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| 1 | Simultaneous Determination of Melamine, Ammelide, Ammeline, and Cyanuric Acid in Milk and Milk Products by Gas Chromatography-tandem Mass Spectrometry显示文摘Objective To develop an analytical method for simultaneously qualitative and quantitative determination of melamine and triazine-related by-products including ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography- tandem mass spectrometry (GC-MS/MS). Methods Melamine and triazine-related by-products namely ammelide, ammeline and cyanuric acid in the samples were extracted in a solvent mixture of diethylamine, water, and acetonitrile (10:40:50, V/V/V). After centrifugation, an aliquot of the supernatant was evaporated to dryness under a gentle stream of nitrogen gas, and then melamine and triazine-related by-products were derivatized using BSTFA with 1% TMCS. The derivatives of melamine and its analogues were determined by gas chromatography/ tandem mass spectrometry using multiple reactional monitoring (MRM) with 2, 6-Diamino-4-chloropyrimidine (DACP) being used as an internal standard. Results The linear detectable ranges were from 0.004 mg/kg to 1.6 mg/kg for melamine, ammelide, ammeline, and cyanuric acid with a correlation coefficient no less than 0.999. The recovery rates of the four compounds in spiked blank milk powder at concentrations 0.5, 1, 2 mg/kg were between 61.4%-117.2%, and the relative standard deviation was no more than 11.5% (n=6). The detection limits of melamine, ammelide, ammeline and cyanuric acid in milk powder were 0.002 mg/kg with a ratio of signal to noise of 3. Conclusion This GC-MS/MS method for simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products is sensitive and specific. | HONG MIAO SAI FAN YONG-NING WU LEI ZHANG PING-PING ZHOU JING-GUANG LI HUI-JING CHEN AND YUN-FENG ZHAO | 2009 | Biomedical and Environmental Sciences2009，22，2： | 21 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 4 | Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection显示文摘The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A. | Hong Bai Xiaoling Gao Lei Zhao Ying Peng Jie Yang Sai Qiao Huili Zhao Shuhe Wang YiJun Fan Antony George Joyee Zhi Yao Xi Yang | 2017 | Cellular & Molecular Immunology2017，14，10： | 7 |
| 5 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 6 | Stevenleaf from Gynostemma Pentaphyllum inhibits human hepatoma cell(HepG2)through cell cycle arrest and apoptotic induction显示文摘The anticancer activity of stevenleaf(SV)on the basis of cell viability,cell cycle,and apoptosis induction in HepG2 cancer cells were evaluated.SV controlled the growth of HepG2 cells with IC50 of 139.82μmol/L for 24 h,IC50 of 119.12μmol/L for 48 h and cell cycle arrested at G0/G1 phase,induced cell apoptosis and enhanced intracellular ROS generation.For cell cycle arrest,the mRNA expression levels of p21,p27 and p53 were up-regulated,while the expression levels of Cyclin A,Cyclin D1,Cyclin E and CDK1/2 were downregulated.SV efficiently up-regulated TNF R1,TRADD1 and FADD and down-regulated Caspase8 for cell death receptors;similarly,up-regulated Bax,Bak,Cytc,Apaf1,Caspase3 and Caspase9,and down-regulated Bcl2,Bcl xl and Bad for mitochondrial signal pathway.SV induced the mTOR-mediated cell apoptosis in HepG2 cells via activation of Akt and AMPK.The mechanistic explanation for the anticancer activity of SV as functional food can be derived from above results. | Sayed Sajid Hussain Fan Zhang Yuanyuan Zhang Kiran Thakur Mahrukh Naudhani Carlos L.Cespedes-Acuna Zhaojun Wei | 2020 | Food Science and Human Wellness2020，9，3： | 3 |
| 7 | Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway显示文摘BackgroundThe 导致了 pluripotent 干细胞(iPSC ) 在心肌的梗塞(MI ) 的细胞的治疗显示出大潜力,当它的申请被 cardiomyocyte 区别的低效率妨碍时。现在的学习被设计从老鼠在 cardiomyocyte 区别上调查 cardiotrophin-1 ( CT-1 )的效果导致的 pluripotent 干细胞( miPSCs )和内在的机制 involved.MethodsThe 为从 miPSCs 的 cardiomyocyte 区别的最佳的治疗状况与理想的集中( 10 ng/mL )和持续时间被建立(从到白天的白天 3 14 ) CT-1 管理。说明了胚胎的 cardiogenesis 的心脏的特定的基因的起来调整的表示被量的 RT-PCR 观察。 α 的提高的数量;肌浆球蛋白重链( α ;-MHC)和心脏的 troponin 我( cTn 我)积极房间被 immunofluorescence 在显微镜的分析揭示了的 CT-1 group.ResultsTransmission 电子染色和流动 cytometry 分析检测与 CT-1 对待的房间更好出现了,这组织了 sacromeric 结构和更多线粒体,它是成熟 cardiomyocytes 的词法特征。当与控制 group.ConclusionsThese 相比调查结果建议 CT-1 能提高 cardiomyocyte 区别以及导致的 pluripotent 干细胞导出的老鼠的成熟,西方的污点证明 CT-1 经由 JAK2/STAT3/Pim-1 小径部分从 miPSCs 支持 cardiomyocyte 区别由调整 JAK2/STAT3/Pim-1signaling 的 cardiomyocytes 小径。 | Tong LIU Ran ZHANG Tao GUO Sai MA Dong HAN Xiu-Juan LI Yan JIN Miao-Miao FAN Ya-Bin WANG Yun-Dai CHEN Feng CAO | 2015 | Journal of Geriatric Cardiology2015，12，6： | 2 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | New construction of hybrid and aperiodic ordered PBG cavity显示文摘The band gap of a photonic crystal (PhC) cavity intrinsically avoids HOM problems. In this paper, we present a new PBG structure based on the possible advantage of using hybrid structures and aperiodic lattices. This novel hybrid and aperiodically ordered cavity was designed for apparently higher Q-factor (more than 10300) and achieving large accelerating field gradient. The HOMs in the cavity are able to be absorbed efficiently. | ZHAO JingXiong WU CongFeng FAN Hao LI Bo DONG Sai | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 10 | Tunable magneto-optical polarization device for terahertz waves based on InSb and its plasmonic structure显示文摘The nonreciprocal circular dichroism and Faraday rotation effect for terahertz(THz) waves in longitudinally magnetized InSb were investigated by theoretical and experimental studies in the THz regime, which indicated its ability for a THz circularly polarized isolator, THz circular polarizer, tunable polarization converter, and polarization modulator by manipulation of different magnetic fields. Furthermore, we demonstrated the InSb plasmonics based on its magneto-optical effects combined with artificial microstructure. We found the magnetooptical enhancement mechanisms in this magneto-plasmonic structure, achieving broadband near-perfect orthogonal linear polarization conversion modulated by the weak magnetic field in an experiment with an extinction ratio of 33 dB. Moreover, the magneto-optical modulation with an amplitude modulation depth of 95.8% can be achieved by this device under a weak magnetic field of 150 mT. InSb and its magneto-plasmonic device have broad potential for a THz isolator, magneto-optical modulator, and polarization convertor in THz application systems. | QIANYI MU FEI FAN SAI CHEN SHITONG XU CHUANZHONG XIONG XIN ZHANG XIANGHUI WANG SHENGJIANG CHANG | 2019 | Photonics Research2019，7，3： | 2 |
| 11 | Microwave-assisted growth and characterization of water-dispersed CdTe/CdS core-shell nanocrystals with high photoluminescence显示文摘 | HE Yao LU Hao-ting SAI Li-man LAI Wen-yong FAN Qu-li WANG Lian-hui HUANG Wei | 2006 | J Phys Chem B2006，110，13： | 1 |
| 12 | P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21 显示文摘 | Su L Sai Y Fan R | 2003 | Lung Cancer2003，40，3： | 1 |
| 13 | Electron-transfer reactivity and enzymatic activity of hemoglobin in a SP sephadex membrane显示文摘 | Wang Haiyan Sun Sai | 2001 | Anal Chem2001，73，： | 1 |
| 14 | Synthesis of CdTe nanocrystals through program process of microwave irradiation显示文摘 | He Y Lu H T Sai L M Lai W Y Fan Q L Wang L H Huang W | | 0，，27： | 1 |
| 15 | Astragalus polysaccharide and oxymatrine can synergistically improve the immune efficacy of Newcastle disease vaccine in chicken显示文摘 | Yuku Chen Deyun Wang Yuanliang Hu Zhenhuan Guo Junmin Wang Xiaona Zhao Yunpeng Fan Liwei Guo Shujuan Yang Fuding Sai Yujuan Xing | 2010 | International Journal of Biological Macromolecules2010，，4： | 1 |
| 16 | Ex-amining the relationship between organizational learningstyles and project performance 显示文摘 | Peter Shek Pui Wong Sai On Cheung Ka Lam Fan | 2009 | Journal of Construc-tion Engineering and Management2009，135，7： | 1 |
| 17 | p53 (codon 72) and p21 (codon31) polymorphisms after in vivo mRNA expres-sion of p21 显示文摘 | Su L Sai Y Fan R | 1996 | Mol Carcinog1996，16，4： | 1 |
| 18 | Electron-transfer reactivity and enzymatic activity of hemoglobin in a SP sephadex membrane显示文摘 | FAN Chun-hai WANG Hai-yan SUN Sai | 2001 | Anal Chem2001，73，： | 1 |
| 19 | Synthesis of CdTe nanocrystals through program process of microwave irradiation 显示文摘 | HeY LuHT Sai L M Lai L M Lai W Y Fan Q L Wang L H Huang W | 2006 | Journal of Physical Chemistry B2006，110，13： | 1 |
| 20 | Theoretical analysis and experimental research on non-cavitation noise modulation mechanism of underwater counter-rotation propeller显示文摘 | ZENG Sai DU Xuanmin FAN Wei | 2018 | Chinese Journal of Acoustics2018，37，2： | 1 |
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