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| 1 | In vitro Anthocyanin Induction and Metabolite Analysis in Malus spectabilis Leaves Under Low Nitrogen Conditions显示文摘Anthocyanins are the most widely produced secondary metabolites in plants,and they play an important role in plant growth and reproduction.The nitrogen source is an important factor affecting anthocyanin production,but the nitrogen concentrations on metabolism and the underlying genetic basis remain unclear.In this study,in vitro anthocyanin induction was conducted on Malus spectabilis.The leaf explants were cultivated in media containing different nitrogen concentrations.The results suggested that when the nitrogen contents decreased in limit,the color of leaf explants turned from green to red,and increased anthocyanin accumulation led to a change in phenotype.Furthermore,the content of other flavonoids,such as dihydroquercetin,epicatechin,and catechin,increased under low nitrogen conditions.The transcription levels of the general flavonoid pathway genes,from phenylalanine ammonia lyase(PAL)to anthocyanidin synthase(ANS),were associated with the concentration of corresponding flavonoid compounds and phenotype changes.In particular,the expression level of ANS increased substantially under a low nitrogen treatment,which was significantly and positively correlated with the anthocyanin levels(R2=0.72,P<0.05).The increased expression patterns of anthocyanin pathway genes were similar to that of the transcription factor MYB10.We further verified MYB10 played an important role in the anthocyanin pathway in leaves of Malus spectabilis.These results suggested that we can improve the desirable ornamental plant phenotypes by controlling nitrogen content.This process may offer clues to further development of new agricultural practices. | Jiaxin Meng Yan Gao Meiling Han Pengyuan Liu Chen Yang Ting Shen Houhua Li | 2020 | Horticultural Plant Journal2020，6，5： | 13 |
| 2 | Modulating the photoelectrons of g-C3N4 via coupling MgTi2O5 as appropriate platform for visible-light-driven photocatalytic solar energy conversion显示文摘Graphitic carbon nitride (g-C3N4) has become an attractive visible-light-responsive photocatalyst because of its semiconductor polymer compositions and easy-modulated band structure. However, the bulk g-C3N4 photocatalyst has the low separation efficiency of photogenerated carriers and unsatisfied surface catalytic performance, which leads to poor photocatalytic performance. As for this, MgTi2O5 with high chemical stability, wide band gap and negative conduction band was used as a suitable platform for coupling with g-C3N4 to enhance charge separation and promoted the photoactivity. Different from common approaches, here, we propose an innovative method to construct g-C3N4/MgTi2O5 nanocomposites featuring “0 + 1 >1' magnification effect to improve g-C3N4 photocatalytic performance under visible light irradiation. Additionally, compositing metal oxides of MgTi2O5 with g-C3N4 has proven to be a proper strategy to accelerate surface catalytic reactions in g-C3N4, and the photoinduced carriers were modulated to maintain thermodynamic equilibrium, which convincingly promotes the photocatalytic activity. The photocatalytic performance of the nanocomposites was measured by hydrogen production and CO2 reduction under visible light. The developed g-C3N4/MgTi2O5 nanocomposites with a 5 wt.% MgTi2O5 exhibits the highest H2 and CO yield under visible light and excellent stability compare to the other MgTi2O5 contents in composites. According to surface photo-voltage spectra, electrochemical CO2 reduction, photoluminescence, etc. The superior performance can be related to an enhanced electron lifetime, the promoted charge transfer and the increased electronic separation property of g-C3N4. Our work provides an approach to overcome the defect of pure g-C3N4, which accesses to composite with the second component matched well. | Jiaxin Shen Yanzhen Li Haoying Zhao Kai Pan Xue Li Yang Qu Guofeng Wang Dingsheng Wang | 2019 | Nano Research2019，12，8： | 6 |
| 3 | Error suppression techniques for energy-efficient high-resolution SAR ADCs显示文摘The successive approximation register(SAR)is one of the most energy-efficient analog-to-digital converter(ADC)architecture for medium-resolution applications.However,its high energy efficiency quickly diminishes when the target resolution increases.This is because a SAR ADC suffers from several major error source,including the sampling kT/C noise,the comparator noise,and the DAC mismatch.These errors are increasing hard to address in high-resolution SAR ADCs.This paper reviews recent advances on error suppression techniques for SAR ADCs,including the sampling kT/C noise reduction,the noise-shaping(NS)SAR,and the mismatch error shaping(MES).These techniques aim to boost the resolution of SAR ADCs while maintaining their superior energy efficiency. | Jiaxin Liu Xiyuan Tang Linxiao Shen Shaolan Li Zhelu Li Wenjuan Guo Nan Sun | 2020 | Journal of Semiconductors2020，41，11： | 2 |
| 4 | Regulation of NLR stability in plant immunity显示文摘Plant nucleotide binding domain and leucinerich repeat (NLR) receptors recognize pathogen effectors directly or indirectly and mediate innate immune responses. NLR-mediated immunity also has direct impacts on plant growth and development, as well as yield and survival. The levels of NLR proteins are therefore intricately controlled in plants to balance defense responses and other processes. In recent years, the ubiquitination-26S proteasome system and the HSP90 chaperones have emerged as having key functions in the regulation of NLR stability. The N-end rule pathway of protein degradation is also directly linked to NLR stability. Recent progress in the regulation of NLR stability and turnover is summarized here, focusing on the key components and pathways. | Tao WANG Jiaxin LI Qian-Hua SHEN | 2019 | Frontiers of Agricultural Science and Engineering2019，6，2： | 2 |
| 5 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 6 | Association of a potential functional pre‐miR‐218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk显示文摘 | Yifang Han Rui Pu Xue Han Jun Zhao Weiping Li Jianhua Yin Yuwei Zhang Qiuxia Shen Jiaxin Xie Qi Zhang Shuang Jiang Juhong Li Hongwei Zhang Hongyang Wang Guangwen Cao | 2014 | Liver Int2014，，5： | 1 |
| 7 | A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis显示文摘The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone reconstruction.It is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect reconstruction.Here,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH nanoparticles.The scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore structure.In addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in hBMSCs.At the same time,the scaffold could inhibit the proliferation of bacteria.After 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone reconstruction.Therefore,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration. | Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng | 2023 | Nano Research2023，16，1： | 1 |
| 8 | Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome显示文摘 | Lijing Luo Jianfang Zeng Bing Liang Zhe Zhao Lulu Sun Dongyan Cao Jiaxin Yang Keng Shen | 2011 | Experimental and Molecular Pathology2011，，2： | 1 |
| 9 | Review of PPP-RTK:achievements,challenges,and opportunities显示文摘The PPP–RTK method,which combines the concepts of Precise of Point Positioning(PPP)and Real-Time Kinematic(RTK),is proposed to provide a centimeter-accuracy positioning service for an unlimited number of users.Recently,the PPP–RTK technique is becoming a promising tool for emerging applications such as autonomous vehicles and unmanned logistics as it has several advantages including high precision,full flexibility,and good privacy.This paper gives a detailed review of PPP–RTK focusing on its implementation methods,recent achievements as well as challenges and opportunities.Firstly,the fundamental approach to implement PPP–RTK is described and an overview of the research on key techniques,such as Uncalibrated Phase Delay(UPD)estimation,precise atmospheric correction retrieval and modeling,and fast PPP ambiguity resolution,is given.Then,the recent efforts and progress are addressed,such as improving the performance of PPP–RTK by combining multi-GNSS and multi-frequency observations,single-frequency PPP–RTK for low-cost devices,and PPP–RTK for vehicle navigation.Also,the system construction and applications based on the PPP–RTK method are summarized.Moreover,the main issues that impact PPP–RTK performance are highlighted,including signal occlusion in complex urban areas and atmosphere modeling in extreme weather events.The new opportunities brought by the rapid development of low-cost markets,multiple sensors,and new-generation Low Earth Orbit(LEO)navigation constellation are also discussed.Finally,the paper concludes with some comments and the prospects for future research. | Xingxing Li Jiaxin Huang Xin Li Zhiheng Shen Junjie Han Linyang Li Bo Wang | 2022 | Satellite Navigation2022，3，3： | 1 |
| 10 | Identification of a cancer stem cell?like side population in the HeLahuman cervical carcinoma cell line显示文摘 | Kefang Wang Jianfang Zeng Lijing Luo Jiaxin Yang Jie Chen Bin Li Keng Shen | 2013 | Oncology Letters2013，，6： | 1 |
| 11 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 12 | Comparative study of the cytotoxicity of the nanosized and microsized tellurium powders on HeLa cells显示文摘为了在 HeLa 房间上比较 cytotoxicity,由 nanosized 和 microsized 碲粉末导致了, HeLa 房间为 12 h 暴露于碲粉末(0, 50, 100, 150 和 200 g/mL ) 的不同集中。在这研究,一系列 biomarkers 的察觉包括反应的氧种类(ROS ) ,谷胱甘肽(GSH ) ,除了 DNA 和蛋白质交叉连接(DPC ) 和 MTTassay, 8-hydroxy-2-deoxyguanosine (8-OHdG ) 被进行评估 cytotoxicity。与控制组相比,在在比为 nanosized 和 microsized 碲粉末的 50 g/mL 低的集中的导致的 cytotoxicity 没有重要差别,这被显示。当出现时,当集中比 100 g/mL 以及为 microsized 碲粉末高时,当集中比 200 g/mL 高时,在为 nanosized 碲的导致的 cytotoxicity 的重要差别搽粉。而且,在 HeLa 房间上导致的 cytotoxicity 与碲粉末的集中展出某个剂量效果关系,这被发现。一个结论被得出了 HeLa 房间上的毒性能被 nanosized 和 microsized 碲粉末导致,并且 nanosized 碲的毒性搽粉,这比 microsized 显著地大。 | Huanan WEN Jiaxin ZHONG Bei SHEN Tao GAN Chao FU Zhihong ZHU Rui LI Xu YANG | 2013 | Frontiers in Biology2013，8，4： | 1 |
| 13 | Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect显示文摘Corneal transplantation is the most effective clinical treatment for corneal defects,but it requires precise size of donor corneas,surgical sutures,and overcoming other technical challenges.Postoperative patients may suffer graft rejection and complications caused by sutures.Ophthalmic glues that can long-term integrate with the corneal tissue and effectively repair the focal corneal damage are highly desirable.Herein,a hybrid hydrogel consisting of porcine decellularized corneal stroma matrix(pDCSM)and methacrylated hyaluronic acid(HAMA)was developed through a non-competitive dual-crosslinking process.It can be directly filled into corneal defects with various shapes.More importantly,through formation of interpenetrating network and stable amide bonds between the hydrogel and adjacent tissue,the hydrogel manifested excellent adhesion properties to achieve suture-free repair.Meanwhile,the hybrid hydrogel not only preserved bioactive components from pDCSM,but also exhibited cornea-matching transparency,low swelling ratio,slow degradation,and enhanced mechanical properties,which was capable of withstanding superhigh intraocular pressure.The combinatorial hydrogel greatly improved the poor cell adhesion performance of HAMA,supported the viability,proliferation of corneal cells,and preservation of keratocyte phenotype.In a rabbit corneal stromal defect model,the experimental eyes treated with the hybrid hydrogel remained transparent and adhered intimately to the stroma bed with long-term retention,accelerated corneal re-epithelialization and wound healing.Giving the advantages of high bioactivity,low-cost,and good practicality,the dual-crosslinked hybrid hydrogel served effectively for long-term suture-free treatment and tissue regeneration after corneal defect. | Xuanren Shen Saiqun Li Xuan Zhao Jiandong Han Jiaxin Chen Zilong Rao Kexin Zhang Daping Quan Jin Yuan Ying Bai | 2023 | Bioactive Materials2023，，2： | 1 |
| 14 | Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles显示文摘We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions.In addition,scale-up experiments and late-stage functionalization of drugs were also performed.Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction. | Feng Li Ziyan Wu Jingjing Wang Siyuan Zhang Jiaxin Yu Zhen Yuan Jingya Liu Renzeng Shen Yao Zhou Lantao Liu | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 15 | Fiber coupled high count-rate single-photon generated from InAs quantum dots显示文摘In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-pillar cavity,so as to improve their light emission extraction in the vertical direction,thereby enhancing the optical SM fiber’s collection capabil-ity(numerical aperture:0.13).By tuning the temperature precisely to make the quantum dot exciton emission resonant to the micro-pillar cavity mode(Q~1800),we achieve a fiber-output single-photon count rate as high as 4.73×10^(6) counts per second,with the second-order auto-correlation g2(0)remaining at 0.08. | Yao Chen Shulun Li Xiangjun Shang Xiangbin Su Huiming Hao Jiaxin Shen Yu Zhang Haiqiao Ni Ying Ding Zhichuan Niu | 2021 | Journal of Semiconductors2021，42，7： | 0 |
| 16 | An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV显示文摘Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent need to develop inexpensive and efficient animal vaccines to prevent and control coronavirus disease 2019(COVID-19)in animals.Rabies virus(RABV)is another important zoonotic pathogen that infects almost all warmblooded animals and poses a great public health threat.The present study constructed two recombinant chimeric viruses expressing the S1 and RBD proteins of the SARS-CoV-2 Wuhan01 strain based on a reverse genetic system of the RABV SRV9 strain and evaluated their immunogenicity in mice,cats and dogs.The results showed that both inactivated recombinant viruses induced durable neutralizing antibodies against SARS-CoV-2 and RABV and a strong cellular immune response in mice.Notably,inactivated SRV-nCoV-RBD induced earlier antibody production than SRV-nCoV-S1,which was maintained at high levels for longer periods.Inactivated SRV-nCoV-RBD induced neutralizing antibodies against both SARS-CoV-2 and RABV in cats and dogs,with a relatively broadspectrum cross-neutralization capability against the SARS-CoV-2 pseudoviruses including Alpha,Beta,Gamma,Delta,and Omicron,showing potential to be used as a safe bivalent vaccine candidate against COVID-19 and rabies in animals. | Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 17 | Molecular characterization of organic matter transformation mediated by microorganisms under anoxic/hypoxic conditions显示文摘Dissolved organic matter(DOM) in the ocean is one of the largest carbon pools on Earth. Microbial metabolism is an important process that shapes the marine DOM pool. Current studies on the interactions between microorganisms and DOM focus mainly on oxic environments. Few studies have addressed the molecular characteristics of DOM in microbial-mediated transformation under anoxic/hypoxic conditions. As a result of deteriorating water quality due to eutrophication and global warming, anoxia occurs frequently in coastal waters. In this study, we performed an experiment to investigate changes in microbial community responses and the molecular characteristics of DOM in microbial-mediated transformation under hypoxic conditions. We compared microbial-mediated DOM transformation at different dissolved oxygen levels(7, 5, and 2 mg L^(-1)) and in different media(natural and artificial seawater with and without laminarin). We also investigated differences in DOM composition between groups using spectroscopic analysis and ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. The results showed decreased microbial metabolic activity and delayed community succession at low oxygen(≤2 mg L^(-1)) in natural seawater supplemented with laminarin. The growth of strictly aerobic bacteria such as Pseudomonadaceae and Sphingomonadaceae was inhibited and the total organic carbon utilization rate was reduced by 36.9–46.7% from 4 to 32days. Moreover, tyrosine-like and tryptophan-like components were preserved, while DOM humification and modified aromaticity indices were significantly reduced under low oxygen conditions. This experiment provides justification for further study of the processes and mechanisms of improved labile DOM preservation in anoxic estuarine and coastal waters. | Shicong XIAO Jiaxin CHEN Yuan SHEN Qi CHEN Yu WANG Yunyun LI Chen HE Ruanhong CAI Quan SHI Nianzhi JIAO Qiang ZHENG | 2023 | Science China Earth Sciences2023，66，4： | 0 |
| 18 | Scalable synthesized high-performance TiO_(2)-Si-C hybrid anode for lithium batteries显示文摘At present,developing a simple strategy to effectively solve the shackles of volume expansion,poor conductivity and interface compatibility faced by Si-C anode in lithium batteries(LIBs)is the key to its commercialization.Here,low-cost nano-Si powders were prepared from Si-waste of solar-cells by sanding treatment,which can effectively reduce the commercialization cost for Si-C anode.Furthermore,micro-nano structured Gr@Si/C/TiO_(2) anode materials with graphite(Gr)as the inner core,TiO_(2)-doped and carbon-coated Si as the outer coating-layer,were synthesized at kilogram-scale per milling batch.Comprehensive characterization results indicate that TiO_(2)-doped carbon layer can improve the interface compatibility with the electrolyte,further promote the reduction of electrode polarization,and finally enhance the battery performance for the Gr@Si/C/TiO_(2) anodes.Accordingly,Gr@Si/C/TiO_(2) composites can output excellent LIB performance,especially with high initial coulombic efficiency(ICE)of 82.51%and large average reversible capacity of~810 mA h g^(-1) at 0.8 A g^(-1) after 1000 cycles.Moreover,Gr@Si/C/TiO_(2)‖NCM811 pouch full cells deliver impressive performance especially with high energy density of~489.3 W h kg^(-1) based on the total weight of active materials,suggesting its promising application in the high performance LIBs. | Liao Shen Chengjie Xu Jingguo Gao Jianming Tao Qiaobao Zhang Yue Chen Yingbin Lin Zhigao Huang Jiaxin Li | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 19 | Assessing the contribution of global wildfire biomass burning to BaP contamination in the Arctic显示文摘Polycyclic aromatic hydrocarbons(PAHs)have become cause for growing concern in the Arctic ecosystems,partly due to their stable levels despite global emission reduction.Wildfire is considered one of the primary sources that influence PAH levels and trends in the Arctic,but quantitative investigations of this influence are still lacking.This study estimates the global emissions of benzo[a]pyrene(BaP),a congener of PAHs with high carcinogenicity,from forest and grassland fires from 2001 to 2020 and simulates the contributions of wildfire-induced BaP emissions from different source regions to BaP contamination in the Arctic.We find that global wildfires contributed 29.3%to annual averaging BaP concentrations in the Arctic from 2001 to 2020.Additionally,we show that wildfires contributed significantly to BaP concentrations in the Arctic after 2011,enhancing it from 10.1%in 2011 to 83.9%in 2020.Our results reveal that wildfires accounted for 94.2%and 50.8%of BaP levels in the Asian Arctic during boreal summer and autumn,respectively,and 74.2%and 14.5%in the North American Arctic for the same seasons.The source-tagging approach identified that local wildfire biomass emissions were the largest source of BaP in the Arctic,accounting for 65.7%of its concentration,followed by those of Northern Asia(17.8%)and Northern North America(13.7%).Our findings anticipate wildfires to play a larger role in Arctic PAH contaminations alongside continually decreasing anthropogenic emissions and climate warming in the future. | Shijie Song Boqi Chen Tao Huang Shuxin Ma Luqian Liu Jinmu Luo Huizhong Shen Jiaxin Wang Liang Guo Min Wu Xiaoxuan Mao Yuan Zhao Hong Gao Jianmin Ma | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 20 | Detection of Recurrent Cervical Cancer by Whole-body FDG PET Scans显示文摘OBJECTIVE To evaluate the role of whole-body{ 18 F}fluro-2-dexoxyglucose(FDG)positron emission tomography(PET)scans in the detection of recurrent cervical cancer. METHODS Between June,2000 and January,2006,25 patients had undergone a PET scan at the Peking Union Medical College Hospital to evaluate possible recurrent cervical cancer.All the PET findings were reviewed and compared to available clinical data to classify each PET scan result as a true positive,true negative,false positive,or false negative. RESULTS A total of 38 PET scans were conducted on the 25 patients whose median age was 46 years.The Stage distributions were IA(n=1),IB(n=11),IIA(n=5),IIB(n=4),IIIB(n=2),IVB(n =1),and unknown Stage(n=1).There were 22 cases of squamous cell carcinoma and 3 cases of adenocarcinoma resulting in 9 true positive PET scans,27 true negatives,2 false positives and no false negatives.The sensitivity of the FDG PET scans for detecting recurrent cervical cancer was 100%,specificity 93.1%,positive predictive value 81.8%,and negative predictive value 100%. CONCLUSION The whole body FDG PET scans are a sensitive and specific imaging modality for the detection of recurrent cervical cancer.However the cost of PET scans is too high at this time.A large prospective study will determine whether this modality should be used routinely and take the place of other imaging methods in the early detection of recurrent cervical | Jiaxin Yang Jinhui Wang Zhaohui Zhu Keng Shen Bocheng Wang | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
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