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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Review:Chromatic Dispersion Manipulation Based on Optical Metasurfaces显示文摘Metasurfaces are densely arrayed two⁃dimensional(2D)artificial planar metamaterials,which can manipulate the polarization,distribution,and amplitude of light by accurately controlling the phase of the scattering light.The flat metasurface has the potential to substantially reduce the thickness and complexity of the structures and allows ease of fabrication and integration into devices.However,the inherent chromatic aberration of the metasurface originating from the resonant dispersion of the antennas and the intrinsic chromatic dispersion limit their quality.How to effectively suppress or manipulate the chromatic aberration of metalenses has attracted worldwide attention in the last few years,leading to a variety of excellent achievements.Furthermore,utilizing the chromatic dispersion of metasurface to realize special functionalities is also of significant importance.In this review,the most promising recent examples of chromatic dispersion manipulation based on optical metasurface materials are highlighted and put into perspective. | Boyan Fu Xiujuan Zou Tao Li Shuming Wang Zhenlin Wang Shining Zhu | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，3： | 2 |
| 3 | Large-area surface-enhanced Raman scattering-active substrates fabricated by femtosecond laser ablation显示文摘A rapid and simple approach to fabricate large-area surface-enhanced Raman scattering-active(SERS-active) substrates is reported.The substrates are fabricated by using femtosecond laser(fs-laser) direct writing on Silicon wafers,followed by thin-film coating of metal such as gold.The substrates are demonstrated to exhibit signal homogeneity and good enhancement ability for SERS.The maximum enhancement factor(EF) up to 3×10 7 of such SERS substrates for rhodamine 6G(R6G) at 785 nm excitation wavelength was measured.This technique could demonstrate a functional microchip with SERS capability of signal homogeneity,high sensitivity and chemical stability. | ZHU ZhiQing YAN ZhenDong ZHAN Peng WANG ZhenLin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 4 | Integrating the optical tweezers and spanner onto an individual single-layer metasurface显示文摘Optical tweezers(OTs)and optical spanners(OSs)are powerful tools of optical manipulation,which are responsible for particle trapping and rotation,respectively.Conventionally,the OT and OS are built using bulky three-dimensional devices,such as microscope objectives and spatial light modulators.Recently,metasurfaces are proposed for setting up them on a microscale platform,which greatly miniaturizes the systems.However,the realization of both OT and OS with one identical metasurface is posing a challenge.Here,we offer a metasurface-based solution to integrate the OT and OS.Using the prevailing approach based on geometric and dynamic phases,we show that it is possible to construct an output field,which promises a high-numerical-aperture focal spot,accompanied with a coaxial vortex.Optical trapping and rotation are numerically demonstrated by estimating the mechanical effects on a particle probe.Moreover,we demonstrate an on-demand control of the OT-to-OS distance and the topological charge possessed by the OS.By revealing the OT–OS metasurfaces,our results may empower advanced applications in on-chip particle manipulation. | TIANYUE LI XIAOHAO XU BOYAN FU SHUMING WANG BAOJUN LI ZHENLIN WANG SHINING ZHU | 2021 | Photonics Research2021，9，6： | 2 |
| 5 | Emissions of Biogenic Sulfur Gases(H2S,COS)from Phragmites australis Coastal Marsh in the Yellow River Estuary of China显示文摘Emissions of biogenic sulfur gases(hydrogen sulfide(H_2S) and carbonyl sulfide(COS)) from Phragmites australis coastal marsh in the Yellow River estuary of China were determined during April to December in 2014 using static chamber-gas chromatography technique with monthly sampling. The results showed that the fluxes of H_2S and COS both had distinct seasonal and diurnal variations. The H_2S fluxes ranged from 0.09 μg/(m^2·h) to 7.65 μg/(m^2·h), and the COS fluxes ranged from –1.10 μg/(m^2·h) to 3.32 μg/(m^2·h). The mean fluxes of H_2S and COS from the P. australis coastal marsh were 2.28 μg/(m^2·h), and 1.05 μg/(m^2·h), respectively. The P. australis coastal marsh was the emission source of both H_2S and COS over the whole year. Fluxes of H_2S and COS were both higher in plant growing season than in the non-growing season. Temperature had a dramatic effect on the H_2S emission flux, while the correlations between COS flux and the environmental factors were not found during sampling periods. More in-depth and comprehensive research on other related factors, such as vegetation, sediment substrates, and tidal action is needed to discover and further understand the key factors and the release mechanism of sulfur gases. | LI Xinhua ZHU Zhenlin YANG Liping SUN Zhigao | 2016 | Chinese Geographical Science2016，26，6： | 2 |
| 6 | A Mechanically Tunable Plasmonic Structure Composed of a Monolayer Array of Metal-Capped Colloidal Spheres on an Elastomeric Substrate显示文摘A highly stretchable plasmonic structure composed of a monolayer array of metal-capped colloidal spheres on an elastomeric substrate has been fabricated using simple and inexpensive self-assembly and transfer-printing techniques.This composite structure supports coupled surface plasmons whose wavelengths are sensitive to the arrangement of the metal-capped colloidal spheres.Upon stretching,the lattice of metal-capped colloidal spheres will be deformed,leading to a large wavelength shift of surface plasmon resonances and simultaneously an obvious color change.This stretchable plasmonic structure offers a promising approach to tune surface plasmon resonances and might be exploited in realizing flexible plasmonic devices with tunability of mechanical strain. | Xiaolong Zhu Lei Shi Xiaohan Liu Jian Zi Zhenlin Wang | 2010 | Nano Research2010，3，11： | 1 |
| 7 | Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury显示文摘Wallerian degeneration,the progressive disintegration of distal axons and myelin that occurs after peripheral nerve injury,is essential for creating a permissive microenvironment for nerve regeneration,and involves cytoskeletal reconstruction.However,it is unclear whether microtubule dynamics play a role in this process.To address this,we treated cultured sciatic nerve explants,an in vitro model of Wallerian degeneration,with the microtubule-targeting agents paclitaxel and nocodazole.We found that paclitaxel-induced microtubule stabilization promoted axon and myelin degeneration and Schwann cell dedifferentiation,whereas nocodazole-induced microtubule destabilization inhibited these processes.Evaluation of an in vivo model of peripheral nerve injury showed that treatment with paclitaxel or nocodazole accelerated or attenuated axonal regeneration,as well as functional recovery of nerve conduction and target muscle and motor behavior,respectively.These results suggest that microtubule dynamics participate in peripheral nerve regeneration after injury by affecting Wallerian degeneration.This study was approved by the Animal Care and Use Committee of Southern Medical University,China(approval No.SMUL2015081) on October 15,2015. | Jingmin Liu Lixia Li Ying Zou Lanya Fu Xinrui Ma Haowen Zhang Yizhou Xu Jiawei Xu Jiaqi Zhang Mi Li Xiaofang Hu Zhenlin Li Xianghai Wang Hao Sun Hui Zheng Lixin Zhu Jiasong Guo | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 8 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 9 | Comparison of six statistical approaches in the selection of appropriate fish growth models显示文摘 | ZHU Lixin LI Lifang LIANG Zhenlin | | 0，，03： | 1 |
| 10 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 11 | Quantum photonics based on metasurfaces显示文摘From metamaterials to metasurfaces,optical nano-structure has been widely investigated for novel and high efficiency functionalities.Apart from the intrisinsic properties of composite material,rich capabilities can be derived from the judi-cious design of metasurfaces,which enable more excellent and highly integrated optical devices than traditional bulk op-tical elements.In the meantime,the abundant manipulation abilites of light in the classical domain can be carried over in-to quantum domain.In this review,we highlight recent development of quantum optics based on metasurfaces,ranging from quantum plasmonics,generation,manipulation and appplication of quantum light to quantum vaccum engineering etc.Finally,some promising avenues for quantum optics with the help of optical metasurface are presented. | Jun Liu Mingqian Shi Zhuo Chen Shuming Wang Zhenlin Wang Shining Zhu | 2021 | Opto-Electronic Advances2021，4，9： | 1 |
| 12 | The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis显示文摘DNA methylation,a conserved epigenetic mark,is critical for tuning temporal and spatial gene expression.The Arabidopsis thaliana DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)initiates active DNA demethylation and is required to prevent DNA hypermethylation at thousands of genomic loci.However,how ROS1 is recruited to specific loci is not well understood.Here,we report the discovery of Arabidopsis AGENET Domain Containing Protein 3(AGDP3)as a cellular factor that is required to prevent gene silencing and DNA hypermethylation.AGDP3 binds to H3K9me2 marks in its target DNA via its AGD12 cassette.Analysis of the crystal structure of the AGD12 cassette of AGDP3 in complex with an H3K9me2 peptide revealed that dimethylated H3 K9 and unmodified H3 K4 are specifically anchored into two different surface pockets.A histidine residue located in the methyllysine binding aromatic cage provides AGDP3 with pH-dependent H3K9me2 binding capacity.Our results uncover a molecular mechanism for the regulation of DNA demethylation by the gene silencing mark H3K9me2. | Xuelin Zhou Mengwei Wei Wenfeng Nie Yue Xi Li Peng Qijie Zheng Kai Tang Viswanathan Satheesh Yuhua Wang Jinyan Luo Xuan Du Rui Liu Zhenlin Yang Honggui La Yingli Zhong Yu Yang Jian-Kang Zhu Jiamu Du Mingguang Lei | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
| 13 | Study of transmission grating diffraction efficiencies for soft X-ray显示文摘Tansmission grating spectrometers are extensively used to measure absthlute X-ray spectra in a photon-energy range below 1000 eV. The transmission grating,as its dispersive element, must be calibrated to obtain its danaction efficiencies. Calibrations of absolute distraction efficiencies of the tlansmission grating at photon energyof 844eV have been carried out on Beliing Synchrotron mediation Facility. With theaid of grating model, all of the grating structure paraxneters have been determinedand the absolute dchaction efficiencies in a photon-energy range below 2000eV havealso been calculated and discussed. | YANG Jiamin DING Yaonan ZHENG Zhijian YI Rongqing SUN Kexu CUI Mingqi CUl Congwu ZHU Peiping CHEN Zhenlin LI Chaoguang WANG Yaomei (Insfifule of Nuclear Physics and Chetnisfry, CAEP, Chengdu 610003*Beijing institute of High Energy Physics, the Ch | 1999 | Nuclear Science and Techniques1999，10，2： | 0 |
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