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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 3 | N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage显示文摘 | Xun Weng Yan Tan Xiang Chu Xiao-Feng Wu Rui Liu Yue Tian Lin Li Feng Guo Qing Ouyang Lei Li | 2015 | Chinese Journal of Traumatology2015，18，5： | 12 |
| 4 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 5 | Estimating survival benefit of adjuvant therapy based on a Bayesian network prediction model in curatively resected advanced gallbladder adenocarcinoma显示文摘BACKGROUND The factors affecting the prognosis and role of adjuvant therapy in advanced gallbladder carcinoma(GBC)after curative resection remain unclear.AIM To provide a survival prediction model to patients with GBC as well as to identify the role of adjuvant therapy.METHODS Patients with curatively resected advanced gallbladder adenocarcinoma(T3 and T4)were selected from the Surveillance,Epidemiology,and End Results database between 2004 and 2015.A survival prediction model based on Bayesian network(BN)was constructed using the tree-augmented na?ve Bayes algorithm,and composite importance measures were applied to rank the influence of factors on survival.The dataset was divided into a training dataset to establish the BN model and a testing dataset to test the model randomly at a ratio of 7:3.The confusion matrix and receiver operating characteristic curve were used to evaluate the model accuracy.RESULTS A total of 818 patients met the inclusion criteria.The median survival time was 9.0 mo.The accuracy of BN model was 69.67%,and the area under the curve value for the testing dataset was 77.72%.Adjuvant radiation,adjuvant chemotherapy(CTx),T stage,scope of regional lymph node surgery,and radiation sequence were ranked as the top five prognostic factors.A survival prediction table was established based on T stage,N stage,adjuvant radiotherapy(XRT),and CTx.The distribution of the survival time(>9.0 mo)was affected by different treatments with the order of adjuvant chemoradiotherapy(cXRT)>adjuvant radiation>adjuvant chemotherapy>surgery alone.For patients with node-positive disease,the larger benefit predicted by the model is adjuvant chemoradiotherapy.The survival analysis showed that there was a significant difference among the different adjuvant therapy groups(log rank,surgery alone vs CTx,P<0.001;surgery alone vs XRT,P=0.014;surgery alone vs cXRT,P<0.001).CONCLUSION The BN-based survival prediction model can be used as a decision-making support tool for advanced GBC patients.Adjuvant chemoradiotherapy is expected to improve the survival significantly for patients with node-positive disease. | Zhi-Min Geng Zhi-Qiang Cai Zhen Zhang Zhao-Hui Tang Feng Xue Chen Chen Dong Zhang Qi Li Rui Zhang Wen-Zhi Li Lin Wang Shu-Bin Si | 2019 | World Journal of Gastroenterology2019，25，37： | 9 |
| 6 | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation显示文摘AIM: Ursolic acid(UA), a pentacyclic triterpenoid, is used as an anti-inflammatory and anti-cancer agent. There were few studies on the effects of UA on differentiation, and this is the first time to elucidate the potential effect and molecular mechanism of UA on inducing differentiation in the human leukemia cell line U937. METHODS: Wright-Giemsa staining, nitroblue tetrazolium reduction assay and flow cytometric analysis were utilized to demonstrate the differentiation of U937 cells induced by UA. Western blotting and immunofluorescence assay were used to investigate the possible mechanism. RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation. Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA. CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia. | DENG Lin ZHANG Rui TANG Feng LI Chen XING Ying-Ying XI Tao | 2014 | Chinese Journal of Natural Medicines2014，12，1： | 8 |
| 7 | Effects of lipid-lowering agents on diabetic retinopathy: a Meta-analysis and systematic review显示文摘AIM: To clarify this controversy and to provide evidence for application of lipid lowering agents in treatment of diabetic retinopathy(DR).METHODS: We searched the databases of Pub Med, Embase and Cochrane Library Central Register of Controlled Trials(CENTRAL) and abstracts from main annual meetings up to January 1, 2017. Google scholar and ClinicalT rials.gov were also searched for unpublished relevant studies. We included randomized controlled trials(RCTs) that studied lipid-lowering agents in type 1 or type 2 diabetes in this Meta-analysis. The primary endpoint was the progression of DR, and the secondary endpoints included vision loss, development of diabetic macular edema(DME) and aggravation of hard exudates. The pooled odds ratios(OR)with corresponding 95% confidence intervals(95%CIs) were calculated.RESULTS: After systemic and manual literature search by two independent investigators, we included 8 RCTs from 7 published articles with 13 454 participants in this Meta-analysis. The results revealed that lipid-lowering drugs were associated with reduced risk in DR progression [OR=0.77(95%CI: 0.62, 0.96), P=0.02]. Lipid-lowering agents might have protective effect on DME compared to placebo, although the difference was not statistically significant [OR=0.60(95%CI: 0.34, 1.08), P=0.09]. However, no significant differences in the worsening of vision acuity [OR=0.96(95%CI: 0.81,1.14), P=0.64] and hard exudates [OR=0.50(95%CI:0.15, 1.74), P=0.28] were found between the lipidlowering drugs and the placebo groups.CONCLUSION: In DR patients, lipid-lowering agents show a protective effect on DR progression and might be associated with reduced risk in the development of DME. However, lipid-lowering agents have no effects on vision loss and hard exudates aggravation. Further clinical trials in larger scale are required to confirm the conclusion of this study and thus justify the use of intensive control lipids with anti-lipid agents at the early stages of DR. | Rui Shi Lei Zhao Feng Wang Fen Liu Zhuo Chen Rong Li Yang Liu Rong Lin | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 8 |
| 8 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | Optimization of equimolar reverse constant-temperature mass-diffusion process for minimum entransy dissipation显示文摘The mass entransy describes the mass-diffusion ability of the solution system, and the mass-diffusion process with the finite concentration difference always leads to the mass-entransy dissipation. This paper studies the equimolar reverse constant-temperature mass-diffusion process with Fick's law( g∝Δ(c)). The optimal concentration paths for the MED(Minimum Entransy Dissipation) are derived and compared with those for the MEG(Minimum Entropy Generation) and CCR(Constant Concentration Ratio) operations. It is indicated that the strategy of the MED is equivalent to that of the CCD(Constant Concentration Difference) of the same component; whether the MED or the MEG is selected as the optimization objective, the strategy of the CCD is much better than that of the CCR. | XIA Shao Jun CHEN Lin Gen SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 7 |
| 11 | Diversity of Microbial Community in a Paddy Soil with cry1Ac/cpti Transgenic Rice显示文摘Two types of cry1Ac/cpti transgenic rice(GM1 and GM2)and their parental non-cry1Ac/cpti rice(CK1 and CK2)were planted in the field at Wufeng,Fujian Province,China for four years to investigate the influence of genetically modified rice on diversity of bacterial and fungal community in the paddy soil.The community composition and abundance of bacteria or fungi in the paddy soil were assessed at different growth stages of rice by denaturing gradient gel electrophoresis and real-time polymerase chain reaction based on 16S rRNA gene or SSU rRNA gene in the 4th year after the experimental establishment.The composition of bacterial or fungal community changed during rice growth,while no significant differences were observed between the fields cultivated with GM1and CK1,or between the fields cultivated with GM2 and CK2 in either bacterial or fungal community composition.The copy numbers of bacterial 16S rRNA gene in the soils with CK1,CK2,GM1 and GM2 ranged from 5.64×1011to 6.89×1011copies g-1dry soil at rice growth stages,and those of fungal SSU rRNA gene from 5.24×108to 8.68×108copies g-1dry soil.There were no marked differences in the copies of bacterial 16S rRNA gene or fungal SSU rRNA gene between CK1 and GM1 or between CK2 and GM2at any growth stage of rice.Planting cry1Ac/cpti transgenic rice had no significant effect on composition and abundance of bacterial and fungal community in paddy soil during the rice growing season at least in the short term. | SONG Ya-Na SU Jun CHEN Rui LIN Yan WANG Feng | 2014 | Pedosphere2014，24，3： | 5 |
| 12 | Clinical and experimental study of therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions显示文摘ClinicalandexperimentalstudyoftherapeuticefectofWeixibaonizhuanpilsongastricprecancerouslesionsZHANGXuChen1,GAORuiFeng2,LI... | ZHANG XuChen1, GAO RuiFeng2, LI BingQing2, MA LianSheng3, MEI LiXin1, WU YuZhen2, LIU FengQin2 and Liao ZhengLin2 | 1998 | World Journal of Gastroenterology1998，4，1： | 5 |
| 13 | Thermal performance analysis of non-uniform height rectangular fin based on constructal theory and entransy theory显示文摘A model of non-uniform height rectangular fin, in which the variation of base's thickness and width are taken into account, is established in this paper. The dimensionless maximum thermal resistance(DMTR) and the dimensionless equivalent thermal resistance(DETR) defined based on the entransy dissipation rate(EDR) are taken as performance evaluation indexes. According to constructal theory, the variations of the two indexes with the geometric parameters of the fin are analyzed by using a finite-volume computational fluid dynamics code, the effects of the fin-material fraction on the two indexes are analyzed. It is found that the two indexes decrease monotonically as the ratio between the front height and the back height of the fin increases subjected to the non-uniform height rectangular fin. When the model is reduced to the uniform height fin, the two indexes increase first and then decrease with increase in the ratio between the height of the fin and the fin space. The fin-material fraction has no effect on the change rule of the two indexes with the ratio between the height of the fin and the fin space. The sensitivity of the DETR to the geometric parameters of the fin is higher than that of the DMTR to the geometric parameters. The results obtained herein can provide some theoretical support for the thermal design of rectangular fins. | YANG Ai Bo CHEN Lin Gen XIE Zhi Hui FENG Hui Jun SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 4 |
| 14 | Rapid Internal Control Reference Recombinase-Aided Amplification Assays for EBV and CMV Detection显示文摘Epstein-Barr virus(EBV)and cytomegalovirus(CMV),two of the most prevalent human herpesviruses,cause a wide spectrum of diseases and symptoms and are associated with serious health problem.In this study,we developed an internal control reference recombinase-aided amplification(ICR-RAA)assay for the rapid detection of EBV and CMV within 30 min.The assay had a sensitivity of 5 and 1 copies/test for EBV and CMV,respectively,with no cross reaction with other pathogens.In comparison with those of the commercial quantitative polymerase chain reaction(qPCR),the sensitivity of the EBV and CMV ICR-RAAs using extracted DNA was 93.33%and 84.84%,respectively;the specificity was 98.75%and 100.00%,respectively;and the Kappa values were 0.930 and 0.892(P<0.05),respectively.In comparison with those of qPCR,the sensitivity of the EBV and CMV ICR-RAAs using the DNA by thermal lysis was 72.22%and 80.00%,respectively;the specificity was 100.00%。 | GAO Yuan TIE Yan Qing ZHAO Lin Qing TAN He DING Nan DING Ya Xin GUO Qi ZHANG Rui Qing WANG Jin Rong CHEN Zi Wei FAN Guo Hao SHEN Xin Xin FENG Zhi Shan MA Xue Jun | 2021 | Biomedical and Environmental Sciences2021，34，8： | 3 |
| 15 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 16 | A new ent-kaurane diterpenoid from Isodon japonica显示文摘One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis. | Di, Xue Mei Yan, Fu Lin Feng, Chuang Xie, Rui Jie Hou, Rui Jie Sun, Han Dong | 2010 | Chinese Chemical Letters2010，21，2： | 3 |
| 17 | Rapid and reversible Na deposition onto Al nanosheet arrays显示文摘Sodium metal battery(SMB)is regarded as a promising candidate for next-generation high-energy battery due to high theoretical capacity and abundant natural resources.However,the growth of sodium dendrites and large volume expansion during the processes of sodium plating and stripping seriously restrict the practical application of SMBs.Here,a three-dimensional skeleton of aluminum nanosheet arrays(Al NSARs)is constructed by a facile etching approach to achieve rapid and reversible Na plating/stripping.The Al NSARs with large geometric specific surface and plentiful cavities can provide rich active nucleation sites,reduce local current density and accommodate Na volume change,which lead to uniform deposition of sodium with dendrite-free morphology.As a result,Na plating/stripping on Al NSARs can stably operate over 650 cycles at 2 mA cm^(-2)/2 mAh cm^(-2)with average Coulombic efficiency(CE)of 100.0%and low potential polarization of 27 mV.Moreover,the full cell of Na_(s)V_(2)(PO_(4))_(3)||Al NSARs@Na can run for over 1800 cycles at a high rate of 20C.These superior properties,combined with relatively low cost and weight of Al,enable our AlNSARs to begreat prospect for practical applications. | Fang Tang Rongqing Xia Dong Chen Yu Yao Lin Liu Yuezhan Feng Xianhong Rui Yan Yu | 2022 | Journal of Energy Chemistry2022，31，11： | 3 |
| 18 | Improvements on physical conditions of bauxite residue following application of organic materials显示文摘Soil formation and ecological rehabilitation is the most promising strategy to eliminate environmental risks of bauxite residue disposal areas. Its poor physical structure is nevertheless a major limitation to plant growth. Organic materials were demonstrated as effective ameliorants to improve the physical conditions of bauxite residue. In this study, three different organic materials including straw(5% W/W), humic acid(5% W/W), and humic acidacrylamide polymer(0.2% and 0.4%, W/W) were selected to evaluate their effects on physical conditions of bauxite residue pretreated by phosphogypsum following a 120-day incubation experiment. The proportion of 2-1 mm macro-aggregates, mean weight diameter(MWD) and geometric mean diameter(GWD) increased following organic materials addition, which indicated that organic materials could enhance aggregate stability. Compared with straw, and humic acid, humic acid-acrylamide polymer application had improved effects on the formation of water-stable aggregates in the residues. Furthermore, organic materials increased the total porosity, total pore volume and average pore diameter, and reduced the micropore content according to nitrogen gas adsorption(NA) and mercury intrusion porosimetry(MIP)analysis, whilst enhancing water retention of the residues based on water characteristic curves. Compared with traditional organic wastes, humic acid-acrylamide polymer could be regarded as a candidate according to the comprehensive consideration of the additive amount and the effects on physical conditions of bauxite residue. These findings could provide a novel application to both Ca-contained acid solid waste and high-molecular polymers on ecological rehabilitation at disposal areas. | Ying Guo Yuzhen Ye Feng Zhu Rui Xue Xianchao Zhang Mingxing Zhu William Hartley Lin Guo Shengguo Xue | 2022 | Journal of Environmental Sciences2022，34，6： | 2 |
| 19 | Tumor suppressor p53:new functions of an old protein显示文摘p53 was discovered 30 years ago.Extensive studies have been done on p53 since then,which makes p53 one of the most extensively studied genes.p53 has long been recognized as a key tumor suppressor.Cell cycle arrest,apoptosis and senescence have been traditionally recognized as the main functions of p53 in tumor suppression.Recently,some novel functions of p53 have been identified,including the regulation of energy metabolism,antioxidant defense,and microRNA expression and maturation,which all contribute to the role of p53 in tumor suppression.Furthermore,the contribution of p53 to normal biologic processes(e.g.reproduction and aging)and some other aspects of diseases(e.g.neurodegenerative diseases)is only now being appreciated.Here we will review recent advances in the study of some new functions of p53. | Zhaohui FENG Rui WU Meihua LIN Wenwei HU | 2011 | Frontiers in Biology2011，6，1： | 2 |
| 20 | Spectrally multiplexed and bright entangled photon pairs in a lithium niobate microresonator显示文摘On-chip bright quantum sources with multiplexing ability are extremely high in demand for integrated quantum networks with unprecedented scalability and complexity.Here,we demonstrate a bright and broadband biphoton quantum source with spectral multiplexing generated in a lithium niobate microresonator system.Without introducing the conventional domain poling,the on-chip microdisk produces photon pairs covering a broad bandwidth promised by natural phase matching in spontaneous parametric down conversion.Experimentally,the multiplexed photon pairs are characterized by 30 nm bandwidth limited by the filtering system,providing over 40 multiplexing channels with a 0.8 nm channel spacing.Meanwhile,the generation rate reaches 5.13 MHz/μW with a coincidence-to-accidental ratio up to 804,and the quantum source manifests a high purity with a heralded single photon correlation g^((2))_(H)(0)=0.0098±0.0021.Furthermore,the energy-time entanglement is demonstrated with an excellent interference visibility of 96.5%±2%.Such a quantum source at the telecommunication band paves the way for high-dimensional entanglement and future integrated quantum information systems. | Bo-Yu Xu Li-Kun Chen Jin-Tian Lin Lan-Tian Feng Rui Niu Zhi-Yuan Zhou Ren-Hong Gao Chun-Hua Dong Guang-Can Guo Qi-Huang Gong Ya Cheng Yun-Feng Xiao Xi-Feng Ren | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，9： | 2 |
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