with specimens from Argentina.This study represents the first formal record of the establishment of W.auropunctata outdoor in Chinese mainland.However,the invasion stage and occurrence degree of W.auropunctata in China are not clear to date.The implementation of quarantine measures,investigation of the occurrence and distribution,and development of monitoring and control strategies are needed to actively respond to the threat posed by this highly invasive ant. | CHEN Si-qi ZHAO Yi LU Yong-yue RAN Hao XU Yi-juan | 2022 | Journal of Integrative Agriculture2022，21，6： | 4 |
| 18 | Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling显示文摘Neurovascular unit(NVU)is organized multi-cellular and multi-component networks that are essential for brain health and brain homeostasis maintaining.Neurovascular unit dysfunction is the central pathogenesis process of ischemic stroke.Thus integrated protection of NVU holds great therapeutic potential for ischemic stroke.Catalpol,classified into the iridoid monosaccharide glycoside,is the main active ingredient of the radix from traditional Chinese medicine,Rehmannia glutinosa Libosch,that exhibits protective effects in several brain-related diseases.In the present study,we investigated whether catalpol exerted protective effects for NVU in ischemic stroke and the underlying mechanisms.MCAO rats were administered catalpol(2.5,5.0,10.0 mg·kg^(−1)·d^(−1),i.v.)for 14 days.We showed that catalpol treatment dose-dependently reduced the infarction volume and significantly attenuated neurological deficits score in MCAO rats.Furthermore,catalpol treatment significantly ameliorated impaired NVU in ischemic region by protecting vessel-neuron-astrocyte structures and morphology,and promoting angiogenesis and neurogenesis to replenish lost vessels and neurons.Moreover,catalpol treatment significantly increased the expression of vascular endothelial growth factor(VEGF)through up-regulating PI3K/AKT signaling,followed by increasing FAK and Paxillin and activating PI3K/AKT and MEK1/2/ERK1/2 pathways.The protective mechanisms of catalpol were confirmed in an in vitro three-dimensional NVU model subjected to oxygen-glucose deprivation.In conclusion,catalpol protects NVU in ischemic region via activation of PI3K/AKT signaling and increased VEGF production;VEGF further enhances PI3K/AKT and MEK1/2/ERK1/2 signaling,which may trigger a partly feed-forward loop to protect NVU from ischemic stroke. | Hong-jin Wang Hai-feng Ran Yue Yin Xiao-gang Xu Bao-xiang Jiang Shi-qi Yu Yi-jin Chen Hui-jing Ren Shan Feng Ji-fen Zhang Yi Chen Qiang Xue Xiao-yu Xu | 2022 | Acta Pharmacologica Sinica2022，43，7： | 4 |
| 19 | Analysis and Simulation of the Stratospheric Quasi-zero Wind Layer over Korla, Xinjiang Province, China显示文摘The stratospheric quasi-zero wind layer (QZWL) is a transition region with low zonal wind speeds in the lower stratosphere at an altitude of ~20 km. The zonal wind direction above the QZWL layer is opposite to that below the QZWL layer and the north –south wind component is small. The atmospheric wind field near the stratospheric QZWL is an important factor affecting the flight altitude and dynamic control of stratospheric airships. It is therefore necessary to study the stratospheric QZWL to provide better environmental information for these aircraft. High-resolution radiosonde data were used to analyze the characteristics of the stratospheric QZWL over Korla, Xinjiang Province, China. A weak wind layer in which the wind direction suddenly reversed from westerly to easterly was observed at ~20 km in the lower stratosphere, characteristic of the stratospheric QZWL. The Weather Research and Forecasting model was used to simulate the profiles of the horizontal wind speed and direction over Korla. The forcing effect of each diagnostic term in the equation on the zonal wind speed was analyzed. The results showed that the advection term was the dominant factor forcing the zonal wind speed. The wave term had a secondary forcing role, although the forcing effect of the wave term on the zonal wind speed was significant in some regions. | Rui YANG Lingkun RAN Yuli ZHANG Yi LIU | 2019 | Advances in Atmospheric Sciences2019，36，10： | 3 |
| 20 | An effective thermal conductivity model for unsaturated compacted bentonites with consideration of bimodal shape of pore size distribution显示文摘An effective thermal conductivity model was proposed for unsaturated compacted bentonites with consideration of the bimodal shape of pore size distribution curves.The pores of soils were grouped into two dominant pore size modes corresponding to the intra-and inter-particle pores,and were simulated with randomly distributed spheroidal inclusions of different aspect ratios.With the assumption of preferential invasion of the wetting fluid(water)into pores of smaller sizes and by virtue of the analytical solution to the inhomogeneous inclusion problem in heat conduction,the model was developed using the Mori-Tanaka(MT),Ponte Casta?eda-Willis(PCW)and self-consistent(SC)homogenization approaches for different considerations of the interactions between pores and the solid phase.The proposed model is functions of the thermal conductivities of the solid,liquid and gas phases,porosity,the degree of saturation,the aspect ratios of pores and/or soil particles,and the fraction of the smaller group of pores.The proposed model was validated against five sets of laboratory measurement data on the MX-80,FEBEX,Kunigel-V1 and GMZ01 bentonites,showing a good agreement between the model predictions and the laboratory measurements.The responses of the model with respect to the geometries of pores and solid particles were examined.Compared to series-parallel structural models,the proposed model may overall exhibit better performance if proper homogenization schemes are adopted,but as an advantage,the model has clearer physical mechanisms and a smaller number of parameters. | CHEN Yi Feng WANG Min ZHOU Song HU Ran ZHOU Chuang Bing | 2015 | Science China(Technological Sciences)2015，58，2： | 3 |
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