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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Significant Effects of Fishing Gear Selectivity on Fish Life History显示文摘Over the past few decades, extreme changes have occurred in the characters of exploited fish populations. The majority of these changes have affected the growth traits of fish life history, which include a smaller size-at-age, an earlier age-at-maturation and among others. Currently, the causes of these life history traits changes still require systematic analyses and empirical studies. The explanations that have been cited are merely expressed in terms of fish phenotypic adaptation. It has been claimed that the original traits of fish can be recovered once the intensity of exploitation of the fish is controlled. Sustained environmental and fishing pressure will change the life history traits of most fish species, so the fish individual's traits are still in small size-at-age and at earlier age-at-maturation in exploited fish populations. In this paper, we expressed our view of points that fishing gear has imposed selectivity on fish populations and individuals as various other environmental factors have done and such changes are unrecoverable. According to the existing tend of exploited fish individual's life history traits, we suggested further researches in this field and provided better methods of fishery management and thereby fishery resources protection than those available early. | LIANG Zhenlin SUN Peng YAN Wei HUANG Liuyi TANG Yanli | 2014 | Journal of Ocean University of China2014，13，3： | 4 |
| 3 | Hardware-in-the-loop simulation for the contact dynamic process of flying objects in space显示文摘在地面上的一个严肃环境,自从人首先由飞目标探索了空间,在空间的零严肃的环境的二个飞的目标的接触过程的模拟是一个挑战性的问题。Hardware-in-the-loop (HIL ) 模拟是一个重要、有效的方法在空间测试真实停靠机制的可用性,可靠性,和安全。为 HIL 模拟系统有四个主要问题:能够高频率反应,高运动精确,高速度,和快速的加速的模拟器的设计;为模拟失真的赔偿;为 HIL 模拟进程的一个控制模型的设计;并且试验性的确认。这里,我们与 6-DOF 3-3 建议一个新奇 HIL 模拟器系统垂直平行机制和 3-DOF 3-PRS 平行机制;发现模拟失真的原则;为模拟器的力量测量系统,动态反应,和结构的动力学介绍失真赔偿模型;并且为 HIL 模拟过程提供一个控制模型。二种实验在被动未受潮的有弹性的杆和停靠机制上被执行测试他们的表演并且验证 HIL 模拟器的有效性和可用性。在这份报纸建议的 HIL 模拟系统为开发停靠的空格是有用的, berthing, refueling,修理,升级,搬运,并且 rescuing 技术。 | GAO Feng QI ChenKun REN AnYe ZHAOXianChao CAO Rui SUN Qiao WANG Qian HU Yan HE Jun JIN ZhenLin LIU RenQiang ZHANG Yong GUO WeiZhong HU ZhenYu TANG Ping NI Bo JING QianFeng WANG WeiJun GAO Peng | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 4 | Dynamic memory paravirtualization transparent to guest OS显示文摘This paper introduces dynamic paravirtualization, which imitates paravirtualization and aims at reducing VM exits of full virtualization with hardware support. In dynamic paravirtualization, VMM (virtual machine monitor) dynamically monitors and replaces the hot instructions, which cause most VM exits. It is transparent to the guest OS such that the legacy OSes can benefit from this optimization. Our study focuses on reducing the overhead of memory virtualization-dynamic memory paravirtualization (DMP). We implant a new memory management mechanism in VMM such that all user-mode page faults can be handled by the guest OS directly without VM exits. We implement a prototype of dynamic memory paravirtulization based on a version of KVM using Intel VT. Our experimental results show that our technique essentially eliminates the overhead of VM exits caused by page faults. Dynamic memory paravirtualization can achieve the effectiveness of paravirtualization without changing the source code of guest OS. | WANG XiaoLin SUN YiFeng LUO YingWei WANG ZhenLin LI Yu ZHANG BinBin CHEN HaoGang LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 5 | Approaches to High-grade Sintered Magnesia from Natural Magnesite显示文摘It is hard to manufacture high purity,dense sintered-magnesia from natural magnesite in the prevailing process of calcining and sintering,for two reasons:a)impurity,and b)low sintering activity of coarse-grained magnesite.In this paper,95%MgO magnesite was used as the starting material and finally magnesia of high density(3.47 g/cm^3)and high purity(98%MgO)was obtained after the flotation purification and a three-step sintering process.An industrial scale of the beneficiation system of natural magnesite was introduced for magnesite purification.In lab experimental,the three-step sintering process was implemented by calcining,hydrating,re-calcining and sintering,which has proven the possibility of densified magnesia from natural magnesite. | GUO Zongqi BI Deli MA Ying SUN Zhenlin | 2020 | China's Refractories2020，29，3： | 3 |
| 6 | Characterization of Bacterial Community Associated with Four Organs of the Yesso Scallop (Patinopecten yessoensis) by High-Throughput Sequencing显示文摘We used Illumina high-throughput sequencing of PCR-amplified V3-V4 16 S rRNA gene regions to characterize bacterial communities associated with the adductor muscles, gills, gonads and intestines of the Yesso scallop(Patinopecten yessoensis) from waters around Zhangzidao, Dalian, China. Overall, 421,276 optimized reads were classified as 25 described bacterial phyla and 308 genera. Firmicutes, Proteobacteria, Tenericutes, Bacteroidetes, Chlamydiae and Spirochaetae accounted for > 97% of the total reads in the four organs. The bacterial 16 S rDNA sequences assigned to Firmicutes and Proteobacteria were abundant in the adductor muscles, gills and gonads; while reads from Tenericutes were dominant in the intestines, followed by those from Firmicutes, Chlamydiae, Proteobacteria and Bacteroidetes. At the genus level, the dominant genera in the adductor muscles, gills and gonads appeared to be Bacillus, Enterococcus and Lactococcus, whereas Mycoplasma was dominant in the intestines. The relative abundances of Bacillus, Enterococcus, Lactococcus, Alkaliphilus, Raoultella, Paenibacillus and Oceanobacillus were significantly lower in the intestine than in the other three organs. Cluster analysis and principal coordinates analysis of the operational taxonomy units profile revealed significant differences in the bacterial community structure between the intestine and the other three organs. Taken together, these results suggest that scallops have intestine-specific bacterial communities and the adductor muscles, gills and gonads harbor similar communities. The difference in the bacterial community between organs may relate to unique habitats, surroundings, diet and their respective physiological functions. | MA Yuexin LI Ming SUN Jingxian HAO Zhenlin LIANG Jun ZHAO Xuewei | 2019 | Journal of Ocean University of China2019，18，2： | 2 |
| 7 | Emissions of Biogenic Sulfur Gases(H2S,COS)from Phragmites australis Coastal Marsh in the Yellow River Estuary of China显示文摘Emissions of biogenic sulfur gases(hydrogen sulfide(H_2S) and carbonyl sulfide(COS)) from Phragmites australis coastal marsh in the Yellow River estuary of China were determined during April to December in 2014 using static chamber-gas chromatography technique with monthly sampling. The results showed that the fluxes of H_2S and COS both had distinct seasonal and diurnal variations. The H_2S fluxes ranged from 0.09 μg/(m^2·h) to 7.65 μg/(m^2·h), and the COS fluxes ranged from –1.10 μg/(m^2·h) to 3.32 μg/(m^2·h). The mean fluxes of H_2S and COS from the P. australis coastal marsh were 2.28 μg/(m^2·h), and 1.05 μg/(m^2·h), respectively. The P. australis coastal marsh was the emission source of both H_2S and COS over the whole year. Fluxes of H_2S and COS were both higher in plant growing season than in the non-growing season. Temperature had a dramatic effect on the H_2S emission flux, while the correlations between COS flux and the environmental factors were not found during sampling periods. More in-depth and comprehensive research on other related factors, such as vegetation, sediment substrates, and tidal action is needed to discover and further understand the key factors and the release mechanism of sulfur gases. | LI Xinhua ZHU Zhenlin YANG Liping SUN Zhigao | 2016 | Chinese Geographical Science2016，26，6： | 2 |
| 8 | Effect of γ-ir- radiation on some physioehemieal properties of konjac glucoman- nan显示文摘 | Xu Zhenlin Sun Yuanming Yang Youhui | 2007 | Carbohydrate Polymers2007，70，4： | 1 |
| 9 | Novel hapten synthesis for antibody production and development of an enzyme- linked immunosorbent assay for determination of furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ)显示文摘 | Xu Zhenlin Shen Yudong Sun Yuanming | 2013 | Talanta2013，103，： | 1 |
| 10 | Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury显示文摘Wallerian degeneration,the progressive disintegration of distal axons and myelin that occurs after peripheral nerve injury,is essential for creating a permissive microenvironment for nerve regeneration,and involves cytoskeletal reconstruction.However,it is unclear whether microtubule dynamics play a role in this process.To address this,we treated cultured sciatic nerve explants,an in vitro model of Wallerian degeneration,with the microtubule-targeting agents paclitaxel and nocodazole.We found that paclitaxel-induced microtubule stabilization promoted axon and myelin degeneration and Schwann cell dedifferentiation,whereas nocodazole-induced microtubule destabilization inhibited these processes.Evaluation of an in vivo model of peripheral nerve injury showed that treatment with paclitaxel or nocodazole accelerated or attenuated axonal regeneration,as well as functional recovery of nerve conduction and target muscle and motor behavior,respectively.These results suggest that microtubule dynamics participate in peripheral nerve regeneration after injury by affecting Wallerian degeneration.This study was approved by the Animal Care and Use Committee of Southern Medical University,China(approval No.SMUL2015081) on October 15,2015. | Jingmin Liu Lixia Li Ying Zou Lanya Fu Xinrui Ma Haowen Zhang Yizhou Xu Jiawei Xu Jiaqi Zhang Mi Li Xiaofang Hu Zhenlin Li Xianghai Wang Hao Sun Hui Zheng Lixin Zhu Jiasong Guo | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 11 | No-vel hapten synthesis for antibody production and develop-ment of an enzyme-linked immunosorbent assay for deter-mination of furaltadone metabolite 3-amino-5-morpholinom-ethyl-2-oxazolidinone (AMOZ)显示文摘 | XU Zhenlin SHEN Yudong SUN Yuanming | | 0，，： | 1 |
| 12 | Synthesis of CaIn2O4 Rods and Its Photocatalytic Performance Under Visible-light Irradiation显示文摘 | Jianjun Ding Song Sun Jun Bao Zhenlin Luo Chen Gao | 2009 | Catalysis Letters (-)2009，，1： | 1 |
| 13 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 14 | Drug discovery of sclerostin inhibitors显示文摘Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy. | Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 15 | Effect of ',/- irradiation on some physiochemical properties of konjac glucomannan 显示文摘 | Zhenlin Xu Yuanming Sun Youhui Yang | 2007 | Carbohydrate Polymers2007，70，4： | 1 |
| 16 | Wall slip behavior of cemented paste backfill slurry during pipeline based on noncontact experimental detection显示文摘Wall slip is a microscopic phenomenon of cemented paste backfill(CPB)slurry near the pipe wall,which has an important influence on the form of slurry pipe transport flow and velocity distribution.Directly probing the wall slip characteristics using conventional experimental methods is difficult.Therefore,this paper established a noncontact experimental platform for monitoring the microscopic slip layer of CPB pipeline transport independently based on particle image velocimetry(PIV)and analyzed the effects of slurry temperature,pipe diameter,solid concentration,and slurry flow on the wall slip velocity of the CPB slurry,which refined the theory of the effect of wall slip characteristics on pipeline transport.The results showed that the CPB slurry had an extensive slip layer at the pipe wall with significant wall slip.High slurry temperature improved the degree of particle Brownian motion within the slurry and enhanced the wall slip effect.Increasing the pipe diameter was not conducive to the formation of the slurry slip layer and led to a transition in the CPB slurry flow pattern.The increase in the solid concentration raised the interlayer shear effect of CPB slurry flow and the slip velocity.The slip velocity value increased from 0.025 to 0.056 m·s^(-1)when the solid content improved from 55wt%to 65wt%.When slurry flow increased,the CPB slurry flocculation structure changed,which affected the slip velocity,and the best effect of slip layer resistance reduction was achieved when the transported flow rate was 1.01 m^(3)·h^(-1).The results had important theoretical significance for improving the stability and economy of the CPB slurry in the pipeline. | Zhenlin Xue Haikuan Sun Deqing Gan Zepeng Yan Zhiyi Liu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，8： | 0 |
| 17 | Distribution Characteristics of Fat Greenling(Hexagrammos otakii) Inhabiting Artificial Reefs Around Qiansandao Island, Haizhou Bay, China显示文摘Chinese government has provided vigorous financial supports to artificial reef(AR)projects to repair marine ecosystem.Qiansandao AR,an important AR project of Fishery Resource Restoration Program in Shandong Province,was built during 2002 to 2007.It has enhanced the local fishery harvest and generated positive economic benefits.Fat greenling(Hexagrammos otakii)is a major commercial reef fish in Qiansandao with high economic values.Its distribution characteristics need to be further studied.In this research,we studied the potential influence of environmental variables and distance from ARs on catch per unit effort(CPUE)and body length of fat greenlings.The results showed that the average body length of fat greenlings distributed within 10 m from ARs was longer than that of fat greenlings distributed more than 600 m away from ARs.Body length also increased with the increased salinity,while it declined as temperature increased.The probability of the presence of fat greenling increased when temperature was below 20℃,then it slightly decreased.CPUE decreased as the distance increased.Our results elucidate the potential effects of environmental variables and distance from ARs on the distribution of fat greenling,which may also be helpful to the distribution research of other reef fish species. | WANG Xinmeng SUN Peng TANG Yanli LIANG Zhenlin | 2019 | Journal of Ocean University of China2019，18，5： | 0 |
| 18 | Recurrent melanonychia on multiple nails and alopecia induced by hydroxyurea therapy显示文摘To the Editor:A 65-year-old Asian woman presented with pigmented nails for'5 years.She had a 9-year history of primarythrombocytosis andwas treatedwith hydroxyurea in varyingdoses rangingfrom500 to1000mgdaily5 years ago.After taking hydroxyurea she noticed that brown-dark pigmented bands had appeared on her nails,but without any other symptom. | Yifang Sun Zhenlin Xu Xiaolan Ding | 2022 | Chinese Medical Journal2022，135，17： | 0 |
| 19 | Study of transmission grating diffraction efficiencies for soft X-ray显示文摘Tansmission grating spectrometers are extensively used to measure absthlute X-ray spectra in a photon-energy range below 1000 eV. The transmission grating,as its dispersive element, must be calibrated to obtain its danaction efficiencies. Calibrations of absolute distraction efficiencies of the tlansmission grating at photon energyof 844eV have been carried out on Beliing Synchrotron mediation Facility. With theaid of grating model, all of the grating structure paraxneters have been determinedand the absolute dchaction efficiencies in a photon-energy range below 2000eV havealso been calculated and discussed. | YANG Jiamin DING Yaonan ZHENG Zhijian YI Rongqing SUN Kexu CUI Mingqi CUl Congwu ZHU Peiping CHEN Zhenlin LI Chaoguang WANG Yaomei (Insfifule of Nuclear Physics and Chetnisfry, CAEP, Chengdu 610003*Beijing institute of High Energy Physics, the Ch | 1999 | Nuclear Science and Techniques1999，10，2： | 0 |
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