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| 1 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 2 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 3 | Two-fluid modeling of Geldart A particles in gas-solid micro-fluidized beds显示文摘The fluidizadon behavior of Geldart A particles in a gas-solid micro-fluidized bed was investigated by Eulerian-Eulerian numerical simulation.The commonly used Gidaspow drag model was tested first.The simulation showed that the predicted minimum bubbling velocities were significantly lower than the experimental data even when an extremely fine grid size(of approximately one particle diameter) was used.The modified Gibilaro drag model was therefore tested next.The predicted minimum bubbling velocity and bed voidage were in reasonable agreement with the experimental data available in literature.The experimentally observed regime transition phenomena from bubbling to slugging were also reproduced successfully in the simulations.Parametric studies indicated that the solid-wall boundary conditions had a significant impact on the predicted gas and solid flow behavior. | Xiaoxing Liu Chuanqiang Zhu Shujun Geng Meiqin Yao Jinhui Zhan Guangwen Xu | 2015 | Particuology2015，13，4： | 8 |
| 4 | Discrete and continuum modeling of granular flow in silo discharge显示文摘 | Tian Tian Jinglin Su Jinhui Zhan Shujun Geng Guangwen Xu Xiaoxing Liu | 2018 | Particuology2018，16，1： | 6 |
| 5 | Intellicise communication system: model-driven semantic communications显示文摘As one of the critical technologies for the 6 th generation mobile communication system(6 G) mobile communication systems, artificial intelligence(AI) technology will provide complete automation for connecting the virtual and physical worlds. In order to construct the future ubiquitous intelligent network, people are beginning to rethink how mobile communication systems transmit and exploit intelligent information. This paper proposes a new communication paradigm, called the Intellicise communication system: model-driven semantic communication. Intellicise communication system is built on top of the traditional communication system and innovatively adds a new feature dimension on top of the traditional source coding, which enables the communication system to evolve from the traditional transmission of bit to the transmission of 'model'. Like the semantic base(Seb) for semantic communication, the model is considered as the new feature obtained from the joint source-channel coding. The sink node can re-construct the original signal based on the received model and the encoded sequence. In addition, the performance evaluation metrics and the implementation details of the Intellicise communication system are discussed in this paper. Finally, preliminary results of model-driven image transmission in the Intellicise communication system are presented. | Zhang Ping Xu Xiaodong Dong Chen Han Shujun Wang Bizhu | 2022 | The Journal of China Universities of Posts and Telecommunications2022，29，1： | 6 |
| 6 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 7 | Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019显示文摘During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection. | Wenkuan Liu Shuyan Qiu Li Zhang Hongkai Wu Xingui Tian Xiao Li Duo Xu Jing Dai Shujun Gu Qian Liu Dehui Chen Rong Zhou | 2022 | Virologica Sinica2022，37，3： | 5 |
| 8 | Evolution Toward Artificial Intelligence of Things Under 6G Ubiquitous⁃X显示文摘With the evolution of cellular networks,6G is a promising technology to provide ubiquity of communications,computing,control,and consciousness(UC4)for“human⁃machine⁃thing⁃genie”and build a ubiquitous intelligent mobile society.Genie,which can act as the artificial intelligence assistance for 6G users,is the key enabler to realize the unprecedented transformation from mobile Internet to network of intelligence.While Internet of Things(IoT)is the digital nervous system,genie acts like the brain of the overall system.Supported by 6G,IoT will step into the Artificial Intelligence of Things(AIoT)era and the AIoT networks have the abilities of intelligent perception,intelligent analysis,and intelligent control.In this paper,the concept of Ubiquitous⁃X is introduced,which is considered as the fundamental architecture of 6G network,and the definition and architecture of AIoT under Ubiquitous⁃X is also presented.Several major technical challenges posed by the service requirements of novel AIoT applications are pinpointed,including massive and intelligent connectivity,efficient computing,security,privacy,authentication,high scalability and efficiency.Potential enabling technologies to support seamless service experiences across terminals to realize AIoT are introduced as well. | Ping Zhang Xiaodong Xu Xiaoqi Qin Yiming Liu Nan Ma Shujun Han | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，3： | 4 |
| 9 | Colloidal CsPbBr3 perovskite nanocrystal films as electrochemiluminescence emitters in aqueous solutions显示文摘 | Zhixiong Cai Feiming Li Wei Xu Shujun Xia Jingbin Zeng Shaogui He Xi Chen | 2018 | Nano Research2018，11，3： | 4 |
| 10 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 11 | Spacing graphene and Ni-Co layered double hydroxides with polypyrrole for high-performance supercapacitors显示文摘The urgent need of high-performance of energy storage devices triggers us to design newly class of materials.Generally,the materials feature with high conductivity,abundant pore s and excellent stability.Here,a sandwiched hybrid composite containing reduced graphene oxide,polypyrrole and Ni-Co layered double hydroxides(RGO/PPy/NiCo-LDH) was prepared in a facile way.The polypyrrole was incorporated in the two dimensional(2D) nanosheets,which not only serve as the spacer to increase the surface area,but also enhance the conductivity of the nanocomposite.The obtained architecture was employed as an advanced electrode in a supercapacitor.The electrode shows an ultrahigh specific capacitance(2534 F g^-1 at 1 A g^-1) and good cycling efficiency(78 % after 5000 cycles).Moreover,an asymmetric cell based RGO/PPy/NiCo-LDH composite demonstrates excellent electrochemical properties and good prospect of practical use. | Jing Liang Cuili Xiang Yongjin Zou Xuebu Hu Hailiang Chu Shujun Qiu Fen Xu Lixian Sun | 2020 | Journal of Materials Science & Technology2020，52，20： | 3 |
| 12 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 13 | Water cycle evolution in the Haihe River Basin in the past 10000 years显示文摘The water shortage problem in the Haihe River Basin is the most severe in China, and has restricted its economic development. Over-extraction of groundwater has been very severe in the past 30 years. To solve this problem, scientific decisions should be made from a historical perspective. It is important to describe water cycle evolution in the Haihe River basin over the past 10000 years. Datasets of paleoclimate, paleogeography, palynoflora, historical record, isotopic abundance ratio and content were collected for research on different time scales. Some interesting conclusions were drawn by a comprehensive analysis method. First, radiation was the intrinsic force driving the evolution of water cycle. Generally, precipitation increased with temperature. Second, precipitation was high during 8 ka-5 ka B.P., the so-called Yangshao warm period of the Middle Holocene, which recharged the major part of the Quaternary groundwater. Third, heavy floods during this period transported sediment to the seaside, forming the Coastal Plain where cities such as Tianjin, Huanghua, Cangzhou are now located. In the last 3000 years, intermittent moderate floods did not have enough energy to transport sediment to the sea. Rivers usually overflowed in the piedmont region of the Taihang Mountains, and sediment deposited there formed the Piedmont Plain, where locate Shijiazhuang, Xingtai, Handan, Baoding and other cities. Precipitation had a high correlation with temperature in Haihe River Basin in the past 10000 years: the high temperature usually coupled with high precipitation. Today precipitation in the Haihe River Basin is relatively low, owing to low temperature. This study reveals the relationship between temperature, precipitation and river networks in the past 10000 years in Haihe River Basin, which has great scientific and practical importance in understanding the current water circulation and water shortage. | LIU JiaHong XU He QIN DaYong WANG Hao WANG JianHua LI HaiHong BAO ShuJun | 2013 | Chinese Science Bulletin2013，58，27： | 3 |
| 14 | Targeted delivery of docetaxel to the metastatic lymph nodes:A comparison study between nanoliposomes and activated carbon nanoparticles显示文摘The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes,which are used as carriers for delivering docetaxel(DTX)to the metastatic lymph nodes.In this study,we first prepared the DTX-loaded activated carbon nanoparticles(DTX-AC-NPs)by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the concentrated nitro-oxide nanocarbon.We then prepared DTX-loaded nanoliposomes(DTX-LPs)by the proliposome method.The physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in vitro.The metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX concentration in metastatic lymph nodes and injection sites.The result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physicochemical properties could be used for in vivo lymph node targeting studies.DTX-AC-NPs significantly increased DTX-AUC_((0-24)) and prolonged DTX-retention in metastatic lymph nodes compared to DTX-LPs and non-modified activate carbon in vivo.This study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes. | Tiantian Ye Wen Xu Tianyu Shi Rui Yang Xinggang Yang Shujun Wang Weisan Pan | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，1： | 2 |
| 15 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 16 | Global exponential stability of impulsive dynamical systems with dis-tributed delays显示文摘 | Shujun Long Daoyi Xu and Wei Zhu | 2007 | Electronic Journal of Quanlitative Theory of Differential Equations2007，10，： | 1 |
| 17 | 3D fingerprint imaging system based on full-field fringe projection profilometry显示文摘 | Shujun Huang Zonghua Zhang Yan Zhao Jie Dai Chao Chen Yongjia Xu E. Zhang Lili Xie | 2014 | Optics and Lasers in Engineering2014，，： | 1 |
| 18 | Coronavirus disease 2019 epidemic prediction in Shanghai under the “dynamic zero-COVID policy”using time-dependent SEAIQR model显示文摘It’s urgently needed to assess the COVID-19 epidemic under the“dynamic zero-COVID policy”in China,which provides a scientific basis for evaluating the effectiveness of this strategy in COVID-19 control.Here,we developed a time-dependent susceptible-exposed-asymptomatic-infected-quarantined-remov ed(SEAIQR)model with stage-specific interventions based on recent Shanghai epidemic data,considering a large number of asymptomatic infectious,the changing parameters,and control procedures.The data collected from March 1st,2022 to April 15th,2022 were used to fit the model,and the data of subsequent 7 days and 14 days were used to evaluate the model performance of forecasting.We then calculated the effective regeneration number(Rt)and analyzed the sensitivity of different measures scenarios.Asymptomatic infectious accounts for the vast majority of the outbreaks in Shanghai,and Pudong is the district with the most positive cases.The peak of newly confirmed cases and newly asymptomatic infectious predicted by the SEAIQR model would appear on April 13th,2022,with 1963 and 28,502 cases,respectively,and zero community transmission may be achieved in early to mid-May.The prediction errors for newly confirmed cases were considered to be reasonable,and newly asymptomatic infectious were considered to be good between April 16th to 22nd and reasonable between April 16th to 29th.The final ranges of cumulative confirmed cases and cumulative asymptomatic infectious predicted in this round of the epidemic were 26,477~47,749 and 402,254~730,176,respectively.At the beginning of the outbreak,Rt was 6.69.Since the implementation of comprehensive control,Rt showed a gradual downward trend,dropping to below 1.0 on April 15th,2022.With the early implementation of control measures and the improvement of quarantine rate,recovery rate,and immunity threshold,the peak number of infections will continue to decrease,whereas the earlier the control is implemented,the earlier the turning point of the epidemic will arrive.The proposed time-dependent SEAIQR dynamic model fits and forecasts the epidemic well,which can provide a reference for decision making of the“dynamic zero-COVID policy”. | Yifei Ma Shujun Xu Qi An Mengxia Qin Sitian Li Kangkang Lu Jiantao Li Lijian Lei Lu He Hongmei Yu Jun Xie | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 19 | Geotectonic evolution of lunar LQ-4 region based on multisource data显示文摘The Sinus Iridum region, the first choice for China's 'Lunar Exploration Project' is located at the center of the lunar LQ-4 area and is the site of Chang'e-3(CE-3)'s soft landing. To make the scientific exploration of Chang'e-3 more targeted and scientific, and to obtain a better macro-level understanding of the geotectonic environment of the Sinus Iridum region, the tectonic elements in LQ-4 region have been studied and the typical structures were analyzed statistically using data from CE-1, Clementine, LRO and Lunar Prospector missions. Also, the mineral components and periods of mare basalt activities in the study area have been ascertained. The present study divides the tectonic units and establishes the major tectonic events and sequence of evolution in the study area based on morphology, mineral constituents,and tectonic element distribution. | Jianping Chen Yanbo Xu Xiang Wang Shujun He Danping Yan Shaofeng Liu Yongliao Zou Yongchun Zheng | 2014 | Geoscience Frontiers2014，5，2： | 1 |
| 20 | Biointerface engineering nanoplatforms for cancer-targeted drug delivery显示文摘Over the past decade,nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy.Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis.Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery.Keeping in mind the biological framework of the tumormicroenvironment,biomembrane-camouflaged nanoplatforms have been a research focus,reflecting their superiority in cancer targeting.In this review,we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancertargeted drug delivery,which are classified according to the membranes fromdifferent cells.The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed. | Huaiyu Zhang Shujun Dong Zhongmin Li Xiangru Feng Weiguo Xu Catrina Mae STulinao Yang Jiang Jianxun Ding | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 1 |
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