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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Influences of different types of magnetic fields on HCFC-141b gas hydrate formation processes显示文摘In this study, visualizations and experiments are carried out on the influence of static and rotating magnetic fields on the characteristics of HCFC-141b gas hydrate formation, such as crystallization form, formation temperature and induction time. It has been found that a proper rotating magnetic field can considerably improve the low-pressure gas hydrate formation process, especially in increasing the formation temperature and shortening the induction time. The mor- phology of the gas hydrate formation appears rather complex and compact. However, a proper static magnetic field can make the gas hydrate crystal more organized, which will be benefit to heat transfer. | SHU Bifen MA Xiaolin GUO Kaihua LI Jianhong | 2004 | Science China Chemistry2004，47，5： | 14 |
| 3 | Mid-long Term Optimal Dispatching Method of Hydro-thermal Power System Considering Scheduled Maintenance显示文摘在中长期水火发电调度中考虑检修计划的影响是目前中长期水火发电调度面临的难题。利用现代整数代数建模技术,建立发电计划和检修计划协调优化的多场景调度模型。在该模型中,鉴于设备检修计划的连续性,在预测场景树的基础上,将场景节点划分成不同的场景,通过节点和场景关联矩阵,实现多场景下设备检修模型的构建。同时,鉴于中长期调度计划中发电计划和检修计划对时段间隔要求的不同,分别设置电量相关节点和电力相关节点,实现中长期发电计划和检修计划的协调。上述模型是一个大规模混合整数线性规划(mixed integer linear programming,MILP)问题,采用商用MILP求解器进行求解。大规模实际水火电系统的实例分析结果表明,所提模型和方法是可行、有效的。 | GE Xiaolin SHU Jun ZHANG Lizi | 2012 | 中国电机工程学报2012，32，13： | 11 |
| 4 | Vacancies and Antisites in B2 FeAl and DO_3 Fe_3Al with a Modified Analytic EAM Model显示文摘A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of vacancy and antisite were also calculated. The present calculations are in agreement with the experimental data and the theoretical results obtained by other authors. | Xiaolin SHU, Wan gyu HU, Hanning XIAO and Huiqiu DENG College of Materials Science and Engineering, Hunan University, Changsha 410082, China Ban gwei ZHANG International Centre of Materials Physics, Chinese Academy of Sciences, S | 2001 | Journal of Materials Science & Technology2001，17，6： | 4 |
| 5 | Allogeneic hematopoietic stem cell transplantation for patients with acute leukemia显示文摘Objective: The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia (AL) and analyze the factors affecting the prognosis of these patients. Methods: The clinical and follow-up data of 93 AL patients (median age, 30 years) undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results: Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease (aGvHD) and extensive chronic GvHD (cGvHD) were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality (TRM) and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival (OS) and disease-free survival (DFS) of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse (all P<0.05). Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis (all P<0.05). Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes (all P<0.05). Conclusions: Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis. | Yan Chen Yajing Xu Gan Fu Yi Liu Jie Peng Bin Fu Xiaoyu Yuan Hongya Xin Yan Zhu Qun He Dengshu Wu Yigang Shu Xiaolin Li Xielan Zhao Fangping Chen | 2013 | Chinese Journal of Cancer Research2013，25，4： | 3 |
| 6 | A putative bHLH transcription factor is a candidate gene for male sterile 32,a locus affecting pollen and tapetum development in tomato显示文摘The tomato(Solanum lycopersicum)male sterile 32(ms32)mutant has been used in hybrid seed breeding programs largely because it produces no pollen and has exserted stigmas.In this study,histological examination of anthers revealed dysfunctional pollen and tapetum development in the ms32 mutant.The ms32 locus was fine mapped to a 28.5 kb interval that encoded four putative genes.Solyc01g081100,a homolog of Arabidopsis bHLH10/89/90 and rice EAT1,was proposed to be the candidate gene of MS32 because it contained a single nucleotide polymorphism(SNP)that led to the formation of a premature stop codon.A codominant derived cleaved amplified polymorphic sequence(dCAPS)marker,MS32D,was developed based on the SNP.Real-time quantitative reverse-transcription PCR showed that most of the genes,which were proposed to be involved in pollen and tapetum development in tomato,were downregulated in the ms32 mutant.These findings may aid in marker-assisted selection of ms32 in hybrid breeding programs and facilitate studies on the regulatory mechanisms of pollen and tapetum development in tomato. | Xiaoyan Liu Mengxia Yang Xiaolin Liu Kai Wei Xue Cao Xiaotian Wang Xiaoxuan Wang Yanmei Guo Yongchen Du Junming Li Lei Liu Jinshuai Shu Yong Qin Zejun Huang | 2019 | Horticulture Research2019，6，1： | 3 |
| 7 | Energetics and structures of hydrogen-vacancy clusters in tungsten based on genetic algorithm显示文摘The behavior of hydrogen(H)in metals has been a longstanding research topic in materials science.One of the most compelling subjects is the deleterious effects of H on the microstructural evolution of materials;these effects include H embrittlement,superabundant vacancy formation,and blistering.Vacancies have been demonstrated through both experiments and computational simulations to have strong H trapping effects[1],resulting in increased H retention[2], | LiFang Wang XiaoLin Shu GuangHong Lu Fei Gao | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，10： | 2 |
| 8 | Point-defect properties in body-centered cubic transition metals with analytic EAM interatomic potentials 显示文摘 | Hu Wangyu Shu Xiaolin Zhang Bangwei | 2000 | Computational Materials Science2000，23，： | 1 |
| 9 | Calculation of formation enthalpies and phase stability for Ru-A1 alloys using an analytic embedded atom model 显示文摘 | Hu Wangyu Zhang Bangwei Shu Xiaolin | 1999 | JAlloys Compd1999，287，： | 1 |
| 10 | Analytical W–He and H–He interatomic potentials for a W–H–He system显示文摘 | Xiao-Chun Li Xiaolin Shu Yi-Nan Liu Yi Yu F. Gao Guang-Hong Lu | 2012 | Journal of Nuclear Materials . 2012 (1-3)2012，，1： | 1 |
| 11 | Monte Carlo simulation of the surface segregation of Pt-Pd and Pt-Ir alloys with an analytic embedded-atom method 显示文摘 | Deng Huiqiu Hu Wangyu Shu Xiaolin | 2002 | Surf Sci2002，517，： | 1 |
| 12 | An efficient stochastic algorithm for mid-term scheduling of cascaded hydro systems显示文摘Due to the stochastic and correlated attributes of natural inflows, the mid-term generation scheduling problem for cascaded hydro systems is a very challenging issue.This paper proposes a novel stochastic optimization algorithm using Latin hypercube sampling and Cholesky decomposition combined with scenario bundling and sensitivity analysis(LC-SB-SA) to address this problem.To deal with the uncertainty of natural inflows, Latin hypercube sampling is implemented to provide an adequate number of sampling scenarios efficiently, and Cholesky decomposition is introduced to describe the correlated natural inflows among cascaded stations.In addition, to overcome the difficulties in solving the objectives of all the scenarios, scenario bundling and sensitivity analysis algorithms are developed to improve the computational efficiency.Simulation results from both two-station and tenstation systems indicate that the proposed method has the merits in accuracy as well as calculation speed for the midterm cascaded hydro generation scheduling.The consideration of natural inflow correlation makes the formulated problem more realistic. | Xiaolin GE Shu XIA Wei-Jen LEE | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 1 |
| 13 | A 3D Geometry-Based Scattering Model for Vehicleto-Vehicle Wideband MIMO Relay-Based Cooperative Channels显示文摘In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical three-cylinder is proposed. Non-line-of-sight(NLOS) propagation condition is assumed in amplify-and-forward(AF) cooperative networks from the source mobile station(S) to the destination mobile station(D) via the mobile relay station(R). We extend the proposed narrowband model to wideband and also introduce the carrier frequency and bandwidth into the model. To avoid complicated procedure in deriving the analytical expressions of the channel parameters and functions, the channel is realized first. By using the realized channel matrix, the channel properties are further investigated. | Xiaolin Liang Xiongwen Zhao Shu Li Qi Wang Wenbing Lu | 2016 | China Communications2016，13，10： | 1 |
| 14 | The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP显示文摘Dear Editor,Chemoresistance is a major problem in the treatment of ovarian cancer patients and leads to poor prognosis,but its underlying mechanism remains elusive.Accumulating evidences have found that the aberrant regulation of the protein ubiquitination pathway plays an essential role in ovarian cancer chemoresistance.13 However,it is unclear whether and how deubiquitinase-USP11 involves in ovarian cancer chemoresistance. | Xiaolin Zhu Yiping Zhang Qingyu Luo Xiaowei Wu Furong Huang Tong Shu Yong Wan Hongyan Chen Zhihua Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 15 | Point defects in L1_0 FePt studied by molecular dynamics simulations based on an analytic bond-order potential显示文摘The point defects and their related physical properties in L10 FePt are investigated by molecular dynamics simulations based on an analytic bond-order potential. The calculated results agree well with the experimental value, indicating that the analytic bond-order potential is suitable to describe the structural properties and surface energies of the FePt alloy in the L10 phase. However, the calculated vacancy formation energy of an Fe atom is higher than that of a Pt atom, which disagrees with some other previously calculated results. This result indicates that the analytic bond-order potential is unable to describe the related point defect properties. The analytic bond-order potential needs to be modified in order to study these defect properties of an FePt alloy. | DONG Hao SHU XiaoLin WANG RongMing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 1 |
| 16 | Effect of hydrogen on grain boundary migration in tungsten显示文摘Motivated by a grain boundary(GB) healing mechanism that GB turns into a mobile sink through migration to eliminate the vacancies in a bulk, we have further investigated the influence of the retained hydrogen(H) on the GB migration in tungsten using a molecular dynamics simulation. We show that H hinders the GB migration at different H concentrations and temperatures, and such friction of GB migration due to the presence of H increases with the H concentration and decreases with temperature. We demonstrate that H follows the GB-migration as the temperature is higher than 300 K. Most importantly, the presence of H induces a disordering of GB, which affects the GB migration significantly. | YU Yi SHU XiaoLin LIU YiNan NIU LiangLiang JIN Shuo GAO Fei LU GuangHong | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，7： | 1 |
| 17 | Direct structural evidence supporting a revolving mechanism in DNA packaging motors显示文摘Viruses have evolved two strategies to package genome:either assembling a capsid around their genomes or packaging the genomes into a preformed capsid with packaging motors.Most of the double-stranded(ds)DNA viruses(e.g.,tailed bacteriophages and herpesviruses)and dsRNA viruses(e.g.,/6 and/12 bacteriophages)take the latter strategy.The packaging motors are usually called the'terminase'complex,which,in bacteriophages comprises two proteins,termed large(TerL)and small(TerS)terminases(Guo et al.1987b),while in herpesviruses contains three components—pUL15,pUL28 and pUL33.The unique/29 motor complex lacks a TerS but instead contains a 174-nt prohead RNA(pRNA)(Guo et al.1987a).However,it has long been debated whether the viral genome packaging motors operate via a rotatory or revolving mechanism and what is their oligomeric state in action—a hexamer or a pentamer?And now,published in a recent issue of Protein&Cell,Yang et al.have hopefully ended these 20-year long fervent debates by determining high-resolution structures of the herpesvirus terminase complex to reveal the six-fold symmetry with a potential revolving mechanism(Yang et al.2020). | Yao-Gen Shu Xiaolin Cheng | 2020 | Biophysics Reports2020，6，5： | 1 |
| 18 | Kinetic Monte Carlo code development and application on the formation of hydrogen-vacancy clusters in tungsten显示文摘We have developed an object kinetic Monte Carlo(OKMC)code and simulated hydrogen-vacancy clustering behavior and dependence on temperature and hydrogen-vacancy ratio in tungsten.For each of the temperatures we simulated from 300 K to1000 K,H_nV clusters with smaller n form before those with larger n.The elevating temperature leads to a decrease in hydrogen vacancies:H_(10)V and H_9V clusters dominate at 300 K and 600 K,whereas H_5V,H_6V,and H_7V clusters dominate when the temperature reaches 1000 K.Furthermore,only H_nV clusters with smaller n formed when a lower hydrogen-vacancy ratio was used due to insufficient availability of hydrogen atoms to occupy vacancies.The results suggest hydrogen emission occurs very rarely at lower temperatures,while higher temperatures facilitate the dissociation of hydrogen from H_nV clusters. | Chao Meng JianNan Hao Ke Xu Li-Fang Wang XiaoLin Shu Shuo Jin Guang-Hong Lu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 1 |
| 19 | Analytical W–He and H–He interatomic potentials for a W–H–He system显示文摘 | Xiao-Chun Li Xiaolin Shu Yi-Nan Liu Yi Yu F. Gao Guang-Hong Lu | 2012 | Journal of Nuclear Materials (-)2012，，1： | 1 |
| 20 | Monte carlo simulation of the surface segregation of Pt-Pd and Pt-Ir alloys with an analytic embedded-atom method显示文摘 | Deng Huiqiu Hu Wangyu Shu Xiaolin | 2002 | Surface Science2002，517，13： | 1 |
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