|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Mesocrystalline TiO2/sepiolite composites for the effective degradation of methyl orange and methylene blue显示文摘 | Ruirui LIU Zhijiang JI Jing WANG Jinjun ZHANG | 2018 | Frontiers of Materials Science2018，12，3： | 4 |
| 3 | Nest-like multilevel structured graphene oxide-on-polyacrylonitrile membranes for highly efficient filtration of ultrafine particles显示文摘Developing filtration media for particulate matter(PM)removal has been proven to be extremely challenging.Here,we report a facile and scalable strategy to fabricate a multi-level structured polyacrylonitrile/graphene oxide(PAN/GO)air filtration membrane to remove ultrafine particles in air by combining multi-jet electrospinning and physical bonding.Our approach allows the thin PAN nanofibers and two-dimensional GO nanosheets to form interpenetrating bonding structures on non-woven fabric and to assemble into stable filtration media.The resultant composite membranes can filtrate 300 nm particles with a high removal efficiency of 98.8%,a low pressure drop of 55 Pa,and a desirable quality factor of 0.34 Pa^(-1).This multi-level PAN/GO filter is expected to have wider applications not only for the ultrafine particle filtration and separation but also for the design of three-dimensional functional structures in the future. | Jing Li Danzhen Zhang Xin Jiang Xuanliang Zhao Ruirui Hu Yujia Zhong Hongwei Zhu | 2019 | Journal of Materiomics2019，5，3： | 4 |
| 4 | Effect of Gubi prescription on caveolin-1 expression and phosphoinositide 3 kinase/protein kinase B and Fas signal pathways in rats with knee osteoarthritis显示文摘OBJECTIVE: To investigate the effects of Gubi prescription on the expression of caveolin-1, and the phosphoinositide 3 kinase/protein kinase B(PI3 K/Akt) and Fas signal pathways in rats with knee osteoarthritis(KOA).METHODS: Forty KOA model rats were established using a modification of Hulth's method. Rats were divided into five groups by the random number method: model, positive drug(Vicolli group), and high-, medium-, and low-dose Gubi prescription groups(n = 8/group). In the sham surgery group(n = 8), only anterior and posterior cruciate ligaments of rats were exposed during surgery. A normal group(n = 8) consisted of rats with no treatment. Rats were intragastrically administered corresponding drugs once every day for eight consecutive weeks. Then, rat synovial membranes were extracted and histomorphological changes were recorded. m RNA expression was measured by q-PCR.Serum superoxide dismutase(SOD), malondialdehyde(MDA), nitric oxide(NO), and interleukin 1β(IL-1β) levels were measured. Western blotting determined the effects of Gubi prescription on protein expressions of caveolin-1, Bax, Bcl-2, Fas, and caspase-3 in chondrocytes from KOA rats. The knee cartilage of rats was excised and cultured under aseptic conditions. After coincubation of chondrocytes with Gubi prescription-containing serum, IL-1β, and si RNA, Western blotting was used to determine the protein expressions of caveolin-1, Bax, Bcl-2, Fas, and caspase-3.RESULTS: The morphological score of the articular synovium in the model group was significantly higher than in the normal group(P < 0.01). The morphological score in the high-and mediumdose Gubi prescription groups was lower than in the model group(P < 0.05). Chondrocytes from the decoction-containing serum group had a lower expression of Bax(P < 0.05), and higher expressions of Bcl-2(P < 0.05) and caspase-3(P < 0.05) compared with the model group. Chondrocytes in the decoction-containing serum group had higher expressions of Bax and Bcl-2(P < 0.01) and lower expressions of caveolin-1 and Fas(P < 0.05) compared with the model group. Compared with the model group, Bax and caspase-3 expressions were reduced in the chondrocytes of all three Gubi prescription groups(P < 0.05) whereas Bcl-2 expression was increased(P < 0.05). Compared with the model group, the expressions of caveolin-1 and Fas(P < 0.05) were reduced in groups that received high-and medium-doses of Gubi prescription. Gubi prescription increased the serum level of SOD and significantly reduced those of MDA, NO and IL-1β(P < 0.05).CONCLUSION: Gubi prescription suppressed the chondrocyte-related PI3 K/Akt and Fas signal pathways and inhibited the overexpression of caveolin-1 in rat chondrocytes. | He Xiaojin Wang Lei Zhou Xueping Xu Luzhou Cao Jing Wang Ruirui Wang Min Xie Guoqian | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 5 | Secondary donor-derived CD19 CAR-T therapy is safe and efficacious in acute lymphoblastic leukemia with extramedullary relapse after first autologous CAR-T therapy显示文摘Despite the advancement of treatments,adults with relapsed/refractory(R/R)B-lineage acute lymphoblastic leukemia(B-ALL)have poor prognosis,with an expected five-year overall survival(OS)rate of 10%‒20%(Nguyen et al.,2008;Oriol et al.,2010).Extramedullary relapse of B-ALL is regarded as a highrisk factor generally associated with poor survival,occurring in about 15%to 20%of all relapsed patients(Ding et al.,2017;Sun et al.,2018).The central nervous system(CNS)and the testes are the most common sites of extramedullary relapse of B-ALL.In addition,extramedullary leukemia can appear in the skin,eyes,breasts,bones,muscles,and abdominal organs.The prognosis of relapsed extramedullary B-ALL after allogeneic hematopoietic stem cell transplantation(allo-HSCT)is extremely poor(Spyridonidis et al.,2012;Dahlberg et al.,2019).Conventional chemotherapy or radiation is often ineffective in such patients.At present,there are no optimal treatment strategies for treating extramedullary leukemia after allo-HSCT. | Delin KONG Tingting YANG Jia GENG Ruirui JING Qiqi ZHANG GuoqingWEI He HUANG Yongxian HU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 2 |
| 6 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 7 | HIV incidence among men who have sex with men in China: a meta-analysis of published studies显示文摘 | Li Hongmin Peng Ruirui Li Jing | 2011 | PLoSOne2011，6，23： | 1 |
| 8 | Effects of stochastic food deprivation on energy budget,body mass and activity in Swiss mice显示文摘When small animals are faced with an unpredictable food supply,they can adapt by altering different components of their energy budget such as energy intake,metabolic rate,rate of non-shivering thermogenesis(NST)or behaviour.The present study examined the effect of stochastic food deprivation(FD)on body mass,food intake,resting metabolic rate(RMR),NST and behaviour in male Swiss mice.During a period of 4 weeks' FD,animals were fed ad libitum for a randomly assigned 4 days each week,but were deprived of food for the other 3 days.The results showed that body mass significantly dropped on FD days compared to controls.Food intake of FD mice increased significantly on ad libitum days,ensuring cumulative food intake,final body mass,fat mass,RMR and NST did not differ significantly from controls.Moreover,gastrointestinal tract mass increased in FD mice,but digestibility decreased.In general,activity was higher on deprived days,and feeding behaviour was higher on ad libitum days suggesting that Swiss mice are able to compensate for stochastic FD primarily by increasing food intake on ad libitum days,and not by reducing energy expenditure related to RMR or NST. | Zhijun ZHAO Jing CAO Ye TIAN Ruirui WANG Guiying WANG | 2009 | Current Zoology2009，55，4： | 1 |
| 9 | DNA-A of a highly pathogenic Indian cassava mosaic virus isolated from Jatropha curcas causes symptoms in Nicotiana benthamiana显示文摘 | Gang Wang YanWei Sun RuiRui Xu Jing Qu ChuanSia Tee XiYuan Jiang Jian Ye | 2014 | Virus Genes2014，，： | 1 |
| 10 | U6 is not a suitable endogenous control for the quantification of circulating microRNAs显示文摘 | Mengqin Xiang Ying Zeng Ruirui Yang Haifan Xu Zhuo Chen Jing Zhong Hailong Xie Yinghui Xu Xi Zeng | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 11 | Synthe- sis and adsorption behavior of surface Cu(Ⅱ)ionim- printed poly(allylamine)-silica gel material显示文摘 | FAN Zhonglei SHEN Jinge LI Ruirui | 2012 | Poly- mer-Plastics Technology and Engineering2012，51，13： | 1 |
| 12 | Anchoring Group Effects of Surface Ligands on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents显示文摘 | Jianfeng Zeng Lihong Jing Yi Hou Mingxia Jiao Ruirui Qiao Qiaojuan Jia Chunyan Liu Fang Fang Hao Lei Mingyuan Gao | 2014 | Adv. Mater2014，，17： | 1 |
| 13 | Characterization of a novel Bacillus methylotrophicus phage BM-P1显示文摘Bacillus species have been widely used as probiotics in a number of food products.However,these are vulnerable to bacteriophage infections,which poses fermentation failure and eventually result in economic losses.Given this,we designed this study in which the bacteriophage of lysogenic Bacillus methylotrophicus,phage BM-P1,was induced successfully,and its biological characteristics and genome information were researched.The obtained results showed that phage BM-P1 belonged to Myoviridae family.The maximum number of infections for this phage was 10,with a burst size of 104.48±2.70 counts expressed per milliter per infective center.Additionally,this phage was temperature-and pH-sensitive and divalent ions(Ca2+,Mg2+)and chloramphenicol did not have a significant influence on its adsorption capacity.Genomic analysis revealed that the genome size of phage BM-P1 was 153087 bp with 41.94%GC content,including 258 coding sequences.Furthermore,52 bac-teriophages of Bacillus were classified into two clades by using phylogenetic analysis.Among them,phage BM-P1 with phage VB_BsuM-Goe3 and vB_BveM-Goe7 had the highest average nucleotide identity values,95.23%and 95.28%,respectively.However,synteny analysis revealed transposition,deletion,and insertion in the genome of BM-P1.Considering this,it could be extrapolated that this phage is a new lysogenic phage.In conclusion,this study furthers the knowledge on the properties of B.methylotrophicus phages and provides seminal insights for designingeffective antiphage strategiesforfermentation industry. | Ruirui Lv Ming Xu She Guo Jingwei Yao Hafiz Arbab Sakandar Jing Guo Can Zhang Xia Chen | 2023 | Food Quality and Safety2023，7，2： | 0 |
| 14 | Influences of various grazing systems on community biomass of a desert grassland in Inner Mongolia,China显示文摘This study investigated the effects of various grazing systems,including continuous grazing,rotational grazing,and no-grazing systems,on the community biomass in the Stipa breviflora Griseb desert grassland during the grazing seasons in 2005,2006,and 2007,based on study sites established in 1999.We found that the seasonal dynamics of the aboveground biomass were quite similar among the three treatments,which reached peak values in period from August to September during each study year.The continuous grazing system reduced the aboveground biomass from 2005 to 2007 under drought conditions,and the rotational grazing and no-grazing systems maintained more aboveground biomass than the continuous grazing system did.The belowground biomass declined with the increase of soil depth among the three treatments,and in the surface 20-cm soil layer it accounted for more than 60% of the total biomass.The belowground biomass was found to be highly correlated with soil depth under rotational grazing.The total belowground biomass within the 0-100-cm soil layer for rotational grazing was significantly higher than for continuous grazing and no-grazing,and had 15,775 kg/ha more biomass.Our results demonstrate that conservative rotational grazing can alleviate grassland deterioration by reserving more aboveground and belowground biomass than the continuous grazing system does. | RuiRui Yan XiaoPing Xin ZhiJun Wei ShiMin Liu Jing Yang GuiXia Yang | 2012 | Research in Cold and Arid Regions2012，4，4： | 0 |
| 15 | Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals:current status and future perspectives显示文摘Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals,due to its natural abundance and mature production technology.Native methylotrophs,which can utilize methanol as the only source of carbon and energy,are ideal hosts for methanol bioconversion due to their high methanol utili-zation rate and have been extensively employed in the production of value-added chemicals from methanol.Here,we review the natural methanol utilization pathways in native methylotrophs,describing the available synthetic biology tools developed for engineering native methylotrophs,and discuss the strategies for improving their methanol utilization efficiency.Finally,the representative examples of engineering the native methylotrophs to produce value-added products from methanol are summarized.Furthermore,we also discuss the major challenges and possible solutions for the application of native methylotrophs in methanol-based biomanufacturing. | Jing Wang Ruirui Qin Yuanke Guo Chen Ma Xin Wang Kequan Chen Pingkai Ouyang | 2023 | Green Chemical Engineering2023，4，2： | 0 |
| 16 | Effects of Combined Stress from Salt and Herbicide on Microbial Remediation of Soil Contaminated by n-Hexadecane and Phenanthrene显示文摘In this study,physicochemical,cluster,and high-throughput sequencing analyses were used to investigate the joint effects of salt and herbicide(glyphosate)stress factors on the microbial remediation of soil contaminated by n-hexadecane and phenanthrene.Based on the soil’s physical and chemical properties,differences in microbial quantity and enzyme activities were analyzed among the samples,and how that influenced distribution of soil community structure was focused upon.After 120 days of indoor simulated remediation,the cumulative degradation rate of n-hexadecane decreased by 94.92%(blank control),96.96%(low concentration salt and glyphosate stress group),65.07%(high concentration salt and glyphosate stress group),while that of phenanthrene decreased by 87.33%(blank control),86.25%(low concentration salt and glyphosate stress group),58.45%(high concentration salt and glyphosate stress group).The combined stress of salt and herbicides was capable of lowering the reduction efficiency of organic matter,total nitrogen,and total phosphorus,and also restricting the growth of microorganisms and enzyme activities.Cluster analysis results indicated that the non-stress group was similar to the low-concentration compound stress group during different remedial period,whereas both of those differed starkly from the high-concentration compound stress group.High-throughput sequencing revealed that the dominant soil bacteria phyla shifted from Firmicutes to Actinobacteria within 120 days of remediation. | Liu Bingkun Zuo Shuai Wang Ruirui Dong Kangning Zhang Xiuxia Li Ruyue Hao Boyu Li Jing Yin Linghao Bai Yuhao Song Jiayu Gu Yingying Sun Juan | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 17 | Ultrathin nanoporous metal-semiconductor heterojunction photoanodes for visible light hydrogen evolution显示文摘Plasmonic 金属半导体 nano 异质接面(NHJ ) 与他们的优异 photocatalytic 表演,为太阳能的有效利用提供机会。然而,科学意义和技术挑战为新产生留在合适的金属半导体 NHJ photoelectrodes 的发展灵活 optoelectronic 设备,它经常要求复杂处理。此处,我们报导综合三维(3D ) NHJ photoelectrodes 由保角地,涂层镉硫化物(CdS ) nanolayers 经由一个灵巧的电极淀积方法拍摄到 ultrathin nanoporous 黄金(NPG ) 上。NPG 的局部性的表面电浆子回声(LSPR ) 提高电子洞对产生和分离。而且,直接接触接口和 NHJ 的高传导性的框架结构增加 photogenerated 搬运人分离和运输。因此, NHJ 展览显然相对在任何一个黄金(Au ) 上扔的 CdS 提高了光电流密度和氢进化率在在可见光的照耀下面的 0 V 对 SCE (浸透的甘汞电极) 的陪衬或做氟的符号的锡氧化物(FTO ) 。而且,他们表明令人惊讶地稳定的 photoelectrochemical 氢进化(PEC -- 他) 在连续照耀的 104 s 上的活动。 | Weiqing Zhang Yunfeng Zhao Kai He Jun Luo Guoliang Li Ruirui Liu Siyu Liu Zhen Cao Pengtao Jing Yi Ding | 2018 | Nano Research2018，11，4： | 0 |
| 18 | Effects of the grazing systems on germinable soil seed bank of desert steppe显示文摘We studied a soil seed bank in the Stipa breviflora desert steppe under three grassland management systems,namely continuous grazing,rotational grazing,and no grazing,from 1999 until 2007.The germinable seed bank species in rotational,continuous and no grazing were 11,9 and 8 species,respectively.Rotational grazing increased the number of seed bank plant species and perennial grasses.The density of germinal soil seed bank was significantly higher in the enclosed area(19,533.33 seeds/m 2) than those in rotational(3,233.33 seeds/m 2) and continuous grazing areas(2,553.60 seeds/m 2).The vertical distribution of the soil seed bank had a similar trend:75.06%-83.19% of the seeds are distributed in the top 0-5 cm soil layer,14.16%-21.68% in the 5-10 cm layer,and 2.65%-4.95% in the 10-15 cm layer,which varied between the grazing treatments.Density of the soil seed bank was significantly higher in the enclosed area,and there was no significant difference between rotational and continuous grazing.The Margalef and Shannon-Wiener indices for the soil seed bank were higher for rotational grazing treatment than for continuous grazing.The Sorensen's similarity index for the soil seed bank between the enclosed and rotational grazing areas reached 0.857. | RuiRui Yan ZhiJun Wei XiaoPing Xin HongMei Liu Jing Yang Qiqige Wuren | 2012 | Research in Cold and Arid Regions2012，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员