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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Life Prediction Model of Machine Tool based on Deep Learning显示文摘In view of the shortage of traditional life prediction methods for machine tools,such as low accuracy of life prediction and few samples basis attributes,a life prediction model of machine tools combined with machine tool attributes is proposed.The life prediction model of machine tool adopts KL dispersion distribution theory,uses modal superposition method to carry out machine tool life analysis,calculates the theoretical life of machine tool,and then carries on the simulation,obtains the machine tool life prediction value.Compared with the traditional method of machine tool life prediction,the model is based on the application life fatigue damage model,which superimposes the service times and maintenance cycle of the machine tool,derives the influence factor of machine tool life,and obtains the linear relationship between the influence factor of machine tool life and the life of machine tool.The influence factor of machine tool life is introduced as the life prediction parameter of machine tool.The data transformation relationship of HT300 parts is constructed.The original part data is enhanced.The effective training set is obtained.The life prediction model of machine tool based on deep learning is completed.The quantitative analysis of machine tool life is carried out.The experiment of machine tool life prediction using training data set proves the validity of the model.Regression test was carried out on the training data set to reflect the robustness of the model.The prediction accuracy of the model is further verified by Weibull test. | HE Jiawei ZHAO Chendi GAO Ruiyu LIU Xuehui WANG Xue | 2021 | International Journal of Plant Engineering and Management2021，26，1： | 2 |
| 3 | Construction of interesting organic supramolecular structures with synthons cooperation in the cocrystals of 1H-benzotriazole and hydroxybenzoic acids显示文摘Multifunctional molecules are capable of assembling via different supramolecular synthons,or hydrogen bond motifs,between the same or different functional groups,leading to the possibility of cocrystal.Utilization of the interplay of dimensionality(1-D,2-D and 3-D),orientation of functional groups of the building blocks,influence of rigid/flexible linking groups,and weak interactions provides an interesting route for the creation of novel supramolecular architectures in the crystal lattice.N-unsubstituted 1H-benzotriazole and carboxylic acid,being self-complementary molecules,offer a broad scope of study of binary compounds based on the complementary combination of H-bonding/donating sites.We report here the construction of three extended molecular networks in cocrystals of the carboxylic acid group of the acid and the 1H-benzotriazole triazole moiety.We have been able to identify four major supramolecualr synthons that would be helpful in the prediction of structural motifs for these kinds of studies.Interestingly,these heterosynthons are strikingly similar,to those of the homosynthons of the individual functional groups.The nature of the aza groups helps to enhance the overall volume of the crystal lattice thus leading to the formation of various supramolecular assemblies.Thermal stability of these compounds has been investigated by thermogravimetric analysis(TGA) of mass loss. | WANG Lei ZHAO Lei XUE RuiYu LU XiFeng WEN YongHong YANG Yu | 2012 | Science China Chemistry2012，55，12： | 2 |
| 4 | Synthesis,characterization,and application of hydotalcites in hydrodesulfurization of FCC gasoline 显示文摘 | Zhao Ruiyu Yin Changlong Zhao Huiji | 2003 | Fuel Processing Technology2003，81，3： | 1 |
| 5 | Unsupervised learning of phonemes of whispered speech in a noisy environment based on convolutive non-negative matrix factorization显示文摘 | ZHOU Zhou LIANG Ruiyu ZHAO Li | 2014 | Information Sciences2014，，257： | 1 |
| 6 | Synthesis, characterization, and application of hydotalcites in hydro- desulfurization of FCC gasoline 显示文摘 | Ruiyu Zhao Changlong Yin Huiji Zhao etal | 2003 | Fuel Processing Technology2003，81，： | 1 |
| 7 | Selective HDS catalysts for FCC gasoline with oxides from hydrotalcite like compounds as supports 显示文摘 | Zhao Ruiyu Yin Changlong Liu Chenguang | 2001 | Preprints : Division of Petroleum Chemistry American Chemical Society2001，46，1： | 1 |
| 8 | Effect of solid-state synthesized alumina properties on the structure and catalytic performance of NiMo catalyst in hydrodesulfurization 显示文摘 | Zhang Min Yang Tao Zhao Ruiyu | 2013 | Applied Catalysis A : General2013，468，： | 1 |
| 9 | Effect of dietary nucleotides on immune function in Balb/C mice显示文摘 | Meihong Xu Ming Zhao Ruiyue Yang Zhaofeng Zhang Yong Li Junbo Wang | 2013 | International Immunopharmacology2013，，1： | 1 |
| 10 | Solvent Ex- traction of Bitumen from Oil Sands显示文摘 | TONG WANG CHAO ZHANG RUIYU ZHAO | 2014 | Energy & Fuels2014，28，： | 1 |
| 11 | Transformation of olefin over Ni/HZSM 5 catalyst显示文摘 | Yin Changlong Zhao Ruiyu Liu Chenguang | 2005 | Fuel2005，84，： | 1 |
| 12 | Transformation of olefin over Ni/HZSM-5 catalyst显示文摘 | Yin C Yin Changlong Zhao Ruiyu | 2005 | Fuel2005，84，： | 1 |
| 13 | Transformation of olefm over Ni/HZSM-5 catalyst显示文摘 | Yin Changlong Zhao Ruiyu Liu Chenguang | 2005 | Fuel2005，84，6： | 1 |
| 14 | Hydrodesulfurization of cracked gasoline with monolayer dispersion catalyst 显示文摘 | Yin Changlong Zhao Ruiyu Liu Chenguang | 2002 | Preprints - American Chemical Society : Division of Petroleum Chemistry2002，47，1： | 1 |
| 15 | Mechanism of hydrodesulfurization of dibenzothiophene and 4 methyldlbenzothiophene on Mo/,- AlzO3 and CoMo/2'-AlzO3 显示文摘 | Xu Yongqiang Zhao Ruiyu Shang Hongyan Zhao Huiji Liu Chenguang | 2003 | Acta Petrolei Sinica: Petroleum Processing Section2003，19，5： | 1 |
| 16 | Investigation of Nitrite Production Pathway in Integrated Partial Denitrification/Anammox Process via Isotope Labelling Technique and the Relevant Microbial Communities显示文摘In this study,the nitrogen removal performance of partial denitrificaiton/anammox(PDA)process was investigated by using an UASB reactor.High total nitrogen(TN)removal efficiency(91.97%)was achieved at an influent nitrogen loading rate of 0.64 kg/(m3·d).Anammox bacteria did execute the function of converting nitrate to nitrite in PDA system according to ^(15)N isotope labeling experiments and the contribution was approximately 36.3%.Candidatus_Brocadia,Candidatus_Kuenenia and Thauera were functional strains for anammox and denitrification process,respectively.Thauera and Candidatus_Brocadia were more important for TN removal at high loading rates(0.64 kg/(m3·d)).This result can provide a theoretical and technical foundation for the application of the PDA process. | Li Yanzhe Gai Jianing Zhang Xiaofei Zhao dongfeng Guo Yadong Yu Gengxing Zhao Chaocheng Liu Fang Zhao Ruiyu Liu Chunshuang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，1： | 0 |
| 17 | Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition显示文摘Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver fibrosis.Our previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed fibrogenesis.However,the mechanisms by which SWT influences H19 remain unclear.Thus,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the liver.Our results showed that SWT markedly improved ECM deposition and bile duct reactions in the liver.Notably,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular injury.This modulation collectively led to reduced ECM deposition.Through extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory pathways.Meanwhile,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver fibrosis.However,these protective effects of SWT were diminished with the overexpression of H19 in vivo.In conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis. | QU Jiaorong XUE Xiaoyong WANG Zhixing MA Zhi JIA Kexin LI Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 18 | Case Study on AI Robotics in Senior Living in China显示文摘Currently,in China,as the elderly population rapidly increases due to the increase in aging,the importance of the elderly’s living environment and quality of life is increasing.Accordingly,the development of technology presents the possibility of providing a better life to the elderly.This study is conducted to investigate and analyze the current status and performance of artificial intelligence robot technology introduced in the elderly residential space in China,and contribute to the improvement of the living and convenience of the elderly.First,we investigate the cases of various types of artificial intelligence robots currently being used in the residential environment for the elderly in China.Second,by evaluating the technical performance and function of each artificial intelligence robot,we will look at how it meets the needs of the elderly’s special bedfall,health care,and social interaction.Third,we analyze the impact of artificial intelligence robots on the daily life of the elderly and investigate users’experiences and effects to understand social effects.Fourth,based on the obtained results,suggestions and future prospects for effectively introducing artificial intelligence robots into the residential environment for the elderly in China are presented.Through this,it is expected to contribute to understanding how artificial intelligence robot technology is being applied in the residential environment of the elderly in China,and to find ways to improve the convenience and quality of life of the elderly. | Xiajie Zhao Ruiyu Li | 2024 | Psychology Research2024，14，2： | 0 |
| 19 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum显示文摘Erratum to Frontiers of Medicine 201711(2):253–265 http://gffzzd3cc09b8251d45dfsf0qcpb65kkp660n9.ffgz.tsg.suse.edu.cn/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some mistakes.The panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2021 | Frontiers of Medicine2021，15，2： | 0 |
| 20 | Research on Nonlinear Frequency Compression Method of Hearing Aid with Adaptive Compression Ratio显示文摘To make full use of the residual audible frequency band of hearing-loss patients and improve the intelligibility of speech,an adaptive nonlinear frequency compression(NFC)algorithm is proposed,which amplifies signals below the cutoff frequency while compresses signals above the cutoff frequency.Firstly,high-frequency signals are decomposed to critical band signals according to the BARK scale.Secondly,the global compression ratio is determined according to the patient's cutoff frequency and maximum audible frequency.Thirdly,the sub-band compression ratio is adaptively determined based on the global compression ratio and normalized average energy of subband signals.Finally,the high frequency signals are transposed to low frequency bands by compression mapping,and the phases are adjusted to the same as the original low frequency signals.Experimental results of speech intelligibility with nine subjects demonstrate that compared to conventional amplitude amplification and nonlinear frequency compression algorithms the proposed algorithm significantly improves the intelligibility of initials and sentences,while not affects the intelligibility of finals and tones significantly. | Xia Wang Hongming Shen Huawei Tao Ruiyu Liang Xing Deng Haijian Shao Li Zhao Cairong Zou | 2019 | Computer Modeling in Engineering & Sciences2019，，11： | 0 |
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