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| 1 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 2 | Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation显示文摘用 Yamanaka 因素产生的导致的 pluripotent 茎(iPS ) 细胞在自体同源的细胞治疗为使用有大潜力。然而, genomic 畸形充分在人的 iPS 房间,和房间不是的大多数老鼠 iPS 存在 pluripotent 由 tetraploid 互补试金评估了 TCA ) ;这很可能与 DNA 损坏反应(DDR ) 被联系在 Yamanaka 因素导致的早 reprogramming 发生了。相反,原子转移忠实地装改编体的房间进胚胎的茎(ES ) 满足 TCA 的房间。我们因此假设了涉及导致卵母细胞的 reprogramming 的因素可以在 reprogramming 期间稳定体的染色体,并且改进结果的 iPS 房间的质量。测试这个假设,我们在 iPS 期间为能减少的因素屏蔽了 DDR 信号房间正式就职。我们决定了那 Zscan4,在有 Yamanaka 因素的联合,不是仅仅显著地减少了 DDR 而且显著地支持了 iPS 房间产生的效率。Zscan4 的包括稳定了 genomic DNA,导致 p53 downregulation。而且, Zscan4 也提高了象通过 telomere 感染以后的 3 天一样早变长的 telomere 基于再结合的机制。作为结果,与 Zscan4 的增加产生的 iPS 房间比古典 iPS 房间展出了更长的 telomeres。惊人地,超过 50% iPS 房间线(11/19 ) 经由这生产了 “ Zscan4 protocol”产生了由 TCA 决定了的实时熊的 all-iPS 房间老鼠,与为用古典 Yamanaka 因素生产的线的 1/12 相比。我们的调查结果提供在 reprogramming 期间维持 genomic 稳定性支持的第一示范高质量的 iPS 房间的产生。 | Jing Jiang Wenjian Lv Xiaoying Ye Lingbo Wang Man Zhang Hui Yang Maja Okuka Chikai Zhou Xuan Zhang Lin Liu Jinsong Li | 2013 | Cell Research2013，23，1： | 14 |
| 3 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 4 | A model for accurately calculating hyper-spectral, middle-shortwave infrared radiative transfer for remote sensing显示文摘Although the calculation of radiative transfer in the middle-shortwave infrared band is important in the field of optical remote sensing, studies in this area of research are rare in China. Both solar reflection and atmospheric emission should be considered when calculating radiative transfer in the middle-shortwave infrared band. This paper presents a new radiative transfer model based on the doubling and adding method. The new model uses approximate calculations of direct solar reflection,multiple scattering, and thermal emissions for a finitely thin atmospheric layer and considers both the solar and thermal sources of radiation. To verify its accuracy, the calculation results produced by the model for four typical scenarios(single layer at night,multi-layer aerosols, double-layer with ice and water clouds, and multi-layer with clouds and aerosols) were compared with those of the DISORT model. With the exception of a few channels, the absolute deviation between the two models was less than2×10^(-6) K. For the same calculation, the computation speed of the new model was approximately two to three times faster than that of the DISORT model. Sensitivity studies were performed to evaluate the error resulting from using simplified calculation methods in the new model. The results obtained in this study indicated that atmospheric thermal emission made a significant contribution to the measured radiance in the strong-absorption band(2230–2400 cm^(-1)), whereas solar radiation could be neglected in this region. However, neglecting solar radiation in the window region(2400–2580 cm^(-1)) introduced error on the order of dozens of K. Employing the average-layer temperature method simplified the calculation of thermal radiation but caused a larger error in the strong-absorption band than in the window region. In the doubling and adding method, the calculation error decreased as the value used for minimum optical thickness decreased. Under the condition of satisfying the requirement of calculation precision, we can consider using the layer-average temperature radiation method and selecting a relative larger minimum optical thickness value to improve the calculation efficiency. The new radiative calculation model proposed herein can be used in the simulation, inversion, and assimilation of middle-shortwave infrared measurements by hyper-spectral satellite instruments. | BAI WenGuang ZHANG Peng ZHANG WenJian MA Gang QI ChengLi | 2018 | Science China Earth Sciences2018，61，3： | 6 |
| 5 | Sodium cantharidinate,a novel anti-pancreatic cancer agent that activates functional p53显示文摘Despite the use of many types of chemotherapies for pancreatic cancer, optimal efficacy has not been obtained so far. Pancreatic cancer shows a high incidence of TP53 mutations, inactivating its tumor suppressor activity. In this study, we identified sodium cantharidinate as a novel, potential anti-pancreatic cancer agent that activates p53 function. Sodium cantharidinate reduced the viability of pancreatic cancer cells, including the human primary pancreatic cancer cells, PANC-1, As PC-1, SW1990 and BXPC-3, in a dose-dependent manner. Sodium cantharidinate induced apoptosis and DNA damage of pancreatic cancer cells. Furthermore, proteome-wide sequencing analysis detected a marked perturbation in p53 signaling pathway on PANC-1 cells upon sodium cantharidinate. Consistent with the previous results, sodium cantharidinate treatment decreased Bcl-2 and mitochondrial cytochrome-c protein expression, as well as phosphorylation of MDM2;meanwhile, it increased the levels of cleaved-caspase-3,cleaved-caspase-9, cleaved-PARP, Bax, and phosphorylated p53, thus inducing the apoptosis of pancreatic cancer cells. The p53-activating effect of sodium cantharidinate was strongly abrogated by treatment with TP53-targeting sh RNA. Moreover, sodium cantharidinate inhibited neoplasm growth via the JAK2-STAT3 pathway, which was inhibited by sh RNA-TP53 and triggered by combination with gemcitabine. Combination therapy indicated that sodium cantharidinate and gemcitabine synergistically reduced ex vivo and in vivo growth of pancreatic neoplasm. Further docking studies revealed the different binding fates of sodium cantharidinate to activate wild-type p53 function. Thus, sodium cantharidinate could be a potential agent with promising anti-pancreatic cancer efficacy. | Xiaoxiao Liu Li Zhang Pyone Myat Thu Wenjian Min Peng Yang Ji Li Ping Li Xiaojun Xu | 2021 | Science China(Life Sciences)2021，64，8： | 5 |
| 6 | Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR显示文摘Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy. | Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 7 | Intrinsically Stretchable Organic-Tribotronic-Transistor for Tactile Sensing显示文摘Stretchable electronics are of great significance for the development of the next-generation smart interactive systems.Here,we propose an intrinsically stretchable organic tribotronic transistor(SOTT)without a top gate electrode,which is composed of a stretchable substrate,silver nanowire electrodes,semiconductor blends,and a nonpolar elastomer dielectric.The drain-source current of the SOTT can be modulated by external contact electrification with the dielectric layer.Under 0-50%stretching both parallel and perpendicular to the channel directions,the SOTT retains great output performance.After being stretched to 50%for thousands of cycles,the SOTT can survive with excellent stability.Moreover,the SOTT can be conformably attached to the human hand,which can be used for tactile signal perception in human-machine interaction and for controlling smart home devices and robots.This work has realized a stretchable tribotronic transistor as the tactile sensor for smart interaction,which has extended the application of tribotronics in the human-machine interface,wearable electronics,and robotics. | Junqing Zhao Tianzhao Bu Xiaohan Zhang Yaokun Pang Wenjian Li Zhi Zhang Guoxu Liu Zhong Lin Wang Chi Zhang | 2020 | Research2020，，1： | 4 |
| 8 | Using Airgun Source Signals to Study Regional Wave Velocity Changes before and after the Yunlong M_S5.0 and Yangbi M_S5.1 Earthquakes显示文摘On the basis of the airgun source signals recorded by the stations from January,2016 to June,2017,we use cross-correlation detection technology to obtain the characteristics of the stable phase travel time change of each station.We used the Yunlong MS5.0 and Yangbi MS5.1 earthquakes as samples.According to regional characteristics,13 stations with high signal-to-noise ratios and complete data were selected(including 3 fixed stations and 10 active source stations).They are divided into four regions,and on the basis of the GNSS baseline data,the characteristics of regional wave velocity changes before and after the earthquake are analyzed.The results show that the station phase travel time change and the regional stress characteristics represented by the GNSS baseline data have good correlation in the short-term.Due to different degrees of regional stress,there are differences in the travel time changes of different stations in the four regions.Before the Yunlong MS5.0 and Yangbi MS5.1 earthquakes,with regional stress adjustment,there is an upward trend in the travel time changes of related stations in the adjacent areas of up to 0.02 s.The difference is that there are differences in the time nodes and duration of the travel time anomalies,and there is a reverse descent process after the Yangbi MS5.1 earthquake.There are different degrees of travel time fluctuations in the relevant stations before and after the two earthquakes,but the fluctuation range before and after the earthquake was small.Compared with the water level change of the reservoir,the adjustment of the regional stress is more likely to have a substantial impact on the travel time changes of the relevant stations. | YANG Jianwen LI Lei ZHANG Pengying YE Beng HE Yingwen CHEN Jia CHA Wenjian | 2019 | Earthquake Research in China2019，33，2： | 4 |
| 9 | Properties of coarse particles in suspended particulate matter of the North Yellow Sea during summer显示文摘Fine particles in seawater commonly form large porous aggregates. Aggregate density and settling velocity determine the behavior of this suspended particulate matter(SPM) within the water column.However, few studies of aggregate particles over a continental shelf have been undertaken. In our case study, properties of aggregate particles, including size and composition, over the continental shelf of the North Yellow Sea were investigated. During a scienti?c cruise in July 2016, in situ ef fective particle size distributions of SPM at 10 stations were measured, while temperature and turbidity measurements and samples of water were obtained from surface, middle, and bottom layers. Dispersed and inorganic particle size distributions were determined in the laboratory. The in situ SPM was divided into(1) small particles(<32 μm),(2) medium particles(32–256 μm) and(3) large particles(>256 μm). Large particles and medium particles dominated the total volume concentrations(VCs) of in situ SPM. After dispersion, the VCs of medium particles decreased to low values(<0.1 μL/L). The VCs of large particles in the surface and middle layers also decreased markedly, although they had higher peak values(0.1–1 μL/L). This suggests that almost all in situ medium particles and some large particles were aggregated, while other large particles were single particles. Correlation analysis showed that primary particles <32 μm in?uenced the formation of these aggregates. Microscopic examination revealed that these aggregates consisted of both organic and inorganic ?ne particles, while large particles were mucus-bound organic aggregates or individual plankton.The vertical distribution of coarser particles was clearly related to water strati?cation. Generally, medium aggregate particles were dominant in SPM of the bottom layer. A thermocline blocked resuspension of?ne material into upper layers, yielding low VCs of medium-sized aggregate particles in the surface layer.Abundant large biogenic particles were present in both surface and middle layers. | ZHANG Kainan WANG Zhenyan LI Wenjian YAN Jun | 2019 | Journal of Oceanology and Limnology2019，37，1： | 4 |
| 10 | Design of unballasted track bridges on Beijing——Tianjin intercity railway显示文摘Beijing-Tianjin intercity railway is the first newly-built passenger dedicated line with operating speed of 350 km/h in our country. During design,new ideas of bridge construction were carried out to ensure the requirements of safety,comfort and stability of the train under high-speed condition. At the same time,concepts of environmental adaptability,service to transportation and comprehensive benefits were observed. On the whole line,long-bridge schemes were adopted and the most advanced technologies of unballasted track were utilized on bridges,the length of which accounts for 87.7 % of the total line. The success of design and construction of the bridges on this rail has accumulated valuable experience for high-speed railway construction on a large scale in the future,and made it a marking,demonstrating,and model project to follow. | Sun Shuli Zhang Wenjian Wang Zhaohu Su Wei Wu Cailan Bu Qinghao | 2011 | Engineering Sciences2011，9，4： | 3 |
| 11 | Platelet-mediated adhesion facilitates leukocyte sequestration in hypoxia-reoxygenated microvessels显示文摘Leukocyte transendothelial migration and sequestration are two distinct outcomes following leukocyte adhesion to endothelium during ischemia-reperfusion injury, in which platelets may play a pivotal role. In the present study, we established an in vitro hypoxia-reoxygenation model to mimic ischemia-reperfusion injury and found platelet pre-incubation significantly increased leukocyte adhesion to endothelial cells after hyoxia-reoxygenation(over 67%). Blockade of endothelial-cell-expressed adhesion molecules inhibited leukocyte direct adhesion to endothelial cells, while platelet-mediated leukocyte adhesion was suppressed by blockade of platelet-expressed adhesion molecules. Further experiments revealed platelets acted as a bridge to mediate leukocyte adhesion, and platelet-mediated adhesion was the predominant pattern in the presence of platelets. However, platelet pre-incubation significantly suppressed leukocyte transendothelial migration after hypoxia-reoxygenation(over 31%), which could be aggravated by blockade of endothelial-cell-expressed adhesion molecules, but alleviated by blockade of platelet-expressed adhesion molecules. This would indicate that platelet-mediated adhesion disrupted leukocyte transendothelial migration. An in vivo mesenteric ischemia-reperfusion model demonstrated leukocyte transfusion alone caused mild leukocyte adhesion to reperfused vessels and subsequent leukocyte infiltration, while simultaneous leukocyte and platelet transfusion led to massive leukocyte adhesion and sequestration within reperfused microvessels. Our studies revealed platelets enhanced leukocyte adhesion to endothelial cells, but suppressed leukocyte transendothelial migration. Overall, this leads to leukocyte sequestration in hypoxia-reoxygenated microvessels. | Senfeng Zheng Yanting Cao Wenjian Zhang Honglin Liu Jia You Yiqing Yin Jinning Lou Chenghui Li | 2016 | Science China(Life Sciences)2016，59，3： | 3 |
| 12 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 13 | Dynamic analysis of preferential orientation of aragonite crystals in nacre from mollusk shell显示文摘Based on the scanning electron microscope (SEM) observations, it is confirmed that the nacre is composed of aragonite crystals and organic matrix with interlaced arrangement, showing ordered 'brick-mortar' structure. The dynamic analysis of preferential orientation of aragonite crystals in the nacre from the abalone (Haliotis diverscolor supertexta) with different shell ages is systematically investigated using X-ray diffraction (XRD) and high resolution transmission electron microscope (HRTEM). Experiments reveal that, in the nacre from the juvenile mollusk shell, there exist three kinds of orientations of aragonite crystals: (113), (002) and (012). However, along with the growing of the mollusk shell, the intensity of (012) and (113) becomes weak, and the (002) becomes the preferred crystal orientation of aragonite in the nacre from the adult mollusk shell, which means that the c axis of aragonite crystals is perpendicular to the nacreous layers. The results obtained show that the nacre possesses a highly ordered structure at the micrometer/nanometer multiscale levels. | ZHANG XueAo WU WenJian WANG JianFang | 2007 | Chinese Science Bulletin2007，52，24： | 2 |
| 14 | Time-dependent relativistic density functional study of Yb and YbO显示文摘The low-lying electronic states of Yb and YbO are investigated by using time-dependent relativistic density functional theory,which is based on the newly developed exact two-component Hamiltonian resulting from symmetrized elimination of the small component.The nature of the excited states is analyzed by using the full molecular symmetry.The calculated results support the previous experimental assignment of the ground and excited states of YbO. | XU WenHua ZHANG Yong LIU WenJian | 2009 | Science China Chemistry2009，52，11： | 2 |
| 15 | Biosensors based on acetylcholinesterase immobilized on mesoporous silica thin films显示文摘Using tetraethoxysilane and 3-aminopropyltriethoxysilane as the silica sources, amino-functionalized mesoporous silica thin films with 3-dimensional cubic structure have been deposited on conducting ITO substrate in the presence of surfactant F127 templates under acid conditions. The acetylcholinesterase (AchE) and cytochrome c (Cyt c) were incorporated into the pores of mesoporous thin films, and an amperometric biosensor was obtained. After adsorption of AchE and Cyt c, the ordered cubic structure of mesoporous silica and the bioactivities and electrochemical activities of the immobilized protein and enzyme molecules were retained. The sensor properties of the biosensor were investigated by using acetylthiocholine iodide as the substrate and Cyt c as the electron transfer mediator. The inhibition versus the logarithm of concentration was found to be linear to organophosphorus pesticide dichlorvos over the concentration ranges of 1.0×10-8 mol/L to 1.0×10-3 mol/L with the detection limit of 3.1×10-9 mol/L. | ZHANG XueAo JIA HongHui WANG XiaoFeng ZHANG HaiLiang YIN HongWei CHANG ShengLi WANG JianFang WU WenJian | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 16 | Direct synthesis and characterization of highly ordered functional mesoporous silica thin films with high amino-groups content显示文摘 | Zhang Xueao Wu Wenjian Wang Jianfang | 2008 | Applied Surface Science2008，254，9： | 1 |
| 17 | Facilitating the applications of support vector machine by using a new kernel显示文摘 | Zhang Rui Wang Wenjian | 2011 | Expert Systems with Applications2011，38，14： | 1 |
| 18 | Histone acetyltransferase p300 promotes MKLl-mediated transactivation of catechol-O-methyltransferase gene显示文摘以前的研究表明了 histone acetyltransferase p300 被招募到某些心脏、光滑的肌肉的倡导者特定的基因到提高 myocardin 的 transactivation 活动,它是在心血管的区别和开发的一个主人管理者。这里,我们发现编码 catechol-O-methyltransferase (COMT ) 的基因,催化雌激素的变换的重要的新陈代谢的酶,也是 myocardin 相关的抄写因素(MRTF ) 的目标基因。Megakaryoblastic 白血病 1 (MKL1,也命名的 MRTF -- 一) 并且 p300 能 synergistically 扩充 COMT 基因的表示,增加雌激素的新陈代谢的率,并且因此减少雌激素刺激的 MCF-7 乳癌房间的增长。 | Zhipeng Liu Xuegang Luo Lei Liu Wenwen Zhao Shu Guo Yu Guo Nan Wang Hongpeng He XinghuaLiao Wenjian Ma Hao Zhou Tongcun Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 1 |
| 19 | A method for detecting target echo in reverberation based on fractional Fourier transform显示文摘当播送信号是线性频率调整信号时,为在回响检测目标回响的一个方法基于部分 Fourier 变换理论被建议。回响的慢变化时间的信封被计算处理回响静止。静止回响用一扇滑动窗户被切成块。一个狭窄乐队的过滤器为每块在 FrFT 领域被使用,信号通过反的 FrFT 被恢复。系统的输出是恢复信号的精力。当目标回响在块之一被包括时,回响噪音被减少,并且产量是目标回响的精力。所有模拟和湖实验结果证明现在的方法的察觉表演比匹配的过滤器的好。 | CHEN Wenjian SUN Hui ZHU Jianjun ZHU Guangping ZHANG Minghui | 2010 | Chinese Journal of Acoustics2010，29，4： | 1 |
| 20 | Identification of WSB1 gene as an important regulator in the development of zebrafish embryo during midblastula transition显示文摘为了揭开,新奇基因潜在地在胚胎包含了开发,特别在中间的胞胚转变(MBT ) 在斑马鱼的发展中的胚胎的阶段, Affymetrix 斑马鱼 GeneChip 微数组分析在 14,900 个基因抄本的表达式上被执行。分析的结果证明 360 基因清楚地是起来调整的, 119 基因是显著地下面调整的。许多这些基因涉及转录因子活动, nucleic 绑定,和房间生长。现在的学习证明在抄本丰富的重要变化发生在 MBT 阶段期间。这 479 基因中的八个的表达式被反向的抄写聚合酶链反应分析识别,证实微数组结果。WSB1 基因,发现由微数组和反向的抄写聚合酶链反应分析下面调整,为进一步的学习被选择。WSB1 基因的顺序分析证明它与 75% 身份编码蛋白质到相应活跃人的 orthologs。另外, WSB1 基因表达在 4 h 柱子授精在 2 h 柱子授精并且在底层在高水平被检测,与薄片结果一致。WSB1 基因的 Overexpression 能在胚胎导致畸形的形成,由激活荧光的房间排序决定了。现在的学习不含糊地证明 WSB1 表示的出现在在斑马鱼胚胎的开发的 MBT 阶段期间是一个重要事件。 | Wenjian Lv Yunbin Zhang Zhili Wu Lin Chu S. S. Koide Yuguang Chen Yuanchang Yan Yiping Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
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