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| 1 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 2 | 宁夏年降水和季节降水的创新趋势分析显示文摘采用创新趋势分析(ITA)方法对1961年至2018年宁夏不同强度降水的时空变化进行研究。结果表明,区域年降水量增加主要是弱降水增加,而区域年降水量减少主要是强降水减少;极端降水的变化趋势明显。不同类型极端降水的贡献随季节变化。春季区域降水增加主要是强降水增加,区域降水减少主要是弱降水减少。夏季和秋季区域降水增加主要是弱降水增加,而区域降水减少是由强降水减少引起。该研究结果为水资源规划和应对干旱和洪涝灾害提供了支持。 | YANG Huiling XIAO Hui GUO Chunwei SUN Yue GAO Ruina | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 4 |
| 3 | Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak显示文摘Background:Spermatogenesis is a cellular differentiation process that includes three major events:mitosis of spermatogonia,meiosis of spermatocytes and spermiogenesis.Steady-state spermatogenesis relies on functions of spermatogonial stem cells(SSCs).Establishing and maintaining a foundational SSC pool is essential for continued spermatogenesis in mammals.Currently,our knowledge about SSC and spermatogenesis is severely limited in domestic animals.Results:In the present study,we examined transcriptomes of testes from domestic yaks at four different stages(3,5,8 and 24 months of age)and attempted to identify genes that are associated with key developmental events of spermatogenesis.Histological analyses showed that the most advanced germ cells within seminiferous tubules of testes from 3,5,8 and 24 months old yaks were gonocytes,spermatogonia,spermatocytes and elongated spermatids,respectively.RNA-sequencing(RNA-seq)analyses revealed that 11904,4381 and 2459 genes were differentially expressed during the gonocyte to spermatogonia transition,the mitosis to meiosis transition and the meiosis to post-meiosis transition.Further analyses identified a list of candidate genes than may regulate these important cellular processes.CXCR4,a previously identified SSC niche factor in mouse,was one of the up-regulated genes in the 5 months old yak testis.Results of immunohistochemical staining confirmed that CXCR4 was exclusively expressed in gonocytes and a subpopulation of spermatogonia in the yak testis.Conclusions:Together,these findings demonstrated histological changes of postnatal testis development in the domestic yak.During development of spermatogonial lineage,meiotic and haploid germ cells are supported by dynamic transcriptional regulation of gene expression.Our transcriptomic analyses provided a list of candidate genes that potentially play crucial roles in directing the establishment of SSC and spermatogenesis in yak. | Guowen Wang Yongchang Li Qilin Yang Shangrong Xu Shike Ma Rongge Yan Ruina Zhang Gongxue Jia Deqiang Ai Qi’en Yang | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 4 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 5 | Synthesis, structure and characterization of binuclear copper(I) complexes显示文摘 | Ruina Yang Kunhua Lin Yimin Hou Dongmei Wang Douman Jin Baosheng Luo Liaorong Chen | 1997 | Transition Metal Chemistry1997，，3： | 1 |
| 6 | Synthesis and Structure of Copper(Ⅱ) Complex显示文摘 | Yang Ruina Li Caiyun Liu Yingfan | 2001 | Chin J Struct Chem2001，20，1： | 1 |
| 7 | Osteoinduction of hydroxyapatite/β-tricalcium phosphate bioceramics in mice with a fractured fibula显示文摘 | Lijia Cheng Feng Ye Ruina Yang | 2010 | Acta Biomaterialia2010，6，： | 1 |
| 8 | Synthesis and properties of binuclear copper complexes containing bis(diphenylphosphine) methane显示文摘 | Yang Ruina Wang Dongmei Jin Douman | 2001 | Russian J Inorg Chem2001，46，7： | 1 |
| 9 | Synthesis and crystal structure of copper complex of bis(diphenylphosphino)methane显示文摘 | Wang Dongmei Yang Ruina Jin Douman | 2000 | Indian J Chem2000，39，： | 1 |
| 10 | MicroRNAs in tumor stem cells显示文摘Micro RNAs(mi RNAs) are a class of non-coding RNAs that are believed to have a significant role in tumorigenesis and cancer metastasis. Cancer stem cells play a major role in tumor recurrence, metastasis, and drug resistance. Research has shown that mi RNAs can promote or inhibit the stemness of cancer stem cells and regulate the differentiation and self-renewal of cancer stem cells. In this article, the phenotype and regulatory mechanisms of mi RNAs in cancer stem cells will be described, together with an explanation of their potential role in tumor diagnosis and treatment. | Xiaochen Hu Junqiang Yang Ruijie Yang Ruina Yang Xinshuai Wang Shegan Gao | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，2： | 0 |
| 11 | Bioaerosol emissions variations in large-scale landfill region and their health risk impacts显示文摘Landfills are widely complained about due to the long-term odor and landfill gas emissions for local residents,while the bioaerosols are always neglected as another threat to on-site workers.In this study,bioaerosols samples were collected from the typical operation scenes in the large-scale modern landfill,and the emission levels of airborne bacteria,pathogenic species,and fungi were quantified and co-related.The corresponding exposure risks were assessed based on the average daily dose via inhalation and skin contact.It was found that the levels of culturable bacteria and fungi in all landfill samples were around 33–22778 CFU/m3 and 8–450 CFU/m3,and the active-working landfill area and the covered area were the maximum and minimum emission sources,respectively,meaning that the bioaerosols were mainly released from the areas related with the fresh waste operation.Acinetobacter sp.,Massilia sp.,Methylobacterium-Methylorubrum sp.and Noviherbaspirillum sp.were the main bacterial populations,with a percentage of 42.56%,89.82%,70.24%and 30.20%respectively in total bioaerosols measured.With regards to the health risk,the health risks via inhalation were the main potential risks,with four orders of magnitude higher than that of skin contact.Active-working area showed the critical point for non-carcinogenic risks,with a hazard quotient of 1.68,where 80 m protection distance is recommended for on-site worker protection,plus more careful protection measures. | Yanfeng Yang Ruina Zhang Ziyang Lou | 2022 | Frontiers of Environmental Science & Engineering2022，16，12： | 0 |
| 12 | Synthesis and Crystal Structure of Tetrabonzoato Bis (2-Aminothiazol) Dicopper(Ⅱ)显示文摘SynthesisandCrystalStructureofTetrabonzoatoBis(2-Aminothiazol)Dicopper(Ⅱ)WangDong-Mei;HouYi-Min;YangRuiNa;HuXiao-Yuan;XuoBao-... | Wang Dong-Mei Hou Yi-Min Yang RuiNa Hu Xiao-Yuan Xuo Bao-Yu Jin DouMan(Henan Institute of Chemistry, Zhengzhou 450003)Chen Liao-Rong, Luo Bao-Sheng(Wuhan University , Wuhan 430072) | 1995 | Chinese Journal of Structural Chemistry1995，14，4： | 0 |
| 13 | Smad8 is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice显示文摘Background:SMAD family proteins(SMADs)are crucial transcription factors downstream of transforming growth factor beta(TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction.However,the role of SMAD family member 8(SMAD8,also known as SMAD9),a member of the SMAD family,in mammalian reproduction remains unclear.Methods:We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells(GCs)to investigate the effects of Smad8 on GC growth and steroidogenesis.Results:Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate of GCs after transfection with Smad8-siRNA for 48 h.Subsequent hormone assays demonstrated a significant decrease in estradiol(E2)levels,whereas progesterone(P4)remained unchanged.Further mechanistic analysis showed that the mRNA expression of proliferating cell nuclear antigen(Pcna),Cyclin D2,cell cycle-dependent kinase 4(Cdk4),B-cell lymphoma-2(Bcl-2),estrogen receptor(Er),luteinizing hormone receptor(Lhr)and cytochrome P450 family 19 subfamily A member 1(Cyp19a1)significantly decreased.Conversely,the mRNA of cysteine aspartate proteinase 3(Caspase 3)significantly increased,wheras Bcl2-associated X(Bax),folliclestimulating hormone receptor(Fshr)and cytochrome P450 family 11 subfamily A member 1(Cyp11a1)remained unchanged compared to the controls.Conclusion:This study indicates that Smad8 knockdown inhibits cell proliferation,promotes apoptosis,reduces Er and Lhr transcription,and decreases E2 production in mouse GCs.These findings suggest that Smad8 may serve as a novel genetic marker for mammalian reproduction. | DAOLUN YU DEYONG SHE KAI GE LEI YANG RUINA ZHAN SHAN LU YAFEI CAI | 2024 | BIOCELL2024，48，1： | 0 |
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